Intestinal Microbiome and Antimicrobial Resistivity: A Study in Recent Times
Abstract:
The world has recently witnessed a pandemic and is now
challenged by continuous environmental changes. Human health is in constant
jeopardy with the rise in bacterial, fungal, and viral infections. Antibiotics
are the most widely used medication for the treatment of any infection. The
urban population does not always maintain a healthy lifestyle due to the
fast-paced nature of life. West Bengal the eastern state of India is no
exception to this directive. Rampant use of antibiotics and their frequent
consumption has widely increased over the years. This is posing a serious
threat to the healthy microbiome of the human intestine. It is resulting in a
decline of the healthy microbiota and the development of antibiotic resistance.
The study aims to understand the effect of antibiotic consumption in the
post-COVID scenario on the gut microbiome of the West Bengal population. The
population includes both rural and urban as it takes into account the different
lifestyles.
References:
[1] Barron M, 2022, The Gut Resistome and the Spread of Antimicrobial
Resistance. American Society of Microbiology, June 2022. The Gut
Resistome and the Spread of Antimicrobial Resistance (asm.org).
[2] CDC Antibotic
Resistance threat report (2019), Date of access: 09/02/2024 2019 Antibiotic
Resistance Threats Report | CDC.
[3] Pascaul C, 2018, Intestinal microbiota and antibiotic
resistance: Perspectives and solutions. Human Microbial Journal, vol. 9,
11-15. Intestinal
microbiota and antibiotic resistance: Perspectives and solutions –
ScienceDirect.
[4] Matzaras R, 2022, Gut Microbiota Modulation and
Prevention of Dysbiosis as an Alternative Approach to Antimicrobial Resistance:
A Narrative Review. Yale J Biol Med, 95(4):
479–494. Focus:
Antimicrobial Resistance: Gut Microbiota Modulation and Prevention of Dysbiosis
as an Alternative Approach to Antimicrobial Resistance: A Narrative Review -
PMC (nih.gov).
[5] Yang
L, 2021, The varying effects of antibiotics on gut microbiota. AMB Expr,
11:116.
https://amb-express.springeropen.com/articles/10.1186/s13568-021-01274-w.
[6] Singh S 2019, The human gut resistome: Current concepts
& future prospects. Indian Journal of Medical Research, 150(4): 345–358. https://doi.org/10.4103%2Fijmr.IJMR_1979_17.
[7] CDC, India Annual
Report (2021) Antimicrobial Resistance, Date of access: 09/02/2024
https://www.cdc.gov/globalhealth/countries/india/anniversary-report/antimicrobial-resistance.html#print.
[8] WHO Report (2020)
Antibiotic Resistance, Date of access: 09/02/2024
https://www.who.int/news-room/fact-sheets/detail/antimicrobial-resistance.
[9] Aliouche H, 2022,
The Effect of Antibiotics on Gut Microbiome. News Medical Life Sciences, 26 Jul
2022. The Effect of Antibiotics on the Gut Microbiome (news-medical.net).
[10] Ibana J, 2016,
Addressing the Antibiotic Resistance Problem with Probiotics: Reducing the Risk
of its Double-Edged Sword Effect. Frontiers in Microbiology, 7:1983.
https://doi.org/10.3389/fmicb.2016.01983.
[11] Tang
Q, 2020, Current Sampling Methods for Gut Microbiota: A Call for More Precise
Devices. Frontiers in Cellular and Infection Microbiology, vol 10,
article 151. https://www.frontiersin.org/articles/10.3389/fcimb.2020.00151/full.
[12] Kapoor
M,2023, Impact of COVID-19 on healthcare system: A systematic review. Journal
of Public Health Research, vol 12(3),1-7. 10.1177_22799036231186349.pdf
(nih.gov).
[13] Massarine
N, 2023, How
Did COVID-19 Impact the Antimicrobial Consumption and Bacterial Resistance
Profiles in Brazil? Antibiotics, 12(9), 1374.
https://www.mdpi.com/2079-6382/12/9/1374.
[14] Rawson T.M., et al. Antimicrobial Use, Drug-Resistant
Infections and COVID-19. Nat. Rev.
Microbiol. 2020; 18:409–410.
doi: 10.1038/s41579-020-0395-y.
