A Case-Control Study to Identify Risk Factors Related to Cholera Outbreak in Kasai Oriental Province, Democratic Republic of Congo, 2018
Abstract:
Cholera remains the major public
health problem in the world. Democratic Republic of Congo is frequently affected
by cholera since the introduction of 7th pandemic in the country in 1974.
The 2018 cholera outbreak which was the second major one affecting the Kasai oriental
(KOR) province started on the week7 and was still persistent on the week40, when
it was decided to conduct a matched cases-controls study to identify its risk factors
so that to readjust responses activities on going on the field. 80 cases were randomly
selected in the line-listing among patients investigated in the treatment centres
or units during cholera response activities and 80 controls were selected according
to matching criteria. Bivariate and multivariate analyses were performed using Epi-info
7 software. The study identified as risk factors: Living in a household with more
than five persons (Adjusted Odds Ratio (AOR):2.99; 95%CI[1.88-6.22]); drinking water
sold along the street (AOR: 4.29; 95%CI[1.85-10.30]); Had been in contact with persons
suffering of diarrhoea (AOR: 7.15; 95%CI[2.10-17.21]); Participated in funerals
(5.16; 95%CI[3.02-29.95]); peoples ignoring how to contract cholera (5.78; 95%CI[2.38-18.10]
and participants ignoring how to protect themselves from contracting cholera (2.49;
95%CI[1.73-5.20]). Cholera vaccination was not tested as risk factors during this
study.
Keywords: Risk factors,
cholera, Kasai Oriental, Democratic Republic
of Congo.
References:
[1]. Adagbada AO., Adesida SA., Nwaokorie FO., Niemogha MT., and
Coker AO., 2012, Cholera Epidemiology in Nigeria: an overview, The Pan African Medical
Journal - ISSN 1937-8688 Online https://www.ajol.info/index.php/pamj/article/view/82694/72839.
[2]. Bompangue D., 2009, Dynamique des épidémies de choléra dans
la région des grands lacs africains : cas de la République Démocratique du Congo,
Thèse de Doctorat en Sciences de la vie et de la santé, Université de Franche-Comté,
France, 265pp
[3]. Bonita R, Beaglehole R., Kjellström T., 2010, Éléments d’épidémiologie,
2nd Ed, World Health Organization, Retrived from https://apps.who.int/iris/bitstream/handle/10665/44055/9789242547078_fre.pdf?sequence=1&isAllowed=y.
[4]. Carneal-Frazer, ND., 2019, Analysis of Control Measures Used
During Cholera Outbreaks Among Internally Displaced Persons ; Doctoral dissertation,
Walden University, USA on line https://scholarworks.waldenu.edu/dissertations
[5]. Centers for Disease Control and Prevention (U.S. CDC)., 2012,
Principles of epidemiology in public health practice An introduction to applied
epidemiology and biostatistic. 3rd ed. Atlanta, GA: U.S. CDC; Retrieved on the November, 12 2019 in
https://stacks.cdc.gov/pdfjs/web/viewer.ht ml?file=https://stacks.cdc.gov/view/cdc/6914/cdc_6914_DS1.pdf.
[6]. Congo Profond (2018) : Présentation de la province du Kasaï
Oriental, Zoom sur l’autre Congo oublié, consulté le 12/12/2019 Online https://congoprofond.net/presentation-de-la-province-du-kasai-oriental/.
[7]. Dubois A., Sinkala M., Kallur P., Makasa-Chikoya. ,2016, Epidemic
cholera in urban Zambia : hand soap and dried fish as protective factors. Epidemiol.
Infect. 134, 1226–1230.
[8]. Echenberg, M., 2011, Africa in the Time of Cholera : A History
of Pandemics from 1817 to the Present. New York, NY, USA : Cambridge University
Press.
[9]. GTFCC : Global Task Force on Cholera Control, 2017, Ending
Cholera - A Global Roadmap to 2030. 32p Retrieved in December2, 2019 from https://www.who.int/cholera/publications/global-roadmap/en/.
[10]. Huang DB and Zhou J., 2007, Effect of intensive handwashing
in the prevention of diarrheal illness among patients with AIDS : à randomized controlled
study. J Med Microbiol.,56(Pt 5) :659-63.
[11]. Janny T., 2004, Epidémies de choléra en
Afrique : Analyse d'une étiologie multifactorielle. Mémoire d’ingénieur du Génie
Sanitaire, Ecole Nationale de Santé Publique Rennes, France. 59 pages. En ligne
https://documentation.ehesp.fr/memoires/2004/igs/janny.pdf.
