Abstract:

Medication usage during pregnancy is increasing twofold, and it should be considered a public health issue due to increasing complications associated with medication. Data on prescribed and self-prescribed medication among Sudani females is limited. Hence, this study aims to assess the prevalence and associated risk factors of drug usage among Sudanese females, including prescribed medication and self-prescribed medication, who are registered in tertiary care facilities. A cross-sectional descriptive study was planned in the hospital setting at Omdurman Maternity Center, Sudan. Data were collected between January 2023 and February 2023 through semi-structured interviews. The sample comprised 878 pregnant females and was divided into two groups: 453 females on medication and 425 females not on medication. The data were analyzed using univariate and multivariate logistic regression, and statistical significance was set at 0.05. The result of this study shows that 51.1% of females were on medication, of which 14.1% were on self-medication. The maximum drugs taken were antibiotics, followed by diabetic and hypertensive medication. Data showed a statistically significant relationship between medicine usage and chronic medical conditions (p<0.001). However, no significant association was reported between medicine usage, body mass index, gravidity, maternal age, and education. The prevalence of medicine usage among Sudani women is high. These findings underscore the importance of enhancing the initiatives undertaken by healthcare professionals, particularly in the prenatal setting, to ensure the appropriate management of medication usage during pregnancy, thereby reducing the risk of potential complications for both the mother and the fetus.

References:

[1].   KHOa, J. V, CHUAab S. S., DALLUMAL, R. M., OMAR,  S. Z., 2017, Medications used by Pregnant Women: any Safety Concerns? Malay. 318:63.6.

[2].   Lupattelli A, Spigset O, Twigg M. J., et al., 2014, Medication Use in Pregnancy: A Cross-Sectional, Multinational Web-Based Study. BMJ Open. Feb 17 4(2):e004365. doi:10.1136/bmjopen-2013-004365

[3].   Mitchell, A. A., Gilboa, S. M., Werler, M. M., Kelley, K. E., Louik, C., Hernández-Díaz, S., 1976-2008, Medication Use During Pregnancy, with Particular Focus on Prescription Drugs:. Am J Obstet Gynecol. Jul 2011; 205(1):51.e1-8. Doi:10.1016/j.ajog.2011.02.029

[4].   Mohammed, M. A., Ahmed, J. H., Bushra, A. W., Aljadhey, H. S., 2013, Medications use among Pregnant Women in Ethiopia: A Cross Sectional Study. Journal of Applied Pharmaceutical Science.; 3(4):116-123.

[5].   Obadeji, S. T., Obadeji, A., Bamidele, J. O., Ajayi, F. T., 2020, Medication use Among Pregnant Women at A Secondary Health Institution: Utilisation Patterns and Predictors of Quantity. Afr Health Sci. Sep 20(3):1206-1216. Doi:10.4314/ahs.v20i3.24

[6].   Haque, M. U., Khatun, M. S., Amin, N. T., et al. 2016, Prevalence and Nature of Selfmedication of Drugs Among Pregnant Women in Rajshahi City, Bangladesh. European Journal of Preventive Medicine. 4(6):125-131.

[7].   Mulder, B., Bijlsma, M. J., Schuiling-Veninga, C. C., et al. 2018, Risks Versus Benefits of Medication use During Pregnancy: What Do Women Perceive? Patient Prefer Adherence. 12:1-8. Doi:10.2147/ppa.S146091.

[8].   Pereira, G., Surita, F. G., Ferracini, A. C., Madeira, C. S, Oliveira, L. S, Mazzola, P. G., 2021, Self-Medication Among Pregnant Women: Prevalence and Associated Factors. Front Pharmacol. 12:659503. Doi:10.3389/fphar.2021.659503.

[9].   Sachdeva, P., Patel, B. G., Patel, B. K. 2009, Drug use in Pregnancy; A Point to Ponder! Indian J Pharm Sci. Jan 71(1):1-7. Doi:10.4103/0250-474x.51941

[10].  Devkota, R, Khan, G. M, Alam, K, Sapkota, B, Devkota, D. 2017, Impacts of Counseling on Knowledge, Attitude and Practice of Medication Use During Pregnancy. BMC Pregnancy Childbirth. Apr 27 17(1):131. Doi:10.1186/s12884-017-1316-6.

[11].  Trønnes, J. N, Lupattelli, A., Nordeng, H., 2017, Safety Profile of Medication Used During Pregnancy: Results of a Multinational European Study. Pharmacoepidemiol Drug Saf. Jul 26(7):802-811. Doi:10.1002/pds.4213

[12].  Cleary, B. J, Butt, H., Strawbridge, J. D, Gallagher, P. J., Fahey, T., Murphy, D. J. 2010, Medication Use in Early Pregnancy-Prevalence and Determinants of Use in A Prospective Cohort of Women. Pharmacoepidemiol Drug Saf. Apr 19(4):408-17. Doi:10.1002/pds.1906.

