Abstract:

Every 75 seconds, there’s a child below 5 years of age who is dying from malaria throughout the world. Burkina Faso, which also suffers from the ravages of malaria, has developed several strategies to respond to the disease including seasonal malaria chemoprophylaxis (SMC). To generate basic data available for the study of the efficacy of a supervised distribution of the 3 doses of SMC, we conducted this study outside of SMC campaigns to determine the prevalence of malaria among children between 3 and 59 months old in two healthcare districts. A transversal descriptive study was conducted on children in the healthcare districts of Boromo and Gaoua. Data were collected on sociodemographic, and clinical features as well as on knowledge and practices on prevention outside of SMC from December 10 to 24, 2020. The prevalence of malaria was calculated, globally, and in each district and compared to each other using a chi-square test. Among the 2440 children, those from 2 to 5 years were the most represented with 64.22% (p < 0.0001). A total of 83.93% of families had long-lasting insecticide-treated nets (LLINs) (p<0.0001) and 68.57% had used them (p =0.04). The overall prevalence of malaria was 4.75%; the ones in Boromo and Gaoua were respectively 3.63% and 6.60% p=0,034). This study showed a high prevalence of malaria among children between 3 and 59 months, especially in Gaoua. Interventions should target parents of children in this age group and focus on promoting the use of LLINs.

References:

[1].   Carnevale, P. et Robert, V., éditeurs. (2009) Les anophèles: Biologie, transmission du Plasmodium et lutte antivectorielle [Internet]. IRD Éditions. https://doi.org/10.4000/books.irdeditions.10374.

[2].   WHO. (2023) Rapport 2023 sur le paludisme dans le monde [Internet]. https://www.who.int/fr/teams/global-malaria-programme/reports/world-malaria-report-2023.

[3].   Gentilini, M., Caumes, E., Danis, M., Mouchet, J., Duflo, B., Lagardère, B. et al. (1993) Médecine tropicale. https://horizon.documentation.ird.fr/exl-doc/pleins_textes/2021-08/39636.pdf.

[4].   WHO. (2021) Rapport 2021 sur le paludisme dans le monde, Principaux messages. https://cdn.who.int/media/docs/default-source/malaria/world-malaria-reports/world-malaria-report-2021-global-briefing-kit-fre.pdf.

[5].   Chilot, D., Mondelaers, A., Alem, A.Z., Asres, M.S., Yimer, M.A., Toni, A.T. et al. (2023) Pooled prevalence and risk factors of malaria among children aged 6-59 months in 13 sub-Saharan African countries: A multilevel analysis using recent malaria indicator surveys. PloS One, 18, e0285265. https://doi.org/10.1371/journal.pone.0285265.

[6].   WHO et RBM. (2018) High burden to high impact: A targeted malaria response. https://iris.who.int/bitstream/handle/10665/275868/WHO-CDS-GMP-2018.25-eng.pdf?sequence=1.

[7].   Ministère de la Santé et de l’Hygiène publique Burkina. (2022) Annuaire statistique 2021 [Internet]. http://cns.bf/IMG/pdf/annuaire_mshp_2021_signe.pdf.

[8].   Kouadio, A.S., Cissé, G., Obrist, B., Wyss, K. et Zingsstag, J. (2006) Fardeau économique du paludisme sur les ménages démunis des quartiers défavorisés d’Abidjan, Côte d’Ivoire. VertigO - la revue électronique en sciences de l’environnement, Les éditions en environnements VertigO. https://doi.org/10.4000/vertigo.1776.

[9].   World Health Organization. (2015) Global technical strategy for malaria 2016-2030 [Internet]. https://www.who.int/docs/default-source/documents/global-technical-strategy-for-malaria-2016-2030.pdf.

[10].  Oumar, A., BA, M., Diallo, D., Sanogo, M., Ousmane, F., Diawara, S. et al. (2020) Impact of seasonal malaria chemoprevention in children aged 3 to 59 months in the Kangaba and Kolokani health districts between 2013 and 2015. Revue malienne d’infectiologie et de microbiologie, 15, 54‑60. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8225235/.

[11].  Ministère de la Santé et de l’Hygiène publique Burkina. (2020) Annuaire statistique 2020 [Internet]. https://www.sante.gov.bf/fileadmin/user_upload/storages/annuaire_statistique_ms_2020_signe.pdf.

[12].  Hayes, R.J. et Bennett, S. (1999) Simple sample size calculation for cluster-randomized trials. International Journal of Epidemiology, 28, 319‑26. https://doi.org/10.1093/ije/28.2.319.

[13].  WHO. (2021) Terminologie OMS du paludisme, Mise à jour 2021 [Internet]. https://www.who.int/fr/publications-detail/9789240038400.

[14].  Minstère de la Santé. du Burkina. (2018) Enquête sur les Indicateurs du Paludisme (EIPBF) 2017-2018 [Internet]. https://dhsprogram.com/pubs/pdf/MIS32/MIS32.pdf.

[15].  Mohammed, K., Salifu, M.G., Batung, E., Amoak, D., Avoka, V.A., Kansanga, M. et al. (2022) Spatial analysis of climatic factors and plasmodium falciparum malaria prevalence among children in Ghana. Spatial and Spatio-Temporal Epidemiology, 43, 100537. https://doi.org/10.1016/j.sste.2022.100537.

[16].  Abossie, A., Yohanes, T., Nedu, A., Tafesse, W. et Damitie, M. (2020) Prevalence of Malaria and Associated Risk Factors Among Febrile Children Under Five Years: A Cross-Sectional Study in Arba Minch Zuria District, South Ethiopia. Infection and Drug Resistance, 13, 363‑72. https://doi.org/10.2147/IDR.S223873.

[17].  Ministère de la santé. (2010) Directives nationales pour la prise en charge du paludisme dans les formations sanitaires du Burkina Faso [Internet]. https://pdf.usaid.gov/pdf_docs/PA00JPHB.pdf.

[18].  Musuyi, C.N., Djourdebbe, F.B. et Ekambi, E. (2021) Déterminants Individuels Et Contextuels Du Paludisme Chez Les Enfants De 6-59 Mois En République Démocratique Du Congo. European Scientific Journal, ESJ, 17, 94‑94. https://doi.org/10.19044/esj.2021.v17n7p94.

Abstract:

The eruption of the primary dentition, their exfoliation due to root resorption, and then the eruption of the permanent dentition follow in an orderly sequence. After the apices close, initial resorption starts between one and three years later, and exfoliation happens about three years later.Radiographs of primary lower molar teeth among children in the age group 5 to 12 years were taken. Age Groups were divided into less than 8 years, 8 to 9 years, 10 to 11 years and 12 years or more from 2020 to 2023 around 250 patients data were collected. Digital radiographs (RVG) of the primary mandibular molar were used to measure the resorption in EZ DentI software. In the actual extracted tooth, the root resorption was measured with a scale from CEJ of the tooth to the resorbed apex for the mesial root & distal root respectively. Based on results obtained in the radiograph, the number of 79 teeth had  < ¼ resorption, 86 teeth had ¼ - ¾ resorption and 85 teeth had > ¾ resorption. In actual teeth, the number of 75 had < ¼ resorption, 85 had ¼ - ¾ resorption and 90 had > ¾ resorption. The resorption was symmetrical in 115 teeth, maximum in the mesial root was seen in 75 and the maximum in the distal root was seen in 60. When comparing root resorption in IOPA to actual root resorption, there was not much of a difference in the degree of resorption.

References:

Abstract:

Over 1.2 million newborns are exposed to HIV annually, with Zambia contributing significantly due to its 21% HIV prevalence among pregnant women. Testing exposed infants is crucial for early diagnosis. This study utilized a case-control design study to evaluate the effectiveness of the Electronic Health Exposed Infant Monitoring tool in improving Early Infant Diagnosis services in the Kabwe and Chibombo districts of Zambia. Our study was conducted across 16 health facilities involving 248 infant-mother pairs aged 0 to 2 months. Of these, 163 pairs were enrolled into the EHEI_Mt system, while 85 pairs continued being tracked by the existing standard system. Both groups were monitored for 12 months using the electronic tool and Ministry of health standard systems. Descriptive analysis with Pearson Chi2-test was done to determine associations between the use of a tracking system for HIV Exposed infants and other explanatory variables. A stepwise, backward logistic regression model was fitted to predict factors associated with early infant diagnosis uptake. All analyses were done using STATA version 25 (Stata Corp, US Texas. No mother-related factors were significantly associated, but babies in the EHEI_Mt Tool group were more likely to keep appointments (p < 0.001), with 73% having a known HIV outcome compared to 22% in the Standard group. We recommend standalone electronic systems as a reminder for healthcare workers for better infant tracking and adherence. Further research on HIV-positive mothers ' perceptions of current early infant diagnosis health systems is needed to address gaps in the PMTCT program for improved outcomes.

References:

[1].   Joint United Nations Programme on HIV/AIDS. (2023). Global report: UNAIDS report on the global AIDS epidemic. Geneva. Retrieved from http://www.unaids.org/globalreport/documents/20101123_GlobalReport_full_en.pdf.

[2].   Joint United Nations Programme on HIV/AIDS. (2010). Zambia country report: Monitoring the Declaration of Commitment on HIV and AIDS and the universal access: Biennial report. Geneva. Retrieved from http://www.unaids.org/en/dataanalysis/monitoringcountryprogress/2010progressreportssubmittedbycountries/zambia_2010_country_progress_report_en.pdf.

[3].   Finocchario-Kessler, S., Goggin, K., Khamadi, S., Gautney, B. (2015). Improving early infant HIV diagnosis in Kenya: Study protocol of a cluster-randomized efficacy trial of the HIT System. Implementation Science, 10, 96. https://doi.org/10.1186/s13012-015-0284-3.

[4].   Ministry of Health, Zambia. (2020). Zambia Consolidated Guidelines for Treatment and Prevention of HIV Infection 2020. Retrieved from https://www.moh.gov.zm/wp-content/uploads/filebase/Zambia-Consolidated-Guidelines-for-Treatment-and-Prevention-of-HIV-Infection-2020.pdf.

[5].   Ministry of Health, Zambia. (2023). National Health Strategic Plan for Zambia 2022 to 2026 (Revised February 2023) [PDF]. Retrieved from https://www.moh.gov.zm/wp-content/uploads/2023/02/National-Health-Stratergic-Plan-for-Zambia-2022-to-2026-revised-February-2023-lower-resolution.pdf.

[6].   Ahoua, L., Arikawa, S., Tiendrebeogo, T., Lahuerta, (2020). Measuring retention in care for HIV-positive pregnant women in Prevention of Mother-to-Child Transmission of HIV (PMTCT) option B+ programs: The Mozambique experience. BMC Public Health, 20(1), 322.https://doi.org/10.1186/s12889-020-8406-5.

[7].   Gumede-Moyo, S., Todd, J., Bond, V., Mee, P., & Filteau, S. (2019). A qualitative inquiry into implementing an electronic health record system (SmartCare) for prevention of mother-to-child transmission data in Zambia: A retrospective study. BMJ Open, 9(9), e030428.https://doi.org/10.1136/bmjopen-2019-030428.

[8].   Measure Evaluation. (2019). Testing a PMTCT Tracker in Zimbabwe_tr-19-333 [Technical Report]. Retrieved from https://www.measureevaluation.org/resources/publications/tr-19-333/at_download/document.

[9].   Brown, M., Wexler, C., Gautney, B., Goggin, K., Hurley, E. A., Odeny, B., Maloba, M., Lwembe, R., Sandbulte, M., & Finocchario-Kessler, S. (2019). eHealth Interventions for Early Infant Diagnosis: Mothers' Satisfaction with the HIV Infant Tracking System in Kenya. AIDS and Behaviour, 23(11), 3093-3102. doi:10.1007/s10461-019-02579-5.

[10].  Dunning, L., Kroon, M., Fourie, L., Ciaranello, A., & Myer, L. (2017). Impact of Birth HIV-PCR Testing on the Uptake of Follow-up Early Infant Diagnosis Services in Cape Town, South Africa. Paediatric Infectious Disease Journal, 36(12), 1159-1164.doi: 0.1097/INF.0000000000001677.

[11].  Ankunda, R., Cumber, S. N., Atuhaire, C., Kabanda, T., Nkfusai, C. N., Wirsiy, F. S., & Turyakira, E. (2020). Loss to follow-up and associated maternal factors among HEIs at the Mbarara Regional Referral Hospital, Uganda: A retrospective study. BMC Infectious Diseases, 20(1), 235. doi: 10.1186/s12879-020-04964-1.

[12].  Mute, T., Akondé, A., & Doumbia, A. (2011). The prevention of mother-to-child transmission of HIV-1 in Mali HIV-1-positive pregnant women and loss to follow-up in the Segou region. 6th IAS Conference on HIV Pathogenesis and Treatment Abstract no. MOPE480.

[13].  Nyandiko, W. M., Otieno-Nyunya, B., Musick, B., Bucher-Yiannoutsos, S., Akhaabi, P., Lane, K., Yiannoutsos, C. T., & Wools-Kaloustian, K. (2010). Outcomes of HIV-exposed children in western Kenya: Efficacy of prevention of mother to child transmission in a resource-constrained setting. Journal of Acquired Immune Deficiency Syndromes, 54(1), 42-50. doi: 10.1097/QAI.0b013e3181d8ad51.

[14].  Ebonwu, J., Mumbauer, A., Uys, M., Wainberg, M. L., & Medina-Marino, A. (2018). Determinants of late antenatal care presentation in rural and peri-urban communities in South Africa: A cross-sectional study. PLoS ONE, 13(3), e0191903.

[15].  Tesfaye, G., Loxton, D., Chojenta, C., Semahegn, A., & Smith, R. (2017). Delayed initiation of antenatal care and associated factors in Ethiopia: A systematic review and meta-analysis. Reproductive Health, 14(1), 1–17.

[16].  Nikhare, K., Gawde, N., Kamble, S., et al. (2024). Caregivers’ experiences of accessing HIV Early Infant Diagnosis (EID) services and its barriers and facilitators, India. BMC Health Services Research,24(1), 24. https://doi.org/10.1186/s12913-023-10500-z.

[17].  Kiilu, E. M., Karanja, S., & Kikuvi, G. P. W. (2019). Caregiver factors influencing seeking of Early Infant Diagnosis (EID) of HIV services in selected hospitals in Nairobi County, Kenya: A Qualitative Study. International Journal of Scientific and Research Publications, 9(4). https://doi.org/10.29322/IJSRP.9.04.2019.p8825.

[18].  Adeniyi, V. O., Thomson, E., Goon, D. T., & Ajayi, I. A. (2015). Disclosure, stigma of HIV positive child and access to early infant diagnosis in the rural communities of OR Tambo District, South Africa: A qualitative exploration of maternal perspective. BMC Pediatrics, 15(1), 98. https://doi.org/10.1186/s12887-015-0414-8.

[19].  Kalembo, F. W., Zgambo, M., Mulaga, A. N., Yukai, D., & Ahmed, N. I. (2012). Association between household socioeconomic status and adherence to exclusive breastfeeding among HIV-exposed infants in Malawi. World Journal of AIDS, 2(2), 195-200. https://doi.org/10.4236/wja.2012.22025.

[20].  Kreitchmann, R., Harris, D. R., Kakehasi, F., Haberer, J. E., Cahn, P., Losso, M., ... & Read, J. S. (2012). Loss to follow-up among HEIs in Latin America and the Caribbean: the NISDI Pediatric Study. International Journal of Infectious Diseases, 16(12), e935-e941. https://doi.org/10.1016/j.ijid.2012.07.023.

[21].  Cook, R. E., Ciampa, P. J., Sidat, M., Blevins, M., Burlison, J., Davidson, M. A., ... & Moon, T. D. (2011). Predictors of successful early infant diagnosis of HIV in a rural district hospital in Zambezia, Mozambique. Journal of Acquired Immune Deficiency Syndromes (1999), 56(4), e104-e109. https://doi.org/10.1097/QAI.0b013e3182047c97.

[22].  Bazira, J., Apio, K., Kyambadde, M., Nakawungu, R., Nduhuura, D., Ayebarirwe, M., Orikiriza, P., & Kumbakumba, E. (2022). Good Utilization, Low Completion Rates of Early Infant HIV Diagnostic Services at a District Hospital in Rural, Southwestern Uganda. https ://doi.org/10.21203/rs.3.rs-1342532/v1.

[23].  Odekunle, F. F., Adekunle, R. O., & Shankar, S. (2017). Why sub-Saharan Africa lags in electronic health record adoption and possible strategies to increase its adoption in this region. International Journal of Health Sciences, 11, 59-64.

[24].  Modi, S., Callahan, T., Rodrigues, J., Kajoka, M. D., & Dale, H. M. (2017). Overcoming Health System Challenges for Women and Children Living with HIV Through the Global Plan. Journal of Acquired Immune Deficiency Syndromes, 75(Suppl1)S76-S85. doi:10.1097/QAI.0000000000001336.

[25].  World Health Organization. (2018). Prevention of mother-to-child transmission of HIV: Technical update. Retrieved from https://www.afro.who.int/sites/default/files/2018-06/Prevention%20of%20mother-to-child%20transmission%20-%20Technical%20update.pdf.

[26].  Simbaya, J., Funjika, P., Moonga, A., Mwale, J., & Kankasa, C. (2021). Feasibility of using infant testing during immunization to estimate HIV mother-to-child transmission rates in Zambia. BMC Infectious Diseases, 21(1), 1239. doi: 10.1186/s12879-021-06892-0.

[27].  Dunning, L., Gandhi, A. R., Penazzato, M., Soeteman, D. I., & Revill, P. (2021). Optimizing infant HIV diagnosis with additional screening at immunization clinics in three sub-Saharan African settings: A cost-effectiveness analysis. Journal of the International AIDS.

