Co-relation between ART (Anti-Retroviral Therapy) Adherence with Nutritional Status and Quality of Life among HIV-Infected Adolescents
Abstract:
Successful
treatment for Perinatally Infected Adolescents (PIA) faces physical challenges like
the risk of co-morbidity, deferred growth, and development, often resulting in late
puberty in girls, and stunting/wasting makes it difficult to reach the transition
phase of adulthood. The
study aims to identify the correlation between ART adherence with nutritional status
and QOL and find the association between adherence scores with selected demographic
variables among adolescents. A randomized Controlled Trial design was adopted. Through
simple random technique, a total of 388 HIV-infected adolescents were divided into experimental (195)
and control (193) groups. The data were collected from four ART clinics in Chennai,
India, through standardized ART adherence, QOL, and structured nutritional assessment
questionnaires. Motivational counselling was given to the experimental group, and
the researcher demonstrated selected asanas. The data were collected from both groups
at ‘0’, ‘3’ & 6-month intervals. Descriptive & inferential statistics were
used for the analysis of data. Regarding
correlation, in the experimental group, baseline assessment showed poor correlation,
but in the 3rd & 6th months there was a fair and moderate
correlation found and was significant at p=0.05** and P=0.001*** respectively. Whereas
in a control group, throughout the assessment period showed that, there was a poor
correlation. Regarding association,
showed adolescents' age, sex, sex of caregivers, relationship with adolescents,
and residence were found significant. Motivational counseling along with asana has a
positive correlation to ART adherence to promote the health and well-being of adolescents
in the experimental group than in the control group.
References:
[1] Cruz ML, Cardoso CA. Perinatally
infected adolescents living with human immunodeficiency virus (perinatally human
immunodeficiency virus). World J Virol. 2015 Aug 12;4(3):277-84. doi: 10.5501/wjv.
v4.i3.277. PMID: 26279988; PMCID: PMC4534818.
[2] Vidya Vijayan KK, Karthigeyan
KP, Tripathi SP, Hanna LE. Pathophysiology of CD4+ T-Cell Depletion in HIV-1 and
HIV-2 Infections. Front Immunol. 2017 May 23; 8:580. doi: 10.3389/fimmu.2017.00580.
PMID: 28588579; PMCID: PMC5440548.
[3] Julie S. Eggleton; Shivaraj Nagalli. Highly
Active Antiretroviral Therapy (HAART) July 4, 2022.https://www.ncbi.nlm.nih.gov/books/NBK554533/.
[4] Bezabhe WM, Chalmers L, Bereznicki
LR, Peterson GM. Adherence to Antiretroviral Therapy and Virologic Failure: A Meta-Analysis.
Medicine (Baltimore). 2016 Apr;95(15):e3361. doi: 10.1097/MD.0000000000003361. PMID:
27082595; PMCID: PMC4839839.
[5] Simona A.
Iacob, Diana G. Iacob and Gheorghita Jugulete. Improving the Adherence to Antiretroviral
Therapy, a Difficult but Essential Task for a Successful HIV Treatment—Clinical
Points of View and Practical Considerations. Front. Pharmacol., 23 November 2017
Sec. Drugs
Outcomes Research and Policies 8 – 2017.
[6] HIV and
AIDS in adolescents, UNICEF. July 2021. https://data.unicef.org/topic/hiv-aids.
[7] Bellavia A, Williams PL,
DiMeglio LA, Hazra R, Abzug MJ, Patel K, Jacobson DL, Van Dyke RB, Geffner ME; International
Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) P219/219C Study, and
the Pediatric HIV/AIDS Cohort Study (PHACS). Delay in sexual maturation in perinatally
HIV-infected youths is mediated by poor growth. AIDS. 2017 Jun 1;31(9):1333-1341.
doi: 10.1097/QAD.0000000000001486. PMID: 28358737; PMCID: PMC5472204.
[8] Bliss JR, Njenga M, Stoltzfus
RJ, Pelletier DL. Stigma as a barrier to treatment for child acute malnutrition
in Marsabit County, Kenya. Matern Child Nutr. 2016 Jan;12(1):125-38. doi: 10.1111/mcn.12198.
Epub 2015 May 18. PMID: 25989353; PMCID: PMC6860141.
[9] Zewen Liu,
Zhangpin Ren, Jun Zhang, Chia-Chen Chuang.Role of ROS and Nutritional Antioxidants
in Human Diseases Front. Physiol., Volume 9.2018 https://doi.org/10.3389/fphys. 2018.00477.
[10] Andrinopoulos
K, Clum G, Murphy DA
Harper G. Health Related Quality Of
Life and Psychosocial Correlates Among HIV-Infected Adolescent And Young Adult Women
In The Us. AIDS Educ Prev. 2011 Aug; 23(4): 367–381.
[11]
Forlanini F, Albani ME, Geluardi Y, Ciceri A, Longoni E, et al.
(2023) Evaluation of Quality of Life, Mental Health, Psychological and Neuro-Cognitive
Aspects in Young Women Living with HIV Infection: Parallel between Vertically and
Behaviorally Acquired HIV Infection. J Family Med Prim Care Open Acc 7: 211.
DOI: https://doi.org/10.29011/2688-7460.100211.
