Abstract:

Treating wound infections is increasingly challenging because of bacterial antibiotic resistance. Plants have recently emerged as a viable strategy for addressing antibiotic resistance and enhancing wound care. The antioxidant activity of Madhuca indica is essential for preventing oxidative stress by free radicals. In silico analysis of the bioactive compound was done by DPPH and the prominent phytochemicals were found in the extract after phytochemical screening. Phytochemical analysis of M. indica revealed that the plant contains flavonoids among many other bioactive compounds. M. indica exhibits concentration dependent radical scavenging activity, according to the DPPH test, where the percentage of radicals inhibited rises with concentrations as 10-50 µg/mL. The antimicrobial resistance patterns of bacterial targets were studied to elucidate the potential of M. indica compounds in combating these resistant strains. Multidrug resistance may be treated as the structural modification of the identified compounds, which may increase their efficiency and selectivity against the target microorganisms. Compounds from M. indica can also be added to already approved antibiotics; these combinations have synergistic effects that can help address the resistance issue. The activity indicated strong free radical scavenging activity that might help fight oxidative stress and aid in wound healing. The result of such computational predictions needs to be further studied in silico to validate the therapeutic application of several identified drugs. These possibilities suggest that novel antimicrobial agents derived from plants may be able to address the ongoing issue of multidrug resistance.

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