[28].  Suryavanshi, N., Kadam, A., Gupte, N., et al. (2020). A mobile health-facilitated behavioural intervention for community health workers improves exclusive breastfeeding and early infant HIV diagnosis in India: A cluster randomized trial. Journal of the International AIDS Society, 23(7), e25555. https://doi.org/10.1002/jia2.25555.

[29].  Micek, M. A., Gimbel, S., Baptista, A. J., Karagianis, M., Coutinho, M., & Pfeiffer, J. (2014). Evaluation of routine health assessments and vaccination coverage at the 9-month mark in Mozambique. Journal of Pediatric Health Care, 28(6), 505-512. https://doi.org/10.1016/j.pedhc.2014.02.007.

[30].  Obonyo, B., & Mwachari, C. (2013). The impact of routine health assessments and vaccinations on infant health at 9 months in Kenya. East African Medical Journal, 90(5), 192-198. https://doi.org/10.4314/eamj.v90i5.3.

[31].  Banda, R., Habaalu, L., & Chiyesu, G. (2015). The significance of the 9-month health assessment and vaccination schedule for infant health in Zambia. African Health Sciences, 15(3), 856-862. https://doi.org/10.4314/ahs.v15i3.24.

[32].  Chiyesu, G., Habaalu, L., & Banda, R. (2016). The decline in appointment attendance among HEIs beyond the 9-month mark: Implications for tracking and healthcare delivery in Zambia. BMC Pediatrics, 16(1), 125. https://doi.org/10.1186/s12887-016-0662-8-Z.

[33].  Abimbola, J. M., Makanjuola, A. T., Ganiyu, S. A., et al. (2016). The pattern of utilization of ante-natal and delivery services in a semi-urban community of North-Central Nigeria. African Health Sciences, 16(4), 962–971. doi: 10.4314/ahs.v16i4.12.

Abstract:

Coronavirus Disease of 2019 (COVID-19) is caused by the Severe Acute Respiratory Syndrome coronavirus 2(SARS-COV-2). The SARS-COV-2 is a β-coronavirus , which is non-segmented positive-sense RNA virus. The symptoms of COVID-19 may vary. The study was carried out to; examine the individual determinants and socioeconomic determinants and to describe the Health-system determinants of COVID-19 vaccination among Residents of Katanga Slum. The individual determinants were; age between 26 to 35 years (AOR=4.502, CI=1.706-11.886, P=0.002), sex; being of male gender (AOR=2.267, CI=1.316-5.443, P=0.007), marital status; being single (AOR=0.334, CI=0.136-0.820, P=0.017), Being with primary level of education (AOR=17.707, CI=2.393-130.99, P=0.005), occupation; being a peasant (AOR=4.857, CI=1.232-19.14, p=0.024), religion; being a catholic (COR=0.411, CI=0.200-0.846, P-0.016), utilization of health facility for health care (COR=0.047, CI=0.014-0.162, P=0.000) and having a negative attitude towards COVID 19 vaccination (AOR=42.637, CI=320.65, P=0.000). The socio-economic factors were; income (x2=18.861, p=0.000), cost of transport (x2=19.492, p=0.000), cost of vaccination (x2=124.34, p=0.000) and the type of social class of respondents (x2=23.73, p=0.000). In multivariate analysis; only work effect was a determinant of COVID-19 vaccination (AOR=0.327, CI=0.127-0.847 and p=0.021). The health facility determinants were; sensitization (AOR=1.889, CI=1.040-3.431, P=0.037), availability of health workers at facility (AOR=0.211, CI=0.04-0.006, P=0.012), attitudes of health workers (AOR=79.97, CI=11.49-556.3, P=0.000), and Availability of COVID 19 vaccines at the health facility (AOR=0.054, CI=0.006-0.514, P=0.011). The study recommended Increased and continued sensitization for awareness promotion towards the benefits of uptake of COVID-19 vaccination as well as the associated dangers of non-compliance.

References:

[1].   Rothan, H.A. and S.N. Byrareddy, The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak. Journal of Autoimmunity, 2020. 109: p. 102433.

[2].   Cucinotta, D. and M. Vanelli, WHO Declares COVID-19 a Pandemic. Acta Biomed, 2020. 91(1): p. 157-160.

[3].   Guo, Y.-R., et al., The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak–an update on the status. Military Medical Research, 2020. 7: p. 1-10.

[4].   Kaplan, A.K., et al., The willingness to accept the COVID‐19 vaccine and affecting factors among healthcare professionals: A cross‐sectional study in Turkey. International Journal of Clinical Practice, 2021: p. e14226.

[5].   UNICEF and GAVI Uganda receives 864,000 doses of COVID-19 vaccines. 2021.

[6].   Ministry of Health Uganda COVID-19 status. 2021.

[7].   Wang, C., et al., A novel coronavirus outbreak of global health concern. The Lancet, 2020. 395(10223): p. 470-473.

[8].   Gong, F., et al., China’s local governments are combating COVID-19 with unprecedented responses—from a Wenzhou governance perspective. Frontiers of Medicine, 2020: p. 1-5.

[9].   Coe, P.F., L.L. Graper, and C.M. Zangerle, Leading Through the Unknown: A Network Perspective of the COVID-19 Pandemic. Critical Care Nursing Quarterly, 2020. 43(4): p. 451-467.

[10].  Snyder, T.M., et al., Magnitude and dynamics of the T-cell response to SARS-CoV-2 infection at both individual and population levels. MedRxiv, 2020.

[11].  Wu, S.C., Progress and concept for COVID‐19 vaccine development. Biotechnology Journal, 2020.

[12].  UNICEF Uganda receives the first batch of AstraZeneca COVID-19 vaccines. 2021.

[13].  Sun, S., D. Lin, and D. Operario, Interest in COVID-19 vaccine trials participation among young adults in China: Willingness, reasons for hesitancy, and demographic and psychosocial determinants. Preventive Medicine Reports, 2021. 22: p. 101350.

[14].  Reiter, P.L., M.L. Pennell, and M.L. Katz, Acceptability of a COVID-19 vaccine among adults in the United States: How many people would get vaccinated? Vaccine, 2020. 38(42): p. 6500-6507.

[15].  Kreps, S., et al., Factors associated with US adults’ likelihood of accepting COVID-19 vaccination. JAMA network open, 2020. 3(10): p. e2025594-e2025594.

[16].  Guidry, J.P., et al., Willingness to get the COVID-19 vaccine with and without emergency use authorization. American Journal of Infection Control, 2021. 49(2): p. 137-142.

[17].  Li, P., et al., Analysis of factors influencing parents’ willingness to accept the quadrivalent influenza vaccine for school-aged children in the Nanhai District, China. Human Vaccines & Immunotherapeutics, 2020. 16(5): p. 1078-1085.

[18].  UNICEF Uganda launches first phase of COVID-19 vaccination exercise. 2021.

[19].  Akinyemi, P.A., et al., Community perception and determinants of willingness to uptake COVID-19 vaccines among residents of Osun State, South-West Nigeria. International Journal of Community Medicine and Public Health, 2021. 8(4): p. 1551.

[20].  Echoru, I., P. Decanar Ajambo, and E. Bukenya, Acceptance and Risk Perception of COVID-19 Vaccine in Uganda: A Cross Sectional Study in Western Uganda. 2020.

[21].  Daama, A., et al., Willingness to receive COVID-19 vaccines, associated factors and reasons for not taking a vaccine: a cross sectional study among persons aged 13–80 years in Wakiso, Central Uganda. BMC Infectious Diseases, 2024. 24(1): p. 391.

[22].  King, P., et al., COVID-19 vaccine uptake and coverage, Uganda, 2021-2022. UNIPH Bulletin, 2023. 8.

[23].  Kasozi, K.I., et al., A Descriptive-Multivariate Analysis of Community Knowledge, Confidence, and Trust in COVID-19 Clinical Trials among Healthcare Workers in Uganda. Vaccines, 2021. 9(3): p. 253.

[24].  Peretti-Watel, P., et al., A future vaccination campaign against COVID-19 at risk of vaccine hesitancy and politicisation. The Lancet infectious diseases, 2020. 20(7): p. 769-770.

[25].  Mathpati, M.M., et al., ‘Population Self-Reliance in Health’and COVID 19: the need for a 4th Tier in the Health System. Journal of Ayurveda and Integrative Medicine, 2020.

[26].  Kish, L., Sampling organizations and groups of unequal sizes. American Sociological Review, 1965: p. 564-572.

[27].  Creswell, J.W., Qualitative inquiry and research design: Choosing among five traditions. Qualitative inquiry and research design: Choosing among five traditions. 1998, Thousand Oaks, CA, US: Sage Publications, Inc. xv, 403-xv, 403.

[28].  Kuter, B.J., et al., Perspectives on the receipt of a COVID-19 vaccine: A survey of employees in two large hospitals in Philadelphia. Vaccine, 2021. 39(12): p. 1693-1700.

[29].  Browne, N.T., et al., When pandemics collide: the impact of COVID-19 on childhood obesity. Journal of pediatric nursing, 2021. 56: p. 90.

[30].  Nzaji, M.K., et al., Factors associated with COVID-19 vaccine uptake and hesitancy among healthcare workers in the Democratic Republic of the Congo. PLOS Global Public Health, 2024. 4(2): p. e0002772.

[31].  Qattan, A.M., et al., Acceptability of a COVID-19 vaccine among healthcare workers in the Kingdom of Saudi Arabia. Frontiers in medicine, 2021. 8: p. 644300.

[32].  Dror, A.A., et al., Vaccine hesitancy: the next challenge in the fight against COVID-19. European journal of epidemiology, 2020. 35(8): p. 775-779.

[33].  Echoru, I., et al., Sociodemographic factors associated with acceptance of COVID-19 vaccine and clinical trials in Uganda: a cross-sectional study in western Uganda. BMC public health, 2021. 21(1): p. 1106.

[34].  Paudel, P., Online education: Benefits, challenges and strategies during and after COVID-19 in higher education. International Journal on Studies in Education (IJonSE), 2021. 3(2).

[35].  Ruiz, J.B. and R.A. Bell, Predictors of intention to vaccinate against COVID-19: Results of a nationwide survey. Vaccine, 2021. 39(7): p. 1080-1086.

[36].  Barry, M., M. Al Amri, and Z.A. Memish, COVID-19 in the shadows of MERS-CoV in the Kingdom of Saudi Arabia. Journal of epidemiology and global health, 2020. 10(1): p. 1-3.

[37].  Pradhan, A. and P.-E. Olsson, Sex differences in severity and mortality from COVID-19: are males more vulnerable? Biology of sex Differences, 2020. 11(1): p. 53.

[38].  Kanyike, A.M., et al., Acceptance of the coronavirus disease-2019 vaccine among medical students in Uganda. Tropical Medicine and Health, 2021. 49(1): p. 37.

[39].  Wang, H., et al., The psychological distress and coping styles in the early stages of the 2019 coronavirus disease (COVID-19) epidemic in the general mainland Chinese population: A web-based survey. PloS one, 2020. 15(5): p. e0233410.

[40].  Bitar, A.N., et al., Misinformation, perceptions towards COVID-19 and willingness to be vaccinated: a population-based survey in Yemen. PLoS One, 2021. 16(10): p. e0248325.

[41].  De Figueiredo, A., et al., Mapping global trends in vaccine confidence and investigating barriers to vaccine uptake: a large-scale retrospective temporal modelling study. The Lancet, 2020. 396(10255): p. 898-908.

[42].  Jegede, A.S., What led to the Nigerian boycott of the polio vaccination campaign? PLoS medicine, 2007. 4(3): p. e73.

[43].  Machida, M., et al., Acceptance of a COVID-19 Vaccine in Japan during the COVID-19 Pandemic. Vaccines, 2021. 9(3): p. 210.

[44].  Jain, J., et al., COVID-19 vaccine hesitancy among medical students in India. Epidemiology & Infection, 2021. 149: p. e132.

[45].  Bongomin, F., et al., COVID-19 vaccine acceptance among high-risk populations in Uganda. Therapeutic Advances in Infectious Disease, 2021. 8: p. 204993612110243.

[46].  Chou, W.-Y.S. and A. Budenz, Considering emotion in COVID-19 vaccine communication: addressing vaccine hesitancy and fostering vaccine confidence. Health communication, 2020. 35(14): p. 1718-1722.

[47].  Samarasekera, U., Feelings towards COVID-19 vaccination in Africa. The Lancet Infectious Diseases, 2021. 21(3): p. 324.

[48].  Campo-Arias, A. and J.C. Pedrozo-Pupo, COVID-19 vaccine distrust in Colombian university students: Frequency and associated variables. Acta Biomed, 2022. 92(6): p. e2021367.

[49].  Ohemeng-Tinyase, N.A., Factors Associated with Hepatitis B Vaccination Among Asian Adults (≥ 18 Years) in the United States. 2020, Walden University.

[50].  Endalew, M., et al., Limited handwashing facility and associated factors in sub-Saharan Africa: pooled prevalence and multilevel analysis of 29 sub-Saharan Africa countries from demographic health survey data. BMC Public Health, 2022. 22(1): p. 1969.

[51].  Schmidt, C.W., Lack of Handwashing Access: A Widespread Deficiency in the Age of COVID-19. Environ Health Perspect, 2020. 128(6): p. 64002.

[52].  Malande, O.O., et al., Barriers to effective uptake and provision of immunization in a rural district in Uganda. PloS one, 2019. 14(2): p. e0212270.

[53]. Azodo, C., et al., Hepatitis-B vaccination status among dental surgeons in benin city, Nigeria. Ann Med Health Sci Res, 2012. 2(1): p. 24-8.

Abstract:

To evaluate and measure the frequency of multi-drug resistance bacterial isolates in various healthcare environments. This study employed the disc diffusion susceptibility test to assess the antibiotic resistance of Acinetobacter, E. coli, Klebsiella sp., and Pseudomonas sp. to carbapenem, extended-spectrum β-lactamase (ESBL), and colistin. In the present study, Acinetobacter was generally found resistant to carbapenem at 72% and 71% at 75 µg/ml and minimum for Carbapenem + Colistin at 11% at 150 µg/ml. E. coli counts of the antibiotic-resistant carbapenem samples were 85% and 71% at 150 µg/ml and the lowest in colistin 12% at 225 µg/ml. The Klebsiella isolates obtained were highly sensitive to carbapenem (98%) at 150 µg/ml, followed by 75 µg/ml (96%) and 225 µg/ml (92%). Low colistin resistance was also observed (7%). The evaluation presented in Pseudomonas sp. of the antibiotic-resistant carbapenem samples was high at 47 at 225 µg/ml, and minimum in ESBL + Colistin at 5% at 150 µg/ml. Klebsiella (92%), Acinetobacter (71%), E. coli (64%), and Pseudomonas sp. (47%) were highly sensitive to 75 µg/ml carbapenem. The MICs of carbapenem-resistant Acinetobacter were shown in the 6.45 (OD values) at 75 µg/mL. Carbapenem and ESBL antibiotic-resistant Klebsiella were found at OD values of 9.14, 9.74, 9.61, and 3.45, 3.21 3.67, (OD values) at 75, 150, and 225 µg/mL, respectively, and the highest susceptibility was observed with Carbapenem 9.74 at 150 µg/mL. The ternary colour frequency of the graph indicates that Klebsiella sp. showed good susceptibility to carbapenem, carbapenem + ESBL, carbapenem, and colistin. Carbapenem is a highly effective therapy against infections caused by antibiotic-resistant Klebsiella sp.

References:

Abstract:

Orthodontic therapy plays a pivotal role in correcting malocclusions and enhancing dental aesthetics. However, the impact of orthodontic treatment on periodontal health remains a subject of debate among dental professionals. This review aims to provide a comprehensive overview of the effects of orthodontic therapy on periodontal health, highlighting both positive and negative outcomes. The periodontal changes induced by orthodontic forces, including gingival inflammation, attachment loss, and root resorption, are explored in detail. Additionally, the role of microbial shifts in the oral microbiome during orthodontic treatment and their implications for periodontal health are discussed. Furthermore, the review examines the importance of proper oral hygiene practices and the use of adjunctive therapies in mitigating potential adverse effects on periodontal tissues during orthodontic therapy. The impact of different types of orthodontic appliances, such as removable and fixed appliances, on periodontal health is also evaluated. Finally, the review outlines recommendations for clinicians to optimize periodontal health outcomes in orthodontic patients, emphasizing the importance of multidisciplinary collaboration and personalized treatment approaches. By elucidating the complex interplay between orthodontic therapy and periodontal health, this review aims to provide valuable insights for dental practitioners and researchers, ultimately contributing to improved patient care and outcomes in orthodontics.

References:

Abstract:

Non-small cell lung cancer (NSCLC) accounts for approximately 85% of lung cancer cases and is often detected at advanced stages, limiting treatment options and adversely affecting patient outcomes. Recognized by the WHO as the leading cause of cancer-related deaths, NSCLC necessitates improved diagnostic and therapeutic strategies. Aloe-emodin (AE), a natural compound with known anticancer properties, has demonstrated efficacy in inducing apoptosis and inhibiting cell proliferation in various cancer types. This study investigates AE's potential in treating NSCLC by targeting the PI3K/Akt/mTOR signalling pathway, crucial for cancer cell survival and proliferation. A549 lung cancer cells were treated with varying concentrations of AE, and cell viability was assessed using the MTT assay. Molecular docking studies were conducted to explore AE's interactions with PI3K, Akt1, and mTOR. Gene expression levels of these proteins were analysed using RT-PCR. Results showed a concentration-dependent decrease in NSCLC cell viability, with significant reductions observed at 72 hours. RT-PCR analysis indicated the downregulation of PI3K, Akt1, and mTOR in AE-treated cells. Docking studies revealed strong binding affinities of AE to PI3K, suggesting its inhibitory potential. These findings highlight AE's promise as a therapeutic agent against NSCLC, warranting further investigation into its mechanisms and clinical applicability.

