Study on Polychlorinated Biphenyls-Induced Changes in the Expression of Pro Inflammatory Markers and the Therapeutic Role of Vitamin C And E
Abstract:
Polychlorinated biphenyls (PCBs) are manmade chemicals which are highly reactive and cause disorders such as diabetes, and cancer and conditions such as breathing difficulties etc., It is endocrine receptors and environmental pollutants. IL1-β and TNF-α are pro-inflammatory markers. Vitamin C and E are antioxidants that have therapeutic effects on PCB. They also protect the body from free radicals, pollutants and toxins. They also help in the defence system and protect the body against cancer, arthritis, etc. The harmful effects and the changes induced by PCBs on pro-inflammatory markers and the therapeutic role of vitamin C and E on PCB were studied using Adult male albino rats. Adipose tissues from control and treated animals were dissected out and used for the assessment of pro-inflammatory markers. The IL1-β and TNF-α mRNA expression levels were measured using the RT-PCR method. The data were analyzed statistically. The results showed that the IL1-β and TNF-α mRNA expression levels of PCB-induced rats were significantly increased (p<0.05). Treatment with Vitamin C and E could effectively reduce the expression of the pro-inflammatory signalling molecules in adipose tissue.
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