The Complexity of Diabetes Mellitus: Pathophysiology, Prevalence, and Innovative Management Strategies

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DOI: 10.21522/TIJPH.2013.SE.24.05.Art034

Authors : Prabhudas Nelaturi, Sangeetha PK, Subramanian RM

Abstract:

In recent years, the global use of nutraceuticals, nutritional supplements, and natural therapies for therapeutic purposes has grown significantly. Traditional synthetic drugs often fall short in addressing the therapeutic needs of managing diabetes. In contrast, herbal medicines offer a promising alternative with fewer side effects. Nutraceuticals include a wide range of biological interventions such as amino acids, fatty acids, botanicals, antioxidants, vitamins, and minerals designed to enhance overall well-being, manage symptoms, and prevent diseases. These agents offer diverse therapeutic benefits and show potential in disease management, prevention, and health promotion. Numerous nutraceuticals in clinical practice address the root causes of diabetes mellitus, metabolic syndrome, and their related complications, thereby positively influencing various biochemical and clinical outcomes. Hypoglycemic agents are commonly used in traditional medicine systems to mitigate the risk of diabetes mellitus. In this review, we highlight the risk factors and regional approaches to utilizing nutraceuticals for diabetes management.

References:

[1].   Forouhi NG, & Wareham NJ. 2019, Epidemiology of diabetes. Medicine, 47(1), 22-7.

[2].   Wild S, Roglic G, Green A, Sicree R, & King H. 2004, Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care, 27(5), 1047-53.

[3].   Rathmann W, & Giani G. 2004, Global Prevalence of Diabetes: Estimates for the Year 2000 and Projections for 2030: Response to Wild et al. Diabetes Care, 27(10), 2568-9.

[4].   Chawla A, Chawla R, & Jaggi S. 2016, Microvasular and macrovascular complications in diabetes mellitus: distinct or continuum? Indian Journal of Endocrinology and Metabolism, 20(4), 546.

[5].   Association AD. 2014, Diagnosis and classification of diabetes mellitus. Diabetes Care,37(Supplement_1), S81-S90.

[6].   O’Donnell C. 34 - Diabetes. In: Efron N, editor. Contact Lens Practice (Third Edition). Elsevier; 2018. p. 314-20.e1.

[7].   Galicia-Garcia U, Benito-Vicente A, Jebari S, Larrea-Sebal A, Siddiqi H, & Uribe KB, et al. 2020, Pathophysiology of type 2 diabetes mellitus. International Journal of Molecular Sciences, 21(17), 6275.

[8].   Santini A, Cammarata SM, Capone G, Ianaro A, Tenore GC, & Pani L, et al. 2018, Nutraceuticals: Opening the debate for a regulatory framework. British Journal of Clinical Pharmacology, 84(4), 659-72.

[9].   da Costa JP. 2017, A current look at nutraceuticals – Key concepts and future prospects. Trends in Food Science & Technology, 62, 68-78.

[10].  Vijay VR, I PK, Kumar MB, & Sagetha J. 2024, Assessment of Quality of Life Among Type 2 Diabetes Mellitus Patients in an Urban Health Center of Tiruvallur District, Tamil Nadu. Cureus, 16(6), e63320.

[11].  Redondo MJ, Steck AK, & Pugliese A. 2018, Genetics of type 1 diabetes. Pediatric Diabetes, 19(3), 346-53.

[12].  Burrack AL, Martinov T, & Fife BT. 2017, T cell-mediated beta cell destruction: autoimmunity and alloimmunity in the context of type 1 diabetes. Frontiers in Endocrinology, 8, 343.

[13].  Coppieters KT, Boettler T, & von Herrath M. 2012, Virus infections in type 1 diabetes. Cold Spring Harbor Perspectives in Medicine, 2(1), a007682.

[14].  Yadalam PK, Arumuganainar D, Ronsivalle V, Di Blasio M, Badnjevic A, & Marrapodi MM, et al. 2024, Prediction of interactomic hub genes in PBMC cells in type 2 diabetes mellitus, dyslipidemia, and periodontitis. BMC Oral Health, 24(1), 385.

