Oral Health and Vitamins: Exploring Nutritional Strategies for Disease Prevention and Healing
Abstract:
Oral health is influenced by various
factors, including nutrition and diet. Oral disease is a relevant public health
issue, which is considered a common disease in many individuals. In this
respect, vitamins may play an important role in the development and healing of
oral diseases while promoting dental and oral health. Additionally, they serve as antioxidants,
electron donors, or transcription effectors. They can be derived from food and
supplements, or in rare situations, our bodies or gut bacteria can produce them
on their own. It has been recommended that certain pathological conditions, such
as obesity, cancer, and cardiovascular disease, can be prevented and treated
with vitamins. Therefore, an approach to determine how various vitamin forms
could enhance dental and oral health is required to advance knowledge of the
possible advantages and disadvantages of using vitamin supplements.
References:
[1]. Kumar, P., Kumar, M., Bedi, O., Gupta, M., Kumar, S., Jaiswal, G., Rahi, V., Yedke, N.G., Bijalwan, A., Sharma, S. and Jamwal, S., 2021. Role of vitamins and minerals as immunity boosters in COVID-19. Inflammopharmacology, 29(4), 1001-1016. https://doi.org/10.1007/s10787-021-00826-7
[2]. Pandiyan, I., Doraikanan, S., Indiran, M.A., Jayakumar, N.D. and Ramakrishnan, K., 2024. Oral Health Status and Oral Health-related Quality of Life among Construction Workers in Chennai City: A Cross-sectional Study. World Journal of Dentistry, 15(3), 248-252. https://doi.org/ 10.5005/jp-journals-10015-2408
[3]. Chakraborty, T., Munigala, A., Kala, T., Yedla, R., Shankar, K.S., Bennadi, D., Tiwari, H.D. and Patel, P., 2024. Assessment of Oral Health Promotion Programs in Schools and their Long-Term Effects. Journal of Pharmacy and Bioallied Sciences, 16(3), S2543-S2545. https://doi.org/10.4103/jpbs.jpbs_287_24
[4]. Pavithra, R.S., Ramaprabha, G., Rajasekar, S. and Lakshmi Sree, S., 2017. Vitamin deficiency and periodontal disease tie in a relationship. Scholars Journal of Applied Medical Sciences (SJAMS), 5(1A), pp.74-81. https://doi.org/10.36347/sjams.2017.v05i01.015
[5]. Anbarcioglu, E., Kirtiloglu, T., Öztürk, A., Kolbakir, F., Acıkgöz, G. and Colak, R., 2019. Vitamin D deficiency in patients with aggressive periodontitis. Oral diseases, 25(1), 242-249. https://doi.org/10.1111/odi.12968
[6]. Ismail, N.H., Mussa, A., Al-Khreisat, M.J., Mohamed Yusoff, S., Husin, A., Johan, M.F. and Islam, M.A., 2023. The global prevalence of vitamin D deficiency and insufficiency in patients with multiple myeloma: A systematic review and meta-analysis. Nutrients, 15(14), 3227. https://doi.org/10.3390/nu15143227
[7]. Fakhoury, H.M., Kvietys, P.R., AlKattan, W., Al Anouti, F., Elahi, M.A., Karras, S.N. and Grant, W.B., 2020. Vitamin D and intestinal homeostasis: Barrier, microbiota, and immune modulation. The journal of steroid biochemistry and molecular biology, 200, 105663. https://doi.org/10.1016/j.jsbmb.2020.105663
[8]. Al Mashhadane, F.A. and Taqa, A.A.R., 2019. Vitamins and their relations to oral health: A review study. International Journal of Research Publications, 22(1),3-16.
