Prevalence of Substance Use Disorders During the Covid-19 Pandemic: A Cross-Sectional Study in Kanyama Township of Lusaka District, Zambia
Abstract:
The
coronavirus disease (Covid-19) pandemic has caused suffering and pain to mankind
leading to many individuals practising self-medication and substance abuse that
could elevate substance use disorders (SUDs). This study assessed the impact of
Covid-19 on SUDs among Kanyama residents of Lusaka district, Zambia. We conducted
a retrospective cross-sectional study using patient files at Kanyama First-Level
Hospital from September 2021 to October 2021. Data analysis was done using IBM SPSS
version 26.0. Of the 101 participants, 86.1% were male. The study showed that Covid-19
had an impact on SUDs with alcohol (83.2%) being the most abused substance. There
was no significant difference in the type of substances abused (p=0.870) and intoxication
symptoms (p=0.331) between the pre-Covid and post-Covid groups. There was a significant
difference between substance use (p=0.001) and withdrawal symptoms (p=0.002) in
both cohorts, with the post-Covid group consuming more substances and experiencing
more withdrawal symptoms. Factors that influenced substance abuse included recent
unemployment (p<0.001), boredom (p<0.001), overcrowding at home (p<0.001),
and gender-based violence (p<0.001) influenced the change in the pattern of substance
use. Recreational use was not associated with a change in the pattern of substance
abuse (p=0. 667). This study found that the Covid-19 pandemic increased the practices
of substance abuse among Kanyama residents, especially those who were unemployed,
bored, overcrowded at home and experienced gender-based violence. There is a need
to heighten the monitoring and restriction of substance use, especially among adolescents
and youths to curb some mental health problems.
References:
[1] Fournier, A.; Laurent, A.; Lheureux,
F.; Ribeiro-Marthoud, M.A.; Ecarnot, F.; Binquet, C.; Quenot, J.P. Impact of
the Covid-19 Pandemic on the Mental Health of Professionals in 77 Hospitals in
France. PLoS One 2022, 17, e0263666, doi: 10.1371/journal.pone.0263666.
[2] Joaquim, R.M.; Pinto, A.L.C.B.;
Guatimosim, R.F.; de Paula, J.J.; Souza Costa, D.; Diaz, A.P.; da Silva, A.G.;
Pinheiro, M.I.C.; Serpa, A.L.O.; Miranda, D.M.; et al. Bereavement and
Psychological Distress during Covid-19 Pandemics: The Impact of Death Experience
on Mental Health. Curr. Res. Behav. Sci. 2021, 2, 100019, doi: 10.1016/j.crbeha.2021.100019.
[3] Dawood, B.; Tomita, A.; Ramlall, S.
‘Unheard,’ ‘Uncared for’ and ‘Unsupported’: The Mental Health Impact of Covid
-19 on Healthcare Workers in KwaZulu-Natal Province, South Africa. PLoS One
2022, 17, e0266008, doi: 10.1371/JOURNAL.PONE.0266008.
[4] Mudenda, S.; Chabalenge, B.;
Matafwali, S.; Daka, V.; Chileshe, M.; Mufwambi, W.; Mfune, R.L.; Chali, J.;
Chomba, M.; Banda, M.; et al. Psychological Impact of Covid-19 on Healthcare
Workers in Africa, Associated Factors and Coping Mechanisms: A Systematic
Review. Adv. Infect. Dis. 2022, 12, 518–532, doi:10.4236/AID.2022.123038.
[5] Pitlik, S.D. Covid-19 Compared to
Other Pandemic Diseases. Rambam Maimonides Med. J. 2020, 11, e0027.
[6] Mudenda, S.; Mukosha, M.; Godman,
B.; Fadare, J.O.; Ogunleye, O.O.; Meyer, J.C.; Skosana, P.; Chama, J.; Daka,
V.; Matafwali, S.K.; et al. Knowledge, Attitudes, and Acceptance of Covid-19
Vaccines among Secondary School Pupils in Zambia: Implications for Future
Educational and Sensitisation Programmes. Vaccines 2022, 10, 2141,
doi:10.3390/VACCINES10122141.
[7] Etando, A.; Amu, A.A.; Haque, M.;
Schellack, N.; Kurdi, A.; Alrasheedy, A.A.; Timoney, A.; Mwita, J.C.;
Rwegerera, G.M.; Patrick, O.; et al. Challenges and Innovations Brought about
by the Covid-19 Pandemic Regarding Medical and Pharmacy Education Especially in
Africa and Implications for the Future. Healthcare 2021, 9, 1722,
doi:10.3390/healthcare9121722.
[8] Kasanga, M.; Mudenda, S.; Gondwe,
T.; Chileshe, M.; Solochi, B.; Wu, J. Impact of Covid-19 on Blood Donation and
Transfusion Services at Lusaka Provincial Blood Transfusion Centre, Zambia. Pan
Afr. Med. J. 2020, 35, 74, doi: 10.11604/pamj.supp.2020.35.2.23975.