[13].  Suthar, J, Patel, R., 2020, Morbidity Pattern and Drug Prescribing Study in Pregnant Women of Rural Part of Charotar Region. Indian Journal of Pharmacy Practice. 13(4)

[14].  Alsammani, M. A., 2021, Incidence and Causes of Stillbirth in Omdurman Maternity Hospital, Sudan: A Prospective Cross-Sectional Study. Cureus. Jun 13(6):e15453. Doi:10.7759/cureus.15453.

[15].  Bader, E, Alhaj, A. M, Hussan, A. A, Adam, I. 2010, Malaria and Stillbirth in Omdurman Maternity Hospital, Sudan. International Journal of Gynecology & Obstetrics. 109(2):144-146. Doi:https://doi.org/10.1016/j.ijgo.2009.11.022.

[16].  Sullivan, K. M, Dean, A, Soe, M. M. 2009, OpenEpi: A Web-Based Epidemiologic and Statistical Calculator For Public Health. Public Health Rep. May-Jun 124(3):471-4. Doi:10.1177/003335490912400320.

[17].  Beyene, K. G, Beza, S. W., 2018, Self-Medication Practice and Associated Factors Among Pregnant Women in Addis Ababa, Ethiopia. Trop Med Health. 46:10. Doi:10.1186/s41182-018-0091-z.

[18].  Hanafy, S. A, Sallam, S. A, Kharboush, I. F., Wahdan, I. H., 2016, Drug Utilization Pattern During Pregnancy in Alexandria, Egypt. Eur J Pharm Med Res. 3(2):19-29.

[19].  Dathe, K, Schaefer, C. 2019, The Use of Medication in Pregnancy. Dtsch Arztebl Int. 116(46):783-790. Doi:10.3238/arztebl.2019.0783

[20].  Araújo, D. D., Leal, M. M., Santos, E. J. V., Leal, L. B., 2013, Consumption of Medicines in High-Risk Pregnancy: Evaluation of Determinants Related to the use of Prescription Drugs and Self-Medication. Brazilian Journal of Pharmaceutical Sciences. 49:491-499.

[21].  Iranpour, A, Kazemian, E, Karamoozian, A, Nakhaee, N, Sharifi, H, Fadakar, M. M., 2023, Prevalence of Substance Use During Pregnancy and the Related Factors: A Study from Southeast Iran. Journal of. 30(5):261-266.

[22].  Tabatabaei, S. M., Behmanesh-Pour, F., Salimi-Khorashad, A., Zaboli, M., Sargazi-Moakhar, Z., Shaare-Mollashahi, S., 2018, Substance Abuse and its Associated Factors Among Pregnant Women: A Cross-Sectional Study in the Southeast of Iran. Addiction & health. 10(3):162.

[23].  Admasie, C, Wasie, B, Abeje, G., 2014, Determinants of Prescribed Drug Use Among Pregnant Women in Bahir Dar City Administration, Northwest Ethiopia: A Cross Sectional Study. BMC Pregnancy Childbirth. 14:325. Doi:10.1186/1471-2393-14-325.

[24].  Tamiru, D., Misgana, T., Tariku, M, et al. 2022, Prevalence and Associated Factors of Common Mental Disorders Among Pregnant Mothers in Rural Eastern Ethiopia. Frontiers in Psychiatry. 13:843984.

[25].  Ayele, Y., Mekuria, A. N., Tola, A., Mishore, K. M., Geleto, F. B., 2020, Prescription Drugs Use During Pregnancy In Ethiopia: A Systematic Review and Meta-Analysis. SAGE Open Med. 8:2050312120935471. Doi:10.1177/2050312120935471.

[26].  Atmadani, R. N., Nkoka, O., Yunita, S. L., Chen, Y. H., 2020, Self-Medication and Knowledge Among Pregnant Women Attending Primary Healthcare Services in Malang, Indonesia: A Cross-Sectional Study. BMC Pregnancy Childbirth. Jan 16 20(1):42. Doi:10.1186/s12884-020-2736-2.

[27].  Baraka, M., Steurbaut, S., Coomans, D, Dupont, A. G., 2014, Determinants of Medication Use in A Multi-Ethnic Population of Pregnant Women: A Cross-Sectional Study. Eur J Contracept Reprod Health Care. 19(2):108-20. doi:10.3109/13625187.2013.879568