[9]. Rathee, M., Bhoria, M. and Kundu, D.R., 2013. Vitamin C and oral health: A review. Indian Journal of Applied Research, 3(9), 1-2. https://doi.org/10.15373/2249555X/SEPT2013/139
[10]. Noce, A., Romani, A. and Bernini, R., 2021. Dietary intake and chronic disease prevention. Nutrients, 13(4),1358. https://doi.org/10.3390/nu13041358
[11]. Stich, H.F., Rosin, M.P., Hornby, A.P., Mathew, B., Sankaranarayanan, R. and Nair, M.K., 1988. Remission of oral leukoplakias and micronuclei in tobacco/betel quid chewers treated with beta‐carotene and with beta‐carotene plus vitamin A. International Journal of Cancer, 42(2), 195-199. https://doi.org/10.1002/ijc.2910420209
[12]. Surman, S.L., Penkert, R.R., Sealy, R.E., Jones, B.G., Marion, T.N., Vogel, P. and Hurwitz, J.L., 2020. Consequences of vitamin A deficiency: immunoglobulin dysregulation, squamous cell metaplasia, infectious disease, and death. International journal of molecular sciences, 21(15), 5570. https://doi.org/10.3390/ijms21155570
[13]. Akhtar, S., Ahmed, A., Randhawa, M.A., Atukorala, S., Arlappa, N., Ismail, T. and Ali, Z., 2013. Prevalence of vitamin A deficiency in South Asia: causes, outcomes, and possible remedies. Journal of health, population, and nutrition, 31(4), 413. https://doi.org/ 10.3329/jhpn.v31i4.19975
[14]. Sobaniec, H., Sobaniec, W., Sendrowski, K., Sobaniec, S. and Pietruska, M., 2007. Antioxidant activity of blood serum and saliva in patients with periodontal disease treated due to epilepsy. Advances in Medical Sciences (De Gruyter Open), 52, 204-206.
[15]. Tariq, M., Arya, S., Kumar, J.S., Kumar, M., Bhatnagar, A. and Kewalia, K., 2022. Role Of Antioxidants in Oral Diseases: A Review of Literature, World Journal of Pharmaceutical Research, 11(4), 341-350.
[16]. Nishida, M., Grossi, S.G., Dunford, R.G., Ho, A.W., Trevisan, M. and Genco, R.J., 2000. Dietary vitamin C and the risk for periodontal disease. Journal of periodontology, 71(8), 1215-1223. https://doi.org/10.1902/jop.2000.71.8.1215
[17]. Swapna, L.A. and Abdulsalam, R., 2022. Vitamin D deficiency and oral health. Journal of Positive School Psychology, 6, 9739-9743.
[18]. Botelho, J., Machado, V., Proença, L., Delgado, A.S. and Mendes, J.J., 2020. Vitamin D deficiency and oral health: a comprehensive review. Nutrients, 12(5), 1471. https://doi.org/10.3390/nu12051471
[19]. Pinzariu, A.C., Sova, I.A., Maranduca, M.A., Filip, N., Drochioi, I.C., Vamesu, C.G., Clim, A., Hurjui, L.L., Moscalu, M., Soroceanu, R.P. and Serban, D.N., 2022. Vitamin D Deficiency in Both Oral and Systemic Manifestations in SARS-CoV-2 Infection: Updated Review. Medicina, 59(1), 68. https://doi.org/10.3390/medicina59010068
[20]. Machado, V., Lobo, S., Proença, L., Mendes, J.J. and Botelho, J., 2020. Vitamin D and periodontitis: A systematic review and meta-analysis. Nutrients, 12(8), 2177. https://doi.org/10.3390/nu12082177
[21]. Santos-Sánchez, N.F., Salas-Coronado, R., Villanueva-Cañongo, C. and Hernández-Carlos, B., 2019. Antioxidant compounds and their antioxidant mechanism, edited by Emad Shalaby, Antioxidants, 10, 1-29.
[22]. Kaur, G., Kathariya, R., Bansal, S., Singh, A. and Shahakar, D., 2016. Dietary antioxidants and their indispensable role in periodontal health. Journal of food and drug analysis, 24(2), 239-246. https://doi.org/10.1016/j.jfda.2015.11.003.
