Determinants of Treatment Adherence and Retention in Care among HIV Positive Pregnant and Breastfeeding Women in a Rural District in Zimbabwe

Download Article

DOI: 10.21522/TIJPH.2013.07.04.Art032

Authors : Addmore Chadambuka, Nicholas Midzi

Abstract:

Background: A preliminary review of St Albert’s Mission Hospital data showed 15% of HIV positive pregnant and breastfeeding women (PPBW) missed drug pick-up appointments and 10% were lost to follow up. This affects Zimbabwe reaching 90% viral suppression target among those on antiretroviral therapy and increases HIV transmission risk to unborn fetus or breastfeeding infant. We determined factors associated with treatment adherence and retention in care among PPBW.

Methods: We conducted a cross-sectional analytic study among PPBW receiving care at the hospital. Women were sampled consecutively on presenting for antenatal or postnatal care. We used interviewer administered questionnaire to elicit information from consenting PPBW. We obtained ethical approval and written informed consent from PPBW.

Results: We interviewed 120 PPBW. The majority were breastfeeding women (60.0%). Over 95% PPBW disclosed their HIV status. The majority used this hospital because the health workers treated them with respect (66.7%), maintained client confidentiality (75.0%) and had good relations with their clients (70.8%). Skipping medication because of travel (adjusted odds ratio (AOR) 95% confidence interval (CI) 0.06 (0.005-0.79 and having an unpleasant experience while seeking care AOR (95% CI) 0.05 (0.002-0.93) were independently associated with lower medication adherence. Disclosure to avoid hiding taking medication AOR (95% CI) 22.07 (1.64-297.66 and attending this hospital because the health workers maintain confidentiality AOR (95% CI) 22.07 (1.64-297.66) were independently associated with higher retention in care.

Conclusion: Health system factors play an important role in adherence and retention of pregnant and breastfeeding women attending care at this facility

References:

[1].   Abdool-Karim, Q., AbouZahr, C., Dehne, K., Mangiaterra, V., Moodley, J., Rollins, N., … de Zoysa, I. (2010). HIV and maternal mortality: Turning the tide. The Lancet, 375(9730), 1948–1949. https://doi.org/10.1016/S0140-6736(10)60747-7.

[2].   Adewuya, A. O., Afolabi, M. O., Ola, B. A., Ogundele, O. A., Ajibare, A. O., Oladipo, B. F., & Fakande, I. (2010). The Effect of Psychological Distress on Medication Adherence in Persons with HIV Infection in Nigeria. Psychosomatics, 51(1), 68–73. https://doi.org/10.1016/S0033-3182(10)70661-7.

[3].   Afolabi, M. O., Ijadunola, K. T., Fatusi, A. O., & Olasode, O. A. (2009). Determinants of adherence to antiretroviral drugs among people living with HIV/AIDS in the Ife-Ijesa zone of Osun state, Nigeria. African Journal of Primary Health Care & Family Medicine, 1(1). https://doi.org/10.4102/phcfm.v1i1.6.

[4].   Alakija Kazeem Salami, Fadeyi, A., Ogunmodede, J. A., & Desalu, O. (2010). Factors Influencing Adherence to Antiretroviral Medication in Ilorin, Nigeria. Journal of the International Association of Physicians in AIDS Care, 9(3), 191–195. https://doi.org/10.1177/1545109710368722.

[5].   Alemu, H., Haile Mariam, D., Tsui, A. O., & Shewamare, A. (2011). Correlates of highly active antiretroviral therapy adherence among urban Ethiopian clients. African Journal of AIDS Research, 10(3), 263–270. https://doi.org/10.2989/16085906.2011.626297.

[6].   Amberbir, A., Woldemichael, K., Getachew, S., Girma, B., & Deribe, K. (2008). Predictors of adherence to antiretroviral therapy among HIV-infected persons: A prospective study in Southwest Ethiopia. BMC Public Health, 8(1). https://doi.org/10.1186/1471-2458-8-265.

[7].   Arnsten, J. H., Demas, P. A., Farzadegan, H., Grant, R. W., Gourevitch, M. N., Chang, C., … Schoenbaum, E. E. (2001). Antiretroviral Therapy Adherence and Viral Suppression in HIVInfected Drug Users: Comparison of SelfReport and Electronic Monitoring. Clinical Infectious Diseases, 33(8), 1417–1423. https://doi.org/10.1086/323201.

