Prevalence of Tuberculosis among Presumptive Tuberculosis Patients Offered HIV Testing Services in Federal Capital Territory, Abuja Nigeria
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Abstract:
Tuberculosis
is a communicable disease caused by Mycobacterium tuberculosis, considered a major
risk to global health security. This study determined the prevalence, treatment
outcomes, and factors associated with tuberculosis among 737 presumptive tuberculosis
patients in Federal Capital Territory Abuja, Nigeria from 1st April 2019
to 30th May 2021 through retrospective
cross-sectional study and multi-stage sampling. From
Non-Municipal Area Councils, Bwari was selected while from Health Facilities, General
Hospital Bwari and Gwarimpa were selected from Bwari and Abuja Municipal Area Council
respectively by simple random sampling and data abstractions were done and analyzed
using Statistical Package for Social Sciences version 23.0 Software. The prevalence
of tuberculosis amongst the patients was 19.4%. The tuberculosis treatment outcome
showed that 66.4% were cured, 14.7% completed treatment, 7.0% failed treatment,
5.6% lost to follow-up and 0.7% removed from the Register. The prevalence of tuberculosis
in the Bwari Area Council was 8.2%. The association between Area Council of Resident
and tuberculosis was significant (p = 0.001). Patients that reside in Bwari Area
Council were 0.078 times less likely to have tuberculosis compared to those who
reside in Abuja Municipal Area Council and, Area Council of Residence was a predictor
of tuberculosis (aOR = 0.001; 95% C.I. = 0.043 - 0.141). The prevalence of tuberculosis
amongst patients with Human Immunodeficiency Virus was 29.6%. The association was
significant (p = 0.001) but not a predictor of tuberculosis (aOR = 0.840; 95% C.I.
= 0.617 - 1.810).
References:
[1] Tiewsoh, J. A., Antony, B., & Boloor, R. (2020).
HIV-TB co-infection with clinical presentation, diagnosis, treatment, outcome,
and its relation to CD4 count, a cross-sectional study in a tertiary care
hospital in coastal Karnataka. Journal of Family Medicine and Primary Care,
9(2), 1160. https://doi.org/10.4103/jfmpc.jfmpc_950_19.
[2] KNCV Tuberculosis Foundation. (n.d.). What is
tuberculosis? - KNCV - Tuberculosefonds. Retrieved March 30, 2021, from https://www.kncvtbc.org/en/about-tb/.
[3] World Health Organization. (2020). Global tuberculosis
report 2020: executive summary. https://apps.who.int/iris/bitstream/handle/10665/337538/9789240016095-eng.pdf.
[4] ALNAP. (2020). Global Tuberculosis Report 2020 |
ALNAP. Retrieved April 10, 2021, from https://www.alnap.org/help-library/global-tuberculosis-report-2020.
[5] World Health Organization. (2020). Global
Tuberculosis Report 2020 | HIV/AIDS Data Hub for the Asia-Pacific Region.
Retrieved April 10, 2021, from https://www.aidsdatahub.org/resource/global-tuberculosis-report-2020.
[6] Floyd, K., Glaziou, P., Zumla, A., & Raviglione,
M. (2018). The global tuberculosis epidemic and progress in care, prevention,
and research: an overview in year 3 of the End TB era. The Lancet Respiratory
Medicine, 6(4), 299–314. https://doi.org/10.1016/S2213-2600(18)30057-2.
[7] USAID. (2009). Standard Operating Procedures for
Implementation of TB Activities at HIV/AIDS Service Delivery Sites
Collaborative TB/HIV Services. Retrieved April 17, 2021, from https://challengetb.org/publications/tools/tb_hiv/SOPCollaborativeTBHIVServices.pdf.
[8] World Health Organization. (2020). Tuberculosis.
Retrieved March 30, 2021, from https://www.who.int/news-room/fact-sheets/detail/tuberculosis.
[9] Centers for Disease Control and Prevention. (2016).
