Male osteoporosis – the problem statement among South India men
Abstract:
Two points worth noting about osteoporosis in India - high incidence
among men and lower age of peak incidence compared to Western countries. 1 out of
8 males and 1 out of 3 females in India suffers from osteoporosis. The incidence
of hip fracture is 1 woman to 1 man. In Western countries, the peak incidence of
osteoporosis occurs at 70-80 years of age, in India it afflicts at age 50-60. But
there is a worrying trend of increasing prevalence of osteoporosis among the younger
men in India that has been under studied. This cross-sectional study was conducted
in a tertiary care centre. With informed consent, male subjects were evaluated clinically
including anthropometry and history, biochemically with 25-OH Vitamin D and radiologically
with DEXA scan. Calculation of T score and categorization as osteoporosis, osteopenia,
and normal BMD was done as per WHO classification and data was analyzed. The male
population having decreased bone mass was more than expected. Osteoporosis and osteopenia
are prevalent in younger male population too contrary to the popular belief. A significantly
large proportion of south Indian men had osteoporosis and vitamin D deficiency.
Further interventional studies are needed to look at reduction in end points like
fractures and morbidity in these subjects.
References:
[1.]
Agrawal N. K and. Sharma B, “Prevalence
of osteoporosis in otherwise healthy Indian males aged 50 years and above,”
Archives of Osteoporosis, vol. 8, no. 1-2, article no. 116, 2013.
[2.]
Arya V, Bhambri R and
Godbole MM(2004) Vitamin D status and its relationship with bone mineral
density in healthy Asian Indians. Osteoporosis Int 15:56–61.
[3.]
Bliuc D,. Nguyen N. D,. Milch V. E,.
Nguyen T. V,. Eisman J. A, and. Center J. R, “Mortality risk associated with
low-trauma osteoporotic fracture and subsequent fracture in men and women,”
JAMA—Journal of the American Medical Association, vol. 301, no. 5, pp. 513–521,
2009.
[4.]
Center JR, Nguyen TV,
Schneider D et al (1999) Mortality after all major types of osteoporotic
fractures in men and women: an observational study. Lancet 353:878–882.
[5.]
Center J. R.,. Nguyen T. V,. Schneider D,.
Sambrook P. N, and. Eisman J. A, “Mortality after all major types of
osteoporotic fracture in men and women: an observational study,” The Lancet,
vol. 353, no. 9156, pp. 878–882, 1999.
[6.]
Chapuy MC, Arlot ME, Duboeuf
F, Brun J, Crouzet B and Arnaud S (1992) Vitamin D3 and calcium to prevent hip
fractures in the elderly women. N Engl J Med 327:1637–1642.
[7.]
Ebelin P. R, “Osteoporosis in men,” The
New England Journal of Medicine, vol. 358, pp. 1474–1482, 2008.
[8.]
Goswami R, Gupta N and
Goswami D (2000) Prevalence and significance of low 25-hydroxyvitamin D
concentrations in healthy subjects in Delhi. Am J ClinNutr 72:472–475.
[9.]
Harinarayan C. V and. Joshi S. R,
“Vitamin D status in India-its implications and remedial measures, “Journal of
Association of Physicians of India, vol. 57, pp. 40–48, 2009.
[10.]
Heaney R. P,. Abrams S,. Dawson-Hughes B
et al., “Peak bone mass,” Osteoporosis International, vol. 11, no. 12, pp.
985–1009, 2000.
[11.] Holick MF (2007) Vitamin D, deficiency. N Engl J Med 357:266 –
281.
[12.]
Kanis J. A,. Johnell O,. Oden A,.
Johansson H, and. McCloskey E, “FRAX and the assessment of fracture probability
in men and women from the UK,” Osteoporosis International, vol. 19, no. 4, pp.
385–397, 2008.
[13.] Khanna P, Bhargav S (1971) Roentgen assessment of bone density in
north Indian Population. Indian J Med Res 59:1599–1609
[14.]
Lekamwasam S, Wijayaratne
L and Rodrigo M (2009) Prevalence and determinants of osteoporosis among men
aged 50 years or more in Sri Lanka: a community-based cross-sectional study.
Arch Osteoporos 4:79–84.
[15.]
Malhotra N and. Mithal A, “Osteoporosis
in Indians,” Indian Journal of Medical Research, vol. 127, no. 3, pp. 263–268,
2008.
[16.]
Marwaha RK, Tandon N and
Garg MK (2011) Bone health in healthy Indian population aged 50 years and
above. Osteoporos Int 22:2829–2836.
[17.]
Melton L. J III,. Atkinson E. J,.
O'Connor M. K,. O'Fallon W. M, and. Riggs B. L, “Bone density and fracture risk
in men,” Journal of Bone and Mineral Research, vol. 13, no. 12, pp. 1915–1923,
1998.
[18.]
Rao S. S, Budhwar N., and Ashfaque A., “Osteoporosis
in men,” American Family Physician, vol. 82, no. 5, pp. 503–508, 2010.
[19.]
Tandon
N, Marwaha RK and Kalra S(2003) Bone mineral parameters in healthy young Indian
adults with optimal vitamin D availability. Natl Med J India 16:298–302.
[20.]
Vupputuri MR, Goswami R
and Gupta N(2006) Prevalence and functional significance of 25-hydroxyvitamin D
deficiency and vitamin D receptor gene.
[21.]
World Health Organization (WHO), “Assessment
of fracture risk and its application to screening for postmenopausal osteoporosis:
report of a WHO study group,” WHO Technical Report 843, WHO, Geneva, Switzerland,
1994.
[22.]
Zargar AH, Ahmad S and
Masoodi SR (2007) Vitamin D status in apparently healthy adults in Kashmir Valley
of Indian subcontinent. Postgrad Med J 83:713–716.