A Study of Correlation between Morphometric Measurement of Lumbar Region with levels of Calcium and Vitamin D in Low Back Pain Individuals
Abstract:
This study aimed to identify morphometric abnormalities in the lumbar spine and their correlation with serum biomarkers, including calcium and vitamin D in individuals with low back pain (LBP). The prospective study was conducted at GSL Medical College Rajahmundry and included 412 participants over 18 years old with LBP. Detailed clinical histories were recorded, fasting blood samples were collected, and lumbar spine MRIs were assessed. Significant differences in disc heights were noted in the L3-L4 and L5-S1 regions. Biomarkers such as Serotransferrin (TRF), alpha-2-macroglobulin (AMG), alpha-1-antitrypsin (AAT), alpha-1-acid glycoprotein 1 (AAG), alpha-1-acid glycoprotein 2 (AGP2) and alpha-1B-glycoprotein (A1BG) were quantified using ELISA and nephelometry. Despite no significant variation in serum calcium and vitamin D levels between pain groups, statistically significant differences in the levels of TRF (P < 0.01), AAT (P < 0.01), AAG (P < 0.01), AGP2 (P < 0.01) and A1BG (P < 0.05) were observed. The findings suggest that lumbar disc morphology and specific serum biomarkers may play a role in LBP pathogenesis.References:
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