Potential Role of Flavonoids as Anti-diabetic Agents-A Comprehensive Review
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Abstract:
Diabetes mellitus is a widespread and debilitating metabolic disorder marked by sustained elevated blood glucose levels, which can culminate in a range of severe complications if unmanaged. Flavonoids, polyphenolic chemicals originating from plants, have attracted a great deal of attention in the field of diabetes research because of their antidiabetic properties. These naturally occurring substances, which are 15 carbons in structure, are widely distributed in fruits, vegetables, and other plant-based diets, have been shown to offer a number of positive benefits, including the capacity to regulate many facets of insulin and glucose homeostasis. These compounds are classified into six major subclasses based on their structural differences. Numerous in vivo and in vitro studies have looked at the antidiabetic potential of flavonoids. Flavonoids have been found to modulate enzymes such as ά-glucosidase and ά-amylase, which are the key enzymes for the reduction of blood glucose levels. Emerging evidence suggests that flavonoids may exert their antidiabetic effects through their ability to modulate various cell signaling pathways involved in glucose metabolism, insulin sensitivity, and inflammation. It has been demonstrated that flavonoids contain anti-inflammatory and antioxidant qualities. These qualities are vital for reducing inflammation and oxidative stress, which are crucial factors to the onset of diabetes. This review aims providing comprehensive elucidation of the cellular and molecular mechanisms underlying the antidiabetic effects of flavonoids, considering their potential impact on various metabolic pathways involved in diabetes.References:
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