References:

[1].   Araghi M, Mannani R, Heidarnejad maleki A, Hamidi A, Rostami S, Safa SH, et al. 2023, Recent advances in non-small cell lung cancer targeted therapy; an update review. Cancer Cell International, 23(1):1–26, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10416536/.

[2].   Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F.2021, Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: a cancer journal for clinicians, 1(3):209-49, https://acsjournals.onlinelibrary.wiley.com/doi/10.3322/caac.21660.

[3].   Jovanoski N, Abogunrin S, Di Maio D, Belleli R, Hudson P, Bhadti S, et al.2023, Systematic Literature Review to Identify Cost and Resource Use Data in Patients with Early-Stage Non-small Cell Lung Cancer (NSCLC). Pharmacoeconomics, 1(11):1437–52, https://pubmed.ncbi.nlm.nih.gov/37389802/.

[4].   Korytowsky B, Radtchenko J, Nwokeji ED, Tuell KW, Kish JK, Feinberg BA.2018,Understanding total cost of care in advanced non-small cell lung cancer pre-and post approval of immuno-oncology therapies. American Journal of Managed Care, 24(20Suppl):S439-47, https://pubmed.ncbi.nlm.nih.gov/30362811/.

[5].   Thimmegowda NR, Park C, Shwetha B, Sakchaisri K, Liu K, Hwang J, et al.2015, Synthesis and antitumor activity of natural compound aloe emodin derivatives. Chemical Biology & Drug Design, 85(5):638–44, https://pubmed.ncbi.nlm.nih.gov/25323822/.

[6].   Jiang D, Ding S, Mao Z, You L, Ruan Y. 2021, Integrated analysis of potential pathways by which aloe-emodin induces the apoptosis of colon cancer cells. Cancer Cell International,21(1):1–12, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8077783/.

[7].   Pecere T, Sarinella F, Salata C, Gatto B, Bet A, Dalla Vecchia F, et al. 2003, Involvement of p53 in specific anti-neuroectodermal tumor activity of aloe-emodin. International Journal of Cancer, 106(6):836–47, https://pubmed.ncbi.nlm.nih.gov/12918060/.

[8].   Li SW, Yang TC, Lai CC, Huang SH, Liao JM, Wan L, et al. 2014, Antiviral activity of aloe-emodin against influenza A virus via galectin-3 up-regulation. European Journal of Pharmacology, 738:125–32, https://pubmed.ncbi.nlm.nih.gov/24877694/.

[9].   Li T, Lu Y, Zhang H, Wang L, Beier RC, Jin Y, et al. 2021, Antibacterial Activity and Membrane-Targeting Mechanism of Aloe-Emodin Against Staphylococcus epidermidis. Frontiers in Microbiology, 12:621866, https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2021.621866/full.

[10].  Xiao-li PAN, Xue-bo LI, Bing WU.2021, Study on the Antioxidant Activity of Aloe-Emodin Metal Complex. Journal of Sichuan University (Medical sciences). 52(2):241–7, https://pubmed.ncbi.nlm.nih.gov/33829698/.

[11].  Park MY, Kwon HJ, Sung MK. 2009, Evaluation of aloin and aloe-emodin as anti-inflammatory agents in aloe by using murine macrophages. Bioscience Biotechnology Biochemistry.73(4):828–32, https://pubmed.ncbi.nlm.nih.gov/19352036/.

[12].  Shen F, Ge C, Yuan P.2020, Aloe-emodin induces autophagy and apoptotic cell death in non-small cell lung cancer cells via Akt/mTOR and MAPK signaling. European Journal of Pharmacology. 886:173550, https://pubmed.ncbi.nlm.nih.gov/32926915/.

[13].  Şeker Karatoprak G, Küpeli Akkol E, Yücel Ç, Bahadır Acıkara Ö, Sobarzo-Sánchez E. 2022, Advances in Understanding the Role of Aloe Emodin and Targeted Drug Delivery Systems in Cancer. Oxidative Medicine and Cellular Longetivity. 2022:7928200, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789423/.

[14].  Wang H, Guo M, Wei H, Chen Y. 2023, Targeting p53 pathways: mechanisms, structures, and advances in therapy. Signal Transduction and Targeted Therapy. 8(1):92, https://pubmed.ncbi.nlm.nih.gov/36859359/.

[15].  Peng Y, Wang Y, Zhou C, Mei W, Zeng C. 2022, PI3K/Akt/mTOR Pathway and Its Role in Cancer Therapeutics: Are We Making Headway? Frontiers in Oncology. 12:819128, https://pubmed.ncbi.nlm.nih.gov/35402264/.

[16].  Szwed A, Kim E, Jacinto E. 2021,Regulation and metabolic functions of mTORC1 and mTORC2. Physiological Reviews. 101(3):1371–426, https://pubmed.ncbi.nlm.nih.gov/33599151/.

[17].  Wiese W, Barczuk J, Racinska O, Siwecka N, Rozpedek-Kaminska W, Slupianek A, et al. 2023,PI3K/Akt/mTOR Signaling Pathway in Blood Malignancies—New Therapeutic Possibilities. Cancers. 15(21):5297, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10648005/.

[18].  Zhu M, He Q, Wang Y, Duan L, Rong K, Wu Y, et al. 2023, Exploring the mechanism of aloe-emodin in the treatment of liver cancer through network pharmacology and cell experiments. Frontiers in Pharmacology. 14:1238841, https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2023.1238841/full.

[19].  Li T, Shi L, Liu W, Hu X, Hui Y, Di M, et al. 2022, Aloe-Emodin Induces Mitochondrial Dysfunction and Pyroptosis by Activation of the Caspase-9/3/Gasdermin E Axis in HeLa Cells. Frontiers in Pharmacology. 13:854526, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9157280/.

[20].  Tseng Hsin Shun TH, Wang YuFen WY, Tzeng YewMin TY, Chen DarRen CD, Liao YaFan LY, et al. 2017, Aloe-emodin enhances tamoxifen cytotoxicity by suppressing Ras/ERK and PI3K/mTOR in breast cancer cells. The American Journal of Chinese Medicine. 45(02):337-50, https://www.worldscientific.com/doi/abs/10.1142/S0192415X17500215.

[21].  Sharma D, Kumar N, Mehrotra T, Pervaiz N, Agrawal L, Tripathi S, et al. 2021, In vitro and in silico molecular docking studies of Rheum emodi-derived diamagnetic SnO2 nanoparticles and their cytotoxic effects against breast cancer. New Journal of Chemistry. 45:1695–711, https://pubs.rsc.org/en/content/articlelanding/2021/nj/d0nj04670a

Abstract:

Mental retardation a developmental disability marked by lower-than-normal intelligence and limited daily living skills, affects 1-3% of children and is typically present at birth. This study employed a pre-experimental design with a quantitative research approach to assess the impact of forward chaining techniques on dressing skills in mentally retarded children. The sample consisted of 30 children aged 6-12 years from a nursing home in Chennai, selected through purposive sampling. The children were divided into three age groups: 6-8 years (33.3%), 8-10 years (30%), and 10-12 years (36.6%). The sample included 66.6% male and 33.3% female children. A majority (90%) had no family history of retardation. Post-intervention, the children required minimal assistance with eating, bathing, upper body dressing, and toileting, while supervision was needed for grooming and lower body dressing. The forward chaining technique significantly improved dressing skills, enhancing the children's self-esteem and quality of life. The findings of this study reveal promising outcomes, suggesting that forward chaining is an effective method for promoting independence in daily living skills among mentally retarded children.

References:

[1].          Rusli, R., Istiqomah, I., & Safitri, J. 2022, Teknik Perantaian Untuk Keterampilan Berpakaian Pada Anak Tunagrahita Sedang. JIP (Jurnal Intervensi Psikologi), 14(2). https://doi.org/10.20885/intervensipsikologi.vol14.iss2.art6.

[2].          Lee, Supawadee & Muccio, Brianne & Osborne, Nina, 2009, The Effect of Chaining Techniques on Dressing Skills of Children with Moderate Mental Retardation: A Single-Subject Design Study. Journal of Occupational Therapy, Schools, & Early Intervention. 2. 178-192. 10.1080/19411240903392590.

[3].          Wibowo, Sarah & Tedjasaputra, Mayke, 2019, The Effectiveness of Backward Chaining in Improving Buttoning Skills in a Child with Moderate Intellectual Disability and Poor Vision: Single-Case Design. 10.2991/iciap-18.2019.11.

[4].          Muharib, Reem & Alzrayer, Nouf & Wood, Charles & Voggt, Ashley, 2019, Backward chaining and speech-output technologies to enhance functional communication skills of children with autism spectrum disorder and developmental disabilities. Augmentative and Alternative Communication. 35. 1-12. 10.1080/07434618.2019.1704433.

[5].          Sadlier, J., Dixon, R.S., & Moore, D.W., 1992, Use of a changing criterion procedure incorporating backward chaining to teach an autistic youth to tie shoe laces. Australasian Journal of Special Education, 15, 14-16.  doi:10.1017/S1030011200022508.

[6].          BATRA, DR & Batra, Vijay., 2005, Effectiveness of forward chaining over Backward chaining technique in children with Mental Retardation. Indian Journal of Occupational Therapy. 38.

[7].          Gaur, Nupur & Dhenwa, Sunita., 2024, Delineating Gender Disparities in Cognitive Abilities and Social Functioning Among Children with Intellectual Disabilities. Educational Administration Theory and Practices. 30. 10.53555/kuey.v30i4.2801.

[8].          McGrath, J. J., Wray, N. R., Pedersen, C. B., Mortensen, P. B., Greve, A. N., & Petersen, L., 2014, The association between family history of mental disorders and general cognitive ability. Translational psychiatry, 4(7), e412. https://doi.org/10.1038/tp.2014.60.

[9].          Kumar, I., Singh, A. R., & Akhtar, S., 2009, Social development of children with mental retardation. Industrial Psychiatry Journal, 18(1), 56–59. https://doi.org/10.4103/0972-6748.57862.

[10].       Sheha, Eman & Abdelhamed Soultan, Asmaa & Malk, Rasha & El-sherbeny, Eman., 2020, Effect of a Planned Health Teaching on Improving Knowledge and Competence of Home Care Practice of Post Stroke Patient Among Caregivers' Achievement. International Journal of Studies in Nursing. 5. 51. 10.20849/ijsn.v5i2.761.

[11].       Muhrodji, P., Wicaksono, H. D. A., Satiti, S., Trisnantoro, L., Setyopranoto, I., & Vidyanti, A. N., 2021, Roles and Problems of Stroke Caregivers: A Qualitative Study in Yogyakarta, Indonesia. F1000Research, 10, 380. https://doi.org/10.12688/f1000research.52135.2.

[12].       Jimenez, D. E., Bartels, S. J., Cardenas, V., Dhaliwal, S. S., & Alegría, M., 2012, Cultural beliefs and mental health treatment preferences of ethnically diverse older adult consumers in primary care. The American journal of geriatric psychiatry: official journal of the American Association for Geriatric Psychiatry, 20(6), 533–542. https://doi.org/10.1097/JGP.0b013e318227f876.

[13].       Udonwa, Rose & Ekaete, & Iyam, Mary & Arikpo, & Chukwudi, Nelson & Ofem, Obono & John, John & Agbu, Michael & Ikong, Michael., 2024, Mentally Retarded Children and Deficits in Daily Living Skills: Case Study of Calabar Municipality Local Government Area, Cross River State, Nigeria. 10.9790/7388-05232126.

[14].       Ugur, H. G., & Erci, B., 2019, The Effect of Home Care for Stroke Patients and Education of Caregivers on the Caregiver Burden and Quality of Life. Acta clinica Croatica, 58(2), 321–332. https://doi.org/10.20471/acc.2019.58.02.16.

[15].       Heward, W. L., & Orlansky, M. D., 2019, Teaching Self-Care Skills to Children with Severe Disabilities. Journal of Applied Behavior Analysis, 23(4), 477-489.

[16].       McConnell, S. R., & Llewellyn, G. C., 2018, Teaching Dressing Skills to Children with Severe Disabilities: Forward Chaining versus Total Task Presentation. Journal of Developmental and Physical Disabilities, 11(2), 129-144.

[17].       Miller, R., & Buehler, K., 2016, Using Forward Chaining to Teach Adaptive Behaviors to Children with Autism. Behavior Modification, 19(3), 377-393.

[18].       Schreibman, L., & Stahmer, A. C., 2002, Effective Behavioral Interventions for Children with Autism." Journal of Autism and Developmental Disorders, 32(4), 289-308.

[19].       Wilder, D. A., & Carr, J. E., 2018, The Use of Forward Chaining to Teach Dressing Skills to Children with Developmental Disabilities. Behavior Modification, 22(3), 278-295.

[20].       Baker, B. L., & Brightman, A., 2016, Training Parents to Use Forward Chaining to Teach Dressing Skills to Their Children with Intellectual Disabilities. Journal of Positive Behavior Interventions, 2(2), 123-134.

[21]. Gagnon, J. C., & O'Connor, J., 2017, Comparative Analysis of Chaining Techniques in Skill Acquisition for Children with Special Needs. Education and Training in Developmental Disabilities, 38(4), 434-447

Abstract:

Ormocarpum cochinchinense (OC), traditionally used for bone healing, is emerging as a plant of interest for its antioxidant and anti-inflammatory properties. This herb, from the Fabaceae family and native to Southeast Asia, India’s Coromandel region, tropical Africa, and Pacific islands, shows promise in addressing oxidative stress and chronic inflammation. In the context of rising health concerns linked to these conditions, OC’s bioactive compounds are being studied for their potential to scavenge free radicals and mitigate disease progression. Its effects on oxidative stress and inflammation are relevant for chronic diseases such as cardiovascular conditions, neurodegenerative disorders, and periodontitis. Despite its traditional uses and regional significance, detailed scientific research on OC’s pharmacological benefits is limited. This study investigates the antioxidant and anti-inflammatory activities of the ethanolic extract of OC through in vitro analyses. The goal is to enhance understanding of OC’s therapeutic potential as a natural remedy for chronic inflammatory diseases.

References:

[1].   Parvathi, K., Krishnan, A. G., Anitha, A., Jayakumar, R., & Nair, M. B., 2018, Poly(L-lactic acid) nanofibers containing  Cissus quadrangularis  induced osteogenic differentiation in vitro, International Journal of Biological Macromolecules, 110, 514–521.

[2].   Somashekar, G., Sudhakar, U., Prakash, S. G., Suresh, S., Srividya, S., & Rao, S. H., 2022, In-vitro antioxidant and in-vitro anti-inflammatory activities of ethanolic leaves extract of Ormocarpum cochinchinense. Journal of Orofacial Sciences, 14(2), 134.

[3].   Kumar, M. D., John, K. M., & Karthik, S., 2013, The bone fracture–healing potential of Ormocarpum cochinchinense, methanolic extract on albino Wistar rats, Journal of Herbs, Spices & Medicinal Plants, 19(1), 1–10.

[4].   4. Pazhanisamy, M., & Ebenezer, G. A., 2013, Phytochemical screening of Ormocarpum cochinchinense leaf extracts, Journal of Academia and Industrial Research, 2, 275–278.

[5].   5. Narayanan, A., Marimuthu, M., Mani, A., Vasu, G., & Subhadra, R., 2023, Studies on the antimicrobial activity of  Ormocarpum cochinchinense leaf extract/PVA‐PVP blended polymer, ChemistrySelect, 8(10), e202203512.

[6].   Srividya, S., & Sridevi, G., 2016, Anti-arthritic and anti-inflammatory activity of ethanolic leaf extract of  Ormocarpum sennoides, International Journal of Pharmacy and Pharmaceutical Sciences, 8, 117–121.

[7].   Mohapatra, S., Leelavathi, L., Rajeshkumar, S., Sakthi, D. S., & Jayashri, P., 2020, Assessment of cytotoxicity, anti-inflammatory and antioxidant activity of zinc oxide nanoparticles synthesized using clove and cinnamon formulation—An in vitro study, Journal of Evolution of Medical and Dental Sciences, 9(25), 1859–1865.

[8].   Nyamboki, D. K., & Wanga, L. A., 2022, Review of the phytochemical and pharmacological studies of the genus Ormocarpum, Pharmacognosy Reviews, 16(32), 95.

[9].   Rajeshkumar, S., Parameswari, R. P., Jayapriya, J., Tharani, M., Ali, H., Aljarba, N. H., et al., 2022, Apoptotic and antioxidant activity of gold nanoparticles synthesized using marine brown seaweed: An in vitro study, Biomedical Research International, 2022, 5746761.

[10].  Rifaath, M., Rajeshkumar, S., Anandan, J., Munuswamy, T., & Govindharaj, S., 2023, Preparation of herbal nano-formulation-assisted mouth paint using titanium dioxide nanoparticles and its biomedical applications, Cureus, 15(11), e48332.

[11].  Aarthi, N., Muthuraj, M., Archana, M., Gopal, V., Balasubramanian, N., & Rajeswari, S., 2024, Wound healing activities of PVA–urea composites from Ormocarpum cochinchinense, Natural Product Research, 38(5), 813–818.

[12].  Nagarajan, D., & Pandian, R., 2018, Anti-cancer potentials of endophytic fungi isolated from Enicostemma axillare and Ormocarpum cochinchinense, Journal of Pharmacognosy and Phytochemistry, 7(3), 3186–3191.

[13].  Narayanan, A., Das, D., Marimuthu, M., Vasu, G., Mani, A., & Subhadra, R., 2024, In vitro cytotoxicity and wound healing activities of quaternary blended carboxymethyl cellulose-hydroxypropyl methylcellulose composite film, Cellulose, 31(4), 2295–2308.

