Assessment of 12 Months Retention in Care among Children living with HIV in a Pediatric Reference Hospital, Yaounde Cameroon

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DOI: 10.21522/TIJPH.2013.05.04.Art020

Authors : Andreas A. B. Frambo

Abstract:

Poor retention in HIV care is a known main challenge for antiretroviral treatment programs resulting to poor performance and increased morbi-mortality. Many studies related to retention are focused on adults including pregnant women, leaving out children, especially in sub Saharan Africa. The objective of this study is to assess 12 months retention and determine factors associated with retention among children on ART. A cross-sectional study was carried out in a pediatric reference in Yaounde, Cameroon. Registers of children enrolled on antiretroviral therapy from Oct 2015 to Oct 2016 were reviewed for retention. Factors associated with retention in children were determined for future improvement.

A total of 416 children were enrolled and after 12 months follow up, 398 (90.9%) were found to be alive and still on treatment. Young age (age less than 1 year) of start on ART and CD4% were the factors associated with poor retention & attrition at 12 months after initiation.

Twelve months retention in care for children living with HIV is near optimal (90.0%) with a high chance of long term survival. Age less than 1 year and CD4% were baseline risk factors for poor retention. Given that children rely on their caregivers for optimal retention, there is need for robust prevention of mother to child transmission programs and pediatric case finding & linkage to care strategies. Quality data will help improve strategies and procedures to boost long term retention required for viral suppression needed end the HIV pandemic.

Keywords: HIV, Assessment, Retention, 12 months, Children, Cameroon.

References:

[1]. Abuogi LL, Smith C, McFarland EJ. Retention of HIV-Infected Children in the First 12 Months of Anti-Retroviral Therapy and Predictors of Attrition in Resource Limited Settings: A Systematic Review. PLoS ONE (2016)11(6): e0156506. doi: 10.1371/ journal.pone.0156506.

[2]. Alvarez-Uria G, Pakam R, Midde M, Naik PK. Entry, Retention, Virological Suppression in an HIV Cohort Study in India: Description of the Cascade of Care and Implications for Reducing -Related Mortality in Low- and Middle-Income Countries. Interdisciplinary Perspectives on Infectious Diseases. 2013; Article ID 384805: 8. PubMed | Google Scholar.

[3]. Amuron B, Namara G, Birungi J, Nabiryo C, Levin J, Grosskurth H, et al. Mortality and loss-to-follow-up during the pre-treatment period in an antiretroviral therapy programme under normal health service conditions in Uganda. BMC Public Health. 2009; 9 (1):290.

[4]. Atemnkeng FN et al. Cause of poor retention in care in adult HIV patients on treatment at the Bafoussam Regional Hospital, Cameroon. STD-AIDS-2015 .Conference series LLC [Internet]. [Cited 2016 Oct 26]. Available from: http://hiv-aids std. conferenceseries.com /abstract /2015 /cause-of-poor-retention-in-care-in-adult-hiv-patients-on-treatment-at-the-bafoussam-regional-hospital-cameroon.

[5]. Bassett IV, Regan S, Chetty S, Giddy J, Uhler LM, Holst H, Ross D, Katz JN, Walensky RP, Freedberg KA, Losina E. Who starts antiretroviral therapy in Durban, South Africa? not everyone who should. AIDS. 2010; 24 (Suppl 1):S37-44. PubMed | Google Scholar.

[6]. Boyles TH, Wilkinson LS, Leisegang R, Maartens G. Factors influencing retention in care after starting antiretroviral therapy in a rural South African programme. PloS One. 2011 May 3; 6(5):e19201.

[7]. Charurat M, Oyegunle M, Benjamin R, Habib A, Eze E, Ele P, Ibanga I, Ajayi S, Eng M, Mondal P, Gebi U, Iwu E, Etiebet M, Abimiku A, Dakum P, Farley J, Blattner W. Patient Retention and Adherence to Antiretrovirals in a Large Antiretroviral Therapy Program in Nigeria: A Longitudinal Analysis for Risk Factors. PLoS ONE. 2010; 5(5): 10584. PubMed | Google Scholar.

[8]. Dahab M, Charalambous S, Hamilton R, Fielding K, Kielmann K, Churchyard GJ, et al. “That is why I stopped the ART”: Patients’ & providers’ perspectives on barriers to and enablers of HIV treatment adherence in a South African workplace programme. BMC Public Health. 2008; 8:63.

[9]. Fox MP, Rosen S. Patient retention in antiretroviral therapy programs up to three years on treatment in sub-Saharan Africa, 2007-2009: systematic review. Trop Med Int Health TM IH. 2010 Jun; 15 Suppl 1:1–15.

