Exploring the Dermoscopic Spectrum and Examination of Non-Melanocytic Benign Skin Tumors in Humans

Download Article

DOI: 10.21522/TIJPH.2013.12.03.Art070

Authors : Maghimaa M, Sai Kavya D, Nikitha C

Abstract:

Dermoscopy unveils distinctive features aiding non-melanocytic benign skin tumor identification. This study aimed to delineate and characterize these unique dermoscopic patterns, essential for precise diagnosis and tailored treatment. The study was conducted between December 2022 and June 2023, this descriptive study in a tertiary hospital assessed 96 patients with various benign skin tumors. Dermoscopic evaluations were blinded, ensuring rigorous data collection. Dermatofibroma displays a central white globule encircled by a peripheral pigmented network, while neurofibroma exhibits finger-print-like pigmentary lines. Mucosal neurofibroma stands out with its vascular reticulate network against a homogenous white background, contrasting with trichoepithelioma's structureless shiny white structures. Angiofibroma presents as unevenly distributed brown pigmentation, distinct from pyogenic granuloma's white collarette. Steatocystoma displays peripheral reticulate brown pigmentation, while keratoacanthoma showcases a central keratin mass. Cylindroma is characterized by a salmon pink-yellow color background with arborizing blood vessels at the periphery, whereas syringoma manifests multiple pigmented clusters. This study emphasizes dermoscopy's significance as a non-invasive tool enhancing diagnostic accuracy and guiding effective treatment modalities in dermatological practice.

References:

[1].   Reszke, R., Pełka, D., Walasek, A., Machaj, Z., Reich, A., 2015. Skin disorders in elderly subjects. Int J Dermatol, 54, e332-8. Doi:10.11.1/ijd.12832.

[2].   Ankad, B., Sakhare, P., Prabhu, M., 2017. Dermoscopy of non-melanocytic and pink tumors in brown skin: A descriptive study. Indian J Dermatopathol Diagn Dermatol, 4, 41. Doi:10.4103/ijdpdd.ijdpdd_10_17.

[3].   Malvehy, J., Pellacani, G., 2017. Dermoscopy, confocal microscopy and other non-invasive tools for the diagnosis of non-melanoma skin cancers and other skin conditions. Acta Derm Venereol, Suppl 218, 22–30. Doi:10.2340/00015555-2720.

[4].   Sagana, M., Ramani, P., Jeevitha, M., 2020. Incidence of non habit associated oral squamous cell carcinoma among patients in a private college hospital - A retrospective study. Indian J Forensic Med Toxicol, Doi:10.37506/ijfmt.v14i4.12484.

[5].   Minagawa, A., 2017. Dermoscopy-pathology relationship in seborrheic keratosis. J Dermatol. 44, 518–524. Doi:10.1111/1346-8138.13657.

[6].   Tonini G, Andreassi A, Cinotti E., 2020, Dermoscopy for benign melanocytic skin tumors, Technology in Practical Dermatology. Cham: Springer International Publishing, pp. 25–36, Doi:10.1007/978-3-030-45351-0_2.

[7].   Martín, J. M., Bella-Navarro, R., Jordá, E., 2012. Vascular patterns in dermoscopy. Actas Dermosifiliogr, 103, 357–375. Doi:10.1016/j.adengl.2012.06.007.

[8].   Ramesh A, Chander R. V, Srinivasan C, Vengadassalapathy S., 2020. Prevalence of angiogenesis, proliferation, and apoptosis markers of cervical cancer and their correlation with clinicopathological parameters. J Oncol, 8541415. Doi:10.1155/2020/8541415.

[9].   Tansushree, B., Tansushree, B., Magendran, J., Magendran, J., 2020. A study on awareness of breast cancer among nursing students. Indian J Forensic Med Toxicol, 14, 152–157. Doi:10.37506/ijfmt.v14i2.2777

[10].  Zelger, B., Zelger, B.G., Burgdorf, W.H.C., 2004. Dermatofibroma-a critical evaluation. Int J Surg Pathol, 12, 333–344. Doi:10.1177/106689690401200406.

[11].  Alves, J. V. P., Matos, D. M., Barreiros, H. F., Bártolo, E. A. F. L. F., 2014. Variants of dermatofibroma--a histopathological study. An Bras Dermatol, 89, 472–477. Doi:10.1590/abd1806-4841.20142629

[12].  Jouhilahti, E. M., Peltonen, S., Callens, T., Jokinen, E., Heape, A. M., Messiaen, L., et al., 2011. The development of cutaneous neurofibromas. Am J Pathol, 178, 500–505. Doi:10.1016/j.ajpath.2010.10.041.

[13].  Ardigo, M., Zieff, J., Scope, A., Gill, M., Spencer, P., Deng, L., et al., 2007. Dermoscopic and reflectance confocal microscope findings of trichoepithelioma, Dermatology, 215, 354–358. Doi:10.1159/000107631.

[14].  Jindal, R., Sethi, S., Chauhan, P., 2021. Dermoscopy of facial angiofibromas in four patients of skin of color with tuberous sclerosis complex: A case-series. Dermatol Pract Concept, 11, e2021036. Doi:10.5826/dpc.1103a36.

[15].  Jha, A., Sonthalia, S., Khopkar, U., 2017. Dermoscopy of pyogenic granuloma. Indian Dermatol Online J, 8, 523. Doi:10.4103/idoj.idoj_389_16.

[16].  Kwiek, B., Schwartz, R.A., 2016. Keratoacanthoma (KA): An update and review. J Am Acad Dermatol, 74, 1220–1233. Doi:10.1016/j.jaad.2015.11.033.

[17].  Aleissa, M., Aljarbou, O., AlJasser, M.I., 2021. Dermoscopy of eruptive syringoma. Skin Appendage Disord, 7, 401–403. Doi:10.1159/000515443.

[18].  Fan, Y., Xu, M., Liang, Y., Wu, N., Wang, F., Du, Q., et al., 2021. Desmoplastic melanoma: A clinicopathological analysis of three cases in the Chinese population. Onco Targets Ther, 14, 2651–2660. Doi:10.2147/OTT.S295716

[19].  Wee, S. J., Park, M. C., Chung, C. M., 2020. Basal cell carcinoma misdiagnosed as trichoepithelioma. Arch Craniofac Surg, 21, 202–205. Doi:10.7181/acfs.2020.00157.

[20].  Supekar, B. B., Wankhade, V. H., Agrawal, S., Singh, R. P., 2021. Isolated unilateral facial angiofibroma or segmental tuberous sclerosis complex. Indian Dermatol Online J, 12, 327–329. doi:10.4103/idoj.IDOJ_272_20.

[21].  Cha, B. B., Park, J. S., Kim, J. S., Huh, G., Choi, Y. J., Lee, G. Y., 2022. Therapeutic endpoint determination using dermoscopy in pyogenic granuloma treatment with long-pulsed laser. Medical Lasers; Engineering, Basic Research, and Clinical Application, 73, 322–322.

[22].  Watanabe, I. C., Magalhães, R. F., de Moraes, A. M., Stelini, R. F., Cintra, G. F., Metze, K., et al., 2015. Keratoacanthoma and keratoacanthoma-like squamous cell carcinoma: Similar morphology but different pathogenesis. Medicine (Baltimore), 94, e934, Doi:10.1097/MD.0000000000000934.

[23].  Dubois, A., Rajan, N., 2020. CYLD cutaneous syndrome, GeneReviews®[Internet]. Available: https://www.ncbi.nlm.nih.gov/books/NBK555820/