[14].  Nunes CD, Barreto Arantes M, Menezes de Faria Pereira S, Leandro da Cruz L, de Souza Passos M, Pereira de Moraes L, Vieira IJ, Barros de Oliveira D., 2020, Plants as sources of anti-inflammatory agents, Molecules, 15;25(16):3726.

[15].  Singh S, Singh TG, Mahajan K, Dhiman S. Medicinal plants used against various inflammatory biomarkers for the management of rheumatoid arthritis., 2020, Journal of Pharmacy and Pharmacology, 72(10):1306-27.

[16].  Salmerón-Manzano E, Garrido-Cardenas JA, Manzano-Agugliaro F., 2020, Worldwide research trends on medicinal plants, International Journal of Environmental Research and Public Health, 17(10):3376.

[17].  Vitale S, Colanero S, Placidi M, Di Emidio G, Tatone C, Amicarelli F, D’Alessandro AM., 2022, Phytochemistry and biological activity of medicinal plants in wound healing: an overview of current research, Molecules, 1;27(11):3566.

[18].  Wang X, Cao Y, Chen S, Lin J, Bian J, Huang D., 2021, Anti-inflammation activity of flavones and their structure–activity relationship, Journal of Agricultural and Food Chemistry, 2021 , 23;69(26):7285-302.

[19].  Jongrungraungchok S, Madaka F, Wunnakup T, Sudsai T, Pongphaew C, Songsak T, Pradubyat N.,2023, In vitro antioxidant, anti-inflammatory, and anticancer activities of mixture Thai medicinal plants, BMC Complementary Medicine and Therapies, 10;23(1):43.

Abstract:

Background: The Expanded Programme on Immunization is an initiative that was introduced by the World Health Organization (WHO) in 1974 to ensure there is equitable access to life-saving vaccines for every child, regardless of their geographic location or socioeconomic status. Availability of cold chain equipment such as vaccine fridges, deep freezers and cold-boxes etc are indispensable. Transportation is and human resource equally important to ensure that vaccines reach their destination. The main aim of the study was to assess the cold chain adequacy for childhood immunization coverage in the Bolgatanga Municipality of Ghana. This cross-sectional study employed quantitative methods. A total population sampling method was used to include all the 56 facilities in the Municipality in the study. Some selected health staff were interviewed. The results show that only 28.6% of health facilities had adequate cold chain arrangements in the study area. The study results showed that the majority (87.5%) of facilities had means of transport to support immunization activities however, 53.6% of facilities covered more than 5 kilometres to reach their nearest cold chain site. Again, 57.1% of facilities had only one staff to manage cold chain and immunization activities which was statistically significant (p-value =0.005). The study concluded that cold chain equipment for the maintenance of vaccine potency and to influence immunization uptake in the Bolgatanga Municipality was inadequate. However, means of transport which aided in the collection and distribution of vaccines were not a challenge. Low staffing to manage cold chain and immunization activities was a predictor of low immunization. The study recommends Ministry of Health/Ghana Health Services (MOH/GHS) and partners to procure and distribute vaccine storage equipment to all health facilities in the Municipality. More staffs should be trained in cold chain and immunization activities.

References:

Abstract:

Although there have been several recent advances in genomic technology over the past two decades, little to no change has occurred in the incorporation of genetics in dental school curricula. Also, there are only a limited number of studies that have reported the knowledge and awareness of genetics in dental professionals. With the available information, the present study was conducted to analyze the knowledge of DNA among dental students. This cross-sectional study was conducted among 302 dental students from various Dental Colleges across Chennai to assess the knowledge of DNA among dental students. It was done using a questionnaire survey from May 2021 to June 2021comprising of 14 questions that were validated owing to the pandemic situation, the survey was conducted online using Google Forms Student T-test was planned to statistically analyze the result. The mean percentage of correct responses from students of various academic years was calculated and it was observed that interns had better knowledge and interest in genetics (81.39%), followed by final-year students (80.9%), first-year students 75%, third-year students (74.76%) and second-year students (73.07%). Considering gender, females (77.21%) had better knowledge of genetics than males (75.2%). The results were not statistically significant. The basic concepts of genetics and applications of genetics have to be incorporated into the dental curriculum. This can also be accomplished by conducting educational programs during the study and continuing dental educational programs after they complete their course.

References:

Abstract:

Marginal adaptation plays an important role in the clinical success of any prostheses. Ideal marginal adaptation can produce less gingival irritation and cement dissolution. The presence of marginal discrepancies increases plaque accumulation, secondary caries, pulpal lesions, postoperative sensitivity, periodontal disease and marginal discoloration leading to abutment failure and in turn failure of the prosthesis. A maxillary first molar typhodont tooth was prepared with an aerator handpiece. To make the monolithic zirconia crowns, the prepared tooth was scanned and the STL file was used to design a crown using CAD/CAM software. To fabricate the indirect composite crowns, a clear acrylic mould was created, in which the indirect composite was filled and the tooth was placed. The samples were then placed in a curing unit. The samples were then examined under a stereomicroscope.  With the aid of imaging software, marked calibrations were calculated at four marked regions- buccal, distal, lingual and mesial margins. Monolithic zirconia adaptation showed statistically significant results when compared to that of indirect composite crowns (p<0.05). According to the site, results varied with zirconia crowns adapting better in buccal and mesial sites whereas indirect composite crowns adapted better in the distal and lingual sites. Overall, monolithic zirconia adapted statistically significantly better to the prepared typhodont tooth than the indirect composite crowns and should be used as a material of choice for crowns.

References:

[1].   Akmal, N. L. H. B. I., & Duraisamy, R., 2020, Evaluation of the marginal fit of implant-supported crowns. Journal of Long-Term Effects of Medical Implants, 30(3), 165-172.

[2].   Vaishali S, Duraisamy R., 2022, Esthetics using monolithic zirconia and hand-layered zirconia fixed partial denture, Bioinformation.;18(7):651.

[3].   Kanat-Ertürk, B., Çömlekoğlu, E. M., Dündar-Çömlekoğlu, M., Özcan, M., & Güngör, M. A., 2015, Effect of veneering methods on zirconia framework-veneer ceramic adhesion and fracture resistance of single crowns. Journal of Prosthodontics, 24(8), 620-628.

[4].   Urapepon, S., & Taenguthai, P., 2015, The effect of zirconia framework design on the failure of all-ceramic crowns under static loading. Journal of Advanced Prosthodontics, 7(2), 146-150.

[5].   Hassan, L. A., & Goo, C. L., 2021, Effect of cement space on marginal discrepancy and retention of CAD/CAM crowns. Dental Materials Journal, 40(5), 1189-1195.

[6].   Papadiochou, S., & Pissiotis, A. L., 2018, Marginal adaptation and CAD-CAM technology: A systematic review of restorative material and fabrication techniques. Journal of Prosthetic Dentistry, 119(4), 545-551.

[7].   Heintze, S. D., 2007, Systematic reviews: I. The correlation between laboratory tests on marginal quality and bond strength. II. The correlation between marginal quality and clinical outcome. Journal of Adhesive Dentistry, 9(Suppl 1), 77-106.

[8].   Chaturvedi, S., Alqahtani, N. M., Addas, M. K., & Alfarsi, M. A., 2020, Marginal and internal fit of provisional crowns fabricated using 3D printing technology. Technology and Health Care, 28(6), 635-642.

[9].   McLean, J. W., & von Fraunhofer, J. A., 1971, The estimation of cement film thickness by an in vivo technique. British Dental Journal, 131(3), 107-111.

[10].  Rekow, D., & Thompson, V. P., 2005, Near-surface damage—a persistent problem in crowns obtained by computer-aided design and manufacturing. Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, 219(4), 233-243.

[11].  Jalalian, E., Younesi, F., Golalipour, S., Khorshidi, S., Mahdavisaedabadi, S. H., & Sayyari, M., 2023, Assessment of marginal and internal adaptation in provisional crowns utilizing three distinct materials. Journal of Contemporary Dental Practice, 24(11), 853-858.

[12].  Ellakwa, A., & Goh, D., 2023, The marginal accuracy of lithium disilicate single crowns is comparable when made from conventional or digital (direct or indirect) workflows. Journal of Evidence-Based Dental Practice, 23(4), 101914.

[13].  Miyazaki, T., Hotta, Y., Kunii, J., Kuriyama, S., & Tamaki, Y., 2009, A review of dental CAD/CAM: current status and future perspectives from 20 years of experience. Dental Materials Journal, 28(1), 44-56.

[14].  Baroudi, K., & Ibraheem, S. N., 2015, Assessment of chair-side computer-aided design and computer-aided manufacturing restorations: A review of the literature. Journal of International Oral Health, 7(4), 96-104.

[15].  Euán, R., Figueras-Álvarez, O., Cabratosa-Termes, J., & Oliver-Parra, R., 2014, Marginal adaptation of zirconium dioxide copings: Influence of the CAD/CAM system and the finish line design. Journal of Prosthetic Dentistry, 112(2), 155-162.

[16].  Contrepois, M., Soenen, A., Bartala, M., & Laviole, O., 2013, Marginal adaptation of ceramic crowns: A systematic review. Journal of Prosthetic Dentistry, 110(6), 447-454.e10.

[17].  Pelekanos, S., Koumanou, M., Koutayas, S. O., Zinelis, S., & Eliades, G., 2009, Micro-CT evaluation of the marginal fit of different In-Ceram alumina copings. European Journal of Esthetic Dentistry, 4(3), 278-292.

[18].  Shah, S., Nallaswamy, D., & Ganapathy, D., 2020, Marginal accuracy of milled versus cast cobalt chromium alloys in long-span implant-supported frameworks: A systematic review and meta-analysis. Journal of Advanced Oral Research, 11(2), 120-127.

[19].  Nejatidanesh, F., Shakibamehr, A. H., & Savabi, O., 2016, Comparison of marginal and internal adaptation of CAD/CAM and conventional cement retained implant-supported single crowns. Implant Dentistry, 25(1), 103-108.

[20].  Reddy, M. S., Ahmed, N., & Shasanka, K. (2020). A retrospective marginal fit evaluation of a fixed dental prosthesis framework fabricated by various dental students. International Journal of Dentistry and Oral Science, 7(11), 1094–1098. Available from November 25, 2020.

[21].  Merchant, A., Nallaswamy, D., Velayudhan, A., & Gada, S., 2020, Radiographic evaluation of marginal accuracy of metal coping in sectioned and unsectioned 3D printed models and gypsum models. World Journal of Dentistry, 11(5), 386-391.

[22].  Rayyan, M. R., 2019, Marginal adaptation of monolithic high-translucency versus porcelain-veneered zirconia crowns. International Journal of Prosthodontics, 32(4), 364-366.

[23].  Paul, N., Raghavendra Swamy, K. N., Dhakshaini, M. R., Sowmya, S., & Meravini, M., 2020, Marginal and internal fit evaluation of conventional metal-ceramic versus zirconia CAD/CAM crowns. Journal of Clinical and Experimental Dentistry, e31-37.

[24].  Neppelenbroek, K. H., 2015, The clinical challenge of achieving marginal adaptation in direct and indirect restorations. Journal of Applied Oral Science, 23(5), 448-449.

[25].  Torabi, K., Vojdani, M., Giti, R., & Taghva, M., 2015, The effect of various veneering techniques on the marginal fit of zirconia copings. Journal of Advanced Prosthodontics, 7(3), 233-239.

Abstract:

Globally, tuberculosis (TB) remains one of the leading causes of preventable death in adults and children. Significantly, several studies revealed that Hospital-acquired infection (HAI) of TB among Health Care Workers (HCWs) and patients occurs in high, middle and low-income countries. However, with the effective practice of TB risk reduction measures (TB Infection Prevention and Control Practices – TB-IPC) among HCWs, the risk of TB transmission should be prevented and controlled. The study aimed to identify perceived barriers against the practice of TB risk reduction measures among HCWs in Asokoro District Hospital (ADH) Abuja FCT Nigeria. A qualitative study design with a purposive sampling technique was adopted and eight informants were interviewed using Key Informant Interviews with unstructured interview guides the following findings were revealed: limited supply of surgical and N95 masks, lack of space, nonexistence of isolation ward and shortage of manpower, insufficient periodic training of HCWs on TB risk reduction measures, increased workload, need for TB policy and TB designated professional, ineffective triage, lack of incentives, feeling of discomfort using N95 mask and stigmatization. The findings pointed to the need for making budgetary allocations towards TB–IPC activities along with having a plan for constant periodic training of all HCWs on TB risk reduction measures. Moreover, healthcare facilities must have TB – -IPC policy/guidelines with a designated professional who monitors and evaluates the practice of TB risk reduction measures among HCWs within the facility.

References:

Abstract:

Burnout describes an occupational psychosocial syndrome that results from the poor management of elevated levels of emotional and social stress in the workplace for prolonged periods. The study aims to determine the methods for preventing burnout syndrome in nurses and to talk about the outcomes for potential future interventions aimed at reducing burnout in these workers. To assess the effect of safety attitude on factors related to burnout among Nurses to find out the association of the effect of safety attitude on factors related to burnout among nurses with selected demographic variables. The research design selected for the study was descriptive research design The samples of the study were nurses working at Saveetha Medical College and Hospital, Chennai. The sample size of the study was 30. nurses working at Saveetha Medical College and Hospital, Chennai. Sampling Technique. The investigator applied a non-probability convenient sampling technique to the sample selection.  Data was collected through a structured questionnaire after obtaining permission from the hospital's medical superintendent. Statistically significant correlation between the demographic variable ward (χ2=13.195, p=0.040) and the amount of influence of safety attitude on parameters associated with burnout among nurses at the p<0.05 level. The degree of safety attitude's influence on characteristics linked to nursing burnout was not statistically significantly correlated with any of the other demographic variables. According to the results, 4(13.3%) had mild to high anxiety, 7(23.3%) had severe anxiety, and 19 (63.4%)had moderate anxiety. Anxiety measured a mean of 21.43±3.57. With a minimum score of 15.0 and a maximum score of 28.0, the median was 21.50. The demographic variable, ward showed a statistically significant correlation with the degree of safety attitude influence on variables associated with nurse burnout at the p<0.05 level.

References:

Abstract:

In this article, some of the common types of granulomatous cervical lymphadenopathy are described. They can be classified as infective and non-infective. Non-infectious include sarcoidosis and sarcoid-like reactions. Their etiology is unknown but they have a better prognosis. Infectious include various organisms and some of the common organisms include Tuberculosis, Syphilis, Tularemia, Cat Scratch Disease, Brucellosis and fungal infections. So an accurate diagnosis is needed with pathological and histological evidence for prompt treatment. Here, we histopathologically describe the three representative types of granulomatous cervical lymphadenopathy namely Tuberculosis, Sarcoidosis and Kikuchi Disease.

References:

Abstract:

Menstrual irregularities such as irregular cycles including length of cycle, heavy or scanty menstruation blood loss are more common among adolescents during the initial year of menarche. When menstrual irregularities affect their day-to-day activities and quality of life it is to be addressed. A survey was taken with a questionnaire from 250 willing adolescent girls from 12-17 years of age. Data was collected regarding age, height, weight, age of menarche, duration of menstrual cycle, menstrual flow, pain, History of Anaemia, PCOS, Thyroid disorders, and necessary family history. Data collected were analysed through tables using proportions and percentages. In our study mean BMI is 22+4.8. Girls with high BMI had more hypomenorrhoea oligomenorrhoea and cycle irregularities when compared to normal and low BMI girls while menorrhagia is seen more among underweight girls and the mean age of menarche is 13+1.4. Menstrual health, menstrual hygiene awareness and early detection and treatment of any irregularities along with lifestyle modification play a key role in well well-being of their community and that of their county for decades.

References:

[1]. World Health Organisation. Geneva: World Health Organisation; 1996, Programming for Adolescent Health and Development, WHO Technical Report Series No. 886. https://www.who.int/publications/i/item/9241208864

[2]. Jain K, Garg SK, Singh JV, Bhatnagar M, Chopra H, Bajpai SK, 2009, Reproductive health of adolescent girls in an urban population of Meerut, Uttar Pradesh. Health and population: Perspectives and issues. 2009; 32:204–9. https://api.semanticscholar.org/CorpusID:73178282 

[3]. Kulkarni M, Durge PM, 2011, Reproductive health morbidities among adolescent girls: Breaking the silence. Ethno Med. 2011; 5:165-8. 

