Abstract:

Temporomandibular Disorder (TMD) patients experience deterioration in their quality of sleep. Targeting these problems may include a wide variety of treatment options, such as the use of plant- and herbal-based medications, which have the potential to improve sleep. Numerous meta-analyses and systematic reviews have established that saffron is a useful natural treatment for mild-to-moderate insomnia. Hence, the present study aimed to determine the effect of saffron extract on sleep quality by altering the melatonin concentration in adults with TMDs. Thirty-four patients were recruited and divided into two groups equally (Group A study group, Group B -Control group) and advised to take saffron (15 mg once daily) or a placebo. Outcome measures include severity of pain collected at baseline and days 0,14 and 28 and the Pittsburgh Sleep Diary (PSD) collected. On day 0 and day 28 serum melatonin concentration will be evaluated using the ELISA kit method. Patients with temporomandibular dysfunction experienced significant reductions in pain after taking saffron supplements as opposed to a placebo. On comparing day 1 and day 28, the saffron-treated participants had substantially improved sleep quality, elevated melatonin levels, and a lower VAS score. The study concluded that Saffron is a potent, safe substitute in the management of TMD pain that has deterioration in sleep quality for its effectiveness in the management of sleep by altering the melatonin concentration. Further studies should be conducted to assess the possible benefits of saffron extract in large clinical settings with a larger number of patients.

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