Fabrication and Characterization of a Novel Dental Filling Herbal Composite Using Biphasic Calcium Phosphate and Leaf Extracts of Cassia occidentalis
DOI: 10.21522/TIJPH.2013.SE.24.03.Art014
Authors : Sridevi Gopathy, Selvaraj Jayaraman, Savitha Niren, Malathy BR, Srividya Seshadri
Abstract:
In the field
of Biomedicine, allogeneic grafts that possess excellent biocompatibility and
immuno-compatibility play a major role in the treatment of untreated dental
bone defects. Filling these defects with
bone substitute material prevents resorption of bone, preserves the alveolar
ridge, and provides sufficient bone for immediate or subsequent implant
placement. In this regard, the present study focused on the fabrication of a
novel herbal bone graft material rich in biopolymers and phytochemicals was
used as bone graft. The bone graft material was synthesized using biphasic
calcium phosphate, casein, chitosan and ethanolic leaf extracts of Cassia
Occidentalis. The prepared bone graft was subjected to various
characterizations like FTIR, X-ray diffraction, thermos-gravimetric analysis,
scanning electron microscopy to show its chemical composition, surface
morphology, stability, mechanical strength to show its chemical composition,
stability and porosity and GCMS analysis, anti-microbial, anti-oxidant,
anti-inflammatory activity to reveal its bioactive components. Results revealed
that the prepared bone graft of Cassia Occidentalis showed excellent osteogenic
and can be well suggested for various biomedical applications like orthopedics,
dental fillings, bone tissue engineering and in the treatment of rheumatoid arthritis.
It also replaces the use of autogenous graft with high biocompatibility and
osteogenesis.
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