[4]. [4] Teri Pearlstein, Meir Steiner, 2008, Premenstrual dysphoric disorder: Burden of illness and treatment update. Journal of Psychiatry Neuroscience. 2008 July;33(4):291-301. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2440788/ 

[5]. Anitha Nath, Suneela Garg, 2008, Adolescent friendly health services in India: A need of the hour. Indian J Med Sci; 2008 Nov; 62(11):465-72. https://pubmed.ncbi.nlm.nih.gov/19265240/ 

[6]. Narayan K A, Srinivasa D K, Pelto P J, Veerammal S, 2001, Puberty rituals, reproductive knowledge, and health of adolescent school girls in South India. Asia-Pacific Population Journal, Volume 16, Issue 2, Mar 2001, p. 225-238. https://www.un-ilibrary.org/content/journals/15644278/16/2/27 

[7]. Mary Ann Campbell, Patrick J. McGrath, 1997, Use of medication by the adolescents for the management of menstrual discomfort. Arch Pediatr Adolesc Med; 1997; 151(9):905-913. https://pubmed.ncbi.nlm.nih.gov/9308868/ 

[8]. Rajsinh V. Mohite, Vaishali R. Mohite, 2013, Correlates of the menstrual problems among rural college students of Satara district. Al Ameen J Med Sci 2013; 6(3):213-218. http://ajms.alameenmedical.org/ArticlePDFs/6%20AJMS%20V6.N3.2013%20p%20213-218.pdf 

[9]. Lambert-Messerlian G, Roberts M B, Urlacher S S, Ah-Ching J, Viali S, Urbanek M, McGarvey S T, 2011, First assessment of menstrual cycle function and reproductive endocrine status in Samoan women. Hum Reprod, 2011 Sep; 26(9):2518-24. https://pubmed.ncbi.nlm.nih.gov/21677061/ 

[10]. Lourdes Ibáñez, Abel López-Bermejo, Marta Díaz, Maria Victoria Marcos, Francis de Zegher, 2011, Early metformin therapy (age 8-12 years) in girls with precocious pubarche to reduce hirsutism, androgen excess, and oligomenorrhea in adolescence. J Clin Endocrinol Metab 2011 Aug;96(8): E1262-7. https://pubmed.ncbi.nlm.nih.gov/21632811/ 

[11]. WORLD HEALTH ORGANISATION, Geneva 1995, Report of a WHO Expert Committee on Physical status: The use and interpretation of anthropometry. WHO technical report series 1995:854(9):1-452. https://iris.who.int/handle/10665/37003 

[12]. WHO Expert Consultation, 2004, Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies. The Lancet 2004 Jan; Volume 363: Issue 9403, 157-163. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(03)15268-3/abstract 

[13]. Zxyyann Jane Lu, 2001, The relationship between menstrual attitudes and menstrual symptoms among Taiwanese women. Journal of Advanced Nursing 2001; 33:621-628. https://pubmed.ncbi.nlm.nih.gov/11298198/ 

[14]. Kural M, Noor NN, Pandit D, Joshi T, Patil A, 2015, Menstrual characteristics and prevalence of dysmenorrhea in college going girls. J Fam Med Prim Care; 2015 Jul-Sep 4(3):426-31. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4535108/ 

[15]. Manjula S. Patil, Angadi M M, 2013, Menstrual pattern among adolescent girls in a rural area of Bijapur. Al Ameen J Med Sci 2013; 6(1):17-20. http://ajms.alameenmedical.org/ArticlePDFs%5CAJMS%20V6.N1.2013%20p%2017-20.pdf 

[16]. Prasad BG, Sharma P, 1972, A study on menstruation of medical college girls at Lucknow. Journal of Obstetrics and Gynaecology of India 1972; 22:690-4. https://jogi.co.in/storage/articles/files/filebase/Archives/1972/dec/1972_690_694_Dec.pdf 

[17]. Omidvar S, Amiri FN, Bakhtiari A, Begum K, 2018, A study on menstruation of Indian adolescent girls in an urban area of South India. J Family Med Prim Care 2018 Jul-Aug; 7(4) :698-702. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6132001/

[18]. Chauhan P, Shaik RA, Anusha DVB, Sotala M, 2019, A study to assess knowledge, attitude, and practices related to menstrual cycle and management of menstrual hygiene among school-going adolescent girls in a rural area of South India. Int J Med Sci Public Health 2019; 8(2):114-9. https://www.bibliomed.org/?mno=15452 

[19]. Rupa Vani K, Veena KS, Subitha L, Hemanth Kumar VR, Bupathy A, 2013, Menstrual Abnormalities in School Going Girls – Are They Related to Dietary and Exercise Pattern? Journal of clinical and diagnostic research 2013 Nov; 7(11): 2537-2540. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879880/ 

[20]. Karout N, Hawai SM, Altuwaijri S, 2012, Prevalence and pattern of menstrual disorders among Lebanese nursing students. East Mediterr Health J 2012 Apr; 18(4):346-52. https://pubmed.ncbi.nlm.nih.gov/22768696/

Abstract:

Obstetric hemorrhage is a significant and potentially life-threatening complication associated with both vaginal and cesarean deliveries. One common etiology is placenta accreta, a condition characterized by the abnormal adherence of the placenta to the myometrium. The primary modality for diagnosing placenta accreta is ultrasonography, although magnetic resonance imaging (MRI) is often employed to assess the extent of placental invasion. Managing placenta accreta requires a multidisciplinary healthcare team due to its complexity and associated risks. While hysterectomy is frequently the treatment of choice, conservative management approaches may be considered in carefully selected cases.

References:

Abstract:

Intubation is a crucial medical procedure that involves the insertion of a tube into the airway to ensure proper breathing and save lives. This technique, which is fundamental in the field of anaesthesia, requires skill and precision. Anaesthesiologists play a key role in mastering, teaching, and performing intubations, making it a cornerstone of their practice for many years. Traditionally, machine learning has been utilized as a reliable method for tracheal cannulation, establishing itself as the gold standard over the past seven decades. In recent times, there has been a notable development in intubation technology with the introduction of alternative devices such as the King Vision Video Laryngoscope (KVVL). Unlike the conventional method that relies on direct visualization, the KVVL utilizes an indirect magnified image for enhanced accuracy during the procedure. A comparative study was conducted between the King Vision Video Laryngoscope and the traditional Macintosh Laryngoscope on two groups of patients, with Group A consisting of 70% male and 30% female, and Group B with 60% male and 40% female participants. The results of the study revealed that while BMI, thyromental distance, and MPC showed no significant differences between the two devices, the King Vision Video Laryngoscope outperformed the Macintosh Laryngoscope in terms of intubation difficulty score and Cormack Lehane grading. Moreover, the former demonstrated superior outcomes in terms of airway trauma, heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), and saturation levels, ensuring a smoother and safer intubation process overall. Based on these findings, the study concluded that the King Vision Video Laryngoscope offers distinct advantages over the traditional Macintosh Laryngoscope, highlighting its potential as a superior tool for efficient and effective airway management in clinical settings.

References:

[1] Mort, T. C. 2004. Emergency tracheal intubation: complications associated with repeated laryngoscopic attempts. Anesthesia & Analgesia, 99(2), 607-613.

[2] Mort, T. C. 2005. Esophageal intubation with indirect clinical tests during emergency tracheal intubation: a report on patient morbidity. Journal of Clinical Anesthesia, 17(4), 255-262.

[3] Tse, J. C., Rimm, E. B., & Hussain, A. 1997. Predicting difficult endotracheal intubation in surgical patients schedules for general anesthesia: a prospective blind study. Journal of Emergency Medicine, 2(15), 266.

[4] Cheney, F. W. 1999. The American Society of Anesthesiologists Closed Claims Project: what have we learned, how has it affected practice, and how will it affect practice in the future?. The Journal of the American Society of Anesthesiologists, 91(2), 552-556.

[5] Peterson, G. N., Domino, K. B., Caplan, R. A., Posner, K. L., Lee, L. A., & Cheney, F. W. 2005. Management of the difficult airway: a closed claims analysis. The Journal of the American Society of Anesthesiologists, 103(1), 33-39.

[6] Cook, T., Woodall, N., Harper, J., Benger, J., & Fourth National Audit Project. 2011. Major complications of airway management in the UK: results of the Fourth National Audit Project of the Royal College of Anaesthetists and the Difficult Airway Society. Part 2: intensive care and emergency departments. British journal of anaesthesia, 106(5), 632-642.

[7] Woodall, N. M., Benger, J. R., Harper, J. S., & Cook, T. M. 2012. Airway management complications during anaesthesia, in intensive care units and in emergency departments in the UK. Trends in Anaesthesia and Critical Care, 2(2), 58-64.

[8] Metzner, J., Posner, K. L., & Domino, K. B. 2009. The risk and safety of anesthesia at remote locations: the US closed claims analysis. Current Opinion in Anesthesiology, 22(4), 502-508.

[9] Aziz, M. F., Dillman, D., Fu, R., & Brambrink, A. M. 2012. Comparative effectiveness of the C-MAC video laryngoscope versus direct laryngoscopy in the setting of the predicted difficult airway. The Journal of the American Society of Anesthesiologists, 116(3), 629-636.

[10] Gaszynska, E., & Gaszynski, T. 2014. The King Vision™ video laryngoscope for awake intubation: series of cases and literature review. Therapeutics and clinical risk management, 475-478.

[11] Akihisa, Y., Maruyama, K., Koyama, Y., Yamada, R., Ogura, A., & Andoh, T. 2014. Comparison of intubation performance between the King Vision and Macintosh laryngoscopes in novice personnel: a randomized, crossover manikin study. Journal of anesthesia, 28, 51-57.

[12] Murphy, L. D., Kovacs, G. J., Reardon, P. M., & Law, J. A. 2014. Comparison of the king vision video laryngoscope with the macintosh laryngoscope. The Journal of emergency medicine, 47(2), 239-246.

[13] Yun, B. J., Brown, C. A., Grazioso, C. J., Pozner, C. N., & Raja, A. S. 2014. Comparison of video, optical, and direct laryngoscopy by experienced tactical paramedics. Prehospital Emergency Care, 18(3), 442-445.

[14] Asai, T. 2012. Videolaryngoscopes: do they truly have roles in difficult airways?. The Journal of the American Society of Anesthesiologists, 116(3), 515-517.

[15] Miceli, L., Cecconi, M., Tripi, G., Zauli, M., & Della Rocca, G. 2008. Evaluation of new laryngoscope blade for tracheal intubation, Truview EVO2©: a manikin study. European journal of anaesthesiology, 25(6), 446-449.

[16] Ezri, T., Warters, R. D., Szmuk, P., Saad-Eddin, H., Geva, D., Katz, J., & Hagberg, C. 2001. The incidence of class “zero” airway and the impact of Mallampati score, age, sex, and body mass index on prediction of laryngoscopy grade. Anesthesia & Analgesia, 93(4), 1073-1075.

[17] Jarvis, J. L., McClure, S. F., & Johns, D. 2015. EMS intubation improves with King Vision video laryngoscopy. Prehospital Emergency Care, 19(4), 482-489.

[18] Apfelbaum, J. L., Hagberg, C. A., Caplan, R. A., Blitt, C. D., Connis, R. T., ... & Ovassapian, A. 2013. Practice guidelines for management of the difficult airway: an updated report by the American Society of Anesthesiologists Task Force on Management of the Difficult Airway. Anesthesiology, 118(2), 251-270.

[19] Schoettker, P., & Corniche, J. 2015. The AirView Study: Comparison of Intubation Conditions and Ease between the Airtraq‐Air View and the King Vision. BioMed research international, 2015(1), 284142.

[20] Cortellazzi, P., Caldiroli, D., Byrne, A., Sommariva, A., Orena, E. F., & Tramacere, I. 2015. Defining and developing expertise in tracheal intubation using a GlideScope® for anaesthetists with expertise in Macintosh direct laryngoscopy: an in‐vivo longitudinal study. Anaesthesia, 70(3), 290-295.

[21] Cierniak, M., Timler, D., Wieczorek, A., Sekalski, P., Borkowska, N., & Gaszynski, T. 2016. The comparison of the technical parameters in endotracheal intubation devices: the Cmac, the Vividtrac, the McGrath Mac and the Kingvision. Journal of clinical monitoring and computing, 30, 379-387.

[22] Alvis, B. D., Hester, D., Watson, D., Higgins, M., & St Jacques, P. 2015. Randomized controlled trial comparing the McGrath MAC video laryngoscope with the King Vision video laryngoscope in adult patients. Minerva anestesiologica, 82(1), 30-35.

[23] Erdivanli, B., Sen, A., Batcik, S., Koyuncu, T., & Kazdal, H. 2018. Comparison of King Vision video laryngoscope and Macintosh laryngoscope: a prospective randomized controlled clinical trial. Revista Brasileira de Anestesiologia, 68(5), 499-506

Abstract:

Depression, diabetes mellitus, and anxiety are metabolic diseases causing chronic hyperglycemia and mood disorders and triggered by the body's fight or flight response to danger, respectively. Recognizing the pervasiveness of the factors mentioned above among the patients who suffer from Type 2 diabetes mellitus, determining how these conditions impair those people's quality of life, and evaluating the impact on patients' glucose levels is the main aim of this study. Over six months, a study was conducted among 150 patients at Vijaya Marie Hospital, Khairtabad, Hyderabad. The individuals having a history of Type 2 diabetes, as well as other comorbid illnesses, were included. Patients with prior clinical depression, anxiety, or stress were excluded. Data from all patients was gathered and analyzed using the Graph Pad Prism software. Among the 150 diabetic patients, age groups between 41 and 50 are more prevalent, 63 of whom were men and 87 of whom were women. According to their HbA1c levels, Type 2 diabetes mellitus is typically treated with lifestyle changes, pharmacological alterations, or both. In our study, people change their lifestyles in addition to taking different oral medications. The study also found that highly severe anxiety (27.3%), moderate depression (932%), and stress levels within normal limits (36%) were prevalent among the patients. The study found a significant association between a patient's Type 2 diabetes mellitus (DM) blood glucose levels and their mental state, with severe anxiety being an essential factor. Mental stress alters glycaemic levels, negatively impacting patients' quality of life and triggering diabetic distress, indicating that depression, anxiety, and stress can predict Type 2 DM risk.

References:

Abstract:

During pregnancy, women undergo specific physiological changes in their bodies which may lead to stress and a rise in blood pressure which may be due to different etiological contributions. One way of reducing their blood pressure as well as stress is by encouraging those women to perform diaphragmatic deep breathing exercises. The current study aimed to investigate the effectiveness of relaxation therapy among antenatal mothers. True experimental pretest-posttest control group research design was conducted in the antenatal clinic of the host institution. The 60 antenatal mothers were recruited as study participants using a non-probability purposive sampling technique. All 60 antenatal mothers were randomly assigned to either the intervention group (Relaxation therapy) or the placebo group by using the lottery method,30 in the interventional group and 30 in the placebo group. For the interventional group, On Day 1, demographic and clinical data were collected from the study participants, followed by a Diaphragmatic deep breathing exercise initiated for 20 minutes daily in the morning for about 28 days. For the placebo group, demographic and clinical data were collected from the study participants, followed by routine hospital care initiated for about 28 days. On Day 29, the study participants were re-assessed for the level of stress, blood pressure and proteinuria in both interventional and placebo groups. The study results concluded that diaphragmatic deep breathing exercise reduced the levels of stress (mean difference score on the level of stress was 37.10  and the calculated paired ‘t’ test value of t = 10.460 was statistically significant at p<0.001 level), blood pressure (statistically significant difference at p<0.001 level between the post-test level of systolic BP between the two groups, there was a statistically significant difference at p<0.01 level between the post-test level of diastolic BP between the two groups), proteinuria (there was a statistically significant difference in the post-test level of proteinuria between the groups), there was no statistically significant difference at p<0.05 level between the post-test level of BMI between the two groups. Performing diaphragmatic deep breathing exercises enhanced, the reduction in the level of blood pressure, stress, BMI and proteinuria among our study participants.

References:

Abstract:

Reconstructing the heel's soft tissue is challenging due to its weight-bearing role and the unique properties of the skin on the sole. The medial plantar artery perforator (MPAP) flap is a well-established option for these defects, providing tissue similar in structure to the plantar foot. This report describes a case of successful reconstruction of a heel defect in a diabetic woman using an MPAP flap. This case highlights the effectiveness of the MPAP flap for medium to large-sized plantar defects with weight bearing, offering benefits such as excellent tissue match, minimal donor site complications, and consistent vascular anatomy.

References:

Abstract:

Internally displaced persons (IDP) are increasing in Nigeria. Women of reproductive age are vulnerable to sexual and reproductive health (SRH) challenges. Little is known about the utilized SRH services, and their associated factors in North-central, Nigeria. Quantitative data was collected using a structured questionnaire. Data were analyzed and descriptive analysis and Logistic regression were performed at p-value < 0.05 to identify significant factors associated with SRH utilization. The finding revealed that the utilized SRH services at the IDP camps were family planning, antenatal care, and HIV testing/voluntary counseling, and 82.40% of the displaced women have used at least one SRH service, while antenatal care was the most utilized (74.60%). At the individual level, the age, marital status, and education of respondents are significantly associated with the utilization of SRH services. At the household level, spousal employment status, age, and education determine the utilization of SRH services. In conclusion, the overall utilization of SRH services among displaced women in the IDP camps is high. Individual and household factors are associated with SRH uptake. Community awareness and addressing the issue of empowerment among women in the IDP camps can help augment the issue of financial incapacity, hence encouraging utilization.

References:

[1]   A. N. Odo, K. Musa, and A. V. Oladugba, “Sexual and reproductive health needs and problems of internally displaced adolescents (IDAs) in Borno State, Nigeria: A mixed method approach,” Afr. J. Reprod. Health, vol. 24, no. 1, pp. 87–96, 2020, doi: 10.29063/ajrh2020/v24i1.9.

[2]   O. Savage, “Appraisal of the sexual and reproductive health of women in Nigeria from the perspective of internally displaced persons,” Nnamdi Azikiwe Univ. J. Int. Law Jurisprud., vol. 12, no. 2, pp. 129–144, 2021.

[3]   A. J. Onoja et al., “Understanding the Needs of Adult Internally Displaced Persons in Three North-Eastern States of Nigeria : The Impact of Humanitarian Response Program,” Int. J. Soc. Sci. Manag., vol. 7, no. 3, pp. 152–158, 2020, doi: 10.3126/ijssm.v7i3.29205.

[4]   A. J. Onoja et al., “Alleviating the Material and Health Challenges of Young Internally Displaced People in North-East Nigeria : The Impact of Sexual and Reproductive Health Program,” Humanit. Soc. Sci. Res., vol. 3, no. 2, 2020.

[5]   H. M. Marlow, M. Kunnuji, A. Esiet, F. Bukoye, and C. Izugbara, “The Sexual and Reproductive Health Context of an Internally Displaced Persons’ Camp in Northeastern Nigeria: Narratives of Girls and Young Women,” Front. Reprod. Heal., vol. 3, no. January, pp. 1–7, 2022, doi: 10.3389/frph.2021.779059.

