The Magnitude and Factors Associated with Antiretroviral Therapy Defaulting in Mabutsane District
Abstract:
BACKGROUND
This study sought to analyse
the magnitude and factors associated with antiretroviral therapy defaulting
using the patient electronic medical record system in Mabutsane health
district.
OBJECTIVES
Objectives of the study are:
to establish the factors associated with defaulting ARV and to analyse the
outcomes of ARV defaulter.
METHODOLOGY
A retrospective
cross-sectional survey was conducted. The target population for this research
is adult clients on antiretroviral therapy registered in Mabutsane between
December 2011 and December 2013. Descriptive statistics, x2 test and cross
tabulation was used to analyse data.
RESULTS
Mabutsaneclinic has a
defaulter rate of 11.3%. .More males (64.3%) defaulted treatment than females
(35.7%). Majority 13 clients (92.9%) were on treatment for more than 1 year
before defaulting.
Reasons for defaulting ART
are as follow: Substances abused 42.9%, side effect of drugs 21.4%, Transport
14.3%, Work 14.3% and Religion7.1%. Mortality rate among defaulter stand at
21.4%.
No significant statistic
relation between social economic variables (sex, substances abused, marriage
status, and employment status) and variable defaulter was found in our study.
CONCLUSIONS
Mabutsane health district
has a lower defaulter rate as compared to most of the African countries;
however this rate is above the Botswana one in 2013.
No significant association
between social economic variables and defaulter was found.
Factors such as substances
abused, work, transport etc…have been mentioned as reasons for defaulting.
Case fatality rate among
defaulters was low than what was observed in most of the Sub Saharan Africa
countries.
KEY
WORDS
Mabutsane has a low
defaulter rate.
References:
1.
AkaluA : Reasons(2009) for defaulting from public
art sites in ADDIS ABABA 2009
2.
Assefa Y, Jerene D, Lulseged S, Ooms G, Van Damme
W: Rapid scale-up of antiretroviral treatment in Ethiopia: successes and
system-wide effects. PLoS Med 2009, 6(4):e1000056.
3.
Bonolo PF, César CC, Acurcio FA, et al.:
Non-adherence among patients initiating antiretroviral therapy: a challenge for
health professionals in Brazil23.
4.
Botswana AIDS Impact Survey III (BAIS III), 2009)
5.
Byakika‐Tusiime J et al. (2003). Ability to purchase and secure stable therapy
are significant predictors of non‐adherence to antiretroviral therapy in Kampala,
Uganda. 10th Conference on Retroviruses and Opportunistic Infections. Boston,
USA. 10‐14 February 2003. Abstract no. 170.
6.
Chesney MA: Factors affecting adherence to
antiretroviral therapy. Clin Infect Dis 2000, 30(suppl 2):S171-S176.
7.
Darder M et al. (2004). Determinants of short and
long‐term adherence to antiretroviral treatment in resource‐poor settings. XV
International AIDS Conference. Bangkok, Thailand. 30 March ‐ 2 April 2004. Abstract no.B11852.
8.
Daniel OJ et al. (2004). Adherence pattern to ARV
drugs among AIDS patients on selfpurchased drugs and those on free medications
in Sagamu, Nigeria. XV International AIDS Conference. Bangkok, Thailand. 30
March ‐ 2 April 2004.
9.
DHAPC (Department of HIV/AIDS Prevention and Care)
2013
10. Dworkin, R.J. (1987).
Hidden bias in the use of archival data. Evaluation and the Health Professions,
10(2), 173-185.
11.
Etienne M et al. Effect of varying models of
adherence support on lost to follow up rates; findings from 34 treatment
facilities in eight resource limited countries. 4th International AIDS Society
Conference on HIV Pathogenesis, Treatment and Prevention, abstract WEPEB101,
Sydney, 2007.
12.
Ferris DC et al. (2004). Self‐reported adherence to
antiretroviral therapy and virologic outcomes in HIV‐infected persons in Durban,
KwaZulu Natal, South Africa. XV International AIDS Conference. Bangkok,
Thailand. 30 March ‐ 2 April 2004. Abstract no. WePeB5829.
13.
Fong OW, Ho CF, Fung LY, Lee FK, Tse WH, Yuen CY,
Sin KP, Wong KH: Determinants of adherence to highly active antiretroviral
therapy (HAART) in Chinese HIV/AIDS patients.HIV Med 2003, 4(2):133-8.
14.
Gugesa, S. Feasibility of using, community outreach
workers, to establish ART patient’s outcome in Amahara region Ethiopia.
Department of epidemiology, university of Washington international training and
education center on HIV (I-TECH).
15.
Havlir DV, Marschner IC, Hirsch MS, et al.:
Maintenance antiretroviral therapies in HIV infected patients with undetectable
plasma HIV RNA after triple-drug therapy. AIDS Clinical Trials Group Study 343
Team.NEngl J Med 1998, 339:1261
16.
