Carcinoma Right Breast (post-operative Chemotherapy and Radiotherapy) with bone and lung metastases: A Case Report and Review of Literature

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DOI: 10.21522/TIJCR.2014.03.01.Art007

Authors : Kavita Gupta

Abstract:

It is generally observed that triple negative breast cancer patients do not get benefited from endocrine targeted therapies. However, by a thorough Systematic review and critical analysis of the literature it could be depicted that a subset with Androgen Receptor expression could respond to anti-androgen therapies up to some extent. Presented here is a 65-years-old Postmenopausal female with a 5-year history of Carcinoma Right Breast (post-operative Chemotherapy and Radiotherapy) with bone and lung metastases, advanced, Grade III tumor diagnosed as Metastatic Adenocarcinoma on histology. This case had been presented to identify the role of Androgen Receptors in inhibiting and suppressing the tumor growth in breast oncology and to conclude that traditional Anti-Androgen therapy, that is, Bicalutamide could be considered as a differential diagnosis of Triple negative breast cancer metastatic tumors. Therefore, the present article represents some deeper insights regarding Androgen, Androgen-Receptor, Anti-Androgen drug-Bicalutamide and their role of action in the post-menopausal Triple Negative Breast cancer women with positive expression of Androgen Receptor.

Keywords: Breast, Lungs, Carcinoma, Metastasis, Bicalutamide, Androgen Receptor, Post-menopausal, Androgen, Estrogen, HER2, TNBC.

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