Abstract:

The present study reports the extracellular one-pot synthesis of zirconium and titanium oxide nanoparticles (Zr/TiO-NPs) mediated by Aspergillus flavus. This green synthesis approach leverages the bio-reductive capabilities of fungal metabolites, providing an environmentally friendly and efficient method for nanoparticle  synthesis . The synthesized nanoparticles were evaluated for their antioxidant and anti-inflammatory activities. Antioxidant activity, assessed at varying concentrations (20–80 µg/ml), demonstrated a concentration-dependent manner , with the highest activity observed at 80 µg/ml. Similarly, the anti-inflammatory efficacy, determined using the albumin denaturation method, revealed maximum activity at 100 µg/ml and the lowest at 20 µg/ml, highlighting their potential to mitigate inflammatory responses. These findings underscore the potential of Aspergillus flavus Zr/TiO-NPs as promising agents for biomedical applications, particularly in combating oxidative stress and inflammation.

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