Vulval Angiomyofibroblastoma - A Rare Case Report
Abstract:
Angiomyofibroblastoma is a benign soft tissue tumour
arising from the mesenchymal cells. It is seen in young females most commonly
arising in the vulval region. This tumour mimics other benign tumours of the vulva
and is pathologically differentiated from Angiofibroma and AMM (Angiomyomyxoma)
which follow a different treatment protocol. This tumour is rare in occurrence
and is unusual in older females. Here we report a rare case of AFMB in an older
woman who presented with a very slow-growing asymptomatic vulval mass involving
the left labia majora.
References:
[1]. Hsu IH, Chang TC, Wu CT, Chen RJ, Chow SN. Angio myofibroblastoma of the
vulva. J Formos Med Assoc 2004;103:467-71.
[2]. Laiyemo
R, Disu S, Vijaya G, Wise B. Post-menopausal vaginal angiomyofibroblastoma: A case
report. Arch Gy necol Obstet 2005;273:129-30.
[3]. Vargas M, Akrivis C, Demou A, Kitsiou E, Antoniou N.
Angiomyofibroblastoma of the vagina in a postmenopausal breast cancer patient
treated with tamoxifen: Clinicopathologic analysis of a case and review of the
literature. Int J Gynecol Cancer 2006;16:581-5.
[4]. Nucci MR, Fletcher CD. Vulvovaginal soft tissue tumours: Update and
review. Histopathology 2000;36:97-108.
[5]. Nielsen GP, Young RH. Mesenchymal tumours and tumour-like lesions of the
female genital tract: A selective review with emphasis on recently described
entities. Int J Gyne col Pathol 2001;20:105-27.
[6]. Horiguchi H, Matsui-Horiguchi M, Fujiwara M, Kaketa M, Kawano M,
Ohtsubo-Shimoyamada R, et al. Angio myofibroblast oma of the vulva: Report of a
case with immunohistochemical and molecular analysis. Int J Gynecol Pathol
2003;22:277-84.
[7]. Omori M, Toyoda H, Hirai T, Ogino T, Okada S. Angiomyo fibroblastoma of
the vulva: A large pedunculated mass formation. Acta Med Okayama
2006;60:237-42.
[8]. Fletcher CD, Tsang WY, Fisher C, Lee KC, Chan JK. A giomyofibroblastoma
of the vulva: a benign neoplasm distinct from aggressive angiomyxoma. Am J
Surg Pathol 1992;16:373-82.
[9]. Ockner DM, Sayadi H, Swanson PE, Ritter JH, Wick MR. Genital
angiomyofibroblastoma: comparison with aggressive angiomyxoma and other myxoid
neoplasms of skin and soft tissue. Am J Clin Pathol 1997;107:36-44.
[10]. Tochika N, Takeshita A, Sonobe H, Matsumoto M, Ko Hayashi M, Araki K.
Angiomyofibroblastoma of the vulva: report of a case. Surg Today
2001;31:557-9.
[11]. Granter SR, Nucci MR, Fletcher CD. Aggressive angio myxoma: reappraisal
of its relationship to angiomyo fibroblastoma in a series of 16 cases. Histopathology
1997;30:3-10
[12]. Lee SH, Yang JW, Do JM, Seo DH, Jung JH, Chung
KH, et al. Angiomyofibroblastoma-like tumour of the scrotum. Korean J Urol. 2010;51:365–7.
[13]. Goyal S, Singla S,
Singla M, Vyas D. Angiomyofibroblastoma of the vulva – A case report and
review. J Case Rep Oncol Ther. 2015;1:112.
[14]. Wolf B, Horn LC,
Handzel R, Einenkel J. Ultrasound plays a key role in imaging and management of
genital angiomyofibroblastoma: A case report. J Med Case Rep. 2015;9:248.
[15]. Fatusic J, Hudic I,
Fatusic Z, Mustedanagic-Mujanovic J. Angiomyofibroblastoma of the vaginal
portion. Med Arch. 2014;68:424–5
[16]. Arumugam P, George R, Jayaseelan V P.,
2021, Aberrations of
m6A regulators are associated with tumorigenesis and metastasis in head and
neck squamous cell carcinoma. Arch Oral Biol. 122: 105030.
doi:10.1016/j.archoralbio.2020.105030.
[17]. Weiss SW, Gnepp DR, Bratthauer GL. Palisaded myofibroblastoma. A benign
mesenchymal tumour of the lymph node. Am J Surg
Pathol. 1989;13:341–6.
[18]. Nasu K., Fujisawa K., Takai N., Miyakawa I.
Angiomyofibroblastoma of the vulva. Int. J.
Gynecol. Cancer. 2002;12:228–231.
[19]. Sims S.M., Stinson K.,
McLean F.W., et al. Angiomyofibroblastoma of the vulva: a case report of a
pedunculated variant and review of the literature. J. Low. Genet. Tract Dis. 2012;16:149–154.
[20]. Pradhan P., Sahu N., Dash K., Misra P.,
Senapati U., Rath S.K. Angiomyofibroblastoma of the vulva: a rare case report
with a brief review of the literature. J.
Mid-life Health. 2019;10:105–107.
