Abstract:

Hereditary Spherocytosis (HS), a non-immune hemolytic anaemia, results from red blood cell (RBC) transmembrane protein abnormalities. Surgical management, like laparoscopic cholecystectomy and splenectomy, poses challenges due to altered liver function and chronic hemolysis. A 20-year-old female with known HS underwent laparoscopic cholecystectomy and splenectomy. The preoperative assessment revealed a blood transfusion history, altered liver function, and anaemia. Examination showed pallor, icterus, and hepatosplenomegaly. Laboratory findings indicated microcytic hyperchromic RBCs and elevated bilirubin. Anaesthetic management involves premedication, induction, and intraoperative monitoring, with attention to hemodynamic stability. Anaesthetic considerations include avoiding acidosis, hypothermia, and hypotension, and managing deranged liver function and preoperative anaemia. Preoperative optimization and prompt complication management are crucial. Anaesthetic management in HS patients undergoing surgery requires an understanding of pathophysiology and complications. Multidisciplinary collaboration and meticulous perioperative care are essential for optimal outcomes.

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