[9] Chileshe, M.; Mulenga, D.; Mfune, R.L.;
Nyirenda, T.H.; Mwanza, J.; Mukanga, B.; Mudenda, S.; Daka, V. Increased Number
of Brought-in-Dead Cases with Covid-19: Is It Due to Poor Health-Seeking
Behaviour among the Zambian Population? Pan Afr. Med. J. 2020, 37, 136,
doi:10.11604/pamj.2020.37.136.25967.
[10] Opanga, S.A.; Rizvi, N.; Wamaitha,
A.; Abebrese Sefah, I.; Godman, B. Availability of Medicines in Community
Pharmacy to Manage Patients with Covid-19 in Kenya; Pilot Study and
Implications. Sch. Acad. J. Pharm. 2021, 10, 36–42, doi:10.36347/sajp. 2021.v10i03.001.
[11] Lee, A.M.; Wong, J.G.W.S.; McAlonan,
G.M.; Cheung, V.; Cheung, C.; Sham, P.C.; Chu, N.M.; Wong, P.C.; Tsang, K.W.T.;
Chua, S.E. Stress and Psychological Distress among SARS Survivors 1 Year after
the Outbreak. Can. J. Psychiatry 2007, 52, 233–240,
doi:10.1177/070674370705200405.
[12] Khalid, I.; Khalid, T.J.; Qabajah,
M.R.; Barnard, A.G.; Qushmaq, I.A. Healthcare Workers Emotions, Perceived
Stressors and Coping Strategies during a MERS-CoV Outbreak. Clin. Med. Res.
2016, 14, 7–14, doi:10.3121/cmr.2016.1303.
[13] Liu, X.; Kakade, M.; Fuller, C.J.;
Fan, B.; Fang, Y.; Kong, J.; Guan, Z.; Wu, P. Depression after Exposure to
Stressful Events: Lessons Learned from the Severe Acute Respiratory Syndrome
Epidemic. Compr. Psychiatry 2012, 53, 15–23, doi: 10.1016/j.comppsych.2011.02.003.
[14] Wu, P.; Liu, X.; Fang, Y.; Fan, B.;
Fuller, C.J.; Guan, Z.; Yao, Z.; Kong, J.; Lu, J.; Litvak, I.J. Alcohol
Abuse/Dependence Symptoms among Hospital Employees Exposed to a SARS Outbreak.
Alcohol Alcohol. 2008, 43, 706–712, doi:10.1093/alcalc/agn073.
[15] Maunder, R.; Hunter, J.; Vincent,
L.; Bennett, J.; Peladeau, N.; Leszcz, M.; Sadavoy, J.; Verhaeghe, L.M.;
Steinberg, R.; Mazzulli, T. The Immediate Psychological and Occupational Impact
of the 2003 SARS Outbreak in a Teaching Hospital. C. Can. Med. Assoc. J. 2003,
168, 1245–1251.
[16] Maunder, R.G. Was SARS a Mental
Health Catastrophe? Gen. Hosp. Psychiatry 2009, 31, 316–317.
[17] Chua, S.E.; Cheung, V.; McAlonan,
G.M.; Cheung, C.; Wong, J.W.S.; Cheung, E.P.; Chan, M.T.; Wong, T.K.; Choy, K.M.;
Chu, C.M.; et al. Stress and Psychological Impact on SARS Patients during the
Outbreak. Can. J. Psychiatry 2004, 49, 385–390, doi:10.1177/070674370404900607.
[18] Jeong, H.; Yim, H.W.; Song, Y.J.;
Ki, M.; Min, J.A.; Cho, J.; Chae, J.H. Mental Health Status of People Isolated
Due to Middle East Respiratory Syndrome. Epidemiol. Health 2016, 38, e2016048,
doi:10.4178/epih. e2016048.
[19] Delanerolle, G.; Zeng, Y.; Shi,
J.-Q.; Yeng, X.; Goodison, W.; Shetty, A.; Shetty, S.; Haque, N.; Elliot, K.;
Ranaweera, S.; et al. Mental Health Impact of the Middle East Respiratory
Syndrome, SARS, and Covid-19: A Comparative Systematic Review and
Meta-Analysis. World J. Psychiatry 2022, 12, 739–765, doi:10.5498/wjp. v12.i5.739.
[20] Abramson, A. Substance Use During the
Pandemic. Am. Psychol. Assoc. 2021, 52, 22.
[21] Melamed, O.C.; Hauck, T.S.; Buckley,
L.; Selby, P.; Mulsant, B.H. Covid-19 and Persons with Substance Use Disorders:
Inequities and Mitigation Strategies. Subst. Abus. 2020, 41, 286–291,
doi:10.1080/08897077.2020.1784363.
[22] Thiyagarajan, A.; James, T.G.;
Marzo, R.R. Psychometric Properties of the 21-Item Depression, Anxiety, and
Stress Scale (DASS-21) among Malaysians during Covid-19: A Methodological
Study. Humanit. Soc. Sci. Commun. 2022, 9, 220, doi:10.1057/s41599-022-01229-x.
[23] Marzo, R.R.; Aye, S.S.; Naing, T.W.;
Kyaw, T.M.; Win, M.T.; Soe, H.H.K.; Soe, M.; Kyaw, Y.W.; Soe, M.M.; Lin, N.