[8].   Bangsberg, D. R. (2006). Less Than 95% Adherence to Nonnucleoside ReverseTranscriptase Inhibitor Therapy Can Lead to Viral Suppression. Clinical Infectious Diseases, 43(7), 939–941. https://doi.org/10.1086/507526.

[9].   Bastard, M., Fall, M. B. K., Lanièce, I., Taverne, B., Desclaux, A., Ecochard, R., … Etard, J.-F. (2011). Revisiting Long-Term Adherence to Highly Active Antiretroviral Therapy in Senegal Using Latent Class Analysis: JAIDS Journal of Acquired Immune Deficiency Syndromes, 57(1), 55–61. https://doi.org/10.1097/QAI.0b013e318211b43b.

[10].  Beyene, K. A., Gedif, T., Gebre-Mariam, T., & Engidawork, E. (2009). Highly active antiretroviral therapy adherence and its determinants in selected hospitals from south and central Ethiopia. Pharmacoepidemiology and Drug Safety, 18(11), 1007–1015. https://doi.org/10.1002/pds.1814.

[11].  Bezabhe, W. M., Chalmers, L., Bereznicki, L. R., Peterson, G. M., Bimirew, M. A., & Kassie, D. M. (2014). Barriers and Facilitators of Adherence to Antiretroviral Drug Therapy and Retention in Care among Adult HIV-Positive Patients: A Qualitative Study from Ethiopia. PLoS ONE, 9(5), e97353. https://doi.org/10.1371/journal.pone.0097353.

[12].  Bhat, V. G., Ramburuth, M., Singh, M., Titi, O., Antony, A. P., Chiya, L., … Msengana, M. (2010). Factors associated with poor adherence to anti-retroviral therapy in patients attending a rural health centre in South Africa. European Journal of Clinical Microbiology & Infectious Diseases, 29(8), 947–953. https://doi.org/10.1007/s10096-010-0949-4.

[13].  Boyer, S., Clerc, I., Bonono, C.-R., Marcellin, F., Bilé, P.-C., & Ventelou, B. (2011). Non-adherence to antiretroviral treatment and unplanned treatment interruption among people living with HIV/AIDS in Cameroon: Individual and healthcare supply-related factors. Social Science & Medicine, 72(8), 1383–1392. https://doi.org/10.1016/j.socscimed.2011.02.030.

[14].  Brinkhof, M. W. G., Pujades-Rodriguez, M., & Egger, M. (2009). Mortality of Patients Lost to Follow-Up in Antiretroviral Treatment Programmes in Resource-Limited Settings: Systematic Review and Meta-Analysis. PLoS ONE, 4(6), e5790. https://doi.org/10.1371/journal.pone.0005790.

[15].  Calvert, C., & Ronsmans, C. (2013). The contribution of HIV to pregnancy-related mortality: A systematic review and meta-analysis. AIDS, 27(10), 1631–1639.

https://doi.org/10.1097/QAD.0b013e32835fd940

[16].  Chi, B. H., Cantrell, R. A., Zulu, I., Mulenga, L. B., Levy, J. W., Tambatamba, B. C., … Stringer, J. S. (2009). Adherence to first-line antiretroviral therapy affects non-virologic outcomes among patients on treatment for more than 12 months in Lusaka, Zambia. International Journal of Epidemiology, 38(3), 746–756. https://doi.org/10.1093/ije/dyp004.

[17].  Cohen, M. S., Chen, Y. Q., McCauley, M., Gamble, T., Hosseinipour, M. C., Kumarasamy, N., … Fleming, T. R. (2011). Prevention of HIV-1 Infection with Early Antiretroviral Therapy. New England Journal of Medicine, 365(6), 493–505. https://doi.org/10.1056/NEJMoa1105243

[18].  Dzangare, J., Takarinda, K. C., Harries, A. D., Tayler-Smith, K., Mhangara, M., Apollo, T. M., … Mugurungi, O. (2016). HIV testing uptake and retention in care of HIV-infected pregnant and breastfeeding women initiated on ‘Option B+’ in rural Zimbabwe. Tropical Medicine & International Health, 21(2), 202–209. https://doi.org/10.1111/tmi.12637