Joyce Kgatwane et al.(2004). Factors that
facilitate or constrain adherence to antiretroviral therapy among adults at four
public health facilities in Botswana: a pre-intervention study
17.
Kastrissios H, Suaárez J-R, Katzenstein D, Girard
P, Sheiner LB, BlaschkeTF:Characterizing patterns of drug-taking behavior with
a multiple drug regimen in an AIDS clinical trial.AIDS 1998, 12:2295-2303.
18.
Kwong-leung, J., Chih-chengChen ,S., Kuo-Yang, W.,
Schouten ,E.& Harries A: True outcome of patients on antiretroviral therapy
who are loss to follow up in Malawi. Bulletin of the world health organization,
Volume, 85number 7,501-508, July 2007.
19.
Lessells, R. J., P. C. Mutevedzi, G. S. Cooke, and
M. L. Newell. "Retention in HIV Care for Individuals Not yet Eligible for
Antiretroviral Therapy: Rural Kwazulu-Natal, South Africa." J Acquir
Immune DeficSyndr 56, no. 3 (2011): e79-86
20.
March ‐ 2 April 2004. Abstract no.: WePeB5760.
21.
Maskew, M., MacPhail, P., Menezes, C&Ruble, D.
Lost to follow-up: Contributing factors and challenges in South African
patients on antiretroviral therapy. South A.2007; 97(9), 853–857.
22.
Mugglin, C., J. Estill, G. Wandeler, N. Bender, M.
Egger, T. Gsponer, and O. Keiser. "Loss to Programme between HIV Diagnosis
and Initiation of Antiretroviral Therapy in Sub-Saharan Africa: Systematic
Review and Meta-Analysis." Trop Med Int Health, (2012).
23.
Muganzi AM et al. (2004). Adherence to HAART in a
rural resource limited country HIV/AIDS treatment programme: the experience of
Arua Anti‐Retroviral (ARV) Treatment Programme‐Uganda.XV International
AIDS Conference. Bangkok, Thailand.
24.
Nieuwkerk PT, Sprangers MA, Burger DM, et al.:
Limited patient adherence to highly active antiretroviral therapy for HIV-1 infection
in an observational cohort study. Arch Intern Med 2001, 161:1962-1968
25.
Nwokike J (2004). Baseline data and predictors of
adherence in patients on antiretroviral therapy in Maun General Hospital,
Botswana. International Conference on Improving Use of Medicines (ICIUM).
Bangkok, Thailand. Abstract no.HI012, 2004.
26.
Orrell C, Bangsberg DR, Badri M, et al.: Adherence
is not a barrier to successful antiretroviral therapy in South Africa. AIDS
2003, 17:1369-1375.
27.
Omes C et al. (2004). Adherence to antiretroviral
(ARV) therapy among advanced‐stage, indigent patients in the funded ESTHER
programme in Kigali, Rwanda. XV International AIDS Conference. Bangkok,
Thailand. 30 March ‐ 2 April 2004. Abstract no. B12315.
28.
Predictors of adherence to antiretroviral therapy
among people living with HIV/AIDS in resource-limited setting of southwest
Ethiopia Ayele Tiyou1, Tefera Belachew2, Fisehaye Alemseged3 and Sibhatu
Biadgilign3*
29.
Patients Rougemont M, Stoll BE, Elia N, Ngang P:
Antiretroviral treatment adherence and its determinants in Sub-Saharan Africa:
a prospective study at Yaounde Central Hospital, Cameroon.AIDSResTher 2009,
6:21
30.
Rosen, S., and M. P. Fox. "Retention in HIV
Care between Testing and Treatment in Sub-Saharan Africa: A Systematic
Review." PLoS Med 8, no. 7 (2011): e1001056.
31.
The World Bank ' Life expectancy at birth, total
(years) 1998-2002' Accessed 26th June 2013
32.
UNAIDS/WHO: AIDS epidemic
update.2009.UNAIDS/09.36E/JC1700E) ..
33.
UNAIDS/WHO: AIDS epidemic
update.2009.UNAIDS/09.36E/JC1700E) ..
34.
(UNAIDS, 2009, NACA Botswana 2007,)
35.
(UNAIDS, 2012, NACA Botswana 2010,)
36.
Weiser S et al. (2003). Barriers to antiretroviral
adherence for patients living with HIV Infection and AIDS in Botswana. Journal
Acquired Immune Deficiency Syndrome, 34:281–288
37.
Wegner N, Gifford A, Liu H, et al.: Patient
characteristics and attitudes associated with antiretroviral adherence.
38.
WHO (2006, August) 'HIV treatment access reaches
over 1 million in sub-Saharan Africa, WHO reports'
39.
Worley SB et al. Development of a system for
identifying and tracking ART Patients to minimize losses to follow-up in
Eastern Cape South Africa. Third South African AIDS Conference, Durban,
Abstract 672, 2007
40.
World Health Organization: Antiretroviral therapy
of HIV infection in infants and children in resource-limited settings: Towards
universal access. Recommendations for a public health approach 2006.