Factors Associated with Psychological Distress among Myanmar Residents during
Covid-19 Pandemic Crises. J. Public Health Res. 2021, 10, jphr.2021.2279,
doi:10.4081/jphr.2021.2279.
[24] Marzo, R.R.; Ismail, Z.; Nu Htay,
M.N.; Bahari, R.; Ismail, R.; Villanueva, E.Q.; Singh, A.; Lotfizadeh, M.;
Respati, T.; Irasanti, S.N.; et al. Psychological Distress during Pandemic
Covid-19 among Adult General Population: Result across 13 Countries. Clin.
Epidemiol. Glob. Heal. 2021, 10, 100708, doi: 10.1016/j.cegh.2021.100708.
[25] Marzo, R.R.; Villanueva, E.Q.;
Faller, E.M.; Baldonado, A.M. Factors Associated with Psychological Distress
among Filipinos during Coronavirus Disease-19 Pandemic Crisis. Open Access
Maced. J. Med. Sci. 2020, 8, 309–313, doi:10.3889/oamjms.2020.5146.
[26] RilleraMarzo, R.; Villanueva, E.Q.;
Chandra, U.; Htay, M.N.N.; Shrestha, R.; Shrestha, S. Risk Perception, Mental
Health Impacts and Coping Strategies during Covid-19 Pandemic among Filipino
Healthcare Workers. J. Public Health Res. 2021, 10, jphr.2021.2604,
doi:10.4081/jphr.2021.2604.
[27] El-Abasiri, R.A.; Marzo, R.R.;
Abdelaziz, H.; Boraii, S.; Abdelaziz, D.H. Evaluating the Psychological
Distress of the Coronavirus Disease 2019 Pandemic in Egypt. Eur. J. Mol. Clin.
Med. 2020, 7, 1–12.
[28] Htay, M.N.N.; Marzo, R.R.; AlRifai,
A.; Kamberi, F.; Radwa Abdullah, E.A.; Nyamache, J.M.; Hlaing, H.A.; Hassanein,
M.; Moe, S.; Su, T.T.; et al. Immediate Impact of Covid-19 on Mental Health and
Its Associated Factors among Healthcare Workers: A Global Perspective across 31
Countries. J. Glob. Health 2020, 10, 020381, doi:10.7189/jogh.10.020381.
[29] Htay, M.N.N.; Marzo, R.R.; Bahari,
R.; AlRifai, A.; Kamberi, F.; El-Abasiri, R.A.; Nyamache, J.M.; Hlaing, H.A.;
Hassanein, M.; Moe, S.; et al. How Healthcare Workers Are Coping with Mental
Health Challenges during Covid-19 Pandemic? - A Cross-Sectional Multi-Countries
Study. Clin. Epidemiol. Glob. Heal. 2021, 11, 100759, doi: 10.1016/j.cegh.2021.100759.
[30] Marzo, R.R.; Singh, A.; Mukti, R.F.
A Survey of Psychological Distress among Bangladeshi People during the Covid-19
Pandemic. Clin. Epidemiol. Glob. Heal. 2021, 10, 100693, doi: 10.1016/j.cegh.2020.100693.
[31] Ali, F.; Russell, C.; Nafeh, F.;
Rehm, J.; LeBlanc, S.; Elton-Marshall, T. Changes in Substance Supply and Use
Characteristics among People Who Use Drugs (PWUD) during the Covid-19 Global
Pandemic: A National Qualitative Assessment in Canada. Int. J. Drug Policy
2021, 93, 103237, doi: 10.1016/j.drugpo.2021.103237.
[32] Layman, H.M.; Thorisdottir, I.E.;
Halldorsdottir, T.; Sigfusdottir, I.D.; Allegrante, J.P.; Kristjansson, A.L.
Substance Use Among Youth During the Covid-19 Pandemic: A Systematic Review.
Curr. Psychiatry Rep. 2022, 24, 307–324.
[33] Ornell, F.; Moura, H.F.; Scherer,
J.N.; Pechansky, F.; Kessler, F.H.P.; von Diemen, L. The Covid-19 Pandemic and
Its Impact on Substance Use: Implications for Prevention and Treatment.
Psychiatry Res. 2020, 289, 113096.
[34] Ignaszewski, M.J. The Epidemiology
of Drug Abuse. J. Clin. Pharmacol. 2021, 61, S10–S17, doi:10.1002/jcph.1937.
[35] Arble, E.; Manning, D.; Arnetz,
B.B.; Arnetz, J.E. Increased Substance Use among Nurses during the Covid-19
Pandemic. Int. J. Environ. Res. Public Health 2023, 20, 2674,
doi:10.3390/ijerph20032674.
[36] Ritchie, H.; Arriagada, P.; Roser,
M. Opioids, Cocaine, Cannabis and Illicit Drugs Available online:
https://ourworldindata.org/illicit-drug-use (accessed on 28 June 2023).
[37] Brooks, S.K.; Webster, R.K.; Smith,
L.E.; Woodland, L.; Wessely, S.; Greenberg, N.; Rubin, G.J. The Psychological
Impact of Quarantine and How to Reduce It: Rapid Review of the Evidence. Lancet
2020, 395, 912–920.
