Metabolic Syndrome in Pregnancy and its Complications in Obstetrics and Newborn
Abstract:
Metabolic syndrome (MS) during pregnancy causes
a serious threat to the mother and child's health that will shortly become a
major public health issue, especially in developing countries. However, in
India, the epidemiological data on MS during pregnancy are still scarce. This
study aimed to determine the prevalence and identification of MS among pregnant
women at Sree Balaji Medical College and Hospital, Chennai, India. This study
was a hospital-based cross-sectional study, carried out among pregnant women followed
up at the Obstetrics and Gynecology OP unit. Proforma was collected from the
participants who were assessed on sociodemographics, lifestyle parameters and
dietary habits. Anthropometric parameters, blood pressure, and biochemical
parameters were measured as per standard operating procedures The study
participants were included in the MS group if she has at least three of the
following criteria: Pre-gestational BMI >30 kg/m2; triglycerides
≥150 mg/dl; HDL cholesterol <50 mg/dl; fasting blood glucose ≥100 mg/d, SBP
≥130 and DBP ≥85 mm/Hgl. The prevalence of MS in pregnant women and its major
determinant is pre-gestational obesity. This work provides quality preliminary
data for the design and improvement plan of prevention strategies.
References:
[1]. Saklayen, M. G., 2018, The global epidemic of metabolic syndrome. Current Hypertension Reports, 20, pp. 12-20.
[2]. Bo, L., Guanqun, C., Ruijie, Z., Huang, D., Tao, L., Dan, H. and Lixin, T., 2021, Temporal trends in the prevalence of metabolic syndrome among middle-aged and elderly adults from 2011 to 2015 in China: The China health and retirement longitudinal study (CHARLS). BMC Public Health, 21, pp. 1045-1056.
[3]. Chatzi, L., Plana, E., Pappas, A., et al. 2009, The metabolic syndrome in early pregnancy and risk of gestational diabetes mellitus. Diabetes and Metabolism, 35(6), pp. 490–494.
[4]. Vryonidou, A, Paschou, S. A., Muscogiuri, G., Orio, F. and Goulis., D. G., 2015, Mechanisms in endocrinology: metabolic syndrome through the female life cycle. Eur J Endocrinol, 173, pp. R153–R163.
[5]. Mohsenzadeh-Ledari, F., Taghizadeh, Z., Motaghi, Z., Keramat, A., Moosazadeh, M. and Najafi, A., 2019, Appropriate interventions for pregnant women with indicators of metabolic syndrome on pregnancy outcomes: a systematic review. International Journal of Preventive Medicine, 10(2), pp. 1-21.
[6]. Wubet, W. T., Kimberly, K. V., Jami, J. and Leanne, M. R., 2024, Effective interventions in preventing gestational diabetes mellitus: A systematic review and meta-analysis. Communications Medicine, 4, pp. 75-89.
[7]. Fossati, P. and Principe, L., 1998, Triglycerides PAP, freeze dried. Clinical Chemistry, 28(10), pp. 2077-2780.
[8]. Trinder, P., 1969, Determination of glucose in blood using glucose oxidase with alternative oxygen acceptor. Annals of Clinical Biochemistry, 6, pp. 24–27.
[9]. Chatzi, L., Plana, E., Daraki, V., et al., 2009, Metabolic syndrome in early pregnancy and risk of preterm birth. American Journal 0f Epidemiology, 70(7), pp. 829–836.
[10]. Dos Prazerez, T. H., Arantes, A. M., Tavares, S. B., et al., 2015, Metabolic syndrome and pregnancy, its prevalence, obstetrical and newborns complications. Open Journal of Obstetric and Gynaecology. 5(11), pp. 618–625.
[11]. Nolan, C. J., and Prentki, M., 2019, Insulin resistance and insulin hyper secretion in the metabolic syndrome and type 2 diabetes: time for a conceptual framework shift. Diabetes and Vascular Disease Research, 16(2), pp. 118–127.
[12]. Wani, K., Sabico, S., Alnaami, A. M., et al. 2020, Early-pregnancy metabolic syndrome and subsequent incidence in gestational diabetes mellitus in Arab women. Frontiers in Endocrinology, 11, pp. 98-105.
[13]. Grieger, J. A., Bianco-Miotto, T., Grzeskowiak L. E., et al. 2018, Metabolic syndrome in pregnancy and risk for adverse pregnancy outcomes: a prospective cohort of nulliparous women. PLoS Medicine, 15(12), pp. 1-10.
[14]. Djeufouata, J. D., Ojong, E. W., Njamen. N. T., Assob, J. C. and Telefo, P. B., 2020, Prevalence and risk factors of metabolic syndrome in pregnant women in the centre and littoral regions of Cameroon. European Journal of Clinical Biomedical Sciences, 6(5), pp. 104–115.
[15]. Rahman, M. M., Abe, S. K., Kanda, M., et al., 2015, Maternal body mass index and risk of birth and maternal health outcomes in low- and middle-income countries: a systematic review and meta-analysis. Obesity Review, 16, pp. 758–770.
[16]. White, S. L., Pasupathy, D., Sattar, N., et al., 2017, Metabolic profiling of gestational diabetes in obese women during pregnancy. Diabetologia, 60, pp. 1903–1912.
[17]. Wani, K., Sabico, S., Alnaami, A. M., et al., 2020, Early-pregnancy metabolic syndrome and subsequent incidence in gestational diabetes mellitus in Arab women. Frontiers in Endocrinology, 11, pp. 98-105.
[18]. Eastwood, K. A., Daly, C., Hunter, A., et al 2017., The impact of maternal obesity on completion of fetal anomaly screening. Journal of Perinatal Medicine, 45(9), pp. 1061–1067.
[19]. Pinto, M. C., Oliveira, A. S., Santos, A. S., De oliveira, B. V., and Ramos, M. M, 2019, Metabolic syndrome in pregnancy and postpartum: prevalence and associated factors. Revista da Associacao Medica Brasileria, 65(12), pp. 1489–1495.
[20]. Mohsenzadeh-Ledari, F., Taghizadeh, Z., Motaghi, Z., Keramat, A., Moosazadeh, M. and Najafi, A. 2019, Appropriate interventions for pregnant women with indicators of metabolic syndrome on pregnancy outcomes: a systematic review. International Journal of Preventive Medcine, ; 10, pp. 1-22.
