Abstract:

Both the molecular characterization of Calcarea Carbonicum 200C using Fourier Transform Infrared Spectroscopy and its clinical effects in post-COVID patients are examined in this study. Twenty patients suffering from persistent symptoms like immunological dysfunction and exhaustion participated in the study held at Sarada Krishna Homoeopathic Medical College. Comparing IgG levels before and after therapy revealed a statistically significant 52% decrease (p = 0.00032) in clinical outcomes; IgG is a critical indicator of immunological regulation. The molecular composition of Calcarea Carbonicum was confirmed by FTIR analysis, which found essential functional groups, such as carbonate ions and hydroxyl groups. The presence of organic contaminants in the spectrum may provide information on how they interact with living organisms. According to these results, Calcarea Carbonicum may help stabilize the immune system and alleviate symptoms in post-viral syndromes. This study provides therapeutic benefits and molecular understanding of the medicine Calcarea Carbonicum, highlighting its potential as a supplemental treatment for chronic COVID-19 symptoms. Nevertheless, future studies should use bigger cohorts and randomized controlled designs to address the limitations, such as the lack of a control group and the limited sample size. These findings open the door to the possibility of including homoeopathy in more comprehensive treatment plans for post-COVID recovery.

References:

[1].   Lal, A., Lim, C., Almeida, G., & Fitzgerald, J., 2022, Minimizing COVID-19 disruption: ensuring the supply of essential health products for health emergencies and routine health services. The Lancet Regional Health–Americas, 6, 1-6.

[2].   Oronsky, B., Larson, C., Hammond, T. C., Oronsky, A., Kesari, S., Lybeck, M., & Reid, T. R., 2023, A review of persistent post-COVID syndrome (PPCS). Clinical Reviews in Allergy & Immunology, 64(1), 66-74.

[3].   Tang, C., Dziedzic, A., Khatib, M. N., Alhumaid, S., Thangavelu, L., Parameswari, R. P., & Rabaan, A. A., 2024, Stem cell therapy for COVID-19 treatment: an umbrella review. International Journal of Surgery, 110(10), 6402-6417.

[4].   Bellavite, P., 2015, Homeopathy and integrative medicine: keeping an open mind. Journal of Medicine and the Person, 13, 1-6.

[5].   Pandey, S., & Pandit, R., 2020, Pelvic inflammatory disease treated with homoeopathic medicine Calcarea carbonica: A case Report. Indian Journal of Research in Homoeopathy, 14(4), 287-292.

[6].   Vimal, S., Madar, I. H., Thirumani, L., Thangavelu, L., & Sivalingam, A. M., 2024, CRISPR/Cas9: Role of genome editing in cancer immunotherapy. Oral Oncology Reports, 100251.

[7].   Siddique, I. M., 2024, Exploring Functional Groups and Molecular Structures: A Comprehensive Analysis Using FTIR Spectroscopy. Chemistry Research Journal, 9(2), 70-76

[8].   Geetha, R. V., & Lakshmi, T., 2023, In Vitro evaluation of antimycotic activity of oregano essential oil on candida species from isolation of patient with chronic periodontitis. Journal of Complementary Medicine Research, 13(5), 60-60.

[9].   Das, D., Das, I., Das, J., Kayal, S. K., & Khuda-Bukhsh, A. R., 2016, Efficacy of two traditionally used potentized homeopathic medicines, Calcarea carbonica and Lycopodium clavatum, used for treating PCOS patients: I. Effects on certain important external guiding symptoms. CellMed, 6(1), 6-1.

[10].  Dixit, A. K., Giri, N., & Singh, S., 2023, Exploring the scope of homoeopathy in combating the unfortunate consequences of post-COVID-19 survivors based on non-COVID conditions: a narrative review. Journal of Complementary and Integrative Medicine, 20(2), 302-315.

[11].  Nayak, D., Gupta, J., Chaudhary, A., Singh, K. G., Deshmukh, A., Das, D., & Khurana, A., 2022, Efficacy of individualized homeopathy as an adjunct to standard of care of COVID-19: A randomized, single-blind, placebo-controlled study. Complementary Therapies in Clinical Practice, 48, 101602.

[12].  Parikh, N., Parikh, D., & Parikh, D., 2020, Role of homoeopathy in COVID-19 Management-A clinical experience. World Journal of Pharmaceutical Research, 9(5), 2459-2466.

[13].  Jagtap, C. Y., Charde, V., Rawat, H., Dane, G., Mishra, A. K., Narasimhaji, C. V., & Acharya, R., 2024, The Structural and Thermal properties of Badarashma Pishti. Journal of Ayurveda and Integrative Medicine, 15(6), 100989.

[14].  Kumar, S.T.G., Beeram, E., Begum, S., Chatterjee, P., Samajdar, D., 2025, Refinement Of Spme-Gc/Ms For The Detection Of Volatile Organic Compounds In Medical Science And Pharmacy. Journal of Applied Bioanalysis, 11(1), 36-45.

[15].  Anooj, E., Charumathy, M., Sharma, V., Vibala, BV., Gopukumar, ST., Jainab, SIB., Vallinayagam, S., 2021,  Nanogels: An overview of properties, biomedical applications, future research trends and developments.  Journal of Molecular Structure,1239:130446.

[16].  Ashokkumar, M., Palanisamy, K., Kumar, A. G., Muthusamy, C., & Kumar, K. J. S., 2024, Green synthesis of silver and copper nanoparticles and their composites using Ocimum sanctum leaf extract displayed enhanced antibacterial, antioxidant and anticancer potentials. Artificial Cells Nanomedicine and Biotechnology, 52(1), 438–448.

[17].  Kumar, A. G., Joseph, B., Nandagopal, S., Sankarganesh, P., & Jagdish, S. K., 2019b, Experimental human root canal irrigant NAOCL against enterococcus faecalis and 3T3, and determination of cytotoxicity effect. Biomedical & Pharmacology Journal, 12(2), 965–974.

[18].  Sankarganesh, P., Parthasarathy, V., Kumar, A. G., Saraniya, M., Udayakumari, N., & Ragu, S., 2022, Development of novel mannitol blended PVA hydrogel membrane and its anticancer and antimicrobial drug delivery potential for wound dressing applications. Journal of Sol-Gel Science and Technology, 103(2), 447–456.

[19]. Elumalai, L., Palaniyandi, S., Anbazhagan, G. K., Mohanam, N., Munusamy, S., GK, S. R., Munusamy, A. P., Chinnasamy, M., & Ramasamy, B., 2023, Synthesis of biogenic cadmium sulfide nanoparticles (MR03-CdSNPs) using marine Streptomyces kunmingensis - MR03 for in-vitro biological determinations and in silico analysis on biofilm virulence proteins: A novel approach. Environmental Research, 235, 116698.

[20]. Rajan, A., Praseetha, P.K., Ariharan, V.N., Gopu Kumar, S.T., 2019, Invitro cytotoxic and anti – cancer studies of polyvinyl alcohol mediated 5fluorouracil conjugated gold nanoparticles.  International Journal of Recent Technology and Engineering,7(6),127–143.