[6]   M. Al-mujtaba et al., “Evaluating Religious Influences on the Utilization of Maternal Health Services among Muslim and Christian Women in North-Central Nigeria,” vol. 2016, 2016.

[7]   O. J. Adewusi, D. C. Ezegwu, D. I. O. Patrick-Ogbogu, and M. Odeyinde, “Inclusive Sexual and Reproductive Health Rights: Knowledge and utilization of SRHR services among women and girls with disabilities in North-central Nigeria,” no. May, 2022.

[8]   H. T. Ismail, M. Mscph, T. G. Amole, F. I. Tsiga-ahmed, R. I. Jalo, and M. H. Aliyu, “Factors Associated with Utilization of Sexual and Reproductive Health Services among Married Adolescent Girls in Kano, Northern,” Int. J. Matern. ChildHealth AIDS, vol. 13, pp. 1–9, 2024, doi: 10.25259/IJMA.

[9]   M. O. Folayan et al., “Factors associated with poor access to HIV and sexual and reproductive health services in Nigeria for women and girls living with HIV during the COVID-19 pandemic,” 2022, doi: 10.2989/16085906.2022.2104169.

[10]   P. M. Sawadogo et al., “Barriers and facilitators of access to sexual and reproductive health services among migrant, internally displaced, asylum seeking and refugee women: A scoping review,” PLoS One, vol. 18, no. 9 September, pp. 1–19, 2023, doi: 10.1371/journal.pone.0291486.

[11]   O. Ivanova, M. Rai, and E. Kemigisha, “A Systematic Review of Sexual and Reproductive Health Knowledge , Experiences and Access to Services among Refugee , Migrant and Displaced Girls and Young Women in Africa,” Int. J. Environ. Res. Public Health, pp. 1–12, 2018, doi: 10.3390/ijerph15081583.

[12]   W. Binu, T. Marama, M. Gerbaba, and M. Sinaga, “Sexual and reproductive health services utilization and associated factors among secondary school students in Nekemte,” pp. 1–10, 2018.

[13]   W. Negash, M. Dessalegn, B. Yitayew, M. Demsie, and M. Wagnew, “Reproductive health service utilization and associated factors : the case of north Shewa zone youth, Amhara region, Ethiopia,” pp. 1–19, 2016, doi: 10.11604/pamj.supp.2016.25.2.9712.

[14]   A. Seidu et al., “Modern contraceptive utilization and associated factors among married and cohabiting women in Papua New Guinea : a population-based cross-sectional study.,” vol. 6, pp. 1–11, 2020.

[15]   K. G. Tlaye, M. A. Belete, T. M. Demelew, and M. A. Getu, “Reproductive health services utilization and its associated factors among adolescents in Debre Berhan town , Central Ethiopia : a community-based cross-sectional study,” pp. 1–11, 2018.

[16]   T. Otu et al., “Prevalence and factors associated with contraceptive use among sexually active adolescent girls in 25 sub-Saharan African countries,” pp. 1–15, 2024, doi: 10.1371/journal.pone.0297411.

[17]   M. Endriyas, A. Eshete, E. Mekonnen, T. Misganaw, and M. Shiferaw, “Contraceptive utilization and associated factors among women of reproductive age group in Southern Nations Nationalities and Peoples ’ Region , Ethiopia : cross- sectional survey , mixed-methods,” Contracept. Reprod. Med., pp. 1–9, 2017, doi: 10.1186/s40834-016-0036-z.

[18]   B. O. Ahinkorah et al., “Individual and community-level factors associated with modern contraceptive use among adolescent girls and young women in Mali : a mixed effects multilevel analysis of the 2018 Mali demographic and health survey,” vol. 7, pp. 1–12, 2020.

[19]   S. A. Feleke, D. N. Koye, A. F. Demssie, and Z. B. Mengesha, “Reproductive health service utilization and associated factors among adolescents ( 15 – 19 years old ) in Gondar town , Northwest,” pp. 1–10, 2013.

[20]   C. Chawhanda, J. Levin, and L. Ibisomi, “Factors associated with sexual and reproductive health service utilisation in high migration communities in six Southern African countries,” BMC Public Health, pp. 1–15, 2022, doi: 10.1186/s12889-022-13308-4.

[21]   A. A. Aliyu, T. Dahiru, and A. M. Oyefabi, “KNOWLEDGE , DETERMINANTS AND USE OF MODERN CONTRACEPTIVES AMONG MARRIED WOMEN IN SABON GARI ZARIA-NORTHERN NIGERIA,” vol. 14, no. 2, pp. 13–21, 2015.

[22]   O. O. Latunji and O. Iyanda, “Qualitative Exploration of factors affecting Uptake and Demand for Contraception and other Family Planning Services in North-West Nigeria,” vol. 23, no. December, pp. 63–74, 2019, doi: 10.29063/ajrh2019/v23i4.8.

[23]   O. . Ilori, A. . Olugbenga-Bello, O. . Goodman, A. . Babakundi, and R. . Oladejo, “Prevalence and pattern of contraceptive uptake among adolescents in an internally displaced camp , North Central , Nigeria,” pp. 1–11, 2024, doi: 10.4081/jphia.2024.xxxx.

[24]   A. G. Nmadu, S. Mohamed, and N. O. Usman, “Adolescents ’ utilization of reproductive health services in Kaduna , Nigeria : the role of stigma,” pp. 1–5, 2020.

[25]   E. A. Envuladu, K. Massar, and J. de Wit, “Adolescents’ Sexual and Reproductive Healthcare‐Seeking Behaviour and Service Utilisation in Plateau State, Nigeria,” Healthc., vol. 10, no. 2, pp. 1–10, 2022, doi: 10.3390/healthcare10020301.

[26]   S. Adewale, “Internally displaced persons and the challenges of survival in Abuja,” African Secur. Rev., vol. 25, no. 2, pp. 176–192, 2016, doi: 10.1080/10246029.2016.1154475.

[27]   C. M. Anierobi et al., “Communal conflicts in Nigeria: Assessment of the impacts on internally displaced persons and settlements amidst COVID-19 pandemic,” Heliyon, vol. 10, no. 9, p. e30200, 2024, doi: 10.1016/j.heliyon.2024.e30200.

[28]   DTM Nigeria, “BIOMETRIC REGISTRATION PROGRESS REPORT,” 2023.

[29]   UNHCR, “GLOBAL TRENDS Trends at a Glance,” United Nation High Comm. Refug., 2020.

[30]   H. Pierce, “Reproductive health care utilization among refugees in Jordan : Provisional support and domestic violence,” 2019, doi: 10.1177/1745506519861224.

[31]   A. Banke-Thomas, K. Agbemenu, and C. Johnson-Agbakwu, “Factors Associated with Access to Maternal and Reproductive Health Care among Somali Refugee Women Resettled in Ohio , United States : A Cross - Sectional Survey,” pp. 1–11, 2019.

[32]   A. S. Adebowale, “Spousal age difference and associated predictors of intimate partner violence in Nigeria,” pp. 1–15, 2018, doi: 10.1186/s12889-018-5118-1.

[33]   A. Seyife, G. Fisseha, H. Yebyo, G. Gidey, and H. G. Id, “Utilization of modern contraceptives and predictors among women in Shimelba refugee camp , Northern Ethiopia,” pp. 1–11, 2019.

[34]   O. Ivanova et al., “A cross-sectional mixed-methods study of sexual and reproductive health knowledge, experiences and access to services among refugee adolescent girls in the Nakivale refugee settlement, Uganda,” Reprod. Health, vol. 16, no. 1, pp. 1–11, 2019, doi: 10.1186/s12978-019-0698-5.

[35]   S. Sampson et al., “Addressing Barriers to Accessing Family Planning Services using Mobile Technology Intervention among Internally Displaced Persons in Abuja, Nigeria,” AJOG Glob. Reports, no. August, p. 100250, 2023, doi: 10.1016/j.xagr.2023.100250.

[36]   J. C. Ene and H. T. Ajibo, “Optimizing the utilization of maternal and reproductive healthcare services among women in low-resourced Nigerian settings,” pp. 1–12, 2023.

[37]   A. I. Ajayi, O. E. Awopegba, E. O. Owolabi, and A. Ajala, “Coverage of HIV testing among pregnant women in Nigeria : progress , challenges and opportunities,” vol. 43, no. 1, pp. 77–84, 2019, doi: 10.1093/pubmed/fdz152.

[38]   P. A. Apanga and M. A. Adam, “Factors influencing the uptake of family planning services in the Talensi District, Ghana,” vol. 8688, pp. 1–9, 2015, doi: 10.11604/pamj.2015.20.10.5301.

[39]   I. C. Akamike, U. C. Madubueze, and I. N. Okedo-alex, “Perception , pattern of use , partner support and determinants of uptake of family planning methods among women in rural communities in Southeast Nigeria,” pp. 1–8, 2020.

[40]   I. N. Okedo-alex, I. C. Akamike, O. B. Ezeanosike, and C. J. Uneke, “Determinants of antenatal care utilisation in sub-Saharan Africa : a systematic review,” 2019, doi: 10.1136/bmjopen-2019-031890.

[41]   T. . Haider and M. Sharma, “Community Health Equity Research & Policy,” pp. 1–6, 2013, doi: 10.2190/IQ.33.4.g.

[42]   E. Tesfa and H. Gedamu, “Factors associated with utilization of long term family planning methods among women of reproductive age attending Bahir Dar health facilities , Northwest Ethiopia,” BMC Res. Notes, pp. 1–7, 2018, doi: 10.1186/s13104-018-4031-0.

[43]   B. R. Dekker, “Evidence on : Pregnancy at Age 35 and Older Evidence on : Pregnancy at Age 35 and Older,” pp. 34–35, 2020.

[44]   A. Zajacova and E. M. Lawrence, “The Relationship Between Education and Health : Reducing Disparities Through a Contextual Approach,” pp. 273–289, 2018.

[45]   C. H. Logie, F. Mackenzie, K. Malama, N. Lorimer, and A. Lad, “Sexual and reproductive health among forcibly displaced persons in urban environments in low and middle ‑ income countries : scoping review findings,” Reprod. Health, pp. 1–26, 2024, doi: 10.1186/s12978-024-01780-7.

[46]   T. Lancet and P. Health, “Editorial Education : a neglected social determinant of health,” Lancet Public Heal., vol. 5, no. 7, p. e361, 2020, doi: 10.1016/S2468-2667(20)30144-4.

[47]   R. A. Hahn and B. I. Truman, “International Journal of Social Determinants of Health and Health Services,” pp. 1–18, 2015, doi: 10.1177/0020731415585986.

[48]   E. Isah, Y. Suleman, and T. Adeleke, “Socio-Cultural Factors and Access To University Education in North-East Region of Nigeria,” East African J. Educ. Res. Policy, vol. 15, no. 1, pp. 59–73, 2020.

[49]   K. H. Bulman and C. Mccourt, “Somali Refugee Women’s experiences of maternity care in West London: A case study,” pp. 1–23, 2002, doi: 10.1080/0958159021000029568.

[50]   L. Andriano, J. Behrman, and C. Monden, “Husbands ’ Dominance in Decision-Making About Women ’ s Health : A Spatial Diffusion Perspective in Sub-Saharan Africa,” vol. 58, no. September, pp. 1955–1975, 2021, doi: 10.1215/00703370-9429489.

[51]   A. G. Nmadu, I. A. Joshua, V. N. Omole, N. O. Usman, C. J.-C. Igboanusi, and A. A. Gobir, “Original article Male involvement in family planning in Northern Nigeria : A review of literature,” pp. 6–9, 2019, doi: 10.4103/jomt.jomt.

Abstract:

References:

[1]. Saklayen, M. G., 2018, The global epidemic of metabolic syndrome. Current Hypertension Reports, 20, pp. 12-20.

[2]. Bo, L., Guanqun, C., Ruijie, Z., Huang, D., Tao, L., Dan, H. and Lixin, T., 2021, Temporal trends in the prevalence of metabolic syndrome among middle-aged and elderly adults from 2011 to 2015 in China: The China health and retirement longitudinal study (CHARLS). BMC Public Health, 21, pp. 1045-1056.

[3]. Chatzi, L., Plana, E., Pappas, A., et al. 2009, The metabolic syndrome in early pregnancy and risk of gestational diabetes mellitus. Diabetes and Metabolism, 35(6), pp. 490–494.

[4]. Vryonidou, A, Paschou, S. A., Muscogiuri, G., Orio, F. and Goulis., D. G., 2015, Mechanisms in endocrinology: metabolic syndrome through the female life cycle. Eur J Endocrinol, 173, pp. R153–R163.

[5]. Mohsenzadeh-Ledari, F., Taghizadeh, Z., Motaghi, Z., Keramat, A., Moosazadeh, M. and Najafi, A., 2019, Appropriate interventions for pregnant women with indicators of metabolic syndrome on pregnancy outcomes: a systematic review. International Journal of Preventive Medicine, 10(2), pp. 1-21.

[6]. Wubet, W. T., Kimberly, K. V., Jami, J. and Leanne, M. R., 2024, Effective interventions in preventing gestational diabetes mellitus: A systematic review and meta-analysis. Communications Medicine, 4, pp. 75-89.

[7]. Fossati, P. and Principe, L., 1998, Triglycerides PAP, freeze dried. Clinical Chemistry, 28(10), pp. 2077-2780.

[8]. Trinder, P., 1969, Determination of glucose in blood using glucose oxidase with alternative oxygen acceptor. Annals of Clinical Biochemistry, 6, pp. 24–27.

[9]. Chatzi, L., Plana, E., Daraki, V., et al., 2009, Metabolic syndrome in early pregnancy and risk of preterm birth. American Journal 0f Epidemiology, 70(7), pp. 829–836.

[10]. Dos Prazerez, T. H., Arantes, A. M., Tavares, S. B., et al., 2015, Metabolic syndrome and pregnancy, its prevalence, obstetrical and newborns complications. Open Journal of Obstetric and Gynaecology. 5(11), pp. 618–625.

[11]. Nolan, C. J., and Prentki, M., 2019, Insulin resistance and insulin hyper secretion in the metabolic syndrome and type 2 diabetes: time for a conceptual framework shift. Diabetes and Vascular Disease Research, 16(2), pp. 118–127.

[12]. Wani, K., Sabico, S., Alnaami, A. M., et al. 2020, Early-pregnancy metabolic syndrome and subsequent incidence in gestational diabetes mellitus in Arab women. Frontiers in Endocrinology, 11, pp. 98-105.

[13]. Grieger, J. A., Bianco-Miotto, T., Grzeskowiak L. E., et al. 2018, Metabolic syndrome in pregnancy and risk for adverse pregnancy outcomes: a prospective cohort of nulliparous women. PLoS Medicine, 15(12), pp. 1-10.

[14]. Djeufouata, J. D., Ojong, E. W., Njamen. N. T., Assob, J. C. and Telefo, P. B., 2020, Prevalence and risk factors of metabolic syndrome in pregnant women in the centre and littoral regions of Cameroon. European Journal of Clinical Biomedical Sciences, 6(5), pp. 104–115.

[15]. Rahman, M. M., Abe, S. K., Kanda, M., et al., 2015, Maternal body mass index and risk of birth and maternal health outcomes in low- and middle-income countries: a systematic review and meta-analysis. Obesity Review, 16, pp. 758–770.

[16]. White, S. L., Pasupathy, D., Sattar, N., et al., 2017, Metabolic profiling of gestational diabetes in obese women during pregnancy. Diabetologia, 60, pp. 1903–1912.

[17]. Wani, K., Sabico, S., Alnaami, A. M., et al., 2020, Early-pregnancy metabolic syndrome and subsequent incidence in gestational diabetes mellitus in Arab women. Frontiers in Endocrinology, 11, pp. 98-105.

[18]. Eastwood, K. A., Daly, C., Hunter, A., et al 2017., The impact of maternal obesity on completion of fetal anomaly screening. Journal of Perinatal Medicine, 45(9), pp. 1061–1067.

[19]. Pinto, M. C., Oliveira, A. S., Santos, A. S., De oliveira, B. V., and Ramos, M. M, 2019, Metabolic syndrome in pregnancy and postpartum: prevalence and associated factors. Revista da Associacao Medica Brasileria, 65(12), pp. 1489–1495.

[20]. Mohsenzadeh-Ledari, F., Taghizadeh, Z., Motaghi, Z., Keramat, A., Moosazadeh, M. and Najafi, A. 2019, Appropriate interventions for pregnant women with indicators of metabolic syndrome on pregnancy outcomes: a systematic review. International Journal of Preventive Medcine, ; 10, pp. 1-22. 

Abstract:

Acrylic resin is the most common material used for the fabrication of bases for prostheses including overdentures. A smooth surface is ideal for the maintenance of dentures and the prevention of bacterial colonization. Polishing materials used and the method of moulding are the few factors that affect surface roughness. Hence the present in vitro study was done to compare the effect of polishing materials and moulding methods on the surface roughness of dentures. 120 specimens (50mm × 3mm) were divided into two equal groups and fabricated by compression and injection moulding techniques. Each group was subdivided into 3 groups based on the polishing method viz: control (pumice), pumice with universal polishing paste and pumice with rouge based on the polishing protocols advocated. Determination of surface roughness was done with a profilometer. Statistical analysis was done with one-way ANOVA and Tukey HSD. The surface roughness ranged between 0.372 ± 1.340 and 0.046 ± 0.027. In both the moulding methods control group with pumice exhibited the greatest surface roughness in comparison with the other two groups and universal polishing paste produced the least. On comparing the two moulding methods the injection moulding method exhibited the least surface roughness. (p=0.0001). From the results of the study, it can be inferred that irrespective of the moulding method polishing using pumice and universal polishing paste would produce a smooth surface with the least roughness and could be implemented by all clinicians to bacterial colonisation and plaque formation in dentures.

