Abstract:

The antibacterial activity of Gymnema sylvestre solvent extracts, including acetone, aqueous, chloroform, ethanol, and hydroxyethanol, is assessed in this study against common wound infections. G. sylvestre is a well-known traditional medicinal herb with a wide range of therapeutic uses that has drawn attention due to its antibacterial actions. The release of bioactive chemicals was optimized by the use of a systematic extraction process with several solvents. Using the agar well diffusion method, the antibacterial activity of the extract was evaluated against a variety of wound pathogens, such as Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Staphylococcus aureus. The findings showed that the antibacterial activity of the various solvent extracts varied significantly. The extracts of ethanol, acetone, chloroform, and hydroxyethanol showed the strongest inhibitory effects, dramatically slowing the growth of the pathogens under examination. Moderate action was demonstrated by aqueous extracts against the acquired infections. These results indicate that the bioavailability of antimicrobial compounds in G. sylvestre is significantly influenced by the extraction solvent. The study emphasizes the potential of G. sylvestre as a natural antibacterial agent, especially about wound healing. The precise bioactive components causing this activity must be determined, and their mechanisms of action must be investigated, through more research. Overall, this research adds to the increasing evidence that supports the use of herbal remedies for managing wound-related infections, providing valuable insights for future therapeutic applications.

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