[15].  Varalakshmi D, Rekha K, & Mohammed R. 2024, Type 2 Diabetes Mellitus Prevalence and Associated Risk Factors in Postmenopausal Women. Cureus, 16(5), e60247.

[16].  Lancet T, & 2023, Diabetes: a defining disease of the 21st century. p. 2087.

[17].  Pinkney J, Tomlinson J, & Stenhouse E. Chapter 2 - Overview of Type 2 Diabetes. In: Bagchi D, Sreejayan N, editors. Nutritional and Therapeutic Interventions for Diabetes and Metabolic Syndrome. San Diego: Academic Press; 2012. p. 15-27.

[18].  Lewandowska M, Więckowska B, & Sajdak S. 2020, Pre-pregnancy obesity, excessive gestational weight gain, and the risk of pregnancy-induced hypertension and gestational diabetes mellitus. Journal of Clinical Medicine, 9(6), 1980.

[19].  Hedderson MM, Darbinian JA, & Ferrara A. 2010, Disparities in the risk of gestational diabetes by race‐ethnicity and country of birth. Paediatric and Perinatal Epidemiology, 24(5), 441-8.

[20].  Kalra EK. 2003, Nutraceutical-definition and introduction. Aaps Pharmsci, 5(3), 25.

[21].  Nasri H, Baradaran A, Shirzad H, & Rafieian-Kopaei M. 2014, New concepts in nutraceuticals as alternative for pharmaceuticals. International Journal of Preventive Medicine,5(12),1487.

[22].  Aronson JK. 2017, Defining ‘nutraceuticals’: Neither nutritious nor pharmaceutical. British Journal of Clinical Pharmacology, 83(1), 8-19.

[23].  Mikolaskova I, Crnogorac-Jurcevic T, Smolkova B, & Hunakova L. 2023, Nutraceuticals as Supportive Therapeutic Agents in Diabetes and Pancreatic Ductal Adenocarcinoma: A Systematic Review. Biology, 12(2), 158.

[24].  Cencic A, & Chingwaru W. 2010, The role of functional foods, nutraceuticals, and food supplements in intestinal health. Nutrients, 2(6), 611-25.

[25].  Mali S, Rathod S, Kale N, & Shinde N. 2022, Overview of nutraceuticals. Asian Journal of Pharmaceutical Research,12(1),61-70.

[26].  Kelsey NA, Wilkins HM, & Linseman DA. 2010, Nutraceutical antioxidants as novel neuroprotective agents. Molecules, 15(11), 7792-814.

[27].  Rysz J, Franczyk B, Kujawski K, Sacewicz-Hofman I, Ciałkowska-Rysz A, & Gluba-Brzózka A. 2021, Are nutraceuticals beneficial in chronic kidney disease? Pharmaceutics, 13(2), 231.

[28].  Abdelrahman KM, & Hackshaw KV. 2021, Nutritional supplements for the treatment of neuropathic pain. Biomedicines, 9(6), 674.

[29].  Sosnowska B, Penson P, & Banach M. 2017, The role of nutraceuticals in the prevention of cardiovascular disease. Cardiovascular Diagnosis and Therapy, 7(Suppl 1), S21.

[30].  Bertuccioli A, Cardinali M, Biagi M, Moricoli S, Morganti I, & Zonzini GB, et al. 2021, Nutraceuticals and Herbal Food Supplements for Weight Loss: Is There a Prebiotic Role in the Mechanism of Action? Microorganisms, 9(12), 2427.

[31].  Tripathi C, Girme A, Champaneri S, Patel RJ, & Hingorani L. 2020, Nutraceutical regulations: An opportunity in ASEAN countries. Nutrition, 74, 110729.

[32].  Basu SK, Thomas JE, & Acharya SN. 2007, Prospects for growth in global nutraceutical and functional food markets: a Canadian perspective. Australian Journal of Basic and Applied Sciences, 1(4), 637-49.

[33].  Derosa G, Limas CP, Macías PC, Estrella A, & Maffioli P. 2014, Dietary and nutraceutical approach to type 2 diabetes. Arch Med Sci, 10(2), 336-44.

[34].  Khodavirdipour A, Haddadi F, & Keshavarzi S. 2020, Chromium supplementation; negotiation with diabetes mellitus, hyperlipidemia and depression. Journal of Diabetes & Metabolic Disorders, 19, 585-95.

