Abstract:

Oral cancer continues to be one of the leading causes of death globally, being more prevalent in developing countries. Radiation, chemotherapy, targeted therapy, immunotherapy, hormone-based therapies, and surgery are common treatment plans for oral cancer that lead to a range of short- and long-term side effects resulting in an urgent need to develop treatment options with minimal or no adverse effects. Recently, numerous bioactive compounds derived from various plants have garnered attention as potential therapeutic options for cancer treatment.Thuja occidentalis, also known as Eastern White Cedar, has been traditionally used for its medicinal properties. The components of this plant like thujone, flavonoids, and polysaccharides, have demonstrated significant pharmacological properties, including antimicrobial, antioxidant, anti-inflammatory, and anti-cancer effects. These compounds work through various mechanisms, such as promoting apoptosis, reducing oxidative stress, and enhancing the immune response. There is no literature available assessing the role of T.occidentalis in Oral Squamous Cell Carcinoma (OSCC) and the current article will be a novel overview discussing its pharmacological properties and its potential role in the treatment of OSCC. However, further research is needed to understand the precise molecular mechanisms, optimal dosage, and evaluate the synergistic effects with conventional cancer therapies.

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