Regenerative Therapy in Dentistry: A Review
Abstract:
Despite millions of people suffering from dental
caries and periodontitis to date, we don’t have effective treatments that guarantee
complete restoration of the impacted tissues. The current procedures mostly help
in delaying the disease progress, and hence, bringing alternative approaches for
whole tooth replacement has become indispensable. Considering the scenario, regenerative
medicine seems to be the novel approach, given its innovative therapeutic techniques
that aid in the repair and replacement of damaged, aged, diseased, or congenitally
defective tissues and organs. While we are yet to overcome various challenges, including
effective ways to control the size, color, and shape of the tooth and come up with
the perfect implantation sites for the jaw to enable in vitro tooth development,
the ongoing research and their favorable results reveal that whole-tooth regeneration
and bioengineered functional tooth are not a distant dream.
References:
[1]
Birjandi, A.
A., Neves, V. C., & Sharpe, P., 2021, Advances in regenerative dentistry; building
with biology. Regenerative medicine, 16(4), 343–345.
[2]
Cooper L. F.,
2009, The current and future treatment of edentulism. Journal of prosthodontics:
official journal of the American College of Prosthodontists, 18(2), 116–122.
[3] Holm-Pedersen, P., Schultz-Larsen, K., Christiansen,
N., & Avlund, K., 2008, Tooth loss and subsequent disability and mortality in
old age. Journal of the American Geriatrics Society, 56(3), 429–435.
[4] Nakao, K., & Tsuji, T., 2008, Dental Regenerative Therapy: Stem
Cell Transplantation & Bioengineered Tooth Replacement, Japanese dental science review, 44(1),70—75.
[5]
Langer, R. S.,
& Vacanti, J. P., 1999, Tissue engineering: the challenges ahead. Scientific
American, 280(4), 86–89.
[6]
Atala A., 2005,
Tissue engineering, stem cells and cloning: current concepts and changing trends.
Expert opinion on biological therapy, 5(7), 879–892.
[7] Sharpe,
P., 2020, Regenerative Dentistry, Front. Dent. Med, 1, 3.
[8] Are Stem
Cells and Regenerative Medicine Living Up To Their Promises? Stem cells and regenerative
medicine: Failed promises or real potential? (medicalnewstoday.com) accessed on 29.03.2023.
[9] Potdar, P. D., & Jethmalani, Y. D., 2015, Human
dental pulp stem cells: Applications in future regenerative medicine. World Journal
of Stem Cells, 7(5), 839–851.
[10]
Aly L. A., 2015,
Stem cells: Sources, and regenerative therapies in dental research and practice.
World Journal of Stem Cells, 7(7), 1047–1053.
[11]
Abou Neel, E.
A., Chrzanowski, W., Salih, V. M., Kim, H. W., & Knowles, J. C., 2014, Tissue
engineering in dentistry. Journal of Dentistry, 42(8), 915–928.
[12] Wang, L., Shen, H., Zheng, W., Tang, L., Yang, Z.,
Gao, Y., Yang, Q., Wang, C., Duan, Y., & Jin, Y., 2011, Characterization of
stem cells from alveolar periodontal ligament. Tissue engineering. Part A, 17(7-8),
1015–1026.
[13]
Soudi, A., Yazdanian,
M., Ranjbar, R., Tebyanian, H., Yazdanian, A., Tahmasebi, E., Keshvad, A., &
Seifalian, A., 2021, Role and application of stem cells in dental regeneration:
A comprehensive overview. EXCLI Journal, 20, 454–489.
[14]
Goldberg, M.,
Farges, J. C., Lacerda-Pinheiro, S., Six, N., Jegat, N., Decup, F., Septier, D.,
Carrouel, F., Durand, S., Chaussain-Miller, C., Denbesten, P., Veis, A., & Poliard,
A., 2008, Inflammatory and immunological aspects of dental pulp repair. Pharmacological
Research, 58(2), 137–147.
[15]
Yen, A. H.,
& Yelick, P. C., 2011, Dental tissue regeneration - a mini-review. Gerontology,
57(1), 85–94.
[16]
Wang, H. L.,
Greenwell, H., Fiorellini, J., Giannobile, W., Offenbacher, S., Salkin, L., Townsend,
C., Sheridan, P., Genco, R. J., & Research, Science and Therapy Committee.,
2005, Periodontal regeneration. Journal of Periodontology, 76(9), 1601–1622.
[17]
Miura, M., Gronthos,
S., Zhao, M., Lu, B., Fisher, L. W., Robey, P. G., & Shi, S., 2003, SHED: stem
cells from human exfoliated deciduous teeth. Proceedings of the National Academy
of Sciences of the United States of America, 100(10), 5807–5812.
[18]
Thesleff I.,
1976, Differentiation of odontogenic tissues in organ culture. Scandinavian Journal
of Dental Research, 84(6), 353–356.