[10].  Forster M, Bailey C, Brinkhof MW, Graber C, Boulle A, Spohr M, Balestre E, May M, Keiser O, Jahn A, Egger M. Electronic medical record systems, data quality and loss to follow-up: survey of antiretroviral therapy programmes in resource-limited settings. Bull World Health Organ. 2008; 86:939-947. PubMed | Google Scholar.

[11].  Frambo B. A. A, Diko A C, Kamga D, Bieme-Ndi E, Ako-Arrey D, Epanya N, Sadate-Ngatchou P, Abessouguie I, Nzuobontane D. Retention in HIV Care and Treatment , 12 months after Initiation on ART. 10th International Workshop on HIV treatment, Pathogenesis and Prevention Research in Resource-Limited settings, May 2016, Abstract Book.

[12].  Jarett O, Mwamburi M. 5th IAS Conference on HIV Pathogenesis, Treatment, and Prevention [Internet]. Medscape. [cited 2016 Oct 28]. Available from: www.medscape.com/viewcollection/30399. Accessed 21 February 2017.

[13].  Lessells RJ, Mutevedzi PC, Cooke GS, Newell ML. Retention in HIV care for individuals not yet eligible for antiretroviral therapy: rural Kwazulu-Natal, South Africa. Journal of Acquired Immune Deficiency Syndromes. 2011; 56(3):79-86. PubMed |Google Scholar.

[14].  Mberi MN, Kuonza LR, Dube NM, Nattey C, Manda S, Summers R. Determinants of loss to follow-up in patients on antiretroviral treatment, South Africa, 2004-2012: a cohort study. BMC Health Serv Res. 2015 Jul 4; 15:259.

[15].  Muula AS, Ngulube TJ, Siziya S, Makupe CM, Umar E, Prozesky HW, Wiysonge CS, Mataya RH. Gender distribution of adult patients on highly active antiretroviral therapy (HAART) in Southern Africa: a systematic review. BMC Public Health. 2007; 7: 63. PubMed | Google Scholar.

[16].  National AIDS Control Organisation (NACO). India HIV Estimates. 2011. Available from http://naco.gov.in/upload/Surveillance/Reports%20&%20Publication/HSS%202010-11_Technical%20Brief_30%20Nov%2012.pdf (Accessed 29th May 2017). Google Scholar.

[17].  Remien RH, Chowdhury J, Mokhbat JE, Soliman C, Adawy ME, Sadr WE. Gender and care: access to HIV testing, care, and treatment. J Acquir Immune Defic Syndr. 2009; 51(Suppl 3):S106-110. PubMed | Google Scholar.

[18].  Rosen S, Fox MP, Gill CJ. Patient retention in antiretroviral therapy programs in Sub-Saharan Africa: a systematic review. PLoS Med. 2007; 4(10):e298. PubMed | Google Scholar.

[19].  Roura M, Busza J, Wringe A, Mbata D, Urassa M, Zaba B. Barriers to sustaining antiretroviral treatment in Kisesa, Tanzania: a follow-up study to understand attrition from the antiretroviral program. AIDS Patient Care STDs. 2009 Mar; 23(3):203–10.

[20].  Sengayi M, Dwane N, Marinda E, Sipambo N, Fairlie L, Moultrie H.  Predictors of loss to follow-up among children in the first and second years of antiretroviral treatment in Johannesburg, South Africa. Global health action. 2013; 6:19248. doi: 10.3402/gha.v6i0.19248 PMID: 23364098.

[21].  Sherer R, Stieglitz K, Narra J, Jasek J, Green L, Moore B, et al. HIV multidisciplinary teams work: support services improve access to and retention in HIV primary care. AIDS Care. 2002 Aug; 14 Suppl 1:S31–44.

[22].  Thida A, Tun STT, Zaw SKK, Lover AA, Cavailler P, Chunn J, et al. Retention and risk factors for attrition in a large public health ART program in Myanmar: a retrospective cohort analysis. PloS One. 2014; 9(9):e108615.

[23].  Ulett KB, Willig JH, Lin H-Y, Routman JS, Abroms S, Allison J, et al. The therapeutic implications of timely linkage and early retention in HIV care. AIDS Patient Care STDs. 2009 Jan; 23(1):41–9.

[24].  WHO | Guidelines: HIV. WHO. [cited 2016 Oct 28]. Available from: http://www.who.int/hiv/pub/guidelines/en/ Accessed 16 March 2017.

[25].  WHO. UNAIDS World AIDS Day Report 2012 Core epidemiology slides. 2012 Available from: http://www.who.int/hiv/data/en/  (Accessed 29 May 2017).Google Scholar.