References:

Abstract:

Angiomyofibroblastoma is a benign soft tissue tumour arising from the mesenchymal cells. It is seen in young females most commonly arising in the vulval region. This tumour mimics other benign tumours of the vulva and is pathologically differentiated from Angiofibroma and AMM (Angiomyomyxoma) which follow a different treatment protocol. This tumour is rare in occurrence and is unusual in older females. Here we report a rare case of AFMB in an older woman who presented with a very slow-growing asymptomatic vulval mass involving the left labia majora.

References:

Abstract:

Atypical lipomatous tumour / well-differentiated liposarcoma (ALT/WDLPS) is a locally aggressive mesenchymal neoplasm composed either entirely or partly of an adipocytic proliferation showing at least focal nuclear atypia in both adipocytes and stromal cells. This case report details a case of a 45-year-old female who presented to OPD with swelling over the medial aspect of the thigh for 3 years. Clinically she was diagnosed with lipoma followed by an excision and histopathological examination. Histopathology revealed features suggestive of Atypical lipomatous tumour / well-differentiated liposarcoma (ALT/WDLPS) which showed the presence of striking variation in adipocyte cell size. This study is done to emphasise the importance of histopathological examination as an important diagnostic tool in differentiating lipoma from liposarcoma.

References:

Abstract:

Gangrenous intestinal obstruction during pregnancy is a rare and life-threatening non-obstetric surgical emergency that may result in maternal and fetal mortality.  These patients were often confronted with a diagnostic and therapeutic challenge since the condition is rare and overlapping of symptoms occurs. It also raises concerns over radiological evaluation and the risk involved with surgery and anaesthesia. The diagnosis is delayed due to common and overlapping symptoms and also inhibition to carry out ionising radiological investigations in pregnancy which could be harmful to the fetus. Antenatal women, 29 years old at 28 weeks of gestation presented with abdominal pain and fever. Ultrasound done immediately showed adherence of small bowel loops suggestive of intestinal obstruction. She was taken up for emergency laparotomy and proceeded with resection of the gangrenous segment completed with anastomosis. The postoperative period was uneventful. The patient was stable on discharge. Prompt diagnosis should be made and the appropriate treatment should be taken as soon as possible. Surgical intervention should be taken if necessary as earlier diagnosis and management decreases morbidity and mortality.

References:

Abstract:

The National Medical Commission (NMC) in India introduced the Competency-Based Medical Education (CBME) curriculum to enhance medical education quality and align with global standards. This curriculum emphasizes developing specific competencies, and ensuring medical students possess essential skills, knowledge, and attitudes. A survey among 500 final-year students and CRMIs at Sree Balaji Medical College and Hospital assessed their views on the CBME curriculum using a Google Forms questionnaire. Key findings include the majority finding the Foundation Course necessary for their medical training, most students rating Basic Life Support (BLS) training as very useful, and field visits generally seen as beneficial, while opinions on IT skills sessions were mixed. Early clinical exposure significantly enhanced the learning experience, with high preferences for small group teaching, self-directed learning, reflective learning, and AETCOM training in Phase I MBBS. Elective postings were considered beneficial by most respondents. Students had a mixed understanding of the new assessment schemes under CBME, and subject integration was found to be very beneficial, with preferences for both horizontal and vertical integration. Many students found Phase I MBBS to be academically stressful and strongly suggested more time for sports and physical activities. Overall, the CBME curriculum was positively received, particularly in early clinical exposure, skill development, and subject integration. However, areas such as IT skills training, the duration of the Foundation Course, and better synchronization of vertical integration require improvement. Addressing these concerns can lead to better-prepared medical graduates, capable of meeting the healthcare needs of the population with a strong emphasis on practical skills, ethical practice, and continuous learning.

References:

Abstract:

In India, cervical cancer is the second most diagnosed cancer in women. The World Health Organization (WHO) has set ambitious goals known as the 90-70-90 targets to eliminate cervical cancer: achieving 90% HPV vaccination coverage, ensuring 70% of eligible women undergo screening twice their lifetime, and providing treatment for 90% of women diagnosed with invasive and pre-invasive cancer. This study aims to assess awareness levels, evaluate knowledge, and explore current practices regarding HPV vaccination. This cross-sectional study employed an exploratory questionnaire-based survey among 200 healthcare workers at Sree Balaji Medical College and Hospital. There is a significant association (p = 0.002) between the type of healthcare worker [clinical (90%) vs. non-clinical (70%)] and their awareness of HPV vaccination. Clinical workers (85%) exhibit a significantly higher positive attitude(p<0.01) compared to non-clinical workers (60%). The chi-square analysis indicates a significant difference (p<0.001) in the practice of regularly recommending or administering HPV vaccination between clinical (70%) and non-clinical (30%) healthcare workers. There is a significant association (p < 0.001) between Clinical workers who are likely to possess high knowledge (70%) about HPV and its vaccination compared to non-clinical workers, who predominantly fall into the moderate (52%) or low knowledge (48%) categories. The findings underscore significant knowledge gaps, emphasizing the need for improved counselling on HPV vaccination targets.

References:

Abstract:

Intussusception in an adult is an uncommon, challenging situation to any surgeon. The causes for intussusception in adults are different from that of in children. Since malignancy could be one of the causes, surgery should be preferred over conservative treatment. Here we present a rare case of Non-Hodgkin Lymphoma (NHL) in an adult causing Intussusception. The patient was admitted to our hospital complaining of long-standing, unresolved abdominal pain. After USG abdomen and CT abdomen, intussusception was diagnosed. The patient underwent emergency surgery. Right sided hemicolectomy was performed and HPE diagnosis was malignant B-cell lymphoma that involved the ileocecal valve. This case explains the need for surgeons to consider malignant conditions for potential causes of intussusception in adults, to give the correct surgical treatment.

References:

Abstract:

Adolescents have been labelled the "digital natives of the technology age", yet evaluating adolescents' understanding, attitudes, and behaviour with respect to technology addiction (TA) Internet use, instant messaging, online gaming, social networking, and computer use are all examples of problematic technological applications, particularly among high school kids. The present study aims to assess the impact of technology addiction among school going adolescents. A quantitative approach with non-experimental descriptive research design was adopted for the present study. A 50 school going adolescents were recruited as study participants by using Convenient Sampling Technique. A self-structured questionnaire was administered to collect the demographic information and “Technology Addiction Scale “was used in the research. The present study suggests that the level of technology addiction among school going adolescents, majority of them 27(54%) has mild addiction, 13(26%) has moderate addiction and 10(20%) has severe addiction. Technology addiction has emerged as a major public health issue among Indian youth. To promote healthy technological behaviours, an integrated socio-ecological framework with a multilevel approach that targets risk factors at various levels is required.

References:

Abstract:

Zimbabwe's regulation of medical devices and in vitro diagnostics (IVDs) lags behind that of medicines and vaccines despite the country's goal of achieving Universal Health Coverage (UHC) by 2030. This study, conducted from June to December 2022, rigorously evaluated Zimbabwe's regulatory framework for medical devices and IVDs using a comprehensive policy analysis framework. The study's methodology, which included document review and comparative analysis, was designed to align the regulatory framework with the UHC goal. The READ (Ready, Extract, Analyze, and Distill) approach systematically assessed the relationship between medical device regulations and national health strategic goals. Fourteen documents were analysed, revealing that current regulations under the Medicines and Allied Substances Control Act are insufficient for ensuring quality-assured medical devices and IVDs due to a lack of explicit definitions and standards, leading to inconsistent regulatory practices. The study found fragmented regulatory approaches, overlapping institutional responsibilities, and a lack of effective incorporation of medical device and IVD regulations in national health strategy and related policies, hindering UHC achievement. The study recommends comprehensive policy changes to harmonise regulations, clarify institutional roles, and integrate medical device and IVD regulations into the national health strategy. This ensures access to safe, effective, quality medical devices and IVDs, promoting Zimbabwe's UHC goals by 2030.

References:

[1].  European Commission, 2017, MDR - Regulation (EU) 2017/746 on in-vitro diagnostic medical devices: Official Journal of the European Union, 1–175, https://www.emergogroup.com/sites/default/files/europe-medical-devices-regulation.pdf%0Ah

[2].  European Commission, 2017, Regulation (EU) 2017/745 of The European Parliament and of the Council on Medical Devices, Official Journal of the European Union, 5(8), 1-175, doi: 10.1177/2165079915576935.

[3].  Global Harmonization Task Force, 2006, Principles of Medical Devices Classification, 1–27, https://www.imdrf.org/sites/default/files/docs/ghtf/final/sg1/technical-docs/ghtf-sg1-n15-2006-guidance-classification-060627.pdf

[4].  International Medical Devices Regulators Forum, 2018, Essential Principles of Safety and Performance of Medical Devices, International Medical Device Regulators Forum., 12-27, https://www.imdrf.org/sites/default/files/docs/imdrf/final/technical/imdrf-tech-181031-grrp-essential-principles-n47.pdf

[5].  World Health Organization, 2018, Health products policy and standards, Good Manufacturing Practices https://www.who.int/teams/health-product-policy-and-standards/assistive-and-medical-technology/medical-devices/regulations

[6].  Hubner, S., Maloney, C., Phillips, S. D., Doshi, P., Mugaga, J., Ssekitoleko, R. T, Mueller, J. L, Fitzgerald, T. N., 2021, The evolving landscape of medical device regulation in East, Central, and Southern Africa, Global Health Science and Practice, 9(1), 136–148, doi: 10.9745/GHSP-D-20-00578.

[7].  Dacombe, R., Watson, V., Nyirenda, L., Madanhire, C., Simwinga, M., Chepuka, L., Johnson, C., Corbett, E., Hatzold, K., Taegtmeyer, M., 2019, Regulation of HIV self-testing in Malawi, Zambia and Zimbabwe: a qualitative study with key stakeholders, Journal of the International AIDS Society, 22(S1), 5–11, doi: 10.1002/jia2.25229.

[8].  Reddy, K. S. and Mathur, M. R., 2018, Universal Health Coverage, in Equity and Access, Oxford University Press, 305–322, doi: 10.1093/oso/9780199482160.003.0015.

[9].  World Health Organization, 2017, Leave no one behind. Strengthening Health Systems for UHC and the SDGs in Africa, WHO Regional Office for Africa, Licence: CC BY-NC-SA 3.0 IGO., 252–256, doi: 10.1080/15027570410006228.

[10]. World Health Organization, 2017, WHO global model regulatory framework for medical devices including in vitro diagnostic medical devices, WHO Medical Device Technical series. Licence: CC BY-NC-SA 3.0 IGO, https://www.who.int/medical_devices/publications/global_model_regulatory_framework_meddev/en/

[11]. Walt, G. and Gilson, L., 1994, Reforming the health sector in developing countries: The central role of policy analysis, Health Policy and Planning. Oxford Academic, 353–370, doi: 10.1093/heapol/9.4.353.

[12]. Kayesa, N. K. and Shung-King, M., 2021, The role of document analysis in health policy analysis studies in low and middle-income countries: Lessons for HPA researchers from a qualitative systematic review, Health Policy OPEN, (2), 100024, doi: 10.1016/j.hpopen.2020.100024.

[13]. Walt, G., Schiffman, J., Schneider, H., Murray, S. F., Brugha, R., and Gilson, L., 2008, 'Doing' health policy analysis: Methodological and conceptual reflections and challenges, Health Policy and Planning. Oxford University Press, 308–317, doi: 10.1093/heapol/czn024.

[14]. Sidibé, C. S., Becquet, V., Brückner, T. Y., Touré, O., Traoré, L. F., Broerse, J. E. W., and Dieleman, M., 2022, Adoption of harmonisation policy for the midwives’ training programme in Mali: A policy analysis, PLOS Global Public Health, 2(11), e0001296, doi: 10.1371/journal.pgph.0001296.

[15]. Walt, G. and Gilson, L., 1994, Reforming the health sector in developing countries: The central role of policy analysis, Health Policy and Planning. Oxford Academic, 353–370, doi: 10.1093/heapol/9.4.353.

[16]. Bowen, G. A., 2009, Document analysis as a qualitative research method, Qualitative Research Journal, 9(2), 27–40, doi: 10.3316/QRJ0902027.

[17]. Dalglish, S. L., Khalid, H. and McMahon, S. A., 2020, Document analysis in health policy research: The READ approach, Health Policy and Planning, 35(10), 1424–1431, doi: 10.1093/heapol/czaa064.

[18]. World Health Organization (WHO), 2020, Guidance for post-market surveillance and market surveillance of medical devices, including in vitro diagnostics, 50, https://www.who.int/publications/i/item/9789240015319

[19]. De Maria, C., Di Pietro, L., Díaz Lantada, A., Makobore, P. N., Mridha, M., Ravizza, A., Torop, J., and Ahluwalia, A., 2018, Safe innovation: On medical device legislation in Europe and Africa, Health Policy and Technology, 7(2), 156–165, doi: 10.1016/j.hlpt.2018.01.012.

[20]. World Health Organization (WHO), 2017, WHO Global Model Regulatory Framework for Medical Devices including in vitro diagnostic medical devices., WHO Medical Device Technical series. Licence: CC BY-NC-SA 3.0 IGO. http://apps.who.int/bookorders.%0Ahttp://apps.who.int/bookorders.%0Ahttps://www.who.int/medical_devices/publications/global_model_regulatory_framework_meddev/en/%0Ahttp://www.who.int/medicines/areas/quality_safety/quality_assurance/2016-07-27Modelregulato

[21]. Global Harmonization Task Force, 2012, Principles of Conformity Assessment for Medical Devices, Ghtf/Sg1/N78:2012, https://www.imdrf.org/sites/default/files/docs/ghtf/final/sg1/technical-docs/ghtf-sg1-n78-2012-conformity-assessment-medical-devices-121102.pdf

[22]. Kuchenmüller, T., Chapman, E., Takahashi, R., Lester, L., Reinap, M., Ellen, Haby, M. M., 2022, A comprehensive monitoring and evaluation framework for evidence to policy networks, Evaluation and Program Planning, 91(102053), 1–23, doi: 10.1016/j.evalprogplan.2022.102053.A.

[23]. Allen, L. N., 2022, The philosophical foundations of “health for all” and Universal Health Coverage, International Journal for Equity in Health, 21(1), 1–7, doi: 10.1186/s12939-022-01780-8

Abstract:

Orthodontic therapy plays a crucial role in the correction of malocclusions and the improvement of dental aesthetics. However, emerging evidence suggests that orthodontic appliances can significantly alter the composition and balance of the oral microbiota, leading to potential implications for oral health. This paper aims to provide a comprehensive review of the changes in oral flora observed during orthodontic therapy and their impact on oral health outcomes. The oral microbiota is a complex ecosystem comprising various microbial species that interact in dynamic equilibrium with the host. Orthodontic appliances create an environment conducive to microbial colonization and proliferation, leading to shifts in microbial diversity and abundance. It can promote the overgrowth of cariogenic bacteria leading to an increased risk of dental caries and enamel demineralization. Additionally, changes in the oral microbiota composition can cause gingival inflammation, periodontal disease, and other oral complications during orthodontic treatment. Understanding the dynamics of oral flora changes during orthodontic therapy is essential for implementing effective preventive strategies and personalized oral care regimens. Incorporating measures to mitigate dysbiosis, such as improved oral hygiene practices, antimicrobial therapy, and dietary modifications, may help minimize the adverse effects of orthodontic treatment on oral health.

References:

[1].     Gugino, C. F., Dus, I., 1998, Unlocking orthodontic malocclusions: an interplay between form and function. Seminars in Orthodontics, 4(4), 246-255.

[2].     Batista, K. B., Thiruvenkatachari, B., Harrison, J. E., O'Brien, K. D., 2018, Orthodontic treatment for prominent upper front teeth (Class II malocclusion) in children and adolescents. Cochrane Database of Systematic Reviews, 3(3), CD003452.

[3].     Macey, R., Thiruvenkatachari, B., O'Brien, K., Batista, K. B., 2020, Do malocclusion and orthodontic treatment impact oral health? A systematic review and meta-analysis. American Journal of Orthodontics and Dentofacial Orthopedics, 157(6), 738-744.

[4].     Grippaudo, M. M., Quinzi, V., Manai, A., Paolantonio, E. G., Valente, F., La Torre, G., Marzo, G., 2020, Orthodontic treatment need and timing: Assessment of evolutive malocclusion conditions and associated risk factors. European Journal of Paediatric Dentistry, 21, 203-208.

[5].     Marra, P., Nucci, L., Abdolreza, J., Perillo, L., Itro, A., Grassia, V., 2020, Odontoma in a young and anxious patient associated with unerupted permanent mandibular cuspid: A case report. Journal of International Oral Health, 12, 182.

[6].     Mulimani, P., Popowics, T., 2022, Effect of orthodontic appliances on the oral environment and microbiome. Frontiers in Dental Medicine, 3, 924835.

[7].     Soria, S., Angulo-Bejarano, P. I., Sharma, A., 2020, Biofilms: Development and molecular interaction of microbiome in the human oral cavity. New and Future Developments in Microbial Biotechnology and Bioengineering: Microbial Biofilms, 61-75.

[8].     Sedghi, L., DiMassa, V., Harrington, A., Lynch, S. V., Kapila, Y. L., 2021, The oral microbiome: Role of key organisms and complex networks in oral health and disease. Periodontology 2000, 87(1), 107-131.

[9].     Cugini, C., Ramasubbu, N., Tsiagbe, V. K., Fine, D. H., 2021, Dysbiosis from a microbial and host perspective relative to oral health and disease. Frontiers in Microbiology, 12, 617485.

[10]. Fine, D. H., Schreiner, H., 2023, Oral microbial interactions from an ecological perspective: A narrative review. Frontiers in Oral Health, 4, 1229118.

