Adipokines, Osteokines and Pancreas: Key Players in Type 2 Diabetes Mellitus - A Review
Abstract:
Recent studies showed the role of adipokines,
osteokines, and the pancreas plays in the development of diabetes. Numerous
studies have conclusively demonstrated the importance of adiponectin, leptin,
insulin, and osteocalcin in the regulation and metabolism of glucose. Along
with other contributing variables, pro-inflammatory and/or oxidative stress
mediators like TNF-alpha and IL-6 are one of several that significantly affect
the pathogenesis of type II DM and the development of insulin resistance. For
many years, it was believed that there was one pathway connecting the pancreas,
adipose tissue, and bone. According to recent research that highlighted the
importance of the connections between these organs, insulin resistance in
adipose tissues is also thought to have a role in beta cell failure. However,
there are still few conclusive studies demonstrating the relationship between
adipose tissue, pancreas, bone and T2DM. Further research is required to
evaluate the link between these organs and developing type 2 DM patients.
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