[38] Venkatesh, A.; Edirappuli, S. Social
Distancing in Covid-19: What Are the Mental Health Implications? BMJ 2020, 369,
m1379.
[39] Conway, F.N.; Samora, J.; Brinkley,
K.; Jeong, H.; Clinton, N.; Claborn, K.R. Impact of Covid-19 among People Who
Use Drugs: A Qualitative Study with Harm Reduction Workers and People Who Use
Drugs. Harm Reduct. J. 2022, 19, 72, doi:10.1186/s12954-022-00653-1.
[40] Dubey, S.; Biswas, P.; Ghosh, R.;
Chatterjee, S.; Dubey, M.J.; Chatterjee, S.; Lahiri, D.; Lavie, C.J.
Psychosocial Impact of Covid-19. Diabetes Metab. Syndr. Clin. Res. Rev. 2020,
14, 779–788, doi: 10.1016/j.dsx.2020.05.035.
[41] Alonso, S.; Català, M.; López, D.;
Álvarez-Lacalle, E.; Jordan, I.; García-García, J.J.; Fumadó, V.;
Muñoz-Almagro, C.; Gratacós, E.; Balanza, N.; et al. Individual Prevention and
Containment Measures in Schools in Catalonia, Spain, and Community Transmission
of SARS-CoV-2 after School Re-Opening. PLoS One 2022, 17, e0263741, doi:
10.1371/journal.pone.0263741.
[42] Giallonardo, V.; Sampogna, G.; Del
Vecchio, V.; Luciano, M.; Albert, U.; Carmassi, C.; Carrà, G.; Cirulli, F.;
Dell’Osso, B.; Nanni, M.G.; et al. The Impact of Quarantine and Physical
Distancing Following Covid-19 on Mental Health: Study Protocol of a
Multicentric Italian Population Trial. Front. Psychiatry 2020, 11, 533,
doi:10.3389/fpsyt.2020.00533.
[43] Piret, J.; Boivin, G. Pandemics
Throughout History. Front. Microbiol. 2021, 11, 631736.
[44] Harker, N.; Johnson, K.; Erasmus,
J.; Myers, B. Covid-19—Impact on Substance Use Treatment Utilization and
Provision in South Africa. Subst. Abus. Treat. Prev. Policy 2022, 17, 15,
doi:10.1186/s13011-022-00446-6.
[45] Panchal, N.; Kamal, R.; Cox, C.;
Garfield, R. The Implications of Covid-19 for Mental Health and Substance Use |
KFF Https://Www.Kff.Org/Coronavirus-Covid-19/Issue-Brief/the-Implications-of-Covid-19-for-Mental-Health-and-Substance-Use/
The Implications of Covid-19 for Mental Health and Substance Use. Kaiser Fam.
Found. 2021, 1–16, doi:10.1377/hpb20201228.198475/full.
[46] Simulundu, E.; Mupeta, F.;
Chanda-Kapata, P.; Saasa, N.; Changula, K.; Muleya, W.; Chitanga, S.; Mwanza,
M.; Simusika, P.; Chambaro, H.; et al. First Covid-19 Case in Zambia —
Comparative Phylogenomic Analyses of SARS-CoV-2 Detected in African Countries.
Int. J. Infect. Dis. 2021, 102, 455–459, doi: 10.1016/j.ijid.2020.09.1480.
[47] Mudenda, S.; Botha, M.; Mukosha, M.;
Daka, V.; Chileshe, M.; Mwila, K.; Banda, M.; Mfune, R.L.; Mufwambi, W.;
Kampamba, M.; et al. Knowledge and Attitudes towards Covid-19 Prevention
Measures among Residents of Lusaka District in Zambia. Aquademia 2022, 6,
ep22005, doi:10.21601/AQUADEMIA/12210.
[48] Mudenda, S.; Witika, B.A.; Sadiq,
M.J.; Banda, M.; Mfune, R.L.; Daka, V.; Kalui, D.; Phiri, M.N.; Kasanga, M.;
Mudenda, F.; et al. Self-Medication and Its Consequences during & after the
Coronavirus Disease 2019 (Covid-19) Pandemic: A Global Health Problem. Eur. J.
Environ. Public Heal. 2020, 5, em0066, doi:10.29333/ejeph/9308.
[49] Amukoto, S. Experiences on Alcohol
Abuse among Adolescents of Kanyama Compound, Lusaka District. Dissertation
2022.
[50] Mudenda, S.; Mukosha, M.; Mwila, C.;
Saleem, Z.; Kalungia, A.C.; Munkombwe, D.; Daka, V.; Witika, B.A.; Kampamba,
M.; Hikaambo, C.N.; et al. Impact of the Coronavirus Disease on the Mental
Health and Physical Activity of Pharmacy Students at the University of Zambia:
A Cross-Sectional Study. Int. J. Basic Clin. Pharmacol. 2021, 10, 324,
doi:10.18203/2319-2003.ijbcp20211010.