[12]. Juan M.Fukuda JM., Yi Q., Chaparro L., Campos M., and Chea
E., 1995, Clinical characteristics and risk factors for Vibrio cholerae infection
in children, J pediatr, 126(6):882-886 Online https://doi.org/10.1016/S0022-3476(95)70201-6Get.
[13]. Kelsey et al.,[nd] Methods in Observational
Epidemiology, 2nd Edition, Table 12-15; and Fleiss, Statistical Methods for Rates
and Proportions, formulas 3.18 & 3.19 Online in http://web1.sph.emory.edu/users/cdckms/sample%20size%202%20grps%20case%20control.html.
[14]. Lamond E. & Kinyanjui J., 2012, Cholera outbreak guidelines
: Preparedness, Prevention and Control ,OXFARM : consulted Online on May 2019, https://www.unicef.org/cholera/Annexes/Supporting_Resources/Annex_6B/OXFAM_Cholera_guidelines.pdf.
[15]. Maheshwari, M., Nelapati, K. and Kiranmayi, B., 2011, Vibrio
cholerae - a review. Veterinary World. 4, pp. 423–428.
[16]. Maponga BA, Chirundu D, Gombe NT, Tshimanga M, Shambira G,
Takundwa L., 2013, Risk factors for contracting watery diarrhoea in Kadoma City,
Zimbabwe, case control study. BMC Infect Dis. 2 ; 13 :567.
[17]. Mbuyi KM, 2003, Facteurs de risque du choléra dans la ville
de Mbuji Mayi. Thèse de Doctorat en médecine. Université de Mbuji-Mayi, Mbuji-Mayi,
RDC, 122p.
[18]. Moore, S., 2016, Dynamics of Cholera Epidemics in Haiti and
Africa, Thèse de doct Univ Aix Marseille, Marseille, France, One line.
[19]. MSF : Médecins Sans Frontières , 2018,
Management of an cholera epidemiie, Practical guide for doctors, nurses, laboratory
technicians, health auxiliaries, health technicians and logisticians; 2018 Edition,
Retrieved in December 2, 2019 from https://medicalguidelines.msf.org/msf-books-hosting/23444436-Francais.pdf.
[20]. Nguyen, V., Sreenivasan, N., Lam, E., 2012, Epi-Aid # 2010-074
Trip Report: Sierra Leone Cholera Outbreak Investigation, Consulted on Dec., 12, 2019.
[21]. Nkoko, BD., Giraudoux P., lisnier PD., Mutombo A.T., and Piarroux
M., 2011, “Dynamics of Cholera Outbreaks in Great Lakes Region of Africa, 1978 –
2008” 17 (October 2010) : 2026–34. Doi :10.3201/eid1711.110170.
[22]. Shomba K.S. and Olela N.N., 2015, Monograph
of the city of Mbuji-Mayi, CRDI, Ed. MES. 104P. Retrieved on December, 7 2019 from
https://www.idrc.ca/sites/default/files/sp/Documents%20EN/Monographie.pdf.
[23]. Sigsworth, M., 1991, Cholera in the large towns of the West
and East Ridings, 1848-1893. Doctoral thesis, Sheffield Hallam University (United
Kingdom). One line http://shura.shu.ac.uk/20811/.
[24]. UNDP : Programme des Nations Unies pour le Développement,
2009, Unité de lutte contre la pauvreté (Mars 2009), Unité de lutte contre la pauvreté,
Province du KOR, Profil résume, Pauvrete et conditions de vie des menages. May,
22, 2019 online http://www.ipamec.be/Documents/Profil_kasai%20oriental_final.pdf.
[25]. WHO : World Health Organization, 2003, Méthodologie de la
recherche dans le domaine de la santé : Guide de formation aux méthodes de la recherche
scientifique, Deuxième Ed. Bureau Régional du Pacifique Occidental, Manille, Philippines
Retrieved from http://www.wpro.who.int/health_research/documents/dhs_hr_health_research_methodology_a_guide_for_training_in_research_methods_second_edition_fr.pdf.
[26]. [24] WHO : World Health Organization, 2004, Cholera Outbreak
: Assessing the Outbreak Response and improving preparedness, Global Task Force
for cholera control. Retrieved in December 2, 2019.
[27]. WHO : Organisation Mondiale de la Santé, 2019, Choléra. Centre
des Médias. Principaux répères, Janvier 2019. Consultable sur http://www.who.int/fr/news-room/fact-sheets/details/cholera.