[23]. IqubAl, M.A., KhAn, M., KuMAr, P., KuMAr, A. and AjAI, K., 2014. Role of vitamin E in prevention of oral cancer: a review. Journal of clinical and diagnostic research: JCDR, 8(10), ZE05. https://doi/10.7860/JCDR/2014/9166.4958
[24]. Chaitanya, N.C., Muthukrishnan, A., Babu, D.B.G., Kumari, C.S., Lakshmi, M.A., Palat, G. and Alam, K.S., 2017. Role of vitamin E and vitamin a in oral mucositis induced by cancer chemo/radiotherapy-a meta-analysis. Journal of clinical and diagnostic research: JCDR, 11(5), ZE06. https://doi/10.7860/JCDR/2017/26845.9905
[25]. Wójcik, D., Krzewska, A., Szalewski, L., Pietryka-Michalowska, E., Szalewska, M., Krzewski, S., Pels, E. and Ben-Skowronek, I., 2018. Dental caries and vitamin D3 in children with growth hormone deficiency: A STROBE compliant study. Medicine, 97(8), e9811. https://doi/10.1097/MD.0000000000009811
[26]. Chitra, S. and Shyamala Devi, C.S., 2008. Effect of vitamin E on protein bound carbhohydrate complexes in radiation treated oral squamous cell carcinoma patients. Indian Journal of Clinical Biochemistry, 23, 92-94. https://doi.org/10.1007/s12291-008-0022-6
[27]. Shearer, M.J., Fu, X. and Booth, S.L., 2012. Vitamin K nutrition, metabolism, and requirements: current concepts and future research. Advances in Nutrition, 3(2), 182-195. https://doi.org/10.3945/an.111.001800
[28]. Akbari, S. and Rasouli-Ghahroudi, A.A., 2018. Vitamin K and bone metabolism: a review of the latest evidence in preclinical studies. BioMed Research International, 2018(1), 4629383. https://doi.org/10.1155/2018/4629383
[29]. Carr, A.C. and Rowe, S., 2020. Factors affecting vitamin C status and prevalence of deficiency: A global health perspective. Nutrients, 12(7), 1963. https://doi.org/10.3390/nu12071963
[30]. Murererehe, J., Uwitonze, A.M., Nikuze, P., Patel, J. and Razzaque, M.S., 2022. Beneficial effects of vitamin C in maintaining optimal oral health. Frontiers in Nutrition, 8, 805809. https://doi.org/10.3389/fnut.2021.805809
[31]. Eydou, Z., Jad, B.N., Elsayed, Z., Ismail, A., Magaogao, M. and Hossain, A., 2020. Investigation on the effect of vitamin C on growth & biofilm-forming potential of Streptococcus mutans isolated from patients with dental caries. BMC Microbiology, 20, 1-11. https://doi.org/10.1186/s12866-020-01914-4
[32]. Scheller, K., Röckl, T., Scheller, C. and Schubert, J., 2013. Lower concentrations of B-vitamin subgroups in the serum and amniotic fluid correlate to cleft lip and palate appearance in the offspring of A/WySn mice. Journal of Oral and Maxillofacial Surgery, 71(9), 1601. https://doi.org/10.1016/j.joms.2013.02.020
[33]. Moskovitz, M., Dotan, M. and Zilberman, U., 2017. The influence of infantile thiamine deficiency on primary dentition. Clinical Oral Investigations, 21, 1309-1313. https://doi.org/10.1007/s00784-016-1875-3
[34]. Kennedy, D.O., 2016. B vitamins and the brain: mechanisms, dose and efficacy—a review. Nutrients, 8(2), 68. https://doi.org/10.3390/nu8020068
[35]. Cavalcoli, F., Zilli, A., Conte, D. and Massironi, S., 2017. Micronutrient deficiencies in patients with chronic atrophic autoimmune gastritis: A review. World journal of gastroenterology, 23(4), 563. https://doi.org/ 10.3748/wjg.v23.i4.563
[36]. Thomas, D.M. and Mirowski, G.W., 2010. Nutrition and oral mucosal diseases. Clinics in Dermatology, 28(4), 426-431. https://doi.org/10.1016/j.clindermatol.2010.03.025
[37]. Stach, K., Stach, W. and Augoff, K., 2021. Vitamin B6 in health and disease. Nutrients, 13(9), 3229. https://doi.org/10.3390/nu13093229
[38]. Green, R., Allen, L.H., Bjørke-Monsen, A.L., Brito, A., Guéant, J.L., Miller, J.W., Molloy, A.M., Nexo, E., Stabler, S., Toh, B.H. and Ueland, P.M., 2017. Vitamin B12 deficiency. Nature reviews Disease Primers, 3(1), 1-20. https://doi.org/10.1038/nrdp.2017.40
[39]. Alekhya, K., Tejaswi, K., Muppirala, S., Divya, D., Soujanya, L.K. And Arutla, R., 2019. Oral Manifestations of Vitamin B12 (Cobalamin) Deficiency: A Review. Inter. Healthcare Research J, 3(1), 9-15. https://doi.org/ 10.26440/IHRJ/0301.04.521066
[40]. Roth, W. and Mohamadzadeh, M., 2021. Vitamin B12 and gut-brain homeostasis in the pathophysiology of ischemic stroke. EBioMedicine, 73, 103676. https://doi.org/10.1016/j.ebiom.2021.103676
[41]. Kim, J., Kim, M.J. and Kho, H.S., 2016. Oral manifestations in vitamin B 12 deficiency patients with or without history of gastrectomy. BMC Oral Health, 16, 1-9. https://doi.org/10.1186/s12903-016-0215-y