[19].  Eholi??, S.-P., Tanon, A., Polneau, S., Ouiminga, M., Djadji, A., Kangah-koffi C., … Bissagnen?, E. (2007). Field Adherence to Highly Active Antiretroviral Therapy in HIV-infected Adults in Abidjan, C??te d???Ivoire: JAIDS Journal of Acquired Immune Deficiency Syndromes, PAP. https://doi.org/10.1097/QAI.0b013e31805d8ad0

[20].  Elul, B., Basinga, P., Nuwagaba-Biribonwoha, H., Saito, S., Horowitz, D., Nash, D., … Asiimwe, A. (2013). High Levels of Adherence and Viral Suppression in a Nationally Representative Sample of HIV-Infected Adults on Antiretroviral Therapy for 6, 12 and 18 Months in Rwanda. PLoS ONE, 8(1), e53586. https://doi.org/10.1371/journal.pone.0053586

[21].  Erah, P. O., & Arute, J. E. (2008). Adherence of HIV/AIDS patients to antiretroviral therapy in a tertiary health facility in Benin City. Original Research, 2 (7), 145–152.

[22].  Etienne, M., Hossain, M., Redfield, R., Stafford, K., & Amoroso, A. (2010). Indicators of Adherence to Antiretroviral Therapy Treatment Among HIV/AIDS Patients in 5 African Countries. Journal of the International Association of Physicians in AIDS Care, 9(2), 98–103. https://doi.org/10.1177/1545109710361383

[23].  Fox, M. P., Brennan, A., Maskew, M., MacPhail, P., & Sanne, I. (2010). Using vital registration data to update mortality among patients lost to follow-up from ART programmes: Evidence from the Themba Lethu Clinic, South Africa. Tropical Medicine & International Health. https://doi.org/10.1111/j.1365-3156.2010.02473.x

[24].  Fox, M. P., & Rosen, S. (2010). Patient retention in antiretroviral therapy programs up to three years on treatment in sub-Saharan Africa, 2007-2009: Systematic review: Patient retention in antiretroviral therapy programs. Tropical Medicine & International Health, 15, 1–15. https://doi.org/10.1111/j.1365-3156.2010.02508.x

[25].  Geng, E. H., Glidden, D. V., Bangsberg, D. R., Bwana, M. B., Musinguzi, N., Nash, D., … Petersen, M. L. (2012). A Causal Framework for Understanding the Effect of Losses to Follow-up on Epidemiologic Analyses in Clinic-based Cohorts: The Case of HIV-infected Patients on Antiretroviral Therapy in Africa. American Journal of Epidemiology, 175(10), 1080–1087. https://doi.org/10.1093/aje/kwr444

[26].  Geng, Elvin H., Glidden, D. V., Bwana, M. B., Musinguzi, N., Emenyonu, N., Muyindike, W., … Martin, J. N. (2011). Retention in Care and Connection to Care among HIV-Infected Patients on Antiretroviral Therapy in Africa: Estimation via a Sampling-Based Approach. PLoS ONE, 6(7), e21797. https://doi.org/10.1371/journal.pone.0021797

[27].  Goudge, J., & Ngoma, B. (2011). Exploring antiretroviral treatment adherence in an urban setting in South Africa. Journal of Public Health Policy, 32(S1), S52–S64. https://doi.org/10.1057/jphp.2011.22

[28].  Hardon, A. P., Akurut, D., Comoro, C., Ekezie, C., Irunde, H. F., Gerrits, T., … Laing, R. (2007). Hunger, waiting time and transport costs: Time to confront challenges to ART adherence in Africa. AIDS Care, 19(5), 658–665. https://doi.org/10.1080/09540120701244943

[29].  Hegazi, A., R.L. Bailey, Ahadzie, B., Alabi, A., & Peterson, K. (2010). Literacy, education and adherence to antiretroviral therapy in The Gambia. AIDS Care, 22(11), 1340–1345. https://doi.org/10.1080/09540121003693514

[30].  Hodgson, I., Plummer, M. L., Konopka, S. N., Colvin, C. J., Jonas, E., Albertini, J., … Fogg, K. P. (2014). A Systematic Review of Individual and Contextual Factors Affecting ART Initiation, Adherence, and Retention for HIV-Infected Pregnant and Postpartum Women. PLoS ONE, 9(11), e111421. https://doi.org/10.1371/journal.pone.0111421

