Drivers, Reasons, and Experiences of Default and Missed Measles Vaccination in Ethiopia: A Qualitative Study

Download Article

DOI: 10.21522/TIJPH.2013.12.04.Art074

Authors : Gulilat Gezahegn Wodajo, Tezera Moshago Berheto, Haimanot Kifle Telila, Yohannes Kebede Lemu

Abstract:

Despite the availability of a safe and free vaccine, measles first and second-dose vaccination coverage is still low in Ethiopia. Studies that examine caregivers' reasons for not receiving the measles vaccination in Ethiopia are scarce. Hence, this qualitative study aimed to uncover drivers, reasons, and experiences of default and missed measles vaccination from a caregiver perspective. A case study was conducted from December 2023 to May 2024 in the east Gurage zone of central Ethiopia. Data were collected through sixteen in-depth interviews with mothers who had measles vaccine-missed children and six focus group discussions with women aged 15-49 with children under five years old and mothers who were over 50. Caregivers were asked to answer open-ended questions regarding reasons for missing the measles vaccination. Data were coded, categorized, and analyzed manually by using an inductive thematic analysis approach. The four fundamental trustworthiness metrics for qualitative research were considered. Finally, we presented the themes and sub-themes supporting them with representative quotations. Geographic barriers, transportation costs, inconvenience of vaccination dates, lack of information when to return, mistrust, rumours, poor attendance in pregnant women's conferences, lack of autonomy to travel, workload, economic dependency, poor male involvement, mother-in-laws’ influence, rounds of vaccination and administration routes, and adverse events following immunization were identified as reasons for missing measles vaccination. These reasons were found at each stage in the immunization journey. Hence, applying a human-centred design with tailored intervention might be important to address barriers at each stage.

References:

[1].   Centers for Disease Control and Prevention, 2024, “About Measles,” Measles (Rubeola). [Online]. Available: https://www.cdc.gov/measles/about/index.html [Accessed: 23-Jun-2024].

[2].   World Health Organization, 2024, “Measles.” [Online]. Available: https://www.who.int/news-room/fact-sheets/detail/measles [Accessed: 23-Jun-2024].

[3].   World Health Organization Regional Office for Africa (WHO-AFRO), 2024, “Vaccine-Preventable Disease Outbreaks on the Rise in Africa,” WHO | Regional Office for Africa. [Online]. Available: https://www.afro.who.int/news/vaccine-preventable-disease-outbreaks-rise-africa [Accessed: 31-Aug-2024].

[4].   World Health Organization, 2024, “Immunization Coverage.” [Online]. Available: https://www.who.int/news-room/fact-sheets/detail/immunization-coverage [Accessed: 31-Aug-2024].

[5].   World Health Organization, 2023, “Measles - Ethiopia.” [Online]. Available: https://www.who.int/emergencies/disease-outbreak-news/item/2023-DON460 [Accessed: 23-Jun-2024].

[6].   United Nations Children’s Fund, 2019, “The 2019 Ethiopia Mini Demographic and Health Survey | UNICEF Ethiopia.” [Online]. Available: https://www.unicef.org/ethiopia/reports/2019-ethiopia-mini-demographic-and-health-survey [Accessed: 14-Jul-2024].

[7].   Burton, A., Kowalski, R., Gacic-Dobo, M., Karimov, R., and Brown, D., 2012, “A formal representation of the WHO and UNICEF estimates of national immunization coverage: A computational logic approach,” PLoS ONE, 7(10), p. e47806. https://doi.org/10.1371/journal.pone.0047806

[8].   Novilla, M. L. B., Goates, M. C., Redelfs, A. H., Quenzer, M., Novilla, L. K. B., Leffler, T., Holt, C. A., Doria, R. B., Dang, M. T., Hewitt, M., Lind, E., Prickett, E., and Aldridge, K., 2023, “Why parents say no to having their children vaccinated against measles: A Systematic Review of the Social Determinants of Parental Perceptions on MMR Vaccine Hesitancy,” Vaccines (Basel), 11(5), p. 926. https://doi.org/10.3390/vaccines11050926

[9].   Adugna, B., Tola, A., Fite, M. B., and Motuma, A., 2024, “Determinants of second-dose measles vaccination dropout in Ethiopia: A community-based matched case-control study,” Heliyon, 10(9), p. e30764. https://doi.org/10.1016/j.heliyon.2024.e30764

[10].   Sabahelzain, M. M., Moukhyer, M., van den Borne, B., and Bosma, H., 2022, “Vaccine hesitancy among parents and its association with the uptake of measles vaccine in Urban Settings in Khartoum State, Sudan,” Vaccines, 10(2), p. 205. https://doi.org/10.3390/vaccines10020205

[11].   Majekodunmi, O. B., Oladele, E. A., and Greenwood, B., “1 Title: Factors Affecting Poor Measles Vaccination Coverage in Sub- 2 Saharan Africa with a Special Focus on Nigeria: A Systematic 3 Review.”

