Coagulation Dynamics in Laparoscopic Cholecystectomy: Investigating the Impact of Carbon Dioxide Pneumoperitoneum
Abstract:
Laparoscopic cholecystectomy is the
widely used procedure to treat various gall bladder pathologies, During the
procedure, pneumoperitoneum is created with carbon dioxide (CO₂) to improve
visualization. This study investigates the impact of CO₂ pneumoperitoneum on
coagulation dynamics in patients undergoing the procedure. Fifty-four patients
were observed to assess preoperative and postoperative changes in coagulation
parameters, including prothrombin time (PT) and D-dimer levels. The study found
that postoperative PT changes were minimal, with a mean decrease from 11.83 to
11.7 seconds. D-dimer levels significantly increased, indicating heightened
fibrinolytic activity, which can cause deep vein thrombosis (DVT) in high-risk
individuals. The study highlights the importance of monitoring coagulation
profiles during laparoscopic procedures and suggests that prophylactic
anticoagulation should be considered for high-risk patients. Further
large-scale investigations are recommended to quantify thrombotic risks
associated with CO₂ pneumoperitoneum.
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