Abstract:

Kidneys are vital organs responsible for maintenance of body fluid, salts and electrolyte concentration. Non protein nitrogen substances have an important role in renal diseases that are serious concern to human health. The present research was carried out during 2006 at SVS Medical College and Hospital, Mahabubnagar, Hyderabad, India with the objective of examining patients with renal diseases with reference to NPN parameters. Blood samples from 30 patients were subjected to analysis of Blood Urea, Serum Creatinine, Serum Uric Acid, Serum Electrolytes, Sodium, Potassium and Chloride. The statistical analysis of the above data showed that there was significant elevation of urea and creatinine levels in the cases of renal failure. The uric acid levels were also elevated when compared to the normal, the difference is not statistically significant. All cases were advised for dialysis. Urea and Creatinine levels are considered to be reliable parameters in assessment of early renal diseases.

Keywords: Acute renal failure (ARF), Chronic Renal Failure (CRF), dialysis, NPN, electrolytes.

References:

[1]. Bishop, M. L., Duben-Engelkirk, J. L. and Fody, E. P. (1992). Clinical Chemistry Principles Procedures Correlations. 2nd Ed. Philadelphia. JB Lippincott. pp: 281.

[2]. Calbreath, D. F. (1992). Clinical Chemistry A Fundamental Text Book. Philadelphia WB. Saunders Co. pp: 371-395.

[3]. Chatterjee, .M. N. and Shinde, R. (2007). Renal Function Test. Text book of Medical Biochemistry .7th Ed. Jaypee. ISBN:9788184481341. pp:609-615.

[4]. Gowenlock, A. H., McMurray, J. M. and Donald, M McLanchlan. (2002). Varley’s Practical Clinical Biochemistry. 6th Ed. pp: 601.

[5]. Heptinstall, R. H. (1992). Pathology of the Kidney. Little Brown. 4th.Ed. ISBN:9780316358002.Vol.I.pp:965-985.

[6]. Kaplan, L. A. and Peace, A. J.(1989). Clinical Chemistry: Theory, analysis and correlation, 2nd Ed., (St. Louis: C.V. Mosy Co. pp: 590-591.

[7]. Kasper, D. L., Braunwald, E., Fauci, A. S., Hauser S. L., Longo, D. L., Jameson, J. L., Loscalzo, J. (2012). Harrison's principles of internal medicine (18th ed.). New York: McGraw-Hill Medical Publishing Division. ISBN 978-0-07-146633-2.

[8]. Murray, R. K., Garanner, D. K., Mayes, P. A. and Rodwell, V. W. (1992). Harper’s Biochemistry 25th Ed Uric acid levels and renal impairment. pp: 962.

[9]. Rose, B. D. (1993).Clinical Physiology of Acid Base and Electrolyte Disorder. 4th Ed. New York: McGraw-Hill, Inc. P-346-348,432, 797-798.

[10]. Shankara, Y. M. S., Ganesh, M. K. and Shivashankara, A. R. (2013). Reaction of NPN Substance. Laboratory Manual for Practical Biochemistry. JP. ISBN:9789350902769. pp:43-44.

[11]. Thomas M. D. (1986). Text Book of Biochemistry with clinical correlation pp:350-366.

[12]. Tietz, N. W. (1990). Text Book of Clinical Guide to Laboratory Test. 2nd Ed. Philadelphia, W.B. Saunders.Co. pp: 98-721.

[13]. Vasudevan, D. M., Sreekumari, S. and Kannan, V. (2013). Kidney Function Test. Text Book of Biochemistry for Medical Students. JP. ISBN: 9789350905302. pp:361-377.