[12].   Abegaz, M. Y., Seid, A., Awol, S. M., and Hassen, S. L., 2023, “Determinants of incomplete child vaccination among mothers of children aged 12–23 Months in Worebabo District, Ethiopia: Unmatched Case-Control Study,” PLOS Global Public Health, 3(8), p. e0002088. https://doi.org/10.1371/journal.pgph.0002088

[13].   Tadesse, T., Getachew, K., Assefa, T., Ababu, Y., Simireta, T., Birhanu, Z., and Hailmichael, Y., 2017, “Factors and misperceptions of routine childhood immunization service uptake in Ethiopia: findings from a nationwide qualitative study,” Pan African Medical Journal, 28. https://doi.org/10.11604/pamj.2017.28.290.14133

[14].   Hailu, C., Fisseha, G., and Gebreyesus, A., 2022, “Determinants of measles vaccination dropout among 12 − 23 Months Aged Children in pastoralist community of Afar, Ethiopia,” BMC Infectious Diseases, 22(1), p. 376. https://doi.org/10.1186/s12879-022-07350-1

[15].   Sako, S., Gilano, G., and Hailegebreal, S., 2023, “Determinants of childhood vaccination among Children Aged 12–23 months in Ethiopia: A community-based cross-sectional study,” BMJ Open, 13(3), p. e069278. https://doi.org/10.1136/bmjopen-2022-069278

[16].   Shearer, J. C., Nava, O., Prosser, W., Nawaz, S., Mulongo, S., Mambu, T., Mafuta, E., Munguambe, K., Sigauque, B., Cherima, Y. J., Durosinmi-Etti, O., Okojie, O., Hadejia, I. S., Oyewole, F., Mekonnen, D. A., Kanagat, N., Hooks, C., Fields, R., Richart, V., and Chee, G., 2023, “Uncovering the drivers of childhood immunization inequality with caregivers, community members and health system stakeholders: Results from a Human-Centered Design Study in DRC, Mozambique and Nigeria,” Vaccines, 11(3), p. 689. https://doi.org/10.3390/vaccines11030689

[17].   Moser, A., and Korstjens, I., “Series: Practical Guidance to Qualitative Research. Part 1: Introduction,” Eur J Gen Pract, 23(1), pp. 271–273. https://doi.org/10.1080/13814788.2017.1375093

[18].   Ethiopian Statistical Service, 2024, “Population Projection.” [Online]. Available: https://www.statsethiopia.gov.et/population-projection/ [Accessed: 13-Oct-2024].

[19].   United Nations Children’s Fund, 2018, “Demand for Health Services | UNICEF Office of Innovation.” [Online]. Available: https://www.unicef.org/innovation/reports/demand-health-services [Accessed: 22-Jun-2024].

[20].   Technical Network for Strengthening Immunization Services (TechNet-21), 2023, “BeSD Childhood Vaccination In-Depth Interview Guides,” TechNet-21. [Online]. Available: https://www.technet-21.org/en/resources/tool/besd-childhood-vaccination-in-depth-interview-guides [Accessed: 01-Sep-2024].

[21].   Ogunbanjo, G., Mabuza, L., Govender, I., and B, M., 2014, “Qualitative Data Analysis and Writing Results (Workshop).”

[22].   Guye, A. H., Nigussie, T., Tesema, M., Shambi, D. B., Diriba, B. S., Tefera, E. M., and Girma, Y., 2023, “Exploring barriers of childhood full vaccination among children Living in Siraro District, West Arsi Zone, Oromia Region, Ethiopia: A Qualitative Study,” Front. Pediatr., 11. https://doi.org/10.3389/fped.2023.1083358

[23].   Sodeinde, K., Amoran, O., Abiodun, O., Adekoya, A., Abolurin, O., and Imhonopi, B., 2020, “A rural/urban comparison of paternal involvement in childhood immunisation in Ogun Central Senatorial District, Nigeria,” The Nigerian postgraduate Medical Journal, 27, pp. 336–342. https://doi.org/10.4103/npmj.npmj_101_20

[24].   Ullah, K., Saleem, J., Zakar, R., Ishaq, M., Khattak, F. A., Majeed, F., Sadiqa, H. A., and Fischer, F., 2024, “Exploring the reasons for defaulting from childhood immunization: A Qualitative Study in Pakistan,” BMC Public Health, 24(1), p. 408. https://doi.org/10.1186/s12889-024-17926-y

[25].   Thirunavukkarasu, A., Alanazi, M. F. A., Al-Hazmi, A. H., ALruwaili, B. F., Alsaidan, A. A., Alruwaili, T. A. M., Algaed, M. A. M., Alsharari, A. K., Alenazi, R. H., Alshalan, A. M., and Alshalan, S. M., 2023, “Maternal perception, hesitancy, and satisfaction toward Childhood Immunization in Primary Health Centers, Hafr Al-Batin: A Multicenter Cross-Sectional Study from Eastern Saudi Arabia,” RMHP, 16, pp. 2357–2368. https://doi.org/10.2147/RMHP.S406933