[12] Bekker LG, Johnson L, Wallace M and Hosek S. Building our youth for the future.J Int AIDS Soc. 2015; 18; 2: (1). doi:
10.7448/IAS.18.2.20027.
[13] Oberdorfer P, Louthrenoo O, Puthanakit T,
Sirisanthana V et al., Quality of Life Among HIV-Infected Children in Thailand.
Journal of the International Association of Physicians in AIDS Care.2008;
7: (3).141-47 doi: 10.1177/1545109708318877.
[14] Verma, C. V., Kamble, A., & Krishnan, V. (2019). Exercises versus Yoga:
Impact on Quality of Life amongst HIV Positive Individuals. New Insights into
Disease and Pathogen Research Vol. 3, 90-98. Retrieved from https://stm1.bookpi.org/index.php/nidpr-v3/article/view/789.
[15] Naoroibam R, Metri KG, Bhargav H, Nagaratna
R et al., Effect of Integrated Yoga (IY) on psychological states and CD4 counts
of HIV-1 infected Patients: A Randomized controlled pilot study. Int J Yoga.
2016; 9 (1): 57-61.
[16] Mary-Ann Davies, Jorge
Pinto, Marlène BrasGetting to 90-90-90 in paediatric HIV: What is needed?: 02 December 2015. https://doi.org/10.7448/IAS.18.7.20770.
[17] Looking Out for Adolescents and Youth From
Key Populations. UNICEF- East Asia and Pacific Regional Office and United Nations
Asia Pacific Interagency Task Team on Young Key Populations, November 2019. https://www.unicef.org/eap/media/4446/file/Looking%20out%20for%20adolescents%20and%20youth%20from%20key%20populations.pdf.
[18] Cardoso CA, Pinto JA, Candiani, TM, Carvalho
IR et al., The impact of highly active antiretroviral therapy on the survival of
vertically HIV-infected children and adolescents in Belo horizonte, Brazil. Memórias
do Instituto Oswaldo Cruz.2012; 102: 532-538. Available in http://dx.doi.org/10.1590/S0074-02762012000400014.
[19] Koech E, Teasdale CA, Wang C, Fayorsey R et
al., Characteristics and outcomes of HIV-infected youth and young adolescents enrolled
in HIV care in Kenya. AIDS. 2014; 28:2729–2738.DOI:10.1097/QAD.0000000000000473.
[20] Cordova E, Yañez J,
Claudia G Ismael R. Safety, and efficacy of antiretroviral therapy in perinatally HIV-1 infected
patients following transition to an adult HIV-care hospital with virological failure
in Buenos Aires, Argentina. Enferm
Infecc Microbiol Clin. 2015;33(2):133–140
doi: 10.1016/j.eimc.2014.05.005.
[21]
Botros D, Somarriba G, NeriD,Miller LT. Interventions to Address Chronic Disease and
HIV: Strategies to Promote Exercise and Nutrition Among HIV-Infected Individuals
Curr HIV/AIDS Rep.2012; 9:
351. doi:10.1007/s11904-012-0135-7.
[22] Kabue MM, Kekitiinwa A, Maganda A, Risser
JM, Chan W, Kline MW. Growth in HIV-infected receiving antiretroviral therapy at
a paediatric infectious disease’s clinic in Uganda. AIDS Patient Care STDS. 2008;
22:245–25.
[23] Eby J, Chapman J, Marukutira T et al., The adherence-outcome
relationship is not altered by diary-driven adjustments of microelectronic monitor
data Pharmaco epidemiol Drug Saf. 2015; 24 (12):1313-20. doi: 10.1002/pds.3887.
Epub 2015 Oct 12.
[24] Swaminathan S, Padmapriyadarshini
C, Yoojin L, Sukumar B et al., Nutritional Supplementation in HIV-Infected Individuals
in South India: A Prospective Interventional Study. Clin Infect Dis. (2010) 51 (1): 51-57.doi: 10.1086/653111
[25] Mannheimer SB, Matts J, Telzak E, et al. Quality
of life in HIV-infected individuals receiving antiretroviral therapy is related
to adherence. AIDS. 2005; 1710–22.
[26] Kuntawee C, Fungladda WT ,Kaewkungwal J, Chotpittayasunon
T. Social factors related to quality of life among HIV infected children in UbonRatchathani
province, Thailand. The Southeast Asian journal
of tropical medicine and public health.2010; 41(5):1136-44.
[27] Nyogea D, Mteng S, Henning L, Franzeck FC
et al., Determinants of antiretroviral adherence among HIV positive children and
teenagers in rural Tanzania: a mixed methods study. BMC Infectious Diseases
(2015) 15: 28.doi 10.1186/s12879-015-0753-y.
[28]
Lowenthal ED , Marukutira T,Tshume
O, BA, ChapmanJ, Parental Absence From Clinic Predicts Human Immunodeficiency
Virus Treatment Failure in Adolescents JAMA Pediatr. 2015 May 1;
169(5): 498–500.doi: 10.1001/jamapediatrics.2014.3785.
[29] Ogalha C, Luz E, Sampaio
E, Souza R et al., A randomized, clinical
trial to evaluate the impact of regular physical activity on the quality of life,
body morphology and metabolic parameters of patients with AIDS in Salvador, Brazil
J Acquir Immune DeficSyndr. 2011; 57(3).
S179-85. doi: 10.1097/QAI.0b013e31821e9bca.