Abstract:

Coronavirus Disease of 2019 (COVID-19) is caused by the Severe Acute Respiratory Syndrome coronavirus 2(SARS-COV-2). The SARS-COV-2 is a β-coronavirus , which is non-segmented positive-sense RNA virus. The symptoms of COVID-19 may vary. The study was carried out to; examine the individual determinants and socioeconomic determinants and to describe the Health-system determinants of COVID-19 vaccination among Residents of Katanga Slum. The individual determinants were; age between 26 to 35 years (AOR=4.502, CI=1.706-11.886, P=0.002), sex; being of male gender (AOR=2.267, CI=1.316-5.443, P=0.007), marital status; being single (AOR=0.334, CI=0.136-0.820, P=0.017), Being with primary level of education (AOR=17.707, CI=2.393-130.99, P=0.005), occupation; being a peasant (AOR=4.857, CI=1.232-19.14, p=0.024), religion; being a catholic (COR=0.411, CI=0.200-0.846, P-0.016), utilization of health facility for health care (COR=0.047, CI=0.014-0.162, P=0.000) and having a negative attitude towards COVID 19 vaccination (AOR=42.637, CI=320.65, P=0.000). The socio-economic factors were; income (x2=18.861, p=0.000), cost of transport (x2=19.492, p=0.000), cost of vaccination (x2=124.34, p=0.000) and the type of social class of respondents (x2=23.73, p=0.000). In multivariate analysis; only work effect was a determinant of COVID-19 vaccination (AOR=0.327, CI=0.127-0.847 and p=0.021). The health facility determinants were; sensitization (AOR=1.889, CI=1.040-3.431, P=0.037), availability of health workers at facility (AOR=0.211, CI=0.04-0.006, P=0.012), attitudes of health workers (AOR=79.97, CI=11.49-556.3, P=0.000), and Availability of COVID 19 vaccines at the health facility (AOR=0.054, CI=0.006-0.514, P=0.011). The study recommended Increased and continued sensitization for awareness promotion towards the benefits of uptake of COVID-19 vaccination as well as the associated dangers of non-compliance.

References:

[1].   Rothan, H.A. and S.N. Byrareddy, The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak. Journal of Autoimmunity, 2020. 109: p. 102433.

[2].   Cucinotta, D. and M. Vanelli, WHO Declares COVID-19 a Pandemic. Acta Biomed, 2020. 91(1): p. 157-160.

[3].   Guo, Y.-R., et al., The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak–an update on the status. Military Medical Research, 2020. 7: p. 1-10.

[4].   Kaplan, A.K., et al., The willingness to accept the COVID‐19 vaccine and affecting factors among healthcare professionals: A cross‐sectional study in Turkey. International Journal of Clinical Practice, 2021: p. e14226.

[5].   UNICEF and GAVI Uganda receives 864,000 doses of COVID-19 vaccines. 2021.

[6].   Ministry of Health Uganda COVID-19 status. 2021.

[7].   Wang, C., et al., A novel coronavirus outbreak of global health concern. The Lancet, 2020. 395(10223): p. 470-473.

[8].   Gong, F., et al., China’s local governments are combating COVID-19 with unprecedented responses—from a Wenzhou governance perspective. Frontiers of Medicine, 2020: p. 1-5.

[9].   Coe, P.F., L.L. Graper, and C.M. Zangerle, Leading Through the Unknown: A Network Perspective of the COVID-19 Pandemic. Critical Care Nursing Quarterly, 2020. 43(4): p. 451-467.

[10].  Snyder, T.M., et al., Magnitude and dynamics of the T-cell response to SARS-CoV-2 infection at both individual and population levels. MedRxiv, 2020.

[11].  Wu, S.C., Progress and concept for COVID‐19 vaccine development. Biotechnology Journal, 2020.

[12].  UNICEF Uganda receives the first batch of AstraZeneca COVID-19 vaccines. 2021.

[13].  Sun, S., D. Lin, and D. Operario, Interest in COVID-19 vaccine trials participation among young adults in China: Willingness, reasons for hesitancy, and demographic and psychosocial determinants. Preventive Medicine Reports, 2021. 22: p. 101350.