Basic TB Facts | TB | CDC. Retrieved March 30, 2021, from https://www.cdc.gov/tb/topic/basics/default.htm.
[10] National Health System. (2019). Tuberculosis (TB) -
Causes - NHS. https://www.nhs.uk/conditions/tuberculosis-tb/causes/.
[11] The Global Fund. (2021). Tuberculosis - The Global
Fund to Fight AIDS, Tuberculosis and Malaria. Retrieved April 10, 2021, from https://www.theglobalfund.org/en/tuberculosis/.
[12] World Health Organization. (2018). HIV/AIDS | WHO |
Regional Office for Africa. Retrieved April 11, 2021, from https://www.afro.who.int/health-topics/hivaids.
[13] Measure evaluation. (n.d.). Frameworks Module
250706.ppt — Measure Evaluation. Retrieved March 31, 2021, from https://www.measureevaluation.org/resources/training/capacity-building-resources/phn/course-modules/week-1/Frameworks
Module 250706.ppt/view.
[14] Federal Ministry of Health Nigeria. (2010). National
Tuberculosis and Leprosy Control Programme: Workers’ manual – Revise 5th
Edition 1. Retrieved April 2, 2021, from https://www.who.int/hiv/pub/guidelines/nigeria_tb.pdf.
[15] Adebisi, Y. A., Agumage, I., Sylvanus, T. D.,
Nawaila, I. J., Ekwere, W. A., Nasiru, M., Okon, E. E., Ekpenyong, A. M., &
Lucero-Prisno III, D. E. (2019). Burden of Tuberculosis and Challenges Facing
Its Eradication in West Africa. International Journal of Infection, 6(3). https://doi.org/10.5812/iji.92250.
[16] Ologunde, C. A., Anidiobu, C. O., Oluwasusi, V. O.,
& Ilesanmi, T. M. (2021). Prevalence of Tuberculosis and Human
Immunodeficiency Virus (HIV) in Ikere-Ekiti, Ekiti State Southwestern Nigeria.
South Asian Journal of Research in Microbiology, 9(1), 1–5. https://doi.org/10.9734/sajrm/2021/v9i130198.
[17] Hassan, A., Olukolade, R., Ogbuji, Q., Onyemocho,
A., Okwuonye, L., Igbabul, S., Okechukwu, J., Kusimo, O., Osho, A., Osinowo,
K., & Ladipo, O. (2016). Evaluation of Tuberculosis Treatment Outcome of
TB/HIV Co-Infection: A Four-Year Retrospective Cohort Study in HIV-Prevalent
Setting of North Central Nigeria. Journal of Tuberculosis Research, 04(03),
122–133. https://doi.org/10.4236/jtr.2016.43015.
[18] Dye, C., Harries, A. D., Maher, D., Hosseini, S. M.,
Nkhoma, W., & Salaniponi, F. M. (2006). Tuberculosis. In Disease and
Mortality in Sub-Saharan Africa. The International Bank for Reconstruction and
Development / The World Bank. http://www.ncbi.nlm.nih.gov/pubmed/21290646.
[19] Centers for Disease Control and Prevention. (2020).
Global Health - Newsroom - Tuberculosis. Retrieved April 10, 2021, from https://www.cdc.gov/globalhealth/newsroom/topics/tb/index.html.
[20] Nwokoro, U. U., Dahiru, T., Olorukooba, A., Daam, C.
K., Waziri, H. S., Adebowale, A., Waziri, N. E., & Nguku, P. (2020).
Determinants of perinatal mortality in public secondary health facilities,
Abuja municipal area council, Federal Capital Territory, Abuja, Nigeria. Pan African
Medical Journal, 37(114), 1–12. https://doi.org/10.11604/pamj.2020.37.114.17108.
