Abstract:

This present study was designed to assess the level of some hematological parameters among pretreatment pulmonary tuberculosis infected patients, treatment in 2 months, 4 months, 6 months pulmonary tuberculosis infection and control, non-infected subjects in Anambra State University Teaching Hospital, Awka. Anambra State, Nigeria. A total of 220 pulmonary tuberculosis (PTB) infected subjects aged 18 – 60 were recruited for the study. Hundred (100) subjects were in their pretreatment stage (group B), and 40 each in their 2 months (group C), 4 months (group D) and 6 months (group E) treatment stages. Eighty (80) non PTB subjects served as control. Blood samples collected from the subjects were used for the determination of Haemoglobin concentration (g/dl), packed cell volume (l/l), Mean cell haemoglobin concentration (g/dl), Erythrocyte sedimentation rate (mm/hr), platelet count (x10⁹/l), total white blood count (x10⁹/l), absolute neutrophil count (x10⁹/l), absolute lymphocyte count (x10⁹/l) and absolute monocyte count (x10⁹/l) using standard laboratory methods for analysis as described by Dacie and Lewis^[1]. Tuberculosis diagnosis was carried out using Ziehl Neelsen technique. The result showed that the mean ±SD Haemoglobin concentration and packed cell volume were significantly lower in pretreatment PTB subjects than the Post treatment subjects (P<0.05 in each case). The mean ±SD mean cell haemoglobin concentration showed no significant difference among the groups. The mean ±SD ESR in pretreatment subjects was significantly higher than the control and post treatment subjects. The mean (±SD) platelet count (x10⁹/l), TWBC (x10⁹/l) and ANC (x10⁹/l) were significantly higher while the ALC (x10⁹/l) was significantly lower respectively in pretreatment PTB patients compared with the control subjects and post treatment PTB subjects (P <0 .05 in each case). The mean (±SD) AMC (x10⁹/l) showed no significant difference when compared among the groups (P<0.05).

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