[31].  Hoffman, R. M., Black, V., Technau, K., van der Merwe, K. J., Currier, J., Coovadia, A., & Chersich, M. (2010). Effects of Highly Active Antiretroviral Therapy Duration and Regimen on Risk for Mother-to-Child Transmission of HIV in Johannesburg, South Africa: JAIDS Journal of Acquired Immune Deficiency Syndromes, 54(1), 35–41. https://doi.org/10.1097/QAI.0b013e3181cf9979

[32].  Hogan, M. C., Foreman, K. J., Naghavi, M., Ahn, S. Y., Wang, M., Makela, S. M., … Murray, C. J. (2010). Maternal mortality for 181 countries, 1980–2008: A systematic analysis of progress towards Millennium Development Goal 5. The Lancet, 375(9726), 1609–1623. https://doi.org/10.1016/S0140-6736(10)60518-1

[33].  Kagee, A., Nothling, J., & Coetzee, B. (2012). The perspectives of users of antiretroviral therapy on structural barriers to adherence in South Africa. South African Family Practice, 54(6), 540–544. https://doi.org/10.1080/20786204.2012.10874289

[34].  Kekwaletswe, C., & Morojele, N. (2014). Alcohol use, antiretroviral therapy adherence, and preferences regarding an alcohol-focused adherence intervention in patients with human immunodeficiency virus. Patient Preference and Adherence, 401. https://doi.org/10.2147/PPA.S55547

[35].  Kip, E., Ehlers, V. J., & van der Wal, D. M. (2009). Patients’ Adherence to Anti-Retroviral Therapy in Botswana. Journal of Nursing Scholarship, 41(2), 149–157. https://doi.org/10.1111/j.1547-5069.2009.01266.x

[36].  Kisenyi, R. N., Muliira, J. K., & Ayebare, E. (2013). Religiosity and Adherence to Antiretroviral Therapy Among Patients Attending a Public Hospital-Based HIV/AIDS Clinic in Uganda. Journal of Religion and Health, 52(1), 307–317. https://doi.org/10.1007/s10943-011-9473-9

[37].  Kunutsor, S., Evans, M., Thoulass, J., Walley, J., Katabira, E., Newell, J. N., … Ikoona, E. (2010). Ascertaining Baseline Levels of Antiretroviral Therapy Adherence in Uganda: A Multimethod Approach: JAIDS Journal of Acquired Immune Deficiency Syndromes, 55(2), 221–224. https://doi.org/10.1097/QAI.0b013e3181e255ec

[38].  Liotta, G., Mancinelli, S., Nielsen-Saines, K., Gennaro, E., Scarcella, P., Magid, N. A., … Marazzi, M. C. (2013). Reduction of Maternal Mortality with Highly Active Antiretroviral Therapy in a Large Cohort of HIV-Infected Pregnant Women in Malawi and Mozambique. PLoS ONE, 8(8), e71653. https://doi.org/10.1371/journal.pone.0071653

[39].  Lozano, R., Wang, H., Foreman, K. J., Rajaratnam, J. K., Naghavi, M., Marcus, J. R., … Murray, C. J. (2011). Progress towards Millennium Development Goals 4 and 5 on maternal and child mortality: An updated systematic analysis. The Lancet, 378(9797), 1139–1165. https://doi.org/10.1016/S0140-6736(11)61337-8

[40].  Lubinga, S. J., Kintu, A., Atuhaire, J., & Asiimwe, S. (2012). Concomitant herbal medicine and Antiretroviral Therapy (ART) use among HIV patients in Western Uganda: A cross-sectional analysis of magnitude and patterns of use, associated factors and impact on ART adherence. AIDS Care, 24(11), 1375–1383. https://doi.org/10.1080/09540121.2011.648600

[41].  Lyimo, R. A., Stutterheim, S. E., Hospers, H. J., de Glee, T., van der Ven, A., & de Bruin, M. (2014). Stigma, Disclosure, Coping, and Medication Adherence Among People Living with HIV/AIDS in Northern Tanzania. AIDS Patient Care and STDs, 28(2), 98–105. https://doi.org/10.1089/apc.2013.0306

