Abstract:

This study aimed to evaluate the biochemical role of liver functions (activity of liver enzymes and proteins) and kidneys (urea and creatinine) in the serum of pregnant women with preeclampsia. A total of 60 blood samples from pregnant women with preeclampsia and hypertension during pregnancy, and 35 healthy pregnant women with matched age and pregnancy stage (control group) were collected and serum separated. Liver and renal function tests were measured, these included serum alkaline phosphate enzyme activity (ALP), alanine aminotransferase activity (ALT), aspartate aminotransferase activity (AST), Gamma-glutamyl transferase activity (GGT), serum total protein, serum albumin, urea test, and Creatinine test. These parameters were significantly (p<0.05) higher in preeclampsia patients compared to the control group. Differences were noticed between the second and third trimesters of pregnancy, and an association was also reported between older age compared to younger. In conclusion, liver and renal function were affected by pregnancy with greater association with preeclampsia in pregnant women and the ageing process has a more aggressive impact on renal and liver abnormalities.

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