Abstract:

Nanotechnology holds the potential to transform biomedicine through the development of nanomaterials that are compatible with biological systems. The application of selenium nanoparticles (SeNPs) synthesized by Cinnamomum verum aqueous extract, is aimed at offering environmentally friendly agents for the biomedical sector, with antibacterial, and antioxidant properties. Exploiting the ability of C. verum extract to reduce Sodium Selenite (Na₂SeO₃) to SeNPs. The synthesized SeNPs analyzed the antibacterial features of microbial pathogens such as gram-positive and gram-negative using standard microbiological methods. Using different characterization techniques like UV-visible spectroscopy and Fourier-Transform Infrared (FTIR), the analysis shows the synthesis of SeNPs succession and clarifies the material’s composition. Scanning Electron Microscopy (SEM) in conjunction with Energy Dispersive X-ray spectroscopy (EDAX) analysis further provides detailed information about SeNP's structural morphology and elemental composition. Furthermore, their antioxidant capabilities are examined, which were evaluated in the range of 30–60 μg/mL for their ability to scavenge free radicals as 80–90% using the DPPH (2,2-Diphenyl-1-Picrylhydrazyl) assay and 100–500 μg/mL concentrations used for the Ferric-Reducing Antioxidant Powder (FRAP) assay. As the concentration of SeNPs increased, their ability to scavenge DPPH and FRAP radicals also increased in a dose-dependent manner. Importantly, SeNPs displayed lower toxicity in brine shrimp assays at lower concentrations, indicating their potential safety for use in biomedical contexts. At the end of this synthesis, C. verum-mediated SeNPs are presented as a promising option beneficial in nanotechnology development applied in medicine and especially treatment of a bacterial infection which can even extend to cancer.

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