Antidiabetic Activity of Allin Isolated from Allium Sativum: Role of P13K/AKT Signalling

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DOI: 10.21522/TIJPH.2013.SE.24.03.Art002

Authors : Selvaraj Jayaraman, Vishnu Priya Veeraraghavan, Sridevi Gopathy, Ponnulakshmi Rajagopal, Heera M. J, Manju P, Kritika C, Sureka Varalakshmi V, Chella Perumal Palanisamy, Ramajayam Govindan

Abstract:

This study presents a comprehensive molecular docking analysis aimed at elucidating the potential antidiabetic activity of allin, a compound isolated from Allium sativum (garlic). Through computational modelling, we investigated the binding interactions between allin and Rheb, revealing that allin exhibited the lowest binding affinities with a binding energy of -3.24 kcal/mol. The docking results unveiled a significant role of the P13K/AKT signalling pathway in mediating the antidiabetic effects of allin. The interaction between allin and Rheb was characterized by the establishment of a single hydrogen bond involving SER-16 and GDP-201. This interaction contributed to the formation of a binding pocket encompassing key residues such as PRO-37, ARG-15, SER-16, THR-88, LEU-123, GLU-126, and GDP-201. The molecular docking analysis sheds light on the intricate molecular mechanisms underlying the antidiabetic potential of allin, providing insights into its specific interactions with key signalling components. Furthermore, our findings suggest a potential modulation of the P13K/AKT signalling pathway by the allin, emphasizing its significance in the context of antidiabetic activity. The results of this study suggest contributes valuable information to the understanding of the molecular basis of allin's therapeutic potential and provides a foundation for further experimental validations and exploration of its application in diabetes management.

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