[14].  Reiter, P.L., M.L. Pennell, and M.L. Katz, Acceptability of a COVID-19 vaccine among adults in the United States: How many people would get vaccinated? Vaccine, 2020. 38(42): p. 6500-6507.

[15].  Kreps, S., et al., Factors associated with US adults’ likelihood of accepting COVID-19 vaccination. JAMA network open, 2020. 3(10): p. e2025594-e2025594.

[16].  Guidry, J.P., et al., Willingness to get the COVID-19 vaccine with and without emergency use authorization. American Journal of Infection Control, 2021. 49(2): p. 137-142.

[17].  Li, P., et al., Analysis of factors influencing parents’ willingness to accept the quadrivalent influenza vaccine for school-aged children in the Nanhai District, China. Human Vaccines & Immunotherapeutics, 2020. 16(5): p. 1078-1085.

[18].  UNICEF Uganda launches first phase of COVID-19 vaccination exercise. 2021.

[19].  Akinyemi, P.A., et al., Community perception and determinants of willingness to uptake COVID-19 vaccines among residents of Osun State, South-West Nigeria. International Journal of Community Medicine and Public Health, 2021. 8(4): p. 1551.

[20].  Echoru, I., P. Decanar Ajambo, and E. Bukenya, Acceptance and Risk Perception of COVID-19 Vaccine in Uganda: A Cross Sectional Study in Western Uganda. 2020.

[21].  Daama, A., et al., Willingness to receive COVID-19 vaccines, associated factors and reasons for not taking a vaccine: a cross sectional study among persons aged 13–80 years in Wakiso, Central Uganda. BMC Infectious Diseases, 2024. 24(1): p. 391.

[22].  King, P., et al., COVID-19 vaccine uptake and coverage, Uganda, 2021-2022. UNIPH Bulletin, 2023. 8.

[23].  Kasozi, K.I., et al., A Descriptive-Multivariate Analysis of Community Knowledge, Confidence, and Trust in COVID-19 Clinical Trials among Healthcare Workers in Uganda. Vaccines, 2021. 9(3): p. 253.

[24].  Peretti-Watel, P., et al., A future vaccination campaign against COVID-19 at risk of vaccine hesitancy and politicisation. The Lancet infectious diseases, 2020. 20(7): p. 769-770.

[25].  Mathpati, M.M., et al., ‘Population Self-Reliance in Health’and COVID 19: the need for a 4th Tier in the Health System. Journal of Ayurveda and Integrative Medicine, 2020.

[26].  Kish, L., Sampling organizations and groups of unequal sizes. American Sociological Review, 1965: p. 564-572.

[27].  Creswell, J.W., Qualitative inquiry and research design: Choosing among five traditions. Qualitative inquiry and research design: Choosing among five traditions. 1998, Thousand Oaks, CA, US: Sage Publications, Inc. xv, 403-xv, 403.

[28].  Kuter, B.J., et al., Perspectives on the receipt of a COVID-19 vaccine: A survey of employees in two large hospitals in Philadelphia. Vaccine, 2021. 39(12): p. 1693-1700.

[29].  Browne, N.T., et al., When pandemics collide: the impact of COVID-19 on childhood obesity. Journal of pediatric nursing, 2021. 56: p. 90.

[30].  Nzaji, M.K., et al., Factors associated with COVID-19 vaccine uptake and hesitancy among healthcare workers in the Democratic Republic of the Congo. PLOS Global Public Health, 2024. 4(2): p. e0002772.

[31].  Qattan, A.M., et al., Acceptability of a COVID-19 vaccine among healthcare workers in the Kingdom of Saudi Arabia. Frontiers in medicine, 2021. 8: p. 644300.

[32].  Dror, A.A., et al., Vaccine hesitancy: the next challenge in the fight against COVID-19. European journal of epidemiology, 2020. 35(8): p. 775-779.

