Abstract:

Reducing high blood cholesterol, a risk factor for cardiovascular disease (CVD) in people with and without a past history of CVD is an important goal of pharmacotherapy. Statins are the first-choice agents. Previous reviews of the effects of statins have highlighted their benefits in people with CVD. The case for primary prevention was uncertain when the last version of this review was published (2011) and in light of new data an update of this review is required.

References:

[1.] Hasnia Ziar, Philippe Gérard, Ali Riazi, (2014). Effect of prebiotic carbohydrates on growth, bile survival and cholesterol uptake abilities of dairy-related bacteria. Journal of the Science of Food and Agriculture, 94, 2

[2.] Jacquelyn, A., Quin, Brack Hattler, Muath Bishawi, Janet Baltz, Sandeep Gupta, Joseph, F., Collins, Frederick, L., Grover, Gerald McDonald, A., Laurie, W., Shroyer (2013). Impact of Lipid-Lowering Medications and Low-Density Lipoprotein Levels on 1-Year Clinical Outcomes after Coronary Artery Bypass Grafting. Journal of the American College of Surgeons, 217, 3, 452

[3.] Jane Stock (2013). HDL function and cardiovascular risk: Debate continues. Atherosclerosis, 229, 1, 38

[4.] Jonathan Chrispin, Seth, S., Martin, Rani, K., Hasan, Parag, H., Joshi, C., Michael Minder, John, W., McEvoy, Payal Kohli, Amber, E., Johnson, Libin Wang, Michael, J., Blaha, Roger, S., Blumenthal(2013). Landmark Lipid-Lowering Trials in the Primary Prevention of Cardiovascular Disease. Clinical Cardiology, 36, 9

[5.] Jennifer, G., Robinson (2013). Statins vs Early Hormone Therapy for the Primary Prevention of Cardiovascular Disease in Women. Current Cardiovascular Risk Reports, 7, 3, 163

[6.] S., Halimi (2013). Cholestérol-Statines, la polémique crée le trouble !. Médecine des Maladies Métaboliques, 7, 5, 397

[7.] Süleyman Bilecen, Joris, A., H., Groot, Cor, J., Kalkman, Alexander, J., Spanjersberg, Karel, G., M., Moons, Arno, P., Nierich (2013). Effectiveness of a cardiac surgery–specific transfusion protocol. Transfusion , 53, 11 pt2

[8.] Sougat Ray, A., K., Jindal, S., Sengupta, S., Sinha (2013). Statins: Can we advocate them for primary prevention of heart disease?. Medical Journal Armed Forces India.