Lipoma or Liposarcoma? - The Diagnostic Challenges
Abstract:
Atypical lipomatous tumour / well-differentiated
liposarcoma (ALT/WDLPS) is a locally aggressive mesenchymal neoplasm composed
either entirely or partly of an adipocytic proliferation showing at least focal
nuclear atypia in both adipocytes and stromal cells. This case report details a
case of a 45-year-old female who presented to OPD with swelling over the medial
aspect of the thigh for 3 years. Clinically she was diagnosed with lipoma
followed by an excision and histopathological examination. Histopathology
revealed features suggestive of Atypical lipomatous tumour /
well-differentiated liposarcoma (ALT/WDLPS) which showed the presence of
striking variation in adipocyte cell size. This study is done to emphasise the
importance of histopathological examination as an important diagnostic tool in
differentiating lipoma from liposarcoma.
References:
[1].
Weiss, S. W., 2019, Enzinger and Weiss's Soft
Tissue Tumors E-Book. Elsevier Health Sciences.
[2]. Moch H. Soft tissue and bone tumours WHO classification of
tumours/volume 3. WHO classification of tumours. 2020, 3.
[3]. Lucas, D. R., Nascimento, A. G., Sanjay, B. K. and Rock, M. G.,
1994, Well-differentiated liposarcoma: the Mayo Clinic experience with 58
cases. American
Journal of Clinical Pathology, 102(5), pp.677-683
[4]. Dei Tos, A. P., 2000, Liposarcoma: new entities and evolving
concepts. Annals
of diagnostic pathology, 4(4), pp.252-266.
[5]. Dei Tos, A. P., 2014, Liposarcomas: diagnostic pitfalls and
new insights. Histopathology, 64(1), pp.38-52.
[6]. Hameed, M., 2007, Pathology and genetics of adipocytic
tumors. Cytogenetic
and Genome Research, 118(2-4), pp.138-147.
[7]. Mashima, E., Sawada, Y. and Nakamura, M., 2021, Recent
advancement in atypical lipomatous tumor research. International journal of
molecular sciences, 22(3), p.994.
[8]. Kallen, M. E. and Hornick, J. L., 2021, The 2020 WHO
classification: What’s new in soft tissue tumor pathology? The American journal of
surgical pathology, 45(1), pp. e1-e23.
[9]. Sbaraglia, M. and Dei Tos, A. P., 2019, The pathology of soft tissue sarcomas. La radiologia medica, 124(4), pp.266-281.