[33].  Echoru, I., et al., Sociodemographic factors associated with acceptance of COVID-19 vaccine and clinical trials in Uganda: a cross-sectional study in western Uganda. BMC public health, 2021. 21(1): p. 1106.

[34].  Paudel, P., Online education: Benefits, challenges and strategies during and after COVID-19 in higher education. International Journal on Studies in Education (IJonSE), 2021. 3(2).

[35].  Ruiz, J.B. and R.A. Bell, Predictors of intention to vaccinate against COVID-19: Results of a nationwide survey. Vaccine, 2021. 39(7): p. 1080-1086.

[36].  Barry, M., M. Al Amri, and Z.A. Memish, COVID-19 in the shadows of MERS-CoV in the Kingdom of Saudi Arabia. Journal of epidemiology and global health, 2020. 10(1): p. 1-3.

[37].  Pradhan, A. and P.-E. Olsson, Sex differences in severity and mortality from COVID-19: are males more vulnerable? Biology of sex Differences, 2020. 11(1): p. 53.

[38].  Kanyike, A.M., et al., Acceptance of the coronavirus disease-2019 vaccine among medical students in Uganda. Tropical Medicine and Health, 2021. 49(1): p. 37.

[39].  Wang, H., et al., The psychological distress and coping styles in the early stages of the 2019 coronavirus disease (COVID-19) epidemic in the general mainland Chinese population: A web-based survey. PloS one, 2020. 15(5): p. e0233410.

[40].  Bitar, A.N., et al., Misinformation, perceptions towards COVID-19 and willingness to be vaccinated: a population-based survey in Yemen. PLoS One, 2021. 16(10): p. e0248325.

[41].  De Figueiredo, A., et al., Mapping global trends in vaccine confidence and investigating barriers to vaccine uptake: a large-scale retrospective temporal modelling study. The Lancet, 2020. 396(10255): p. 898-908.

[42].  Jegede, A.S., What led to the Nigerian boycott of the polio vaccination campaign? PLoS medicine, 2007. 4(3): p. e73.

[43].  Machida, M., et al., Acceptance of a COVID-19 Vaccine in Japan during the COVID-19 Pandemic. Vaccines, 2021. 9(3): p. 210.

[44].  Jain, J., et al., COVID-19 vaccine hesitancy among medical students in India. Epidemiology & Infection, 2021. 149: p. e132.

[45].  Bongomin, F., et al., COVID-19 vaccine acceptance among high-risk populations in Uganda. Therapeutic Advances in Infectious Disease, 2021. 8: p. 204993612110243.

[46].  Chou, W.-Y.S. and A. Budenz, Considering emotion in COVID-19 vaccine communication: addressing vaccine hesitancy and fostering vaccine confidence. Health communication, 2020. 35(14): p. 1718-1722.

[47].  Samarasekera, U., Feelings towards COVID-19 vaccination in Africa. The Lancet Infectious Diseases, 2021. 21(3): p. 324.

[48].  Campo-Arias, A. and J.C. Pedrozo-Pupo, COVID-19 vaccine distrust in Colombian university students: Frequency and associated variables. Acta Biomed, 2022. 92(6): p. e2021367.

[49].  Ohemeng-Tinyase, N.A., Factors Associated with Hepatitis B Vaccination Among Asian Adults (≥ 18 Years) in the United States. 2020, Walden University.

[50].  Endalew, M., et al., Limited handwashing facility and associated factors in sub-Saharan Africa: pooled prevalence and multilevel analysis of 29 sub-Saharan Africa countries from demographic health survey data. BMC Public Health, 2022. 22(1): p. 1969.

[51].  Schmidt, C.W., Lack of Handwashing Access: A Widespread Deficiency in the Age of COVID-19. Environ Health Perspect, 2020. 128(6): p. 64002.

[52].  Malande, O.O., et al., Barriers to effective uptake and provision of immunization in a rural district in Uganda. PloS one, 2019. 14(2): p. e0212270.

[53]. Azodo, C., et al., Hepatitis-B vaccination status among dental surgeons in benin city, Nigeria. Ann Med Health Sci Res, 2012. 2(1): p. 24-8.