Abstract:

Fucokinase is involved in the fucosylation of carbohydrates, which are involved in various biological and pathological processes in eukaryotic organisms, such as tissue development, angiogenesis, and fertilization. In our study, FUK in addition to Some enzymes, Hormones, Lipid profiles, oxidants and antioxidants, and other biochemical parameters were measured in serum for (175) women of ages ranging from (18 – 40) years Also, 80 serum samples were collected from women suffering from menopause in the same ages from Mosul city. The results showed that there is a decrease in the FUK, vitamin D, Triglyceride (TG), Very low-density lipoprotein (VLDL), glutathione (GSH) and high levels of alkaline phosphatase (ALP), total bilirubin (TB) and calcium (Ca), Progesterone, Testosterone, low-density lipoprotein (LDL), Atherogenic index and malondialdehyde (MDA) in MP women compared to healthy women. The hormonal changes associated with MP lead to increased liver enzyme levels, indicating a potential risk for liver dysfunction and increased bone turnover, while Ca levels may decline due to decreased estrogen. Total bilirubin and phosphorus levels appear to be less affected. The lipid profile of MP shows significant adverse changes compared to normal premenopausal women. Menopausal women tend to have lower levels of GSH and higher levels of MDA and ONOO-, indicating increased oxidative stress. The comparison of FUK values between MP and healthy women highlights the potential impact of hormonal changes on metabolic pathways. Further research is needed to elucidate the specific mechanisms by which FUK activity is altered in early menopause and to explore the clinical implications of these changes.

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