[35].  Sales CH, & Pedrosa LdFC. 2006, Magnesium and diabetes mellitus: Their relation. Clinical Nutrition, 25(4), 554-62.

[36].  Barbagallo M, & Dominguez LJ. 2015, Magnesium and type 2 diabetes. World J Diabetes,6(10),1152-7.

[37].  Pessoa JC, Etcheverry S, & Gambino D. 2015, Vanadium compounds in medicine. Coordination Chemistry Reviews, 301, 24-48.

[38].  Jain AB, & Jain VA. 2012, Vitamin E, its beneficial role in diabetes mellitus (DM) and its complications. Journal of Clinical and Diagnostic Research: JCDR, 6(10), 1624.

[39].  Hajhashemy Z, Rouhani P, & Saneei P. 2022, Dietary calcium intake in relation to type-2 diabetes and hyperglycemia in adults: a systematic review and dose–response meta-analysis of epidemiologic studies. Scientific Reports, 12(1), 1050.

[40].  Thenmozhi P, Sekar R, Bhuvaneswari G, & Tamilselvi S. 2024, Vitamin D supplementation of glycemic control in type 2 diabetes mellitus patients: a randomized controlled study. International Journal of Nutrition, Pharmacology, Neurological Diseases, 14(3).

[41].  Mason SA, Keske MA, & Wadley GD. 2021, Effects of vitamin C supplementation on glycemic control and cardiovascular risk factors in people with type 2 diabetes: a GRADE-assessed systematic review and meta-analysis of randomized controlled trials. Diabetes Care, 44(2), 618-30.

[42].  Elbadawy AM, Abd Elmoniem RO, & Elsayed AM. 2021, Alpha lipoic acid and diabetes mellitus: potential effects on peripheral neuropathy and different metabolic parameters. Alexandria Journal of Medicine, 57(1), 113-20.

[43].  Golbidi S, Badran M, & Laher I. 2011, Diabetes and alpha lipoic acid. Frontiers in Pharmacology, 2, 69.

[44].  Shen Q, Pierce JD, & 2015, Supplementation of coenzyme Q10 among patients with type 2 diabetes mellitus. MDPI. p. 296-309.

[45].  Testai L, Martelli A, Flori L, Cicero AF, & Colletti A. 2021, Coenzyme Q10: clinical applications beyond cardiovascular diseases. Nutrients, 13(5), 1697.

[46].  Chauhan S, Kodali H, Noor J, Ramteke K, & Gawai V. 2017, Role of omega-3 fatty acids on lipid profile in diabetic dyslipidaemia: single blind, randomised clinical trial. Journal of Clinical and Diagnostic Research: JCDR, 11(3), OC13.

[47].  Mingrone G. 2004, Carnitine in type 2 diabetes. Ann N Y Acad Sci, 1033, 99-107.

[48].  Virmani MA, & Cirulli M. 2022, The role of l-carnitine in mitochondria, prevention of metabolic inflexibility and disease initiation. International Journal of Molecular Sciences, 23(5), 2717.

[49].  Rajasekar P, & Anuradha CV. 2007, Effect of L-carnitine on skeletal muscle lipids and oxidative stress in rats fed high-fructose diet. Exp Diabetes Res, 2007, 72741.

[50].  Modak M, Dixit P, Londhe J, Ghaskadbi S, & Devasagayam TPA. 2007, Indian herbs and herbal drugs used for the treatment of diabetes. Journal of Clinical Biochemistry and Nutrition, 40(3), 163-73.

[51].  Mishra AP, Srivastav N, Singh A, Nigam M, Pezzani R, & Egbuna C, et al. 2022, The Role of Nutraceuticals as Food and Medicine, Types and Sources. In: Egbuna C, Sawicka B, Khan J, editors. Food and Agricultural Byproducts as Important Source of Valuable Nutraceuticals. Cham: Springer International Publishing, 1-18.

[52].  Das L, Bhaumik E, Raychaudhuri U, & Chakraborty R. 2012, Role of nutraceuticals in human health. Journal of Food Science and Technology, 49, 173-83.