Abstract:

Endometriosis refers to the existence of functional endometrial glands and tissue in locations beyond the uterus. This condition frequently leads to persistent pelvic discomfort, occasionally severe, and inflammation is recognized as a contributing factor in the development of endometriosis. Finding a non-invasive indicator for endometriosis would greatly assist in its early detection and treatment. Therefore, the present study was conducted to study the levels of inflammatory mediators - Complement 3 (C3) and C-reactive protein (CRP) in endometriosis condition. The study was conducted in 40 women who have been laparoscopically diagnosed with endometriosis, and the levels of C3 and serum CRP were estimated in the plasma by ELISA analysis. The results demonstrated significant rise in the levels of serum CRP and C3 in endometriotic women as compared to the levels in non-endometriotic women. Due to the altered regulation of the complement system and the effects of pelvic adhesions and deep infiltrating endometriosis, there is a significant rise in the levels of complement 3 and serum CRP respectively. While immune infiltration and constant inflammatory milieu foster the disease, the biggest pathological consequences arise from aberrant complement activation. Hence, with the aid of pre-clinical and clinical trials, a detailed strategy can be formulated to suppress complement activation and alleviate the devastating effects of endometriosis.

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