[15] Alhazzani W., et al. Surviving Sepsis Campaign: Guidelines on
the Management of Critically Ill Adults with Coronavirus Disease 2019
(COVID-19) Crit. Care Med. 2020;48: e440–e469. doi: 10.1097/CCM.0000000000004363.
[16] Furlan L 2021. The Regrettable Story of the “COVID Kit” and
the “Early Treatment of COVID-19” in Brazil. The Lancet Regional Health Americas, 2021; 4:100089. The regrettable story of the “Covid Kit”
and the “Early Treatment of Covid-19” in Brazil - The Lancet Regional Health –
Americas.
[17] Nandi A, 2023, Global antibiotic use during the COVID-19
pandemic: analysis of pharmaceutical sales data from 71 countries, 2020–2022. eClinical
Medicine 2023; 57: 101848. https://doi.org/10.1016/j.eclinm.2023.101848.
[18] WHO Report (2020)
Antibiotic Resistance, Date of access: 09/02/2024
https://www.who.int/news-room/fact-sheets/detail/antimicrobial-resistance.
[19] Yang X 2009, More
than 9,000,000 Unique Genes in Human Gut Bacterial Community: Estimating Gene
Numbers Inside a Human Body. PLoS ONE. vol 4 issue 6 e6074. (PDF) More
than 9,000,000 Unique Genes in Human Gut Bacterial Community: Estimating Gene
Numbers Inside a Human Body (researchgate.net).
[20] Conlon
M, 2015, The
Impact of Diet and Lifestyle on Gut Microbiota and Human Health. Nutrients
7, 17-44. doi:10.3390/nu7010017.
[21] Nicholson J.K., Holmes E., Kinross J., Burcelin R., Gibson
G., Jia W., Pettersson S. Host-gut microbiota metabolic interactions. Science. 2012;
336:1262–1267. doi: 10.1126/science.1223813.
[22] Lutgendorff F., Akkermans L.M.A., Soderholm J.D. The role of
microbiota and probiotics in stress-induced gastrointestinal damage. Curr. Mol. Med. 2008;
8:282–298.
doi: 10.2174/156652408784533779.
[23] Huxley R.R., Ansary-Moghaddam A., Clifton P., Czernichow S.,
Parr C.L., Woodward M. The impact of dietary and lifestyle risk factors on risk
of colorectal cancer: A quantitative overview of the epidemiological
evidence. Int. J. Cancer. 2009; 125:171–180. doi: 10.1002/ijc.24343.
[24] McKoy
J, 2022. Antibiotic Misuse in India could exacerbate drug resistance. Boston
University School of Public Health News Article, 28 October 2022. https://www.bu.edu/sph/news/articles/2022/antibiotic-misuse-in-india-could-exacerbate-drug-resistance/.
[25] Kasirga
E 2019, The importance of stool tests in diagnosis and follow-up of
gastrointestinal disorders in children. Turkish Archives of Pediatrics.
2019; 54(3): 141-148. https://doi.org/10.14744%2FTurkPediatriArs.2018.00483.
[26] Slideshare (2012),
Formation of faeces and defecation, Date of access: 09/02/2024
https://www.slideshare.net/cikyon87/formation-of-faeces-and-defecation.
[27] Agarwal S
2020, The
role of immunity in the physical and mental well-being of women in India during
Covid-19 pandemic. Parana Journal of Science and Education. Vol. 6, No.
7, 2020, pp. 1-8. http://tiny.cc/PJSE24476153v6i7p001-008.
[28] Agarwal S 2021,
Prevention is always better than Cure: Immunity Boosting to Fight Infections. Open
Journal of Medical Sciences, 1, 28-42.
scipublications.com/journal/index.php/ojms/article/view/89.
[29] Agarwal S 2020,
Immunity augmenting food supplements for susceptible individuals in combating
pandemic COVID-19 (Review). Parana Journal of Science and Education. v.
6, n. 4, (79-88). https://zenodo.org/records/3880638.
[30]
Darbar
S 2021, Effective food habits to improve immunity against Covid-19. J Basic
Pharmacol Toxicol. 5(1):1-6.
https://www.scigreen.com/index.php/JBPT/article/view/75.