[51] Mudenda, S.; Mainza, P.; Mfune,
R.L.; Mufwambi, W.; Hangoma, J.; Kampamba, R.M.; Muungo, T.L.; Hikaambo, C.N.;
Kampamba, M.; Mohamed, S.; et al. Psychological Impact of Covid-19 on Community
Pharmacists: A Cross-Sectional Study in Lusaka District, Zambia. Fortune J.
Heal. Sci. 2022, 5, 579–587.
[52] Mudenda, S.; Chomba, M.; Mukosha,
M.; Daka, V.; Chileshe, M.; Okoro, R.N.; Fadare, J.; Al-Fayyadh, S.; Munsaka,
S.; Kampamba, M.; et al. Psychological Impact of Coronavirus Disease (Covid-19)
on Health Professions Students at the University of Zambia: A Cross-Sectional
Study. Pan Afr. Med. J. 2022, 42, 237, doi:10.11604/PAMJ.2022.42.237.34041.
[53] Mudenda, S. Coronavirus Disease 2019
(Covid-19) and Its Psychological Impact on Students in Zambia. Acad. Lett.
2021, 837, doi:10.20935/AL837.
[54] Lorenz, H.S.; Stuebing, M.D.;
Nambeye, C.; Lungu, G.; Littlefield, L.M. Substance Use Treatment Using
Cultural Arts and 12 Steps: Curriculum Training and Community-Led
Implementation in Zambia. Addict. Behav. Reports 2022, 15, 100424, doi:
10.1016/j.abrep.2022.100424.
[55] Tyler, K.A.; Handema, R.; Schmitz,
R.M.; Phiri, F.; Kuyper, K.S.; Wood, C. Multi-Level Risk and Protective Factors
for Substance Use Among Zambian Street Youth. Subst. Use Misuse 2016, 51,
922–931, doi:10.3109/10826084.2016.1156702.
[56] Hammerstein, N.; Paul, R.; Ncheka,
J. Increasing Problem of Alcohol Abuse among the Zambian Population in the
Psychiatric Setting. Heal. Press Zambia Bull 2017, 1, 29–34.
[57] Masiye, I.; Ndhlovu, D. Drug and
Alcohol Abuse Prevention Education in Selected Secondary Schools in Zambia:
Policy Guidelines Used. Int. J. Humanit. Soc. Sci. Educ. 2016, 3, 42–48,
doi:10.20431/2349-0381.0311006.
[58] Charan, J.; Biswas, T. How to
Calculate Sample Size for Different Study Designs in Medical Research? Indian
J. Psychol. Med. 2013, 35, 121–126, doi:10.4103/0253-7176.116232.
[59] Chacon, N.C.; Walia, N.; Allen, A.;
Sciancalepore, A.; Tiong, J.; Quick, R.; Mada, S.; Diaz, M.A.; Rodriguez, I.
Substance Use during Covid-19 Pandemic: Impact on the Underserved Communities.
Discoveries 2021, 9, e141, doi:10.15190/d.2021.20.
[60] Zaami, S.; Marinelli, E.; Varì, M.R.
New Trends of Substance Abuse During Covid-19 Pandemic: An International
Perspective. Front. Psychiatry 2020, 11, 700, doi:10.3389/fpsyt.2020.00700.
[61] Wang, Q.Q.; Kaelber, D.C.; Xu, R.;
Volkow, N.D. Covid-19 Risk and Outcomes in Patients with Substance Use
Disorders: Analyses from Electronic Health Records in the United States. Mol.
Psychiatry 2021, 26, 30–39, doi:10.1038/s41380-020-00880-7.
[62] Spagnolo, P.A.; Montemitro, C.;
Leggio, L. New Challenges in Addiction Medicine: Covid-19 Infection in Patients
with Alcohol and Substance Use Disorders—the Perfect Storm. Am. J. Psychiatry
2020, 177, 805–807.
[63] Dodge, K.A.; Skinner, A.T.; Godwin,
J.; Bai, Y.; Lansford, J.E.; Copeland, W.E.; Benjamin Goodman, W.; McMahon,
R.J.; Goulter, N.; Bornstein, M.H.; et al. Impact of the Covid-19 Pandemic on
Substance Use among Adults without Children, Parents, and Adolescents. Addict.
Behav. Reports 2021, 14, 100388, doi: 10.1016/j.abrep.2021.100388.
[64] Avena, N.M.; Simkus, J.;
Lewandowski, A.; Gold, M.S.; Potenza, M.N. Substance Use Disorders and
Behavioral Addictions During the Covid-19 Pandemic and Covid-19-Related
Restrictions. Front. Psychiatry 2021, 12, 653674.
[65] European Monitoring Centre for Drugs
and Drug Addiction; Europol EU Drug Markets: Impact of Covid-19; 2020.
[66] Ismail, R.; Manaf, M.R.A.; Hassan,
M.R.; Nawi, A.M.; Ibrahim, N.; Lyndon, N.; Amit, N.; Zakaria, E.; Razak,
M.A.A.; Nor, N.I.Z.; et al. Prevalence of Drug and Substance Use among
Malaysian Youth: A Nationwide Survey. Int. J. Environ. Res. Public Health 2022,
19, 4684, doi:10.3390/ijerph19084684.
