Abstract:

Verbascoside (VERB), a phenylethanoid-phenylpropanoid glycoside, has garnered significant interest due to its potential therapeutic effects, particularly its anticancer properties. This study investigates the molecular mechanisms underlying the anticancer activity of VERB against A549 cells, a model of non-small cell lung cancer (NSCLC). Our findings demonstrate that VERB induces apoptosis in A549 cells through the modulation of key apoptotic signaling pathways. Specifically, VERB treatment resulted in the activation of caspases, upregulation of pro-apoptotic proteins, and downregulation of anti-apoptotic proteins. Additionally, VERB was observed to inhibit the NF-kB pathway, thereby reducing inflammation and promoting apoptotic cell death. These results suggest that VERB exerts its anticancer effects by targeting multiple cellular pathways involved in cell survival and apoptosis, providing a promising avenue for the development of novel NSCLC therapies.

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