Prevalence of Undiagnosed Diabetes Mellitus amongst Hypertensive Patients Attending an Outpatient Clinic in Harare, Zimbabwe

Download Article

DOI: 10.21522/TIJPH.2013.04.04.Art009

Authors : Pasipanodya Ian Machingura, Rosinah Murambiwah

Abstract:

Diabetes mellitus is amongst the largest health emergencies of the 21st century. However studies have reported that a substantial proportion of people with diabetes mellitus had not previously been diagnosed. On the other hand hypertension prevalence has been reported to be on the increase. Hypertension has also been associated with the development of diabetes mellitus. The study sought to determine the prevalence of undiagnosed diabetes mellitus in hypertensive patients attending an outpatient clinic in Harare, Zimbabwe.

A cross sectional study was conducted at Parirenyatwa Group of Hospitals Outpatient Clinic. All hypertensive patients attending the outpatient during the study period were given the information about the study. All hypertensive patients who were previously not diagnosed of diabetes mellitus who consented to participate in the study were consecutively enrolled. A questionnaire was administered and blood samples were collected for Glycosylated hemoglobin analysis. Glycosylated hemoglobin was analysed using a Mindray BS800 Chemistry Analyser.

One hundred and four hypertensive patients were enrolled into the study whose mean age was 60.91(± standard deviation of 14.06) years. Patients with duration of hypertension greater than 10 years constituted 34% (35) of the study population. The prevalence of undiagnosed diabetes mellitus was 22.1% (23). Among the previously undiagnosed diabetic patients 56.5% (13) were females and 43.5% (10) males.

The prevalence of undiagnosed diabetes mellitus was found to be 22, 1% among hypertensive patients which is higher than that reported in Kenya but lower than that reported in Uganda. Diabetes mellitus can be highly prevalent in hypertensive patients thus there is need for constant monitoring for the development of diabetes mellitus and further research using a national representative sample.

Keywords: Diabetes mellitus, pre-diabetes, glycosylated haemoglobin

References:

[1] Bruno RM, Taddei S. New-onset diabetes in hypertensive patients and mortality: timing is everything. Eur Heart J. 2016 Mar 21;37(12):975–7.

[2] International Diabetes Federation. International Diabetes Federation Diabetes Atlas Seventh Edition [Internet]. 2015 [cited 2016 Jul 20]. Available from: www.diabetesatlas.org

[3] Iloh GUP. Risk Factors of Pre-Diabetes among Adult Nigerians with Essential Hypertension in a Resource-Constrained Setting of a Primary Care Clinic in Eastern Nigeria. Am J Health Res. 2013;1(3):56.

[4] Joshi SR, Saboo B, Vadivale M, Dani SI, Mithal A, Kaul U, et al. Prevalence of Diagnosed and Undiagnosed Diabetes and Hypertension in India—Results from the Screening India’s Twin Epidemic (SITE) Study. Diabetes Technol Ther. 2012 Jan;14(1):8–15.

[5] Korhonen P, Aarnio P, Saaresranta T, Jaatinen P, Kantola I. Glucose Homeostasis in Hypertensive Subjects. Hypertension. 2008 Apr 1;51(4):945–9.

[6] Lüders S, Hammersen F, Kulschewski A, Venneklaas U, Züchner C, Gansz A, et al. Diagnosis of impaired glucose tolerance in hypertensive patients in daily clinical practice. Int J Clin Pract. 2005;59(6):632–8.

[7] Ministry of Health and Child Welfare Republic of Zimbabwe. 6th Essential Medicines list and standard treatment guidelines for Zimbabwe. 2011.

[8] Mutebi E, Nakwagala FN, Nambuya A, Otim M. Undiagnosed diabetes mellitus and impaired glucose tolerance among hypertensive patients in Mulago Hospital, Kampala, Uganda. Afr J Diabetes Med [Internet]. 2012 [cited 2016 Oct 28];20. Available from: http://www.africanjournalofdiabetesmedicine.com/articles/May_2012/AJDM%20MAY%20PP%2020-23.pdf

[9] Meme N, Amwayi S, Nganga Z, Buregyeya E. Prevalence of undiagnosed diabetes and pre-diabetes among hypertensive patients attending Kiambu district Hospital, Kenya: a cross-sectional study. Pan Afr Med J [Internet]. 2015 [cited 2016 Oct 28];22. Available from: http://www.panafrican-med-journal.com/content/article/22/286/full/

[10] Organisation mondiale de la santé. Global status report on noncommunicable diseases 2014: attaining the nine global noncommunicable diseases targets; a shared responsibility. Geneva: World Health Organization; 2014.

[11] Organization WH, others. Use of glycated haemoglobin (HbA1c) in diagnosis of diabetes mellitus: abbreviated report of a WHO consultation. 2011 [cited 2016 Oct 28]; Available from: http://apps.who.int/iris/handle/10665/70523

[12] Orozco LJ, Buchleitner AM, Gimenez-Perez G, Roqué i Figuls M, Richter B, Mauricio D. Exercise or exercise and diet for preventing type 2 diabetes mellitus. In: The Cochrane Collaboration, editor. Cochrane Database of Systematic Reviews [Internet]. Chichester, UK: John Wiley & Sons, Ltd; 2008 [cited 2016 Oct 28]. Available from: http://doi.wiley.com/10.1002/14651858.CD003054.pub3

[13] The International Expert Committee. International Expert Committee Report on the Role of the A1C Assay in the Diagnosis of Diabetes. Diabetes Care. 2009 Jul 1;32(7):1327–34.