[67] Jadnanansing, R.; Blankers, M.;
Dwarkasing, R.; Etwaroo, K.; Lumsden, V.; Dekker, J.; Bipat, R. Prevalence of
Substance Use Disorders in an Urban and a Rural Area in Suriname. Trop. Med.
Health 2021, 49, 12, doi:10.1186/s41182-021-00301-7.
[68] Zewdu, S.; Hanlon, C.; Fekadu, A.;
Medhin, G.; Teferra, S. Treatment Gap, Help-Seeking, Stigma and Magnitude of
Alcohol Use Disorder in Rural Ethiopia. Subst. Abus. Treat. Prev. Policy 2019,
14, 4, doi:10.1186/s13011-019-0192-7.
[69] Kaggwa, M.M.; Abaatyo, J.; Alol, E.;
Muwanguzi, M.; Najjuka, S.M.; Favina, A.; Rukundo, G.Z.; Ashaba, S.; Mamun,
M.A. Substance Use Disorder among Adolescents before and during the Covid-19
Pandemic in Uganda: Retrospective Findings from a Psychiatric Ward Registry.
PLoS One 2022, 17, e0269044, doi: 10.1371/journal.pone.0269044.
[70] Compton, W.M.; Flannagan, K.S.J.;
Silveira, M.L.; Creamer, M.L.R.; Kimmel, H.L.; Kanel, M.; Blanco, C.; Volkow,
N.D. Tobacco, Alcohol, Cannabis, and Other Drug Use in the US Before and During
the Early Phase of the Covid-19 Pandemic. JAMA Netw. open 2023, 6, e2254566,
doi:10.1001/jamanetworkopen.2022.54566.
[71] Sylvestre, M.P.; Dinkou, G.D.T.;
Naja, M.; Riglea, T.; Pelekanakis, A.; Bélanger, M.; Maximova, K.; Mowat, D.;
Paradis, G.; O’Loughlin, J. A Longitudinal Study of Change in Substance Use
from before to during the Covid-19 Pandemic in Young Adults. Lancet Reg. Heal.
2022, 8, 100168, doi: 10.1016/j.lana.2021.100168.
[72] Karn, M.; Kandel, D.; Subedi, N.
Prevalence of Substance Abuse and Its Associated Factors among Medical
Students: A Cross-Sectional Study. F1000Research 2022, 10, 797,
doi:10.12688/f1000research.54585.2.
[73] Blows, S.; Isaacs, S. Prevalence and
Factors Associated with Substance Use among University Students in South
Africa: Implications for Prevention. BMC Psychol. 2022, 10, 309,
doi:10.1186/s40359-022-00987-2.
[74] Mavura, R.A.; Nyaki, A.Y.; Leyaro,
B.J.; Mamseri, R.; George, J.; Ngocho, J.S.; Mboya, I.B. Prevalence of
Substance Use and Associated Factors among Secondary School Adolescents in
Kilimanjaro Region, Northern Tanzania. PLoS One 2022, 17, e0274102, doi:
10.1371/journal.pone.0274102.
[75] Olanrewaju, J.A.; Hamzat, E.O.;
Enya, J.I.; Udekwu, M.O.; Osuoya, Q.; Bamidele, R.; Feyisike Johnson, O.;
Johnson, B.S.; Olanrewaju, I.; Owolabi, J.O. An Assessment of Drug and
Substance Abuse Prevalence: A Cross-Sectional Study among Undergraduates in
Selected Southwestern Universities in Nigeria. J. Int. Med. Res. 2022, 50,
03000605221130039, doi:10.1177/03000605221130039.
[76] Siziya, S.; Muula, A.S.; Besa, C.;
Babaniyi, O.; Songolo, P.; Kankiza, N.; Rudatsikira, E. Cannabis Use and Its
Socio-Demographic Correlates among in-School Adolescents in Zambia. Ital. J.
Pediatr. 2013, 39, 13, doi:10.1186/1824-7288-39-13.
[77] Jones, C.M.; Clayton, H.B.; Deputy,
N.P.; Roehler, D.R.; Ko, J.Y.; Esser, M.B.; Brookmeyer, K.A.; Hertz, M.F.
Prescription Opioid Misuse and Use of Alcohol and Other Substances Among High
School Students - Youth Risk Behavior Survey, United States, 2019. MMWR Suppl.
2020, 69, 38–46, doi:10.15585/mmwr.su6901a5.
[78] Byregowda, H.; Alinsky, R.; Wang, X.;
Johnson, R.M. Non-Medical Prescription Opioid Use among High School Students in
38 U.S. States. Addict. Behav. Reports 2023, 17, 100498, doi: 10.1016/j.abrep.2023.100498.
[79] Creamer, M.L.R.; Everett Jones, S.;
Gentzke, A.S.; Jamal, A.; King, B.A. Tobacco Product Use Among High School
Students - Youth Risk Behavior Survey, United States, 2019. MMWR Suppl. 2020,
69, 56–63, doi:10.15585/mmwr.su6901a7.
