Exploring the Interplay Between Polyphenols, Gut Microbiota, and Polycystic Ovary Syndrome (PCOD): A Comprehensive Review
Abstract:
Polycystic
Ovary Syndrome (PCOD) is a common endocrine disorder in women of reproductive
age, marked by hyperandrogenism, insulin resistance, and chronic anovulation.
Emerging research indicates that the gut microbiota significantly contributes
to the pathophysiology of PCOD, affecting both metabolic and hormonal balance.
Polyphenols, bioactive compounds found in various foods, have shown promise in
modulating gut microbiota composition and function, offering potential
therapeutic benefits for PCOD. This review examines the intricate interplay
between polyphenols, gut microbiota, and PCOD, focusing on how polyphenols may
influence PCOD pathogenesis through gut microbiota modulation. We explore the
alterations in gut microbiota observed in PCOD patients and how polyphenols may
help restore microbial balance, potentially improving metabolic and
reproductive health. The review also discusses the underlying molecular
mechanisms, such as the regulation of inflammatory pathways, oxidative stress,
and insulin signaling, through which polyphenols may exert their effects. By
synthesizing findings from preclinical and clinical studies, we highlight the
potential of dietary polyphenols as a complementary strategy in PCOD management,
while also underscoring the need for more research to determine the most
effective dietary interventions and polyphenol formulations. Understanding the
relationship between polyphenols and gut microbiota in the context of PCOD
offers promising new avenues for developing microbiota-targeted therapies that
leverage the beneficial effects of polyphenols to improve outcomes for women
with this condition.
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