Actinomycosis with pericardio-pleural effusion and ascites. A Rare presentation
Abstract:
Background- Actinomycosis is an uncommon disease caused by Actinomyces spp., Gram-positive, anaerobic or microaerobic
bacteria that normally colonize the human mouth and GIT and genital tracts. Cardio-pulmonary
actinomycosis with peritoneal involvement is a rare presentation.
Case report – A 29 years old female normotensive
and euglycemic, smoker with poor oral hygiene was referred to us an outside hospital
with complaints of right lower chest pain with severe shortness of breath and low
grade fever last 4 hrs . On examination she showed dental caries, right chest bulging
with diminished breath sounds, distended abdomen, raised WBC counts and normal ECG,
Chest X-Ray showed right sided pleural effusion and bilateral opacities, pericardial
effusion and ascites which were confirmed by 2D echo, CT chest & abdomen . Lab
tests were negative for tuberculosis or malignancy. Finally she was diagnosed as
an actinomycosis israelii based on culture and biopsy. She was treated with long
course of appropriate antibiotics and fluid drainage.
Conclusion-Patients with actinomycosis
require prolonged high doses of penicillin G or amoxicillin and other sensitive
antibiotics and drainage. Early diagnosis will reduce the hospital stay or mortality
in such kind of patients.
References:
[1.] Garini G, Brodi C,
Mazzi A, Thoracic actinomycosis with lung, mediastinal and pericardial involvement:
a case report. Recenti Prog Med (1995);86:107–11.
[2.] Litwin KA, Jadbabaie
F, Villanueva M. Case of pleuropericardial disease caused by Actinomyces odontolyticus
that resulted in cardiac tamponade. Clin Infect Dis (1999);29:219–20.
[3.] Shinagawa N, Yamaguchi
E, Takahashi T, Pulmonary actinomycosis followed by pericarditis and intractable
pleuritis. Intern Med (2002);41:319–22.
[4.] Wong VK, Turmezei TD, Weston VC. Actinomycosis. BMJ. (2011);343:d6099.
[5.] Smego RA Jr, Foglia G. Actinomycosis. Clin Infect Dis.
(1998);26(6): 1255–1261.
[6.] Pulverer G, Schütt-Gerowitt H, Schaal KP. Human cervicofacial
actinomycoses: microbiological data for 1997 cases. Clin Infect Dis. (2003);37(4):490–497.
[7.] Fazili T, Blair D, Riddell S, Kiska D, Nagra S. Actinomyces meyeri
infection: case report and review of the literature. J Infect. (2012);65(4):357–361.
[8.] Cone LA, Leung MM, Hirschberg J. Actinomyces odontolyticus bacteremia.
Emerg Infect Dis. 2003;9(12):1629–1632.
[9.] Sabbe LJ, Van De Merwe D, Schouls L, Bergmans A, Vaneechoutte M, Vandamme P. Clinical spectrum of infections due to the newly described Actinomyces species A. turicensis, A.
radingae, and A. europaeus.J Clin Microbiol. 1999;37(1):8–13.
[10.] Clarridge JE 3rd, Zhang Q. Genotypic diversity of clinical Actinomyces
species: phenotype, source, and disease correlation among genospecies. J Clin
Microbiol. 2002;40(9):3442–3448.
[11.] Kim SR, Jung LY, Oh IJ,. Pulmonary actinomycosis during the first
decade of 21st century: cases of 94 patients. BMC Infect Dis. 2013;13(1):216.
[12.] Kim TS, Han J, Koh WJ, Thoracic actinomycosis: CT features with
histopathologic correlation. AJR Am J Roentgenol. 2006;186(1): 225–231.
[13.] Song JU, Park HY, Jeon K, Um SW, Kwon OJ, Koh WJ. Treatment of
thoracic actinomycosis: a retrospective analysis of 40 patients. Ann Thorac Med.
2010;5(2):80–85.
[14.] Kolditz M, Bickhardt J, Matthiessen W, Holotiuk O, Höffken G,
Koschel D. Medical management of pulmonary actinomycosis: data from 49 consecutive
cases. J Antimicrob Chemother. 2009;63(4):839–841.
[15.] Felz MW, Smith MR. Disseminated actinomycosis: multisystem mimicry
in primary care. South Med J. 2003;96(3):294–299.
[16.] Lewis R, McKenzie D, Bagg J, Dickie A. Experience with a novel
selective medium for isolation of Actinomyces spp. from medical and dental
specimens. J Clin Microbiol. 1995;33(6):1613–1616.
[17.] Garner O, Mochon A, Branda J. Multi-centre evaluation of mass
spectrometric identification of anaerobic bacteria using the VITEK® MS system.
Clin Microbiol Infect. Epub July 4, 2013.
[18.] Hall V, Talbot PR, Stubbs SL, Duerden BI. Identification of clinical
isolates of Actinomyces species by amplified 16S ribosomal DNA restriction analysis.
J Clin Microbiol. 2001;39(10):3555–3562.
[19.] Hall V. Actinomyces – gathering evidence of human colonization
and infection. Anaerobe. 2008;14:1–7.
[20.] Smith AJ, Hall V, Thakker B, Gemmell CG. Antimicrobial susceptibility
testing of Actinomyces species with 12 antimicrobial agents.J Antimicrob Chemother.
2005;56(2):407–409.
[21.] Chaudhry SI, Greenspan JS. Actinomycosis in HIV infection: a
review of a rare complication. Int J STD AIDS. 2000;11(6):349–355.
[22.] Fife TD, Finegold
SM, Grennan T. Pericardial actino-mycosis: case report and review. Rev Infect –Dis
(1991) ;13:120–6.
[23.] Garini G, Brodi
C, Mazzi A, Thoracic actinomycosis with lung, mediastinal and pericardial involvement:
a case report. Recenti Prog Med (1995);86:107–11.
[24.] Litwin KA, Jadbabaie F, Villanueva M. Case of pleuropericardial
disease caused by Actinomyces odontolyticus that resulted in cardiac tamponade.
Clin Infect Dis (1999);29:219–20.