[21] Hamisu, A. W., Etapelong, S. G., Ayodeji, I. H.,
Furera, Z., Ningi, N., Jimoh, A., Fiona, B., Banda, R., Tegegne, S. G., Ajogwu,
A., Nwachukwu, J., John, D., Abdurrahman, S., Ahmed, F., Adesola, L., Teresa,
N., Adesola, O., Rahmat, A., Elizabeth, A., & Lydia, T. (2020). Assessment
of the contribution of community active surveillance to covid-19 case detection
in the Federal Capital Territory, Abuja, Nigeria. African Journal of Biology
and Medical Research, 3(2), 98–110. www.abjournals.org.
[22] Ifeadike, C., Ironkwe, O., Nnebue, C., Nwabueze, S.,
Ubajaka, C., Adogu, P. O. U., & Emelumadu, O. (2012). Prevalence and
pattern of bacteria and intestinal parasites among food handlers in the Federal
Capital Territory of Nigeria. Nigerian Medical Journal, 53(3), 166. https://doi.org/10.4103/0300-1652.104389.
[23] Kamweli, M., Id, A., Kwaga, J., Okolocha, E., &
Mba, N. (2019). Prevalence and risk factors for multi-drug resistant Escherichia
coli among poultry workers in the Federal Capital Territory, Abuja , Nigeria
Prevalence and risk factors for multi-drug resistant Escherichia coli among
poultry workers in the Federal Capit. November. https://doi.org/10.1371/journal.pone.0225379.
[24] National Tuberculosis and Leprosy Control Programme.
(2019). 2019 Annual TB Report. https://www.health.gov.ng/doc/Draft-2019-NTBLCP-Annual-report-22032020.pdf.
[25] Dememew, Z. G., Jerene, D., Datiko, D. G., Hiruy,
N., Tadesse, A., Moile, T., Bekele, D., Yismawu, G., Melkieneh, K., Reshu, B.,
& Suarez, P. G. (2020). The yield of community-based tuberculosis and HIV
among key populations in hotspot settings of Ethiopia: A cross-sectional
implementation study. PLoS ONE, 15(5), e0233730. https://doi.org/10.1371/journal.pone.023373.
[26] Ejeh, F. E., Undiandeye, A., Okon, K., Kazeem, H.
M., & Kudi, A. C. (2020). Isolation and Immunological Detection of
Mycobacterium Tuberculosis from HIV and Non-HIV Patients in Benue State,
Nigeria. Ethiopian Journal of Health Sciences, 30(1), 55–64. https://doi.org/10.4314/ejhs.v30i1.8.
[27] Inyinbor, H. E., Omosigho, P. O., Akobi, O. A.,
Gideon, Emumwen, E., Ogedengbe, S. O., Shehu, Kudu Mohammed, Abdullahi1, M. N.,
Aliyu2, N. J., Oshinsanya1, T. T., Favour, A., Emumwen4, E., & . (2020).
Prevalence of Pulmonary Tuberculosis in Bida, North Central Nigeria: A fiveYear
Retrospective Study. J Med Lab Sci, 30(4), 26–34.
[28] Ajide, B., Chuku, A., Lawson, L., Orole, K., &
and Adogo, L. (2020). Prevalence of Mycobacterium tuberculosis in North Central
Nigeria. Nigerian Journal of Microbiology, 34(2), 5325–5332. http://www.nsmjournal.org.ng/2020-34-2/12.pdf.
[29] Ekeke, N., Aniwada, E., Chukwu, J., Nwafor, C.,
Meka, A., Alphonsus, C., Ezeakile, O., Ajayi, A., Soyinka, F., Bakpa, F.,
Uwanuruochi, V., Aniekwensi, E., & Eze, C. (2020). Screening diabetes
mellitus patients for tuberculosis in southern nigeria: A pilot study. Advances
in Respiratory Medicine, 88(1), 6–12. https://doi.org/10.5603/ARM.2020.0072.
[30] Gebretsadik, D., Ahmed, N., Kebede, E., Mohammed,
M., & Belete, M. A. (2020). Prevalence of Tuberculosis by Automated
GeneXpert Rifampicin Assay and Associated Risk Factors Among Presumptive
Pulmonary Tuberculosis Patients at Ataye District Hospital, Northeast Ethiopia.