[42].  Malama, C., Kvalsund, M. P., Kaile, T., Malama, K., Birbeck, G. L., Sinyama, A. M., … Byers, P. A. (2011). Neuropsychiatric and Socioeconomic Status Impact Antiretroviral Adherence and Mortality in Rural Zambia. The American Journal of Tropical Medicine and Hygiene, 85(4), 782–789. https://doi.org/10.4269/ajtmh.2011.11-0187

[43].  Maqutu, D., & Zewotir, T. (2011). Optimal HAART adherence over time and time interval between successive visits: Their association and determinants. AIDS Care, 23(11), 1417–1424. https://doi.org/10.1080/09540121.2011.565028

[44].  Maqutu, D., Zewotir, T., North, D., Naidoo, K., & Grobler, A. (2010). Factors affecting first-month adherence to antiretroviral therapy among HIV-positive adults in South Africa. African Journal of AIDS Research, 9(2), 117–124. https://doi.org/10.2989/16085906.2010.517478

[45].  Marcellin, F., Boyer, S., Protopopescu, C., Dia, A., Ongolo-Zogo, P., Koulla-Shiro, S., … the EVAL Study Group*. (2008). Determinants of unplanned antiretroviral treatment interruptions among people living with HIV in Yaoundé, Cameroon (EVAL survey, ANRS 12-116). Tropical Medicine & International Health, 13(12), 1470–1478. https://doi.org/10.1111/j.1365-3156.2008.02170.x

[46].  Mbonye, M., Seeley, J., Ssembajja, F., Birungi, J., & Jaffar, S. (2013). Adherence to Antiretroviral Therapy in Jinja, Uganda: A Six-Year Follow-Up Study. PLoS ONE, 8(10), e78243. https://doi.org/10.1371/journal.pone.0078243

[47].  Memiah, P., Shumba, C., Etienne-Mesubi, M., Agbor, S., Hossain, M. B., Komba, P., … Biadgilign, S. (2014). The Effect of Depressive Symptoms and CD4 Count on Adherence to Highly Active Antiretroviral Therapy in Sub-Saharan Africa. Journal of the International Association of Providers of AIDS Care (JIAPAC), 13(4), 346–352. https://doi.org/10.1177/2325957413503368

[48].  Muya, A. N., Geldsetzer, P., Hertzmark, E., Ezeamama, A. E., Kawawa, H., Hawkins, C., … Spiegelman, D. (2015). Predictors of Nonadherence to Antiretroviral Therapy among HIV-Infected Adults in Dar es Salaam, Tanzania. Journal of the International Association of Providers of AIDS Care (JIAPAC), 14(2), 163–171. https://doi.org/10.1177/2325957414539193

[49].  Nachega, J. B., Mills, E. J., & Schechter, M. (2010). Antiretroviral therapy adherence and retention in care in middle-income and low-income countries: Current status of knowledge and research priorities: Current Opinion in HIV and AIDS, 5(1), 70–77. https://doi.org/10.1097/COH.0b013e328333ad61

[50].  Naidoo, P., Peltzer, K., Louw, J., Matseke, G., Mchunu, G., & Tutshana, B. (2013). Predictors of tuberculosis (TB) and antiretroviral (ARV) medication non-adherence in public primary care patients in South Africa: A cross sectional study. BMC Public Health, 13(1). https://doi.org/10.1186/1471-2458-13-396

[51].  Nam, S. L., Fielding, K., Avalos, A., Dickinson, D., Gaolathe, T., & Wenzel Geissler, P. (2008). Corrigendum to: “The relationship of acceptance or denial of HIV-status to antiretroviral adherence among adult HIV patients in urban Botswana” [Soc. Sci. Med. 67 (2008) 301–310]. Social Science & Medicine, 67(11), 1934. https://doi.org/10.1016/j.socscimed.2008.09.023

[52].  Navario, P. (2009). PEPFAR’s biggest success is also its largest liability. The Lancet, 374(9685), 184–185. https://doi.org/10.1016/S0140-6736(09)61312-X

[53].  Negash, T., & Ehlers, V. (2013). Personal Factors Influencing Patients’ Adherence to ART in Addis Ababa, Ethiopia. Journal of the Association of Nurses in AIDS Care, 24(6), 530–538. https://doi.org/10.1016/j.jana.2012.11.004

[54].  Newman, J., Iriondo-Perez, J., Hemingway-Foday, J., Freeman, A., Akam, W., Balimba, A., … Kiumbu, M. (2012). Older Adults Accessing HIV Care and Treatment and Adherence in the IeDEA Central Africa Cohort. AIDS Research and Treatment, 2012, 1–8. https://doi.org/10.1155/2012/725713

[55].  Palella, F. J., Delaney, K. M., Moorman, A. C., Loveless, M. O., Fuhrer, J., Satten, G. A., … Holmberg, S. D. (1998). Declining Morbidity and Mortality among Patients with Advanced Human Immunodeficiency Virus Infection. New England Journal of Medicine, 338(13), 853–860. https://doi.org/10.1056/NEJM199803263381301

[56].  Paterson, D. L., Swindells, S., Mohr, J., Brester, M., Vergis, E. N., Squier, C., … Singh, N. (2000). Adherence to Protease Inhibitor Therapy and Outcomes in Patients with HIV Infection. Annals of Internal Medicine, 133(1), 21. https://doi.org/10.7326/0003-4819-133-1-200007040-00004

[57].  Peltzer, K., Friend-du Preez, N., Ramlagan, S., & Anderson, J. (2010). Antiretroviral treatment adherence among HIV patients in KwaZulu-Natal, South Africa. BMC Public Health, 10(1). https://doi.org/10.1186/1471-2458-10-111

[58].  Penn, C., Watermeyer, J., & Evans, M. (2011). Why don’t patients take their drugs? The role of communication, context and culture in patient adherence and the work of the pharmacist in HIV/AIDS. Patient Education and Counseling, 83(3), 310–318. https://doi.org/10.1016/j.pec.2011.02.018

[59].  Ramadhani, H. O., Thielman, N. M., Landman, K. Z., Ndosi, E. M., Gao, F., Kirchherr, J. L., … Crump, J. A. (2007). Predictors of Incomplete Adherence, Virologic Failure, and Antiviral Drug Resistance among HIV-Infected Adults Receiving Antiretroviral Therapy in Tanzania. Clinical Infectious Diseases, 45(11), 1492–1498. https://doi.org/10.1086/522991

[60].  Ross, A. J., Aung, M., Campbell, L., & Ogunbanjo, G. A. (2011). Factors that positively influence adherence to antiretroviral therapy by HIV and/or AIDS patients and their caregivers. African Journal of Primary Health Care & Family Medicine, 3(1). https://doi.org/10.4102/phcfm.v3i1.196

[61].  Sanjobo, N., Frich, J. C., & Fretheim, A. (2008). Barriers and facilitators to patients’ adherence to antiretroviral treatment in Zambia: A qualitative study. SAHARA-J: Journal of Social Aspects of HIV/AIDS, 5(3), 136–143. https://doi.org/10.1080/17290376.2008.9724912

[62].  Say, L., Chou, D., Gemmill, A., Tunçalp, Ö., Moller, A.-B., Daniels, J., … Alkema, L. (2014). Global causes of maternal death: A WHO systematic analysis. The Lancet Global Health, 2(6), e323–e333. https://doi.org/10.1016/S2214-109X(14)70227-X

[63].  Shisana, O., Human Sciences Research Council, United States, & Centers for Disease Control and Prevention (U.S.) (Eds.). (2014). South African national HIV prevalence, incidence and behaviour survey, 2012. Cape Town, South Africa: HSRC Press.

[64].  Skovdal, M., Campbell, C., Nhongo, K., Nyamukapa, C., & Gregson, S. (2011). Contextual and psychosocial influences on antiretroviral therapy adherence in rural Zimbabwe: Towards a systematic framework for programme planners: INFLUENCES ON ART ADHERENCE IN RURAL ZIMBABWE. The International Journal of Health Planning and Management, 26(3), 296–318. https://doi.org/10.1002/hpm.1082

[65].  Tiyou, A., Belachew, T., Alemseged, F., & Biadgilign, S. (2010). Predictors of adherence to antiretroviral therapy among people living with HIV/AIDS in resource-limited setting of southwest ethiopia. AIDS Research and Therapy, 7(1), 39. https://doi.org/10.1186/1742-6405-7-39

[66].  Tumwine, C., Neema, S., & Wagner, G. (2012). Reasons Why High Religiosity Can Co-exist with and Precipitate Discontinuation of Anti-retroviral Therapy among Different HIV Clients in Uganda: An Exploratory Study. Religions, 3(3), 817–832. https://doi.org/10.3390/rel3030817

[67].  Tweya, H., Gugsa, S., Hosseinipour, M., Speight, C., Ng’ambi, W., Bokosi, M., … Phiri, S. (2014). Understanding factors, outcomes and reasons for loss to follow-up among women in Option B+ PMTCT programme in Lilongwe, Malawi. Tropical Medicine & International Health, 19(11), 1360–1366. https://doi.org/10.1111/tmi.12369

[68].  UNAIDS. (2017). Regional Antiretroviral Therapy. Retrieved from http://www.unaids.org/sites/default/files/media_asset/UNAIDS_FactSheet_en.pdf

[69].  Unge, C., Södergård, B., Marrone, G., Thorson, A., Lukhwaro, A., Carter, J., … Ekström, A. M. (2010). Long-Term Adherence to Antiretroviral Treatment and Program Drop-Out in a High-Risk Urban Setting in Sub-Saharan Africa: A Prospective Cohort Study. PLoS ONE, 5(10), e13613. https://doi.org/10.1371/journal.pone.0013613

[70].  Uzochukwu, B. S. C., Onwujekwe, O. E., Onoka, A. C., Okoli, C., Uguru, N. P., & Chukwuogo, O. I. (2009). Determinants of non-adherence to subsidized anti-retroviral treatment in southeast Nigeria. Health Policy and Planning, 24(3), 189–196. https://doi.org/10.1093/heapol/czp006

[71].  Vreeman, R. C., Wiehe, S. E., Pearce, E. C., & Nyandiko, W. M. (2008). A Systematic Review of Pediatric Adherence to Antiretroviral Therapy in Low- and Middle-Income Countries: The Pediatric Infectious Disease Journal, 27(8), 686–691. https://doi.org/10.1097/INF.0b013e31816dd325

[72].  Wanyama, J., Castelnuovo, B., Wandera, B., Mwebaze, P., Kambugu, A., Bangsberg, D. R., & Kamya, M. R. (2007). Belief in divine healing can be a barrier to antiretroviral therapy adherence in Uganda: AIDS, 21(11), 1486–1487. https://doi.org/10.1097/QAD.0b013e32823ecf7f

[73].  Watt, M. H., Maman, S., Jacobson, M., Laiser, J., & John, M. (2009). Missed Opportunities for Religious Organizations to Support People Living with HIV/AIDS: Findings from Tanzania. AIDS Patient Care and STDs, 23(5), 389–394. https://doi.org/10.1089/apc.2008.0195

[74].  Weiser, S., Wolfe, W., Bangsberg, D., Thior, I., Gilbert, P., Makhema, J., … Marlink, R. (2003). Barriers to Antiretroviral Adherence for Patients Living with HIV Infection and AIDS in Botswana: JAIDS Journal of Acquired Immune Deficiency Syndromes, 34(3), 281–288. https://doi.org/10.1097/00126334-200311010-00004

[75].  Whetten, K., Shirey, K., Pence, B. W., Yao, J., Thielman, N., Whetten, R., … for the CHAT Research Team. (2013). Trauma History and Depression Predict Incomplete Adherence to Antiretroviral Therapies in a Low Income Country. PLoS ONE, 8(10), e74771. https://doi.org/10.1371/journal.pone.0074771

[76].  World Health Organization, UNICEF, United Nations Population Fund, & World Bank. (2010). Trends in maternal mortality: 1990 to 2008: estimates. Geneva: World Helath Organization.

[77]. Zaba, B., Calvert, C., Marston, M., Isingo, R., Nakiyingi-Miiro, J., Lutalo, T., … Ronsmans, C. (2013). Effect of HIV infection on pregnancy-related mortality in sub-Saharan Africa: Secondary analyses of pooled community-based data from the network for Analysing Longitudinal Population-based HIV/AIDS data on Africa (ALPHA). The Lancet, 381(9879), 1763–1771. https://doi.org/10.1016/S0140-6736(13)60803-X