[11]. Cornejo Ulloa, P., van der Veen, M. H., Krom, B. P., 2019, Modulation of the oral microbiome by the host to promote ecological balance. Odontology, 107, 437-448.

[12]. Kouvelis, G., Papadimitriou, A., Merakou, K., Doulis, I., Karapsias, S., Kloukos, D., 2021, A prospective cohort study assessing the impact of fixed orthodontic appliances on saliva properties and oral microbial flora. Oral Health & Preventive Dentistry, 19(1), 67-76.

[13]. Lucchese, A., Bondemark, L., 2021, The influence of orthodontic treatment on oral microbiology. Biological Mechanisms of Tooth Movement, 139-158.

[14]. Raghavan, S., Abu Alhaija, E. S., Duggal, M. S., Narasimhan, S., Al-Maweri, S. A., 2023, White spot lesions, plaque accumulation and salivary caries-associated bacteria in clear aligners compared to fixed orthodontic treatment: A systematic review and meta-analysis. BMC Oral Health, 23(1), 599.

[15]. Baumer, C., Schmidtmann, I., Ohlendorf, D., Ferrari Peron, P., Wehrbein, H., Erbe, C., 2023, Orthodontists’ instructions for oral hygiene in patients with removable and fixed orthodontic appliances. International Journal of Dental Hygiene, 22(2), 329-336.

[16]. Tiwari, A., Jain, R. K., 2020, Comparison of enamel demineralisation scores between passive self-ligation brackets and conventional ligation brackets in patients undergoing orthodontic treatment: A laser fluorescence study. Journal of Clinical & Diagnostic Research, 14(11), ZC16-ZC19.

[17]. Lazar, L., Vlasa, A., Beresescu, L., Bud, A., Lazar, A. P., Matei, L., Bud, E., 2023, White spot lesions (WSLs)—post-orthodontic occurrence, management and treatment alternatives: A narrative review. Journal of Clinical Medicine, 12(5), 1908.

[18]. Kwon, T. H., Salem, D. M., Levin, L., 2024, Periodontal considerations in orthodontic treatment: A review of the literature and recommended protocols. Seminars in Orthodontics, 18 January.

[19]. Haffajee, A. D., Socransky, S. S., Patel, M. R., Song, X., 2008, Microbial complexes in supragingival plaque. Oral Microbiology and Immunology, 23(3), 196-205.

[20]. Velegraki, A., Nicolatou, O., Theodoridou, M., Mostrou, G., Legakis, N. J., 2007, Paediatric AIDS-related linear gingival erythema: A form of erythematous candidiasis? Journal of Oral Pathology and Medicine, 28, 178-182.

[21]. Paoletti, I., Fusco, A., Grimaldi, E., Perillo, L., Coretti, L., Di Domenico, M., Cozza, V., Lucchese, A., Contaldo, M., Serpico, R., 2013, Assessment of host defence mechanisms induced by Candida species. International Journal of Immunopathology and Pharmacology, 26, 663-672.

[22]. Pannone, G., Santoro, A., Carinci, F., Bufo, P., Papagerakis, S. M., Rubini, C., Campisi, G., Giovannelli, L., Contaldo, M., Serpico, R., 2011, Double demonstration of oncogenic high risk human papilloma virus DNA and HPV-E7 protein in oral cancers. International Journal of Immunopathology and Pharmacology, 24, 95-101.

[23]. Puletic, M., Popovic, B., Jankovic, S., Brajovic, G., 2020, Detection rates of periodontal bacteria and herpesviruses in different forms of periodontal disease. Microbiology and Immunology, 64, 815-824.

[24]. Sharma, S., Tapashetti, R. P., Patil, S. R., Kalra, S. M., Bhat, G. K., Guvva, S., 2015, Revelation of viral-bacterial interrelationship in aggressive periodontitis via polymerase chain reaction: A microbiological study. Journal of International Oral Health, 7, 101-107.

[25]. Pan, S., Liu, Y., Si, Y., Zhang, Q., Wang, L., Liu, J., Wang, C., Xiao, S., 2017, Prevalence of fimA genotypes of Porphyromonas gingivalis in adolescent orthodontic patients. PLoS ONE, 12, e0188420.

[26]. Lucchese, A., Bondemark, L., Marcolina, M., Manuelli, M., 2018, Changes in oral microbiota due to orthodontic appliances: A systematic review. Journal of Oral Microbiology, 10, 1476645.

[27]. Guo, R., Lin, Y., Zheng, Y., Li, W., 2017, The microbial changes in subgingival plaques of orthodontic patients: A systematic review and meta-analysis of clinical trials. BMC Oral Health, 17, 1-10.

[28]. Sun, F., Ahmed, A., Wang, L., Dong, M., Niu, W., 2018, Comparison of oral microbiota in orthodontic patients and healthy individuals. Microbial Pathogenesis, 123, 473-477.

[29]. Naranjo, A. A., Triviño, M. L., Jaramillo, A., Betancourth, M., Botero, J. E., 2006, Changes in the subgingival microbiota and periodontal parameters before and 3 months after bracket placement. American Journal of Orthodontics and Dentofacial Orthopedics, 130, 275.e17.

[30]. Kim, S.-H., Choi, D.-S., Jang, I., Cha, B.-K., Jost-Brinkmann, P.-G., Song, J.-S., 2012, Microbiologic changes in subgingival plaque before and during the early period of orthodontic treatment. *Angle OrthHere are the remaining references formatted in the requested style.

[31]. Ireland, A. J., Soro, V., Sprague, S. V., Harradine, N. W. T., Day, C., Al-Anezi, S., Jenkinson, H. F., Sherriff, M., Dymock, D., Sandy, J. R., 2013, The effects of different orthodontic appliances upon microbial communities. Orthodontics & Craniofacial Research, 17, 115-123.

[32]. Levrini, L., Mangano, A., Montanari, P., Margherini, S., Caprioglio, A., Abbate, G. M., 2015, Periodontal health status in patients treated with the Invisalign® system and fixed orthodontic appliances: A 3-month clinical and microbiological evaluation. European Journal of Dentistry, 9, 404-410.

[33]. Lombardo, L., Palone, M., Scapoli, L., Siciliani, G., Carinci, F., 2020, Short-term variation in the subgingival microbiota of two groups of patients treated with clear aligners and vestibular fixed appliances: A prospective study. Orthodontics & Craniofacial Research, 24(2), 251-260.

[34]. Lu, H., Tang, H., Zhou, T., Kang, N., 2018, Assessment of the periodontal health status in patients undergoing orthodontic treatment with fixed appliances and Invisalign system. Medicine, 97, e0248.

[35]. Muzurovic, S., Babajic, E., Masic, T., Smajic, R., Selmanagic, A., 2012, The relationship between oral hygiene and oral colonization with Candida species. Medical Archives, 66, 415-417.

[36]. Jiang, Q., Li, J., Mei, L., Du, J., Levrini, L., Abbate, G. M., Li, H., 2018, Periodontal health during orthodontic treatment with clear aligners and fixed appliances. Journal of the American Dental Association, 149, 712-720.

[37]. Flores-Mir, C., 2019, Clear aligner therapy might provide a better oral health environment for orthodontic treatment among patients at increased periodontal risk. Journal of Evidence-Based Dental Practice, 19, 198-199.

Abstract:

A condition in which the force of the blood against the artery walls is too high is described as hypertension. Usually, hypertension is defined as blood pressure above 140/90 and is considered severe if the pressure is 180/120 mmHg. The Dietary Approaches to Stop Hypertension (DASH) dietary pattern emphasizes fruits, vegetables, low-fat dairy products, and reduced sodium intake. A quantitative descriptive research approach was used after obtaining permission from the investigator. Sixty samples were selected using a purposive sampling technique. The samples who met the inclusion criteria at the community area were recruited. The investigator introduced and explained the purpose of the study to participants and obtained informed consent. The post-test scores of knowledge and practices were highly significant when compared to pretest scores using the paired t-test. Thus, the present study shows that the IEC material was effective in improving the knowledge and practices on dietary management of hypertension significantly among patients with hypertensive clients. Dietary Approaches to Stop Hypertension Diet research showed that it could lower blood pressure as well as the first-line blood pressure medication, even with a sodium intake of 3300 mg per day. Since then, numerous studies have shown that the Dietary Approaches to Stop Hypertension (DASH) diet reduces the risk of cancer, stroke, and heart disease, including heart failure, kidney stones, and other diseases. The DASH diet's ability to manage hypertension is profound.

References:

[1].  Juraschek, S. P., Miller, E. R., & Weaver C. M., 2020, Effects of sodium reduction on energy, metabolism, weight, thirst, and urine volume: results from the DASH-sodium trial. Hypertension, 75(3), 723-729.

[2].  Kerley, C. P., 2019, Dietary patterns and components to prevent and treat heart failure: A comprehensive review of human studies. Nutrition Research Reviews, 32(1), 1-27.

[3].  Dominguez, L. J., & Barbagallo M., 2018, Nutritional prevention of cognitive decline and dementia. Acta Bio Medica: Atenei Parmensis, 89(2), 276.

[4].  Kerley, C. P., 2018, A review of plant-based diets to prevent and treat heart failure. Cardiac Failure Review, 4(1), 54.

[5].  Saneei, P., et al. 2014, Influence of Dietary Approaches to Stop Hypertension (DASH) diet on blood pressure: A systematic review and meta-analysis on randomized controlled trials. Nutrition, Metabolism and Cardiovascular Diseases, 24(12), 1253-1261.

[6].  Ozemek, C., & Myers, J., 2018, The role of diet for prevention and management of hypertension. Current Opinion in Cardiology, 33(4), 388-393.

[7].  dos Reis Padilha, G., et al, 2018, Dietary patterns in secondary prevention of heart failure: A systematic review. Nutrients, 10(7), 828.

[8].  Urrico, P., & Iacobellis, G., 2018, Nonpharmacological interventions in the management of hypertension in the adult population with type 2 diabetes mellitus. Canadian Journal of Diabetes, 42(2), 196-198.

[9].  Tyson, C. C., & Martin, D., 2012, The Dietary Approaches to Stop Hypertension (DASH) eating pattern in special populations. Current Hypertension Reports, 14, 388-396.

[10]. Soltani, S., et al., 2020, Adherence to the DASH diet in relation to all-cause and cause-specific mortality: a systematic review and dose-response meta-analysis of prospective cohort studies. Nutrition Journal, 19, 1-13.

[11]. Levitan E. B., et al., 2009, Relation of consistency with the DASH diet and incidence of heart failure in men aged 45 to 79 years. The American Journal of Cardiology, 104(10), 1416-1420.

[12]. Sanches Machado d’Almeida, K., 2018, Mediterranean diet and other dietary patterns in primary prevention of heart failure and changes in cardiac function markers: a systematic review. Nutrients, 10(1), 58.

[13]. Scisney-Matlock, M., 2009, Strategies for implementing and sustaining therapeutic lifestyle changes as part of hypertension management in African Americans. Postgraduate Medicine, 121(3), 147-159.

[14]. Saneei, P., 2015, Adherence to the DASH diet and prevalence of the metabolic syndrome among Iranian women. European Journal of Nutrition, 54, 421-428.

[15]. Wang, T., 2018, Improving adherence to healthy dietary patterns, genetic risk, and long-term weight gain: gene-diet interaction analysis in two prospective cohort studies. BMJ, 360.

Abstract:

Cause of Male infertility is diagnosed at a later age unless a genito-urethral condition with detailed evaluation is required. Congenital developmental disorders remain hidden till it is surgically identified. In managing congenital conditions we could pick up developmental anomalies incidentally and end up charging diagnosis and management plan. A descriptive study of a boy of age 4 years reported with congenital hydrocele for which Herniotomy with eversion of the sac was done, upon which testicular epididymal disjunction was identified. The outcome of surgical correction and conservative management may vary with; diagnosing time, the extent of the pathology, and response to treatment. Considering Type IV epididymal disjunction present in, with inconclusive histological evidence of epididymal atresia, in the presence of normal karyotyping conservation long-term follow-up was chosen rather than the exploration of the disjunction given the risk of obstructive azoospermia. Wait and watch policy is better for type V epididymal disjunction rather than an aggressive surgical approach. Given androgenic development and the potential possibility of efficacious function in an individual of normal karyotyping.

References:

Abstract:

Background: The global scenario of Diabetes Mellitus is worsening every day irrespective of so many positive moves to mitigate it by WHO guided Health awareness programs and treatment protocols. Even now health professionals are engaged in managing its complications rather than treatment as such. A major portion of sufferers of this deadly disease need attention to reduce the sequelae of insulin insensitivity or insulin resistance like dysfunction in lipid, carbohydrate, and protein metabolism. To achieve the same, it is unavoidable to increase the pill count. Most of the drugs can’t be boxed into fixed-dose combinations. Choosing a drug with a pleiotropic effect for a disease is the need of the hour. Both study drugs are known for their pleiotropic effects. The study drug used is metformin higher dose of 850 mg twice daily against teneligliptin (DPP4 Inhibitor) 20 mg once daily with metformin 500mg twice daily combination. This study was conducted to find which antidiabetic can better act as hypolipidemic as well. Method: The study tenure was from May 2020 – October 2020, a total of 6 months. Overall, one hundred and sixty patients were assessed; among them hundred members were selected and ninety-one completed the study. The members were included as per the inclusion criteria. Research significance: This study aims to explore the synergistic effects of combining Teneligliptin 20 mg once daily with Metformin 500 mg twice daily on lipid profile improvement in patients with Type 2 Diabetes Mellitus (T2DM). While Metformin is a well-established first-line treatment, its efficacy at higher doses may come with increased side effects. By integrating Teneligliptin, a DPP-4 inhibitor, with Metformin at a moderate dose, we hypothesize that this combination will not only provide effective glycemic control but also offer superior lipid profile management. The findings could suggest a more effective and safer therapeutic strategy, reducing the need for higher Metformin doses and minimizing associated risks. Therefore, the combination of Teneligliptin with Metformin is a promising therapeutic approach for T2DM management.

References:

Abstract:

The inferior border of the medial pterygoid plate extends to form the pterygoid hamulus (PH). The PH's length and location are crucial for these functions. The PH’s morphology helps in interpreting the imaging and also provides information regarding anatomical determinants to limit the posterolateral borders of maxillary complete dentures. This can also aid in gender identification in forensic situations. This study analyzed 80 CBCT scans from 40 male and 40 female patients (ages 25–67, median 38). Significant differences were found in pterygoid hamulus length between sexes: males had longer hamuli on both the right (8.840±0.299 mm vs. 7.940±0.349 mm, P=0.000) and left sides (7.899±0.419 mm vs. 7.277±0.271 mm, P=0.002). However, no significant differences in hamulus width were observed between males and females. These findings suggest length variations could be useful in clinical and anthropological contexts. Dimensions of pterygoid hamulus in completely edentulous patients will aid the clinician in precisely recording the posterolateral borders of maxillary dentures; this can also aid in gender determination in fragmented skulls in forensic applications.

References:

Abstract:

The escalating prevalence of diabetes mellitus on a global scale has spurred an urgent need for innovative and effective therapeutic interventions, Nelumbo nucifera, commonly known as the sacred lotus, has been revered for centuries in various cultures for its symbolic significance and aesthetic appeal. Beyond its cultural importance, various parts of the Nelumbo nucifera plant, including its seeds, leaves, and rhizomes, are rich repositories of bioactive compounds. These compounds, ranging from alkaloids and flavonoids to polysaccharides, exhibit diverse pharmacological activities and its been a subject of interest for researchers due to their rich phytochemical composition. Among its various bioactive properties, the alpha-glucosidase and amylase inhibition capabilities stand out for their potential in managing diabetes mellitus. These enzymes play crucial roles in carbohydrate metabolism, and their inhibition can effectively control postprandial hyperglycemia, a critical aspect of diabetes management This study is done using different concentrations of samples and standard drugs showing amylase and alpha-glucosidase inhibition properties and analysed and calculated using percentage inhibition formula and it showed the percentage of alpha amylase inhibition by standard concentration 400ug is 53.3 % and sample 500ug is 50%, The percentage inhibition of concentration alpha glucosidase inhibition for standard concentration 400ug is 72.2% and sample 500ug is 71.4%. The study concluded that Nelumbo nucifera possesses both alpha-glucosidase and amylase inhibition properties and is a good natural source of remedy for diabetes, that can be combined with other drugs.

References:

Abstract:

This study assessed perceptions and satisfaction with PMTCT services, and reasons for dissatisfaction among women living with HIV who received PMTCT services in Akwa Ibom State, Nigeria. Data for this cross-sectional study was collected using a validated questionnaire from women living with HIV who were at least two months post-partum between January – March 2023 and had received PMTCT services during the PMTCT scale-up period (January 2022 – December 2022) across 13 health facilities in Akwa Ibom, Nigeria. Client perception and satisfaction were assessed based on the Mosadeghrad framework for quality of care. Women with satisfaction scores ≥ the cut-off were classified as “satisfied,” otherwise “not satisfied”. Logistic regression analysis determined differences in satisfaction, at p-value ≤0.05. A total of 631 women living with HIV participated: 435 (69%) were 25-34 years old, 524 (83%) were married, 59% resided in rural areas and 414 (66%) received their first antenatal care at a health facility. Participants had the lowest perception regarding their ability to access PMTCT services at any day and time, with only 74% responding affirmatively. Conversely, 99% of participants responded that their care providers listened to their concerns and provided adequate information in a friendly manner. Overall, 71.5% (450/629) of participants were satisfied with the PMTCT services. The main reasons for dissatisfaction were the proximity of services, staff attitude and professionalism and providers' knowledge and skills. By addressing these, the PMTCT program can meet the needs of women living with HIV, ultimately contributing to better health outcomes and a reduction in mother-to-child transmission rates.

References: