Novel Bonegraft Composite using Hydroxyapatite, Egg-Shell Powder and Chitosan Fortified with Terminalia chebula
DOI: 10.21522/TIJPH.2013.SE.24.03.Art011
Authors : Srividya Seshadri, Selvaraj Jayaraman, Sridevi Gopathy, Malathy BR, Rajalaxmi V
Abstract:
Allogeneic bone grafts are
considered to be an integral part of implant dentistry. These grafts have rich
osteoconductivity, osteoinductivity and osteogencity and can act as a substrate
material to fill the defects on bone surfaces and can augment bone fracture and
tooth fracture healing. Based on such principles, this current study fabricated
a novel graft composite for bone using egg shell powder (ESP), Hydroxyapatite (HA), Chitosan (CH) and
Aqueous extract of fruits of Terminalia chebula (TC). The prepared new bone
graft (ESP-HA-CH-Tc) was analyzed using various physico-chemical
characterization techniques like FT-IR, XRD, TGA, and SEM to understand the
chemical composition, evaluate its surface morphology and stability standard.
The aqueous fruit extract of Terminalia chebula (Tc) was analysed for its
phytochemical composition by GCMS and invitro pharmacological properties like
antioxidant, anti-inflammatory, antimicrobial and the biocompatibility of the
graft were assessed by cell culture studies in Breast cancer (MCF-7) cell lines. The incorporation of fruit extract of Terminalia
chebula strengthens and augments the ossification property of the graft material
and can extend its use in the treatment of fractures and further biomedical
applications.
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