[80] Sung, C.W.; Chen, C.H.; Fan, C.Y.;
Chang, J.H.; Hung, C.C.; Fu, C.M.; Wong, L.P.; Huang, E.P.C.; Lee, T.S.H. Mental
Health Crisis in Healthcare Providers in the Covid-19 Pandemic: A
Cross-Sectional Facility-Based Survey. BMJ Open 2021, 11, e052184,
doi:10.1136/bmjopen-2021-052184.
[81] Nguemeni Tiako, M.J. Addressing
Racial & Socioeconomic Disparities in Access to Medications for Opioid Use
Disorder amid Covid-19. J. Subst. Abuse Treat. 2021, 122, 108214, doi:
10.1016/j.jsat.2020.108214.
[82] Yazdi-Feyzabadi, V.; Mehrolhassani,
M.H.; Zolala, F.; Haghdoost, A.A.; Oroomiei, N. Determinants of Risky Sexual
Practice, Drug Abuse and Alcohol Consumption in Adolescents in Iran: A
Systematic Literature Review. Reprod. Health 2019, 16, 115,
doi:10.1186/s12978-019-0779-5.
[83] Singh, S.; Balhara, Y.P.S.; Gupta,
P.; Christodoulou, N.G. Primary and Secondary Prevention Strategies against Illicit
Drug Use among Adults Aged 18–25: A Narrative Review. Australas. Psychiatry
2020, 28, 84–90.
[84] Medina-Mora, M.E. Prevention of
Substance Abuse: A Brief Overview. World Psychiatry 2005, 4, 25–30.
[85] Griffin, K.W.; Botvin, G.J.
Evidence-Based Interventions for Preventing Substance Use Disorders in
Adolescents. Child Adolesc. Psychiatr. Clin. N. Am. 2010, 19, 505–526.
[86] Kvillemo, P.; Hiltunen, L.; Demetry,
Y.; Carlander, A.K.; Hansson, T.; Gripenberg, J.; Elgán, T.H.; Einhorn, K.;
Skoglund, C. How to Prevent Alcohol and Illicit Drug Use among Students in
Affluent Areas: A Qualitative Study on Motivation and Attitudes towards
Prevention. Subst. Abus. Treat. Prev. Policy 2021, 16, 83,
doi:10.1186/s13011-021-00420-8.
[87] Hsiung, H.; Patel, K.; Hundal, H.;
Baccouche, B.M.; Tsao, K.-W. Preventing Substance Abuse in Adolescents: A
Review of High-Impact Strategies. Cureus 2022, 14, e27361,
doi:10.7759/cureus.27361.
[88] Griswold, M.G.; Fullman, N.; Hawley,
C.; Arian, N.; Zimsen, S.R.M.; Tymeson, H.D.; Venkateswaran, V.; Tapp, A.D.;
Forouzanfar, M.H.; Salama, J.S.; et al. Alcohol Use and Burden for 195
Countries and Territories, 1990-2016: A Systematic Analysis for the Global
Burden of Disease Study 2016. Lancet (London, England) 2018, 392, 1015–1035,
doi:10.1016/S0140-6736(18)31310-2.
[89] Enrico, C.; Caldiroli, A.; Di Brita,
C.; Colmegna, F.; Nava, R.; Colzani, L.C.; Sibilla, M.; Prodi, T.; Buoli, M.;
Clerici, M. Profile of Patients Attending Psychiatric Emergency Care during the
Coronavirus 2019 (Covid 19) Pandemic: A Comparative Cross-Sectional Study
between Lockdown and Post-Lockdown Periods in Lombardy, Italy. Int. J.
Psychiatry Clin. Pract. 2022, 26, 132–138, doi:10.1080/13651501.2021.1939385.
[90] Syed, N.K.; Griffiths, M.D.
Nationwide Suicides Due to Alcohol Withdrawal Symptoms during Covid-19
Pandemic: A Review of Cases from Media Reports. J. Psychiatr. Res. 2020, 130,
289–291.
[91] Kristensen, P.; Weisaeth, L.; Heir,
T. Bereavement and Mental Health after Sudden and Violent Losses: A Review.
Psychiatry 2012, 75, 76–97.
[92] de Miquel, C.; Domènech-Abella, J.;
Felez-Nobrega, M.; Cristóbal-Narváez, P.; Mortier, P.; Vilagut, G.; Alonso, J.;
Olaya, B.; Haro, J.M. The Mental Health of Employees with Job Loss and Income
Loss during the Covid-19 Pandemic: The Mediating Role of Perceived Financial
Stress. Int. J. Environ. Res. Public Health 2022, 19, 3158,
doi:10.3390/ijerph19063158.
[93] Blomqvist, S.; Högnäs, R.S.;
Virtanen, M.; LaMontagne, A.D.; Magnusson Hanson, L.L. Job Loss and Job
Instability during the Covid-19 Pandemic and the Risk of Depression and Anxiety
among Swedish Employees. SSM - Popul. Heal. 2023, 22, 101424, doi:
10.1016/j.ssmph.2023.101424.
[94] Griffiths, D.; Sheehan, L.; van
Vreden, C.; Petrie, D.; Grant, G.; Whiteford, P.; Sim, M.R.; Collie, A. The
Impact of Work Loss on Mental and Physical Health During the Covid-19 Pandemic:
Baseline Findings from a Prospective Cohort Study. J. Occup. Rehabil. 2021, 31,
455–462, doi:10.1007/s10926-021-09958-7.