[19]
Peterka, M.,
Mandys, V., & Peterková, R.,1991, A modification of tooth germ cultivation in
vitro and in ovo. Cytotechnology, 7(1), 49–53.
[20] Isogawa, N., Terashima, T., Nakano, Y., Kindaichi, J., Takagi, Y.,
Takano, Y., 2004, The induction of enamel and dentin complexes by subcutaneous implantation
of reconstructed human and murine tooth germ elements. Arch Histol Cytol, 67(1),
65–77.
[21]
Hu, B., Nadiri,
A., Kuchler-Bopp, S., Perrin-Schmitt, F., Peters, H., & Lesot, H., 2006, Tissue
engineering of tooth crown, root, and periodontium. Tissue engineering, 12(8), 2069–2075.
[22] Kuo, T.F., Huang, A.T., Chang, H.H., Lin, F.H., Chen, S.T., Chen,
R.S., Chou, C.H., Lin, H.C., Chiang, H., Chen, M.H., 2008, Regeneration of dentin-pulp
complex with cementum and periodontal ligament formation using dental bud cells
in gelatin-chondroitin-hyaluronan tricopolymer scaffold in swine. J Biomed Mater
Res A, 86(4), 1062–1068.
[23]
Zhang, L., Morsi, Y., Wang, Y.,
Li, Y., Ramakrishna, S., 2013, Review Scaffold Design & Stem Cells for Tooth
Regeneration, Japanese dental science review, 49(1), 14-26.
[24] Demarco, F. F., Conde, M. C., Cavalcanti, B. N.,
Casagrande, L., Sakai, V. T., & Nör, J. E., 2011, Dental pulp tissue engineering.
Brazilian dental journal, 22(1), 3–13.
[25]
Cavalcanti,
B. N., Zeitlin, B. D., & Nör, J. E., 2013, A hydrogel scaffold that maintains
viability and supports differentiation of dental pulp stem cells. Dental materials:
official publication of the Academy of Dental Materials, 29(1), 97–102.
[26]
Chisini, L.
A., Conde, M. C., Alcázar, J. C., Silva, A. F., Nör, J. E., Tarquinio, S. B., &
Demarco, F. F., 2016, Immunohistochemical Expression of TGF-β1 and Osteonectin in
engineered and Ca (OH)2-repaired human pulp tissues. Brazilian oral research, 30(1),
e93.
[27]
Demarco, F.
F., Casagrande, L., Zhang, Z., Dong, Z., Tarquinio, S. B., Zeitlin, B. D., Shi,
S., Smith, A. J., & Nör, J. E., 2010, Effects of morphogen and scaffold porogen
on the differentiation of dental pulp stem cells. Journal of Endodontics,
36(11), 1805–1811.
[28] Demarco, G, T., Kirschnick, L, B., Watson, L.B., Conde, M, C, M., Demarch,
F.F., Chisnini, L, A., 2017, What is the Clinical Applicability of Regenerative
Therapies in Dentistry? Rev Gauch Odontol, 65(4), 359-367.
[29]
Pradeep, A.
R., Rao, N. S., Agarwal, E., Bajaj, P., Kumari, M., & Naik, S. B., 2012, Comparative
evaluation of autologous platelet-rich fibrin and platelet-rich plasma in the treatment
of 3-wall intrabony defects in chronic periodontitis: a randomized controlled clinical
trial. Journal of Periodontology, 83(12), 1499–1507.
[30]
Pradeep, A.
R., Nagpal, K., Karvekar, S., Patnaik, K., Naik, S. B., & Guruprasad, C. N.,
2015, Platelet-rich fibrin with 1% metformin for the treatment of intrabony defects
in chronic periodontitis: a randomized controlled clinical trial. Journal of
Periodontology, 86(6), 729–737.
[31]
Kim, J. Y.,
Xin, X., Moioli, E. K., Chung, J., Lee, C. H., Chen, M., Fu, S. Y., Koch, P. D.,
& Mao, J. J., 2010, Regeneration of dental-pulp-like tissue by chemotaxis-induced
cell homing. Tissue engineering. Part A, 16(10), 3023–3031.
[32]
Kim, K., Lee,
C. H., Kim, B. K., & Mao, J. J., 2010, Anatomically shaped tooth and periodontal
regeneration by cell homing. Journal of dental research, 89(8), 842–847.
[33]
Sonoyama, W.,
Liu, Y., Fang, D., Yamaza, T., Seo, B. M., Zhang, C., Liu, H., Gronthos, S., Wang,
C. Y., Wang, S., & Shi, S., 2006, Mesenchymal stem cell-mediated functional
tooth regeneration in swine. PloS one, 1(1), e79.
[34]
Balic A., 2018,
Biology Explaining Tooth Repair and Regeneration: A Mini-Review. Gerontology, 64(4),
382–388.
[35] Morsczeck, C., & Reichert, T. E. ,2018, Dental
stem cells in tooth regeneration and repair in the future. Expert opinion on biological
therapy, 18(2), 187–196.