[26].   Yitbarek, K., Abraham, G., and Morankar, S., 2019, “Contribution of Women’s Development Army to maternal and Child Health in Ethiopia: A Systematic Review of Evidence,” BMJ Open, 9(5), p. e025937. https://doi.org/10.1136/bmjopen-2018-025937

[27].   Adesina, M. A., Olufadewa, I. I., Oladele, R. I., Solagbade, A., and Olaoyo, C., 2023, “Determinants of childhood immunization among Rural Mothers in Nigeria,” Popul. Med., 5(September), pp. 1–7. https://doi.org/10.18332/popmed/171542

[28].   Kolawole, O. T., Akinyemi, A., and Solanke, B. L., 2023, “Household Vulnerability and Childhood Immunization Status in Nigeria,” SAGE Open. https://doi.org/10.1177/21582440231179943

[29].   Amoah, A., Issaka, J., Ayebeng, C., and Okyere, J., 2023, “Influence of women empowerment on childhood (12–23 Months) Immunization Coverage: Recent Evidence from 17 Sub-Saharan African Countries,” Tropical Medicine and Health, 51(1), p. 63. https://doi.org/10.1186/s41182-023-00556-2

[30].   Simegn, W., Diress, M., Gela, Y. Y., Belay, D. G., Ayelign Kibret, A., Chilot, D., Sinamaw, D., Abdu Seid, M., Andualem, A. A., Anmut Bitew, D., Eshetu, H. B., and Mohammed Seid, A., 2023, “Childhood Vaccination Practices and Associated Factors among Mothers/Caregivers in Debre Tabor Town, Northwest Ethiopia: A Cross-Sectional Study,” Front Pediatr, 11, p. 1070722. https://doi.org/10.3389/fped.2023.1070722

[31].   Powelson, J., Kalepa, J., Kachule, H., Nkhonjera, K., Matemba, C., Chisema, M., Chumachapera, T., and Lawrence, E., 2024, “Using Community-Based, Participatory Qualitative Research to Identify Determinants of Routine Vaccination Drop-out for Children under 2 in Lilongwe and Mzimba North Districts, Malawi,” BMJ Open, 14(2), p. e080797. https://doi.org/10.1136/bmjopen-2023-080797

[32].   Gelagay, A. A., Geremew, A. B., Teklu, A., Mekonnen, Z. A., Gera, R., Ba-Nguz, A., and Tilahun, B., 2021, “Full Immunization Coverage and Its Determinants among Children Aged 12-23 Months in Wogera District, Northwest Ethiopia,” Ethiopian Journal of Health Development, 35(3). [Online]. Available: https://www.ajol.info/index.php/ejhd/article/view/217886 [Accessed: 07-Jul-2024].

[33].   Okafor, I. P., Chukwudi, C. L., Igwilo, U. U., and Ogunnowo, B. E., 2022, “‘Men Are the Head of the Family, the Dominant Head’: A Mixed Method Study of Male Involvement in Maternal and Child Health in a Patriarchal Setting, Western Nigeria,” PLOS ONE, 17(10), p. e0276059. https://doi.org/10.1371/journal.pone.0276059

[34].   Mogoi, D., Muchiri, E. M., and Mutuma, A. M., 2020, “Vaccine Coverage of Newly Introduced Vaccines and Factors Influencing among Children Less Than 23 Months in Laikipia North Subcounty,” Open Journal of Preventive Medicine, 10(2), pp. 9–43. https://doi.org/10.4236/ojpm.2020.102002

[35].   Malande, O. O., Munube, D., Afaayo, R. N., Annet, K., Bodo, B., Bakainaga, A., Ayebare, E., Njunwamukama, S., Mworozi, E. A., and Musyoki, A. M., 2019, “Barriers to Effective Uptake and Provision of Immunization in a Rural District in Uganda,” PLoS One, 14(2), p. e0212270. https://doi.org/10.1371/journal.pone.0212270

[36].   Bangura, J. B., Xiao, S., Qiu, D., Ouyang, F., and Chen, L., 2020, “Barriers to Childhood Immunization in Sub-Saharan Africa: A Systematic Review,” BMC Public Health, 20(1), p. 1108. https://doi.org/10.1186/s12889-020-09169-4

[37].   Pugliese-Garcia, M., Heyerdahl, L. W., Mwamba, C., Nkwemu, S., Chilengi, R., Demolis, R., Guillermet, E., and Sharma, A., 2018, “Factors Influencing Vaccine Acceptance and Hesitancy in Three Informal Settlements in Lusaka, Zambia,” Vaccine, 36(37), pp. 5617–5624. https://doi.org/10.1016/j.vaccine.2018.07.042