[95] Veeroja, P.; Goodall, Z.;
Guity-Zapata, N.A.; Stone, W. Private Renters in Shared Housing: Investigating
Housing Conditions and Mental Well-Being in Australia during Covid-19. J. Hous.
Built Environ. 2023, 1–22, doi:10.1007/s10901-023-10038-w.
[96] Dubey, S.; Sahoo, K.C.; Dash, G.C.;
Sahay, M.R.; Mahapatra, P.; Bhattacharya, D.; Barrio, M.O. del; Pati, S. Housing-Related
Challenges during Covid-19 Pandemic among Urban Poor in Low- and Middle-Income
Countries: A Systematic Review and Gap Analysis. Front. Public Heal. 2022, 10,
1029394.
[97] Newton, D.; Lucock, M.; Armitage,
R.; Monchuk, L.; Brown, P. Understanding the Mental Health Impacts of Poor
Quality Private-Rented Housing during the UK’s First Covid-19 Lockdown. Heal.
Place 2022, 78, 102898, doi: 10.1016/j.healthplace.2022.102898.
[98] Sediri, S.; Zgueb, Y.; Ouanes, S.;
Ouali, U.; Bourgou, S.; Jomli, R.; Nacef, F. Women’s Mental Health: Acute
Impact of Covid-19 Pandemic on Domestic Violence. Arch. Womens. Ment. Health
2020, 23, 749–756, doi:10.1007/s00737-020-01082-4.
[99] Raj, A.; Johns, N.E.; Barker, K.M.;
Silverman, J.G. Time from Covid-19 Shutdown, Gender-Based Violence Exposure,
and Mental Health Outcomes among a State Representative Sample of California
Residents. EClinicalMedicine 2020, 26, 100520, doi: 10.1016/j.eclinm.2020.100520.
[100] Mittal, S.; Singh, T. Gender-Based
Violence During Covid-19 Pandemic: A Mini-Review. Front. Glob. Women’s Heal.
2020, 1, 570087, doi:10.3389/FGWH.2020.00004/BIBTEX.
[101] Alibudbud, R. Gender in Mental
Health: Gender-Based Violence, Suffering, Recovery, and the Greater
Responsibility of Society during the Covid-19 Pandemic. Asian J. Psychiatr.
2022, 67, 102953.
[102] Madanes, S.B.; Levenson-Palmer, R.;
Szuhany, K.L.; Malgaroli, M.; Jennings, E.L.; Anbarasan, D.; Simon, N.M. Acute
Stress Disorder, and the Covid-19 Pandemic. Psychiatr. Ann. 2020, 50, 295–300,
doi:10.3928/00485713-20200611-01.
[103] Zhang, J.; Shuai, L.; Yu, H.; Wang,
Z.; Qiu, M.; Lu, L.; Cao, X.; Xia, W.; Wang, Y.; Chen, R. Acute Stress,
Behavioural Symptoms and Mood States among School-Age Children with Attention-Deficit/Hyperactive
Disorder during the Covid-19 Outbreak. Asian J. Psychiatr. 2020, 51, 102077, doi:
10.1016/j.ajp.2020.102077.
[104] Taylor, S.; Paluszek, M.M.; Rachor,
G.S.; McKay, D.; Asmundson, G.J.G. Substance Use and Abuse, Covid-19-Related
Distress, and Disregard
for Social Distancing: A Network Analysis. Addict. Behav. 2021, 114, 106754, doi:
10.1016/j.addbeh.2020.106754.
[105] Marzo, R.R.; Vinay, V.; Bahari, R.;
Chauhan, S.; Ming, D.A.F.; Nelson Fernandez, S.F.A.; Johnson, C.C.P.;
Thivakaran, A.Q.A.; Rahman, M.M.; Goel, S. Depression and Anxiety in Malaysian
Population during Third Wave of the Covid-19 Pandemic. Clin. Epidemiol. Glob.
Heal. 2021, 12, 100868, doi: 10.1016/j.cegh.2021.100868.
[106] Kamberi, F.; Sinaj, E.; Jaho, J.;
Subashi, B.; Sinanaj, G.; Jaupaj, K.; Stramarko, Y.; Arapi, P.; Dine, L.;
Gurguri, A.; et al. Impact of Covid-19 Pandemic on Mental Health, Risk
Perception and Coping Strategies among Health Care Workers in Albania -
Evidence That Needs Attention. Clin. Epidemiol. Glob. Heal. 2021, 12, 100824, doi:
10.1016/j.cegh.2021.100824.
[107] Marzo, R.R.; Khanal, P.; Ahmad, A.; Rathore, F.A.; Chauhan, S.; Singh, A.; Shrestha, S.; Alrifai, A.; Lotfizadeh, M.; Younus, D.A.; et al. Quality of Life of the Elderly during the Covid-19 Pandemic in Asian Countries: A Cross-Sectional Study across Six Countries. Life 2022, 12, 365, doi:10.3390/life12030365.