Possible Interventional Anticancer Therapy by Phytomedicines - A Review
DOI: 10.21522/TIJPH.2013.SE.24.03.Art008
Authors : Sridevi Gopathy, S. Srividya, Shanmuga Priya K, Anuradha
Abstract:
Cancer is the rapid proliferation that causes abnormal cells which metastasize to distant tissues. This aberrant signalling mechanism disrupts the regulation of cell proliferation and persistence, ultimately becoming the primary cause of mortality worldwide. The need for novel medications for the treatment and prevention of this deadly disease is constantly rising. Herbal therapies have significance for both preventing and treating a variety of malignancies. Anticancer medications have been discovered and developed from many herbal medicines by the presence of their bioactive phytochemicals such as phenolics, alkaloids, flavonoids, carotenoids, and other secondary metabolites. These herbal products are said to have less toxic side effects when compared to modern treatment strategies. Therapeutic medicinal herbs suppress the progression of cancerous cells by influencing the action of particular enzymes and hormones. The bioactive phytochemicals obstruct cancerous cell multiplication, promote apoptosis of malignant cells, enforce the necrosis of tumors, and inhibit their translocation. They also exert their action by enhancing the number of leukocytes and platelets, promoting the reverse transformation from tumor cells back to usual cells, and they similarly prevent carcinogenesis of regular cells. This review paper enlightens the significance of herbal medicines as anticancer agents and explains, in brief, the mechanism of action and the effects of the herbal bioactive compound. This review helps to explore the potential therapeutic plants as a basis for the discovery of chemotherapy medications.References:
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