Meta-Analysis: A Key Statistical Method in Clinical Research Through A Review of Preterm Birth and Childhood Wheezing Disorders

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Authors : Pradnya Mahatme

Abstract:

Meta-analysis is a statistical approach to combine the data derived from a systematic-review. Therefore, every meta-analysis should be based on an underlying systematic review, but not every systematic review leads to a meta-analysis. Meta-analysis offers a rational and helpful way of dealing with a number of practical difficulties that beset anyone trying to make sense of effectiveness research.

This article review was written after details and critical assessment of the research conducted by Been JV et.al. The researchers undertook meta-analysis and a systematic review investigating risks of asthma/wheezing disorders in children born preterm, including the increasing numbers who, as a result of advances in neonatal care, now survive very preterm birth. The trigger of research was accumulating evidence which implicates early life factors in the aetiology of non-communicable diseases, including asthma/wheezing disorders.

It was evident that preterm birth particularly very preterm birth increases the risk of asthma. Been JV et.al concluded that these is greater need to focus on understanding mechanisms and translate it into preventive actions.

KEY WORDS

Meta-analysis, Systemic Review, Preterm Birth, Asthma, Wheezing, Disorders

References:

1.      Aspberg S, Dahlquist G, Kahan T, Kallen B (2010) Confirmed association between neonatal phototherapy or neonatal icterus and risk of childhood asthma. Pediatr Allergy Immunol 21: e733–e739.

2.      Civelek E, Cakir B, Orhan F, Yuksel H, Boz AB, et al. (2011) Risk factors for current wheezing and its phenotypes among elementary school children. PediatrPulmonol 46: 166–174.

3.      Doi SA, Thalib L. “A quality-effects model for meta-analysis” Epidemiology 2008 Jan;19(1) 94–100

4.      Goldenberg RL, Culhane JF, Iams JD, Romero R (2008) Epidemiology and causes of preterm birth. Lancet 371: 75–84.

5.      Helfenstein U. Data and models determine treatment proposals—an illustration from meta-analysis" Postgrad Med J 2002 Mar;78(917) 131–4

6.      Joshi S, Powell T, Watkins WJ, Drayton M, Williams EM, et al. (2013) Exercise induced bronchoconstriction in school-aged children who had chronic lung disease in infancy. J Pediatr 162: 813–818.

7.      Kumar R, Tsai HJ, Hong X, Gignoux C, Pearson C, et al. (2012) African ancestry, early life exposures, and respiratory morbidity in early childhood. ClinExp Allergy 42: 265–274.

8.      Kumar R, Yu Y, Story RE, Pongracic JA, Gupta R, et al. (2008) Prematurity, chorioamnionitis, and the development of recurrent wheezing: a prospective birth cohort study. J Allergy Clin Immunol 121: 878–884.

9.      Maastricht University, http://www.maastrichtuniversity.nl/, retrieved on 25 June 2014

10.  Nurmatov U, Devereux G, Sheikh A (2011) Nutrients and foods for the primary prevention of asthma and allergy: systematic review and meta-analysis. J Allergy Clin Immunol 127: 724–733.

11.  PLoS Medicine, http://www.PLoSmedicine.org/, retrieved on 25 June 2014

12.  Riley RD, Higgins JP, Deeks JJ. (2011) "Interpretation of random effects meta-analyses". British Medical Journal Feb 10;342:d549.

13.  Robison RG, Kumar R, Arguelles LM, Hong X, Wang G, et al. (2012) Maternal smoking during pregnancy, prematurity and recurrent wheezing in early childhood. PediatrPulmonol 47: 666–673.

14.  Vogt H, Lindstrom K, Braback L, Hjern A (2011) Preterm birth and inhaled corticosteroid use in 6- to 19-year-olds: a Swedish national cohort study. Pediatrics 127: 1052–1059.

15.  Vollsaeter M, Roksund OD, Eide GE, Markestad T, Halvorsen T (2013) Lung function after preterm birth: development from mid-childhood to adulthood. Thorax 68: 767–776.