Infection and Drug Resistance, 13, 1507–1516. https://doi.org/10.2147/IDR.S248059.
[31] Ugwu, K. O., Agbo, M. C., & Ezeonu, I. M.
(2021). Prevalence of tuberculosis, drug-resistant tuberculosis and HIV/TB
co-infection in Enugu, Nigeria. African Journal of Infectious Diseases, 15(2),
24–30. https://doi.org/10.21010/ajid.v15i2.5.
[32] Tola, A., Minshore, K. M., Ayele, Y., & Mekuria,
A. N. (2019). Tuberculosis Treatment Outcomes and Associated Factors among TB
Patients Attending Public Hospitals in Harar Town, Eastern Ethiopia: A
Five-Year Retrospective Study. Tuberculosis Research and Treatment, 2019, 1–11.
https://doi.org/10.1155/2019/1503219.
[33] Teferi, M. Y., Didana, L. D., Hailu, T.,
Woldesenbet, S. G., Bekele, S., & Mihret, A. (2021). Tuberculosis treatment
outcome and associated factors among tuberculosis patients at Wolayta Sodo
Teaching and Referral Hospital, Southern Ethiopia: a retrospective study.
Journal of Public Health Research, 10(3). https://doi.org/10.4081/JPHR.2021.2046.
[34] Tanue, E. A., Nsagha, D. S., Njamen, T. N., &
Clement Assob, N. J. (2019). Tuberculosis treatment outcome and its associated
factors among people living with HIV and AIDS in Fako Division of Cameroon.
PLOS ONE, 14(7), e0218800. https://doi.org/10.1371/JOURNAL.PONE.0218800.
[35] Narasimhan, P., Wood, J., Macintyre, C. R., &
Mathai, D. (2013). Risk Factors for Tuberculosis. 2013, 11. https://doi.org/10.1155/2013/828939.
[36] Abdulkader, M., Van Aken, I., Niguse, S.,
Hailekiros, H., & Spigt, M. (2019). Treatment outcomes and their trend
among tuberculosis patients treated at peripheral health settings of Northern
Ethiopia between 2009 and 2014: A registry-based retrospective analysis. BMC
Research Notes, 12(1), 1–5. https://doi.org/10.1186/S13104-019-4824-9/FIGURES/1.
[37] Mamo, A., Mama, M., Solomon, D., & Mohammed, M. (2021).
Treatment Outcomes and Predictors Among Tuberculosis Patients at Madda Walabu University Goba Referral Hospital, Southeast Ethiopia
. Infection and Drug Resistance, 13, 4763–4771. https://doi.org/10.2147/IDR.S285542.[38] Getahun, B., Ameni, G., Medhin, G., &
Biadgilign, S. (2013). Treatment outcome of tuberculosis patients under
directly observed treatment in Addis Ababa, Ethiopia. The Brazilian Journal of
Infectious Diseases, 17(5), 521–528. https://doi.org/10.1016/J.BJID.2012.12.010.
[39] Io, O., Ti, C., & Em, O. (2021). Detection of
HIV and Mycobacterium tuberculosis among University Students in Port Harcourt,
Nigeria 1. MedRxiv, 2021.03.06.21253050. https://doi.org/10.1101/2021.03.06.21253050.
[40] Moglad, E. H. O., Ahmed, D. A. O., Awad AL-Kareem,
S. M. M., Elgoraish, A. G., Ali, H. T. O., & Altayb, H. N. (2020).
Prevalence of human immunodeficiency virus among pulmonary tuberculosis
patients: A cross-sectional study. Microbiology and Immunology, 64(12),
810–814. https://doi.org/10.1111/1348-0421.12856.
[41] Mesfin YM, Hailemariam D, Biadgilign S, Kibret KT
(2014) Association between HIV/AIDS and Multi-Drug Resistance Tuberculosis: A
Systematic Review and Meta-Analysis. PLoS ONE 9(1): e82235. doi:
10.1371/journal.pone.0082235.