Evaluation of Systemic Inflammation in Lichen Planus Using Neutrophil CD64
Abstract:
Lichen Planus
(LP) is a chronic inflammatory condition caused by T-cell-mediated immune
responses, primarily affecting the skin and oral mucosa. The inflammatory
marker CD64, which is expressed on neutrophils in response to inflammation, has
demonstrated promise as a biomarker in several inflammatory disorders; however,
its function in LP and its applicability for diagnosis and prognosis remain
unknown. This study aims to evaluate systemic inflammation of LP patients using
neutrophil CD64 as a potential biomarker. A total of five patients with LP
diagnoses and five healthy controls were included in this study. nCD64
expression was measured by flow cytometric analysis from the peripheral blood
samples of patients and healthy controls. The mean fluorescence intensity of
nCD64 was noted and the data of patients and healthy controls were compared. A
robust systemic inflammatory response was seen in LP patients, as evidenced by
a substantially higher average nCD64 mean fluorescence intensity of 208.4 in
comparison to 45.6 in healthy controls (p=0.05). Patients with LP exhibited a
range of clinical features, including gingival desquamation, erosive lesions,
and white striae. The clinical severity of LP lesions was correlated with the
nCD64 mean fluorescence intensity whereas the severity of the disease was not
correlated with the existing marker, erythrocyte sedimentation rate values.
Thus nCD64 may be a useful biomarker for identifying systemic inflammation in patients
with Lichen Planus and this may lead to better diagnosis and treatment in such
patients